检索结果-南通市图书馆

Histotype-based prognostic classification of gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第9期18卷 896-904页

作者： Anna Maria Chiaravalli Catherine Klersy Alessandro vanoli Andrea Ferretti Carlo Capella Enrico Solcia Department of Human Morphology and Centro Insubre di Biotecnologie per la Salute Umana University of Insubria and Ospedale di Circolo Unit of Biometry and Clinical Epidemiology Fondazione IRCCS Policlinico San Matteo Department of Human Pathology University of Pavia and Fondazione IRCCS Policlinico San Matteo

AIM： To test the efficiency of a recently proposed his- totype-based grading system in a consecutive series of gastric cancers.

关键词： Gastric cancer High-grade histotype Low-grade histotype Lymphoid response Epstein-Barr vi-rus Microsatellite instability

Conservative approach to the acute management of a large mesenteric cyst

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2017年第9期5卷 360-363页

作者： Billy C Leung Ruth Sankey Matteo fronza Mohamed Maatouk Department of General and Colorectal Surgery Milton Keynes HospitalEaglestone

Mesenteric cysts are rare, benign gastrointestinal cystic lesions, which are often non-troublesome and present as an incidental radiological finding. However, surgery is often performed in the acute setting to remove lesions that are symptomatic. This report highlights the case of a large, symptomatic mesenteric cyst managed successfully with initial conservative measures followed by planned elective surgery. A 44-year-old female presented with a four-day history of generalised abdominal pain associated with distension, fever, diarrhoea and vomiting. Computer tomography revealed a large(21.7 cm × 11.8 cm × 14 cm) mesenteric cyst within the left abdomen cavity. She was admitted and treated conservatively with intravenous fluids and antibiotics for four days, which lead to complete symptom resolution. Follow-up at intervals of one and three months revealed no return of symptoms. An elective laparotomy and excision of the mesenteric cyst was then scheduled and performed safely at nine months after the initial presentation. Compared to acute surgery, acute conservative management followed by planned elective resection of a symptomatic mesenteric cyst may prove safer. The withholding of an immediate operation may potentially avoid unnecessary operative risk and should be considered in patients without obstructive and peritonitic symptoms. Our case demonstrated the safe use of initial conservative management followed by planned elective surgery of a mesenteric cyst found in the acute setting, which was symptomatic but was not obstructive or causing peritonitic symptoms.

关键词： Conservative management Acute setting Mesenteric cysts Elective operation

Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease:Need for mucosal viral load measurement

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第6期21卷 1915-1926页

作者： Rachele Ciccocioppo Francesca Racca Stefania Paolucci Giulia Campanini Lodovica Pozzi Elena Betti Roberta Riboni Alessandro vanoli Fausto Baldanti Gino Roberto Corazza Centre for the Study and Cure of Inflammatory Bowel Disease Clinica Medica I IRCCS San Matteo Hospital Foundation University of Pavia SS Virologia Molecolare - SC Virologia e Microbiologia Fondazione IRCCS Policlinico San Matteo Servizio di Endoscopia Digestiva Fondazione IRCCS Policlinico San Matteo Servizio di Anatomia Patologica Fondazione IRCCS Policlinico San Matteo

AIM:To evaluate the best diagnostic technique and risk factors of the human Cytomegalovirus(HCMV)and Epstein-Barr virus(EBV)infection in inflammatory bowel disease(IBD).METHODS:A cohort of 40 IBD patients(17 refractory)and 40 controls underwent peripheral blood and endoscopic colonic mucosal sample *** infection was assessed by quantitative real-time polymerase chain reaction and immunohistochemistry,and correlations with clinical and endoscopic indexes of activity,and risk factors were ***:All refractory patients carried detectable levels of HCMV and/or EBV mucosal load as comparedto 13/23(56.5%)non-refractory and 13/40(32.5%)*** median DNA value was significantly higher in refractory(HCMV 286 and EBV 5.440 copies/105cells)than in non-refractory(HCMV 0 and EBV 6copies/105 cells;P<0.05 and<0.001)IBD patients and controls(HCMV and EBV 0 copies/105 cells;P<0.001 for both).Refractory patients showed DNA peak values≥103 copies/105 cells in diseased mucosa in comparison to non-diseased mucosa(P<0.0121 for HCMV and<0.0004 for EBV),while non-refractory patients and controls invariably displayed levels below this threshold,thus allowing us to differentiate viral colitis from mucosal ***,the mucosal load positively correlated with the values found in the peripheral blood,whilst no correlation with the number of positive cells at immunohistochemistry was *** use was identified as a significant risk factor for both HCMV(P=0.018)and EBV(P=0.002)***,a course of specific antiviral therapy with ganciclovir was successful in all refractory patients with HCMV colitis,whilst refractory patients with EBV colitis did not show any improvement despite steroid tapering and discontinuation of the other ***:Viral colitis appeared to contribute to mucosal lesions in refractory IBD,and its correct diagnosis and management require quantitative real-time polymerase chain reaction assay of mucosal specime

关键词： Inflammatory bowel disease quantitative real-time

COVID-19疫苗相关性心肌炎心肌损伤的MRI表现

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2022年第6期45卷 728-729页

作者： M.fronza P.Thavendiranathan V.Chan G.R.Karur J.A.Udell R.M.Wald 郭慧敏

摘要目前缺乏对新型冠状病毒肺炎（COVID-19）疫苗相关性心肌炎病人心肌损伤模式和严重程度的研究。目的探讨接种 COVID-19 疫苗后心肌炎心肌损伤的 MRI 影像特

关键词：

Role of the advanced glycation end products receptor in Crohn's disease inflammation

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第45期19卷 8269-8281页

作者： Rachele Ciccocioppo Alessandro vanoli Catherine Klersy Venerina Imbesi Vincenzo Boccaccio Rachele Manca Elena Betti Giuseppina Cristina Cangemi Elena Strada Roberta Besio Antonio Rossi Colomba Falcone Sandro Ardizzone Paolo Fociani Piergiorgio Danelli Gino Roberto Corazza Department of Internal Medicine Fondazione IRCCS Policlinico San Matteo University of Pavia 27100 Pavia Italy Department of Human Pathology Fondazione IRCCS Policlinico San Matteo University of Pavia 27100 Pavia Italy Biometry and Clinical Epidemiology Unit Fondazione IRCCS Policlinico San Matteo 27100 Pavia Italy Endoscopy Unit Fondazione IRCCS Policlinico San Matteo 27100 Pavia Italy Department of Molecular Medicine University of Pavia 27100 Pavia Italy Center of Research in Molecular Medicine-CIRMC University of Pavia 27100 Pavia Italy IBD Unit Chair and Division of Gastroenterology Luigi Sacco Hospital University of Milan 20157 Milan Italy Department of Pathology Luigi Sacco HospitalUniversity of Milan 20157 Milan Italy Department of Surgery Luigi Sacco Hospital University of Milan 20157 Milan Italy

AIM:To investigate the level of mucosal expression and the involvement of the receptor for the advanced glycation end products(RAGE)in delayed apoptosis and tumor necrosis factor(TNF)-αproduction in Crohn’s disease(CD).METHODS:Surgical and endoscopic specimens from both inflamed and non-inflamed areas of the ileum and/or colon were collected from 20 and 14 adult CD patients,respectively,and used for the assessment of RAGE expression by means of immunohistochemistry and western blotting *** tissues from 21 control subjects were used for *** same polyclonal anti-human RAGE antibody(R and D System)was used in all experimental *** staining was quantized by a score including both the amount of positive cells and intensity of immunoreactivity;cellular pattern was also *** effects of RAGE blocking on apoptotic rate and TNF-αproduction were investigated on immune cells freshly isolated from CD mucosa and incubated both with and without the muramyl dipeptide used as antigenic *** analysis was performed via the test for trend,with regression models to account for intra-patient correlations.A 2-sided P<0.05 was considered ***:In inflamed areas,RAGE expression in both the epithelial and lamina propria compartments was higher than control tissues(P=0.001 and 0.021,respectively),and a cluster of positive cells were usually found in proximity of ulcerative *** results were obtained in the lamina propria compartment of non-inflamed areas(P=0.025).The pattern of staining was membranous and granular cytosolic at the epithelial level,while in the lamina propria it was diffuse *** evaluating the amount of protein expression by immunoblotting,a significant increase of both surface area and band intensity(P<0.0001 for both)was observed in CD inflamed areas compared to control tissue,while in non-inflamed areas a significant increase was found only for band intensity(P<0.005).Moreover,a si

关键词： Apoptosis Crohn’s disease Chronic inflammation Immunohistochemistry Receptor for advanced glycation end products Tumor necrosis factor-α