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corrosion behavior of Mg-Zn-Zr-RE alloys under physiological environment-Impact on mechanical integrity and biocompatibility

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Journal of Magnesium and Alloys 2022年第6期10卷 1542-1572页

作者： Marwa AbdelGawad chaudhry A.Usman vasanth c.shunmugasamy Ibrahim Karaman Bilal Mansoor Mechanical Engineering Program Texas A&M University at QatarEducation CityDoh1Qatar Department of Mechanical Engineering Texas A&M University3123 TAMUCollege StationTX 77843United States of America Department of Materials Science and Engineering Texas A&M University3003 TAMUCollege StationTX 77843United States of America

Benefits of RE addition on Mg alloys strength and corrosion resistance are widely reported but their effects on biodegradability and biocompatibility are still of *** paper investigates the effect of RE additions on biodegradability of Mg-Zn alloys under simulated physiological *** this context,two commercial Mg-Zn-Zr-RE alloys,namely ZE41 and EZ33,with same RE addition but different concentrations are studied in Hank’s Balanced Salt Solution(HBSS)at 37℃and with pH of ***-loss,hydrogen evolution,real-time insitu drop test,electrochemical impedance spectroscopy(EIS)and potentiodynamic polarization are deployed to study corrosion *** mechanical integrity of both alloys is assessed by mechanical testing post ***,in vitro biocompatibility is evaluated by indirect cytotoxicity tests using NIH3T3 *** reveal that although both alloys showed similar microstructure,size and distribution of precipitates played a significant role on its corrosion *** and open circuit potential results show stable film formation on EZ33,while ZE41 showed passive layer formation followed by its deterioration,over the analyzed time *** real-time drop test,it was shown in ZE41 alloy that both T-phase and Zr-rich precipitates acted as micro cathodes,resulting in an unstable surface *** EZ33,Zr-rich regions did not influence corrosion response,resulting in better corrosion resistance that was corroborated by post-immersion surface morphology *** higher degradation observed in ZE41 alloy resulted in higher drop in flexural and tensile strength compared to EZ33 *** addition,cytotoxicity tests on NIH3T3 cells revealed that cell viability of EZ33 increased with increasing incubation time,contrary to ZE41,owing to its lower biodegradation behavior and despite higher concentrations of *** results show that an increase in RE concentration in EZ33,relative to ZE41,had a positive effect on

关键词： Magnesium alloy corrosion EIS Mechanical integrity cytotoxicity

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In vitro and in vivo study on fine-grained Mg-Zn-RE-Zr alloy as a biodegradeable orthopedic implant produced by friction stir processing

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Bioactive Materials 2023年第10期28卷 448-466页

作者： vasanth c.shunmugasamy Marwa AbdelGawad Muhammad Umar Sohail Talal Ibrahim Talha Khan Thomas Daniel Seers Bilal Mansoor Mechanical Engineering Program Texas A&M University at QatarEducation CityDohaQatar Department of Mechanical Engineering Texas A&M University3123 TAMUCollege StationTX 77843USA Proteomics core Weill Cornell MedicineEducation CityDohaQatar Department of Surgery Division of Orthopedic SurgerySidra MedicineDohaQatar clinical Orthopedic Surgery Weill Cornell MedicineEducation CityDohaQatar Petroleum Engineering Program Texas A&M University at QatarEducation CityDohaQatar Department of Materials Science and Engineering Texas A&M University3003 TAMUCollege StationTX 77843USA

Magnesium alloys containing biocompatible components show tremendous promise for applications as temporary biomedical devices. However, to ensure their safe use as biodegradeable implants, it is essential to control their corrosion rates. In concentrated Mg alloys, a microgalvanic coupling between the α-Mg matrix and secondary precipitates exists which results in increased corrosion rate. To address this challenge, we engineered the microstructure of a biodegradable Mg-Zn-RE-Zr alloy by friction stir processing (FSP), improving its corrosion resistance and mechanical properties simultaneously. The FS processed alloy with refined grains and broken and uniformly distributed secondary precipitates showed a relatively uniform corrosion morphology accompanied with the formation of a stable passive layer on the alloy surface. In vivo corrosion evaluation of the processed alloy in a small animal model showed that the material was well-tolerated with no signs of inflammation or harmful by-products. Remarkably, the processed alloy supported bone until it healed till eight weeks with a low in vivo corrosion rate of 0.7 mm/year. Moreover, we analyzed blood and histology of the critical organs such as liver and kidney, which showed normal functionality and consistent ion and enzyme levels, throughout the 12- week study period. These results demonstrate that the processed Mg-Zn-RE-Zr alloy offers promising potential for osseointegration in bone tissue healing while also exhibiting controlled biodegradability due to its engineered microstructure. The results from the present study will have profound benefit for bone fracture management, particularly in pediatric and elderly patients.

关键词： Biodegradable magnesium Bone healing Friction stir processing Microstructure corrosion resistance

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Relationship of High Sensitivity c-Reactive Protein with cardiovascular, Diabetic, and Hepatic Biomarkers

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International Journal of clinical Medicine 2023年第9期14卷 389-401页

作者： Hari Krishnan Krishnamurthy Swarnkumar Reddy vasanth Jayaraman Karthik Krishna Qi Song Karenah E. Rajasekaran Tianhao Wang Kang Bei John J. Rajasekaran Vibrant Sciences LLc San Carlos CA USA Vibrant America LLc San Carlos CA USA

Biomarkers are early predictors of various disorders, circulating level of c-reactive protein is a sensitive biomarker of systemic inflammation and may also be associated with the development of diabetic, hepatic, and cardiovascular diseases. In the present study, we aimed to investigate the association between circulating levels of high sensitive c-reactive protein (hs-cRP) and various biomarkers for hepatic, diabetic, and cardiovascular health. The retrospective analysis included 438 individuals who were tested for these panels simultaneously at Vibrant America clinical Laboratory. The study population included free-living individuals without any preexisting clinical conditions. Among the cardiovascular markers, a positive correlation and significant association was found between high levels of hs-cRP and serum levels of triglycerides (r = 0.0964, p −0.1423, p −0.1216, p circulating levels of hs-cRP. Among all the diabetic markers, glucose (r = 0.1547, p cated serum protein (r = 0.1725, p correlated with circulating hs-cRP. In the hepatic panel, AST, a transaminase that plays a vital role in amino acid metabolism, was found to have a strong positive correlation with hs-cRP (r = 0.2139, p conclusion, the results clearly show the association of hs-cRP with diabetic, hepatic, and cardiovascular risk factors indicating its central value as a key marker for several lifestyle-associated disorders.

关键词： High Sensitive c-Reactive Protein Systemic Inflammation cardiovascular Disorders Diabetes Triglycerides

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Relationship of High Sensitivity c-Reactive Protein with cardiovascular,Diabetic, and Hepatic Biomarkers

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International Journal of clinical Medicine（临床医学国际期刊） 2023年第9期

作者： Hari Krishnan Krishnamurthy Swarnkumar Reddy vasanth Jayaraman Karthik Krishna Qi Song Karenah E.Rajasekaran Tianhao Wang Kang Bei John J.Rajasekaran

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