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Septic cardiomyopathy phenotype in the critically ill may depend on antimicrobial resistance

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Journal of Intensive Medicine 2024年第3期4卷 355-361页

作者： vasiliki tsolaki Kyriaki Parisi George E.Zakynthinos Efrosini Gerovasileiou Nikitas Karavidas Vassileios Vazgiourakis Epaminondas Zakynthinos Demosthenes Makris Intensive Care Unit University Hospital of LarissaUniversity of Thessaly Faculty of MedicineLarissaGreece Third Cardiology Clinic University of AthensSotiria HospitalAthensGreece Respiratory Department University Hospital of LarissaUniversity of Thessaly Faculty of MedicineLarissaGreece

Background Sepsis is a life-threatening organ dysfunction,and septic cardiomyopathy(SCM)may complicate the course of the *** with multidrug-resistant(MDR)pathogens has been linked with worse *** study aims to evaluate SCM in patients with infections caused by different antimicrobial-resistant *** This retrospective study included patients with sepsis/septic shock,hospitalized,and intubated in the intensive care unit of the University Hospital of Larissa between January 2022 and September 2023 with echocardiographic data during the first two days after infection *** patients were divided into two groups:non-MDR-SCM group and MDR-SCM *** cardiac function was compared between the two *** A total of 62 patients were included in the ***-four patients comprised the MDR-SCM and 18 the non-MDR-SCM ***-six patients(41.9%)presented with left ventricular(LV)systolic dysfunction,and≤35%right ventricular fractional area change(RVFAC)was present in 56.4%.LV systolic function was more severely impaired in the non-MDR-SCM group(left ventricular ejection fraction,35.8%±4.9%vs.45.6%±2.4%,P=0.049;LV outflow tract velocity time integral,[10.1±1.4]cm vs.[15.3±0.74]cm,P=0.001;LV-Strain,–9.02%±0.9%vs.–14.02%±0.7%,P=0.001).The MDR-SCM group presented with more severe right ventricular(RV)dilatation(right ventricular end-diastolic area/left ventricular end-diastolic area,0.81±0.03 vs.0.7±0.05,P=0.042)and worse RV systolic function(RVFAC,32.3%±1.9%vs.39.6%±2.7%,P=0.035;tricuspid annular plane systolic excursion,[15.9±0.9]mm vs.[18.1±0.9]mm,P=0.165;systolic tissue Doppler velocity measured at the lateral tricuspid annulus,[9.9±0.5]cm/s vs.[13.1±0.8]cm/s,P=0.002;RV-strain,–11.1%±0.7%vs.–15.1%±0.9%,P=0.002).Conclusion SCM related to MDR infection presents with RV systolic dysfunction predominance,while non-MDR-SCM is mainly depicted with LV systolic dysfunction impairment.

关键词： Septic cardiomyopathy Multidrug-resistant pathogen Left ventricular failure Right ventricular dysfunction Left/right ventricular longitudinal strain Ventriculoarterial Coupling

Radial and longitudinal density variations in Abies cephalonica and Pinus halepensis

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Journal of Forestry Research 2023年第3期34卷 853-863页

作者： vasiliki Dimou Anna Tsaliki Kyriaki Kitikidou Laboratory of Forest Technology Department of Forestry and Management of the Environment and Natural ResourcesDemocritus University of Thrace193 Pandazidou68200 OrestiadaPCGreece Laboratory of Forest Biometry-Biostatistics Department of Forestry and Management of the Environment and Natural ResourcesDemocritus University of Thrace193 Pandazidou68200 OrestiadaPCGreece

Basic wood density is an excellent indicator of quality,it is correlated with numerous physical,physiological and mechanical characteristics of a species and is a good descriptor of wood quality and important indicator of tree performance in community *** accurate method is thus needed to estimate wood *** standard way is to calculate the ratio of the oven-dried mass of a wood sample divided by its green volume,but wood characteristics within and between growth rings are highly variable;the density can vary in the longitudinal and the radial *** present study investigates the longitudinal and radial fl uctuations in the basic density of Abies cephalonica Loud and Pinus halepensis *** logs were cut from four diff erent trees for each species and 16 discs were formed(two discs from each log,one at the base and one at the top).Each disc was cut into cubes where their distance from the pith was measured and then sorted into 2 cm wide concentric *** results revealed a mild decreasing trend in basic density from the foot of the trunk upward for both *** pith in both species also seems to have a relatively high density,which in the immediate next growth rings decreases only to resume increasing toward the bark.

关键词： Aleppo pine Physical properties Specifi c gravity Wood quality

Evaluation of the post-fire erosion and flood control works in the area of Cassandra(Chalkidiki, North Greece)

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Journal of Forestry Research 2015年第1期26卷 209-217页

作者： Kastridis Aristeidis Kamperidou vasiliki Laboratory of Mountainous Water Management Control Faculty of Forestry and Natural EnvironmentAristotle University of Thessaloniki Laboratory of Wood Products and Furniture Technology Faculty of Forestry and Natural Environment Aristotle University of Thessaloniki

We quantified morphological and hydrographical characteristics of two drainage basins（Chanioti and N. Skioni） on Cassandra peninsula of Chalkidiki（North Greece）, and evaluated the effectiveness of post-fire flood and erosion control works. The drainage basins were chosen because of their severe damage by fire, post-fire potential for erosion and flood due to the steep relief, and the importance of the area for residential and tourism development. The first measures taken in the area after the fire were salvage cutting of burned trees, a total ban on grazing, and construction of three types of works, log erosion barriers（LEBs）, log check dams and contour branch barriers. Almost all necessary post-fire works were completed in both catchments but many construction failures were recorded. Approximately 75 % of the LEBs and45 % of the contour branch barriers functioned properly,while the remainder failed. Nearly 80 % of the log dams were sedimented to 0–20 % of the dam height, 14.3 %were 20–40 % filled and 5.9 % collapsed. Despite these failures, peak discharge declined by 10.5 % in Chanioti and 20.4 % in N. Skioni catchment. The main reasons for works failures were the rush of construction and the limited supervision of workers, which resulted in floods during the years that followed.

关键词： Erosion Catchment Contour branch barrier Flood Log erosion barrier Post-fire management

The non-coding RNA SVALKA locus produces a cis-natural antisense transcript that negatively regulates the expression of CBF1 and biomass production at normal temperatures

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Plant Communications 2023年第4期4卷 77-87页

作者： vasiliki Zacharaki Shiv Kumar Meena Peter Kindgren UmeåPlant Science Centre Department of Forest Genetics and Plant PhysiologySwedish University of Agricultural Sciences90187 Umea°Sweden

Non-coding transcription is present in all eukaryotic genomes,but we lack fundamental knowledge about its importance for an organism’s ability to develop *** plants,emerging evidence highlights the essential biological role of non-coding transcription in the regulation of coding ***,we have few molecular insights into this ***,we show that a long isoform of the long noncoding RNA SVALKA-L(SVK-L)forms a natural antisense transcript to the host gene CBF1 and negatively regulates CBF1 mRNA levels at normal temperatures in the model plant Arabidopsis ***,we show detailed evidence for the specific mode of action of *** pathway includes the formation of double-stranded RNA that is recognized by the DICER proteins and subsequent downregulation of CBF1 mRNA ***,the CBF1-SVK regulatory circuit is not only important for its previously known role in cold temperature acclimation but also for biomass production at normal *** study characterizes the developmental role of SVK-L and offers mechanistic insight into how biologically important overlapping natural antisense transcripts can act on and fine-tune the steady-state levels of their host gene’s mRNA.

关键词： SVALKA cis-natural antisense transcript non-coding transcription CBF1 Arabidopsis

Response of colour and hygroscopic properties of Scots pine wood to thermal treatment

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Journal of Forestry Research 2013年第3期24卷 571-575页

作者： vasiliki Kamperidou Ioannis Barboutis Vasileios Vasileiou Aristotle University of Thessaloniki Faculty of Forestry and Natural Environment Laboratory of Wood Products and Furniture Technology54124 Thessaloniki Greece

The effect of heat treatment on the surface colour and hygro- scopic properties of pine wood were investigated in this study. Boards of Scots pine wood （Pinus sylvestris L.） were subjected to thermal treatment at 200℃, for 4, 6, and 8 h. The change of equilibrium moisture content and density values of the specimens in order to facilitate the understand- ing of the treated material behavior. The colour parameters L＊ a＊ and b＊, used to depict the total colour change （dE） of wood surface, were shown to change proportionally to the treatment intensity. Moreover, swelling in the tangential and radial directions and absorption of the specimens ap- peared to be enhanced in great extent by the thermal treatment process. The mean value of swelling percentage in the tangential direction de- creased 10.26%, 17.22%, and 19.60% for specimens treated for 4, 6, and 8 h, respectively, referring to the final measurement after 72 h of immer- sion. In radial direction, mean value of swelling percentage decreased 19.56%, 32.75%, and 34.65% for treated for 4, 6 and 8 h, respectively, after 72 h immersion, which attests the decrease in swelling and im- provement in the hygroscopic behavior of Scots pine wood.

关键词： Colour Hygroscopic properties Modification Thermaltreatment Scots pine

Stem cell-derived three-dimensional (organoid) models of Alzheimer's disease: a precision medicine approach

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Neural Regeneration Research 2021年第8期16卷 1546-1547页

作者： Sujung Jun Kim Jiaxin Li vasiliki Mahairaki Department of Neurology Johns Hopkins School of MedicineBaltimoreMDUSA Department of Ophthalmology Wilmer Eye InstituteJohns Hopkins University School of MedicineBaltimoreMDUSA The Richman Family Precision Medicine Center of Excellence in Alzheimer’s Disease Johns Hopkins Medicine and Johns Hopkins Bayview Medical CenterBaltimoreMDUSA

The major challenges of the "brain disorders" field-dementia,schizophrenia,other neuropsychiatric disorders-are that these are defined by clinical phenotypes whose underlying biology is poorly *** is great variability in definition,prognosis,trajectory,and treatment response indicating that the next step is defining subgroups by combining clinical and biologic information at the level of the *** challenges are especially relevant and urgent in the case of dementia and related disorders.

关键词： clinical Alzheimer prognosis

A novel comparison framework for epidemiological strategies applied to age-based restrictions versus horizontal lockdowns

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Infectious Disease Modelling 2024年第4期9卷 1301-1328页

作者： vasiliki Bitsouni Nikolaos Gialelis Vasilis Tsilidis Department of Mathematics University of PatrasGR-26504Rio PatrasGreece Department of Mathematics National and Kapodistrian University of AthensGR-15784AthensGreece School of Medicine National and Kapodistrian University of AthensGR-11527AthensGreece

During an epidemic,such as the COVID-19 pandemic,policy-makers are faced with the decision of implementing effective,yet socioeconomically costly intervention strategies,such as school and workplace closure,physical distancing,*** this study,we propose a rigorous definition of epidemiological *** addition,we develop a scheme for comparing certain epidemiological strategies,with the goal of providing policy-makers with a tool for their systematic ***,we put the suggested scheme to the test by employing an age-based epidemiological compartment model introduced in Bitsouni et al.(2024),coupled with data from the literature,in order to compare the effectiveness of age-based and horizontal *** general,our findings suggest that these two are comparable,mainly at a low or medium level of intensity.

关键词： Epidemiological strategy Comparison scheme Basic reproductive number Horizontal restrictions Aged-based interventions Asymptomatic infectious

Implications of obesity and adiposopathy on respiratory infections;focus on emerging challenges

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World Journal of Clinical Cases 2023年第13期11卷 2925-2933页

作者： Ioannis G Lempesis vasiliki E Georgakopoulou Department of Infectious Diseases-COVID-19 Unit Laiko General HospitalAthens 11527Greece

Obesity is characterized by excessive adipose tissue accumulation,which impacts physiological,metabolic,and immune *** respiratory infections,including bacterial pneumonia,influenza,and coronavirus disease 2019,appear to be linked to unfavorable results in individuals with *** may be attributed to the direct mechanical/physiological effects of excess body fat on the lungs’***,adipose tissue dysfunction is associated with a lowgrade chronic inflammatory status and hyperleptinemia,among other *** have all been linked to immune system dysfunction and weakened immune responses to these infections.A better understanding and clinical awareness of these risk factors are necessary for better disease outcomes.

关键词： COVID-19 Influenza Lung disease Immune system Obesity

Minimum sample size estimates for trials in inflammatory bowel disease:A systematic review of a support resource

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World Journal of Gastroenterology 2021年第43期27卷 7572-7581页

作者： Morris Gordon Svetlana Lakunina vasiliki Sinopoulou Anthony Akobeng Biomedical Evidence Synthesis and Translation to Practice Unit School of MedicinePreston PR17BHUnited Kingdom Division of Gastroenterology Sidra Med and Res CtrDoha 26999Qatar

BACKGROUND Of 25%of randomised controlled trials(RCTs)on interventions for inflammatory bowel disease(IBD)have no power *** To systematically review RCTs reporting interventions for the management of IBD and to produce data for minimum sample sizes that would achieve appropriate power using the actual clinical *** We included RCTs retrieved from Cochrane IBD specialised Trial register and CENTRAL investigating any form of therapy for either induction or maintenance of remission against control,placebo,or no intervention of IBD in patients of any *** relevant data was extracted,and the studies were grouped according to the intervention *** recalculated sample size and the achieved difference,as well as minimum sample sizes needed in the *** A total of 105 trials were *** was a large discrepancy between the estimated figure for the minimal clinically important difference used for the calculations(15%group differences observed vs 30%used for calculation)explaining substantial actual sample size *** minimum sample sizes indicated for future trials based on the 25 years of trial data were calculated and grouped by the *** A third of intervention studies in IBD within the last 25 years are underpowered,with large variations in the calculation of sample *** authors present a sample size estimate resource constructed on the published evidence base for future researchers and key stakeholders within the IBD trial field.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Gastroenterology Statistics Sample size