检索结果-南通市图书馆

Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT1R axis and attenuates cardiac inflammation and apoptosis

引用

Asian Pacific Journal of Tropical Biomedicine 2023年第9期13卷 384-392页

作者： Anitha Roy vasantha mallenahalli neelakantappa Jayashree Ganesan Balakrishnan Ramajayam Asokan Srinivasan Kulandaivel V.V.Sathibabu Uddandrao Sengottuvelu Singaravel Center for Transdisciplinary Research Department of PharmacologySaveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennaiTamil NaduIndia-600077 Department of Pharmacology Kasturba Medical CollegeMangoloreManipal Academy of Higher EducationManipalIndia-5750013 Department of Pharmacology Aarupadai Veedu Medical College&HospitalVinayaka Mission Research FoundationPuducherryIndia-607403 Department of Pharmaceutical Chemistry Nandha College of PharmacyErodeTamilnaduIndia-638052 Department of Biochemistry K.S.Rangasamy College of Arts and Science(Autonomous)TiruchengodeNamakkal DistrictTamilnaduIndia-637215 Department of Pharmacology Nandha College of PharmacyErodeTamil NaduIndia-638052

Objective:To investigate the cardioprotective effect of beta-glucan against isoproterenol-induced cardiotoxicity in rats,and elucidate the underlying ***:Rats were orally pretreated with beta-glucan(40 mg/kg body weight)for 30 d,and isoproterenol(20 mg/100 g body weight)was administered on days 31 and *** effects of beta-glucan on markers of cardiac injury,hemodynamic changes,production of proinflammatory cytokines,and the corresponding mRNA expressions were *** addition,histological analysis was ***:Pretreatment with beta-glucan prevented isoproterenol-induced cardiac injury by preserving the structural and functional integrity of the plasma membrane and attenuating the production of proinflammatory cytokines(NF-κB,TNF-α,IL-6,IL-1β,and IFN-γ)in the ***,beta-glucan significantly downregulated the mRNA expression of ACE,AT1R,TNF-α,IL-6,NF-κB,caspase-3,TLR-4,and Bax,and upregulated Bcl-2 in the *** the same time,pretreatment with beta-glucan alleviated myocardial damage as reflected in a reduction in myonecrosis,edema,and erythrocyte extravasation with almost imperceptible ***:Beta-glucan can protect against isoproterenol-induced cardiotoxicity by attenuating cardiac inflammation and apoptosis and regulating the ACE-AT1R axis,thereby preventing cardiac remodeling.

关键词： Βeta-glucan Isoproterenol Cardiac inflammation Cardiac apoptosis Cardiovascular diseases Heart failure Myocardial infarction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：