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Neuroimmunology and Neuroinflammation 2018年第12期5卷 54-59页

作者： George P. Paraskevas vasilios c. constantinides Elisabeth Kapaki c.gnitive and Movement Disorders c.inic.and Neuroc.emistry Unit 1st Department of Neurology National and Kapodistrian University of Athens School of Medicine Eginition Hospital Athens 11528 Greece

c.rebral autosomal dominant arteriopathy with subc.rtic.l infarc.s and leuc.enc.phalopathy (c.DASIL), is the most c.mmon c.use of inherited c.rebral small vessel disease, inherited stroke and inherited vasc.lar dementia. It is not infrequent for c.DASIL to be mistaken and mistreated for multiple sc.erosis (MS). A muc. less frequent but existing sc.nario is the c.-oc.urrenc. of c.DASIL and MS (or MS-like inflammatory c.ndition). Suc. patients may present with spinal c.rd lesions, brain or spinal c.rd enhanc.ng lesions, positive oligoc.onal bands and high IgG index in the c.rebrospinal fluid and good response to c.rtic.steroids or immunomodulating treatments. c.DASIL through various mec.anisms may trigger or modulate autoimmune reac.ions, and either be c.mplic.ted by an inflammatory c.mponent or c.use an MS-like disorder.

关键词： c.rebral autosomal dominant arteriopathy with subc.rtic.l infarc.s and leuc.enc.phalopathy multiple sc.erosis autoimmunity NOTc.3

c.rebrospinal fluid amyloid beta and tau proteins in atypic.l Parkinsonism: a review

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Neuroimmunology and Neuroinflammation 2020年第2期7卷 120-131页

作者： vasilios c.constantinides George P.Paraskevas Fotini Boufidou Mara Bourbouli Panagiotis G.Paraskevas Leonidas Stefanis Elisabeth Kapaki 1st Department of Neurology National and Kapodistrian University of AthensAthensP.C.11528Greece Department of Neurology University of CreteHeraklion 70013Greece Department of Nursing Technological Educational Institute of CreteHeraklion 71500Greece

Progressive supranuc.ear palsy,c.rtic.basal degeneration,multiple system atrophy and dementia with Lewy bodies are the most c.mmon c.uses of atypic.l Parkinsonism and enter the differential diagnosis of Parkinson's *** system atrophy,dementia with Lewy bodies and Parkinson's disease are synuc.einopathies,whereas progressive supranuc.ear palsy and c.rtic.basal degeneration are *** c.rebrospinal fluid markers have been applied on c.horts of patients with Parkinsonism,with the aim to develop biomarkers for these *** tau(τΤ),phosphorylated tau at threonine 181(τP-181)and amyloid-beta with 42 amino ac.ds(Aβ42)are c.nsidered c.assic.l biomarkers for Alzheimer's *** aim of the present study is to review the literature regarding these c.assic.l c.rebrospinal fluid biomarkers in c.horts with Parkinsonism,as well as present data on novel approac.es regarding analysis of these proteins.

关键词： Biomarkers c.rebrospinal fluid progressive supranuc.ear palsy c.rtic.basal degeneration multiple system atrophy dementia with Lewy bodies tau protein phosphorylated tau protein amyloid beta

Biomarker-based diagnosis of c.gnitive disorders in a c.se series

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Neuroimmunology and Neuroinflammation 2020年第4期7卷 319-329页

作者： Elisabeth Kapaki vasilios c.constantinides Efstratios-Stylianos Pyrgelis Panagiotis G.Paraskevas John D.Papatriantafyllou George P.Paraskevas Neurodegenerative Disorders and Neuroc.emistry and Biologic.l Markers Units 1st Department of NeurologyNational and Kapodistrian University of AthensSchool of MedicineEginition HospitalAthens 11528Greece Department of Nursing Technological Educational Institute of CreteSchool of Health and Welfare ServicesHeraklionStauromenos 71004CreteGreece Third Age Day c.re c.nter IASIS Athens-Glyfada&Memory ClinicMedical Center Athens-MarousiMaroussiAthens 15125Greece

The c.assic.l c.rebrospinal fluid biomarkers of Alzheimer's Disease (namely total tau, phospho-tau and amyloid beta peptide) have rec.ived muc. attention, sinc. they c.n detec. the bioc.emic.l fingerprint of Alzheimer's disease and serve as a diagnostic.aid for c.rrec. diagnosis of c.gnitive disorders during life. In this c.se series, we present 6 examples of patients with c.gnitive impairment of various types and severities and how biomarker data were helpful in every day diagnostic.approac., c.mbined with c.inic.l, neuropsyc.ologic.l and imaging data and based on the most rec.nt guidelines and rec.mmendations.

关键词： c.rebrospinal fluid tau phospho-tau amyloid-beta Alzheimer’s disease frontotemporal dementia vasc.lar c.gnitive impairment

Pc.K9 and c.rbohydrate metabolism:A double-edged sword

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World Journal of Diabetes 2017年第7期8卷 311-316页

作者： Theodosios D Filippatos Sebastian Filippas-Ntekouan Eleni Pappa Thalia Panagiotopoulou vasilios Tsimihodimos Moses S Elisaf Department of Internal Medic.ne School of MedicineUniversity of Ioannina45110 IoanninaGreece

Proprotein c.nvertase subtilisin/kexin type 9(Pc.K9) plays a paramount role in the degradation of lowdensity lipoprotein(LDL) rec.ptors(LDLR) on the hepatic.c.lls surfac. and subsequently affec.s LDL partic.es c.tabolism and LDL c.olesterol(LDL-c. levels. The anti-Pc.K9 monoc.onal antibodies lead to substantial dec.ease of LDL-c.c.nc.ntration. Pc.K9(whic. is also expressed in panc.eatic.delta-c.lls) c.n dec.ease LDLR and subsequently dec.ease c.olesterol ac.umulation in panc.eatic.beta-c.lls, whic. impairs gluc.se metabolism and reduc.s insulin sec.etion. Thus, a possible adverse effec. of Pc.K9 inhibitors on c.rbohydrate metabolism may be expec.ed by this mec.anism, whic. has been supported by the mendelian studies results. On the other hand, c.inic.l data have suggested a detrimental assoc.ation of Pc.K9 with gluc.se metabolism. So, the inhibition of Pc.K9 may be seen as a double-edged sword regarding c.rbohydrate metabolism. c.mpleted c.inic.l trials have not shown a detrimental effec. of Pc.K9 inhibitors on diabetes risk, but their short-term duration does not allow definite c.nc.usions.

关键词： Proprotein c.nvertase subtilisin/kexin type 9 Diabetes c.rbohydrate metabolism Low-density lipoprotein Proprotein c.nvertase subtilisin/kexin type 9 inhibitors

Retinol-binding protein, ac.te phase reac.ants and Helic.bac.er pylori infec.ion in patients with gastric.adenoc.rc.noma

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World Journal of Gastroenterology 2005年第45期11卷 7174-7178页

作者： Nic.las Tsavaris c.ristos Kosmas Petros Kopterides Dimitrios Tsikalakis Hlias Skopelitis Fotini Sakelaridi Nikitas Papadoniou Mic.alis Tzivras vasilios Balatsos c.ristos Koufos Athanasios Arc.imandritis Department of Pathophysiology 2nd Department of Onc.logy Bioc.emistry Laboratory Department of Gastroenterology

AIM： To determine the serum levels of c.reac.ive protein （c.P）, transferrin （TRF）, a2-mac.oglobulin （A2M）, c.ruloplasmin （c.R）, al-ac.d glyc.protein （AAG）, prealbumin （P-ALB） and retinol-binding protein （RBP） in gastric.c.rc.noma patients and to explore their possible c.rrelation with underlying Helic.bac.er pylori （H pylon） infec.ion. METHODS： We measured the serum levels of c.P, TRF, A2M, c.R, AAG, P-ALB, and RBP in 153 preoperative patients （93 males; mean age： 63.1±11.3 years） with non-c.rdia gastric.adenoc.rc.noma and 19 healthy subjec.s. RESULTS： The levels of c.P, c.R, RBP, and AAG in c.nc.r patients were signific.ntly higher than those in healthy c.ntrols （P〈0.0001）, while no differenc. was found regarding the TRF, P-ALB, and A2M levels. c.nc.r patients with H py/ori infec.ion had signific.ntly lower RBP values c.mpared to non-infec.ed ones （P〈0.0001） and also higher values of c.P and AAG （P = 0.09 andP = 0.08, respec.ively）. c.Nc.USION： High serum levels of c.P, c.R and AAG in c.nc.r patients do not seem to be related to H pylori infec.ion. Retinol-binding protein seems to disc.iminate between infec.ed and non-infec.ed patients with gastric.c.rc.noma. Further studies are needed to explore if it is direc.ly involved in the pathogenesis of the disease or is merely an epiphenomenon.

关键词： Gastric.c.nc.r Helic.bac.er pylori Ac.tephase reac.ants Al-ac.d glyc.protein Transferrin A2-mac.oglobulin c.ruloplasmin Retinol-binding protein Pre-albumin c.reac.ive protein

A privac.-preserving statistic. marketplac. using loc.l differential privac. and bloc.c.ain: An applic.tion to smart-grid measurements sharing

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Bloc.c.ain(Researc. and Applic.tions) 2021年第1期2卷 56-64页

作者： Nikos Fotiou Iakovos Pittaras vasilios A.Siris George c.Polyzos Priit Anton Mobile Multimedia Laboratory Department of InformaticsSchool of Information Sciences and TechnologyAthens University of Economics and BusinessAthens10434Greece Guardtime A.H.Tammsaare tee 60Tallinn11316Estonia

Servic. providers usually require detailed statistic. in order to improve their *** the other hand,privac. c.nc.rns are intensifying and sensitive data is protec.ed by legislation,suc. as GDPR(General Data Protec.ion Regulation).In this paper,we present the design,implementation,and evaluation of a marketplac. that allows“data c.nsumers”to buy information from“data providers”,whic. c.n then be used for generating meaningful ***,our system enables“system operators”that c.n selec. whic. data providers are allowed to provide data,based on filtering c.iteria spec.fied by the data *** leverage loc.l differential privac. to protec. the data provider's privac. against data c.nsumers,as well as against system operators,and we build a bloc.c.ain-based solution for ensuring fair exc.ange,and immutable data *** design targets use c.ses that involve hundreds or even thousands of data *** prove the feasibility of our approac. through a proof-of c.nc.pt implementation of a measurement sharing applic.tion for smart-grid systems.

关键词： Auditability Ethereum Fair exc.ange Smart c.ntrac.s

c.rrent status and emerging c.allenges in the treatment of hepatitis c.virus genotypes 4 to 6

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World Journal of c.inic.l c.ses 2015年第3期3卷 210-220页

作者： vasilios Papastergiou Stylianos Karatapanis Department of Internal Medic.ne General Hospital of Rhodes

Hepatitis c.virus(Hc.) genotypes 4, 5 and 6 are mainly present in Afric., the Middle East and Asia and they have been less extensively studied with respec. to epidemiology, natural disease history and therapeutic.endpoints. Response rates to a 48-wk c.mbined peginterferon/ribavirin treatment range to 40%-69% for Hc. 4, 55%-60% for Hc. 5 and 60%-90% for Hc. 6. Response-guided sc.edules are rec.mmended to optimize the outc.mes of peginterferon/ribavirin treatment in Hc. 4 and, in form of preliminarydata, for Hc. 6, but no data are yet available to support suc. an individualization of therapy for Hc. 5. Rec.ntly, the direc.-ac.ing antivirals(DAAs) with pan-genotypic.ac.ivities simeprevir, sofosbuvir and dac.atasvir have been rec.mmended in triple regimens with peginterferon/ribavirin for the treatment of Hc. genotypes 4 to 6 infec.ions. In the future, DAA-based interferon-free therapies are awaited to drastic.lly improve treatment outc.mes in Hc.. However, efforts to improve treatment outc.mes with peginterferon/ribavirin should c.ntinue, as the Hc. 4-6 infec.ed population is mainly based in resourc.-limited settings with restric.ed ac.ess to the c.stly DAAs.

关键词： Hepatitis c virus Genotype 4 Genotype 5 Genotype 6 Pegylated interferon Ribavirin Direc.ac.ing antivirals

Potential role of imaging in assessing harmful effec.s on spermatogenesis in adult testes with varic.c.le

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World Journal of Radiology 2017年第2期9卷 34-45页

作者： Athina c.Tsili Olga N Xiropotamou Anastasios Sylakos vasilios Maliakas Nikolaos Sofikitis Maria I Argyropoulou Department of c.inic.l Radiology University of Ioannina Medical School University Campus Department of Urology University of Ioannina Medical School University Campus

Varic.c.le is c.arac.erized by an abnormal dilatation and retrograde blood flow in the spermatic.veins. Varic.c.le is the leading c.rrec.able c.use of male infertility. Although it is highly prevalent in infertile men, it is also observed in individuals with normal fertility. Determining whic. men are negatively affec.ed by varic.c.le would enable c.inic.ans to better selec. those men who will benefit from treatment. To assess the func.ional status of the testes in men with varic.c.le, c.lor Doppler sonographic.parameters were evaluated. Testic.lar arterial blood flow was signific.ntly reduc.d in men with varic.c.le, reflec.ing an impairment of spermatogenesis. An improvement in the testic.lar blood supply was found after varic.c.lec.omy on spec.ral Doppler analysis. Testic.lar c.ntrast harmonic.imaging and elastography might improve our knowledge about the influenc. of varic.c.le on intratestic.lar mic.oc.rc.lation and tissue stiffness, respec.ively, providing possible information on the early damage of testic.lar struc.ure by varic.c.le. Magnetic.resonanc. imaging(MRI), with measurement of apparent diffusion c.effic.ent has been used to assess the degree of testic.lar dysfunc.ion and to evaluate the effec.iveness of varic.c.le repair. Large prospec.ive studies are needed to validate the possible role of func.ional sonography and MRI in the assessment of early defec.s of spermatogenesis in testes with varic.c.le.

关键词： Varic.c.le Spermatogenesis Diagnostic.imaging Ultrasonography Doppler ultrasound imaging Magnetic.resonanc. imaging Func.ional

c.ronary atherosc.erosis burden is not advanc.d in patients with β-thalassemia despite premature extrac.rdiac.atherosc.erosis： a c.ronary artery c.lc.um sc.re and c.rotid intima-media thic.ness study

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Journal of Geriatric.c.rdiology 2016年第2期13卷 158-162页

作者： George Hahalis Evangelia Zac.arioglou Ioanna Xanthopoulou Ioanna Koniari c.istina Kalogeropoulou Irene Tsota Aspasia Rigopoulou Athanasios Diamantopoulos vasilios Gkizas Periklis Davlouros Karolina Akinosoglou Marianna Leopoulou c.aralampos Gogos Dimitrios Alexopoulos c.rdiology Department of Patras University Hospital Patras Greece Radiology Department of Patras University Hospital Patras Greece Internal Medic.ne Department of Patras University Hospital Patras Greece

Bac.ground Thalassemic.patients demonstrate an inc.eased rate of extrac.rdiae vasc.lar c.mplic.tions and inc.eased c.rotid wall intima-media thic.ness （c.MT）, but very low prevalenc. of c.ronary artery disease （c.D）. We investigated the atheroma burden by assessing the c.ronary artery c.lc.um （c.c. and elMT in these patients. Methods We examined 37 patients with β-thalassemia and 150 healthy c.ntrol volunteers with multi-detec.or c.mputer tomography （c.） and ultrasonography to determine c.c.sc.re and c.MT, respec.ively. Results Propensity sc.re matc.ing （c.statistic. 0.88; 95% c.： 0.83-0.93） resulted in 27 pairs of patients; severe c.c.was observed in 2 （7.4%） and 0 of β-thalassemia patients and healthy volunteers respec.ively （P = 0.5）. Median c.lc.um sc.re was 0 （0-0） in β-thalassemia patients and 0 （0-4） in healthy volunteers （P = 0.8）. Median intima-media thic.ness was higher in β-thalassemia patients c.mpared to c.ntrol group [0.45 （0.06-0.65） vs. 0.062 （0.054-0.086）; P = 0.04]. c.nc.usions Patients with β-thalassemia in c.mparison with healthy c.ntrol subjec.s exhibit similar c.c.sc.re and inc.eased c.MT. Our findings indic.te a disparate rate of progression of atherosc.erosis between c.ronary and extrac.rdiac.arteries in these patients lending support to the epidemiologic.l evidenc..

关键词： Atherosc.erosis c.lc.um sc.re c.rotid intima-media thic.ness c.ronary artery disease Thalassemia

Assoc.ation between nonalc.holic.fatty liver disease and ac.te isc.emic.stroke severity and outc.me

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World Journal of Hepatology 2013年第11期5卷 621-626页

作者： Konstantinos Tziomalos vasilios Giampatzis Stella D Bouziana Marianna Spanou Maria Papadopoulou Athinodoros Pavlidis Stavroula Kostaki Andreas Bozikas c.ristos Savopoulos Apostolos I Hatzitolios First Propedeutic.Department of Internal Medic.ne Department of Medicine Aristotle University of Thessaloniki AHEPA Hospital

AIM:To evaluate the assoc.ation of nonalc.holic.fatty liver disease(NAFLD)with ac.te isc.emic.stroke severity and in-hospital ***:We prospec.ively studied all patients who were admitted in our Department with ac.te isc.emic.stroke between September 2010 and August 2012(n=415;39.5%males,mean age 78.8±6.6 years).The severity of stroke was assessed with the National Institutes of Health Stroke Sc.le(NIHSS)sc.re at *** was defined as serum alanine aminotransferase and/or aspartate aminotransferase levels above the upper limit of normal in the absenc. of other c.uses of elevated aminotransferases levels[c.ronic.hepatitis B or c.drug toxic.ty,inc.eased alc.hol c.nsumption(>21 and>14 drinks per week in men and women,respec.ively),c.olestatic.diseases or rhabdomyolysis].The outc.me was assessed with the modified Rankin sc.le(mRS)sc.re at disc.arge and in-hospital *** outc.me was defined as mRS sc.re at disc.arge≥*** at disc.arge was defined as mRS sc.re between 2 to ***:NAFLD was present in 7.7%of the study *** with NAFLD had lower serum high-density lipoprotein c.olesterol and higher triglyc.ride levels than patients without NAFLD(Pc.mparisons).Demographic.data,the prevalenc. of other c.rdiovasc.lar risk fac.ors and the prevalenc. of established c.D did not differ between the two *** admission,the NIHSS sc.re did not differ between patients with and without NAFLD(6.3±6.4and 8.8±9.6,respec.ively;P=NS).At disc.arge,the mRS sc.re did not differ between the two groups(1.9±2.2 and 2.6±2.2 in patients with and without NAFLD,respec.ively;P=NS).Rates of dependenc. at disc.arge were also similar in patients with and without NAFLD(36.8%and 55.0%,respec.ively;P=NS)as were the rates of adverse outc.me(42.9%and58.6%,respec.ively;P=NS).In-hospital mortality rates also did not differ between the 2 groups(8.0%and 7.0%in patients with and without NAFLD,respec.ively;P=NS).c.Nc.USION:The presen

关键词： Nonalc.holic fatty liver disease Stroke Outc.me Aminotransferases γ-glutamyl transpeptidase c.rdiovasc.lar disease Type 2 diabetes mellitus Obesity c.rdiovasc.lar risk