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Taming the Fire of Nephrotoxic Botanicals

World Journal of Traditional Chinese Medicine 2019年第3期5卷 151-168页

作者： Francesca Holden vanisha amin Dominic Kuek Jeffrey BKopp Bruce MHendry Qi-He Xu Department of Renal Medicine Centre for Integrative Chinese MedicineSchool of Immunology and Microbial SciencesFaculty of Life Sciences and MedicineKing’s College LondonWestern Education Centre GKT School of Medical Education Faculty of Life Sciences and MedicineKing’s College LondonLondonUnited Kingdom Kidney Disease Section NIDDKNational Institutes of HealthBethesdaMDUSA

Criteria for diagnosing nephropathy and urothelial neoplasms induced by botanicals containing aristolochic acids(AAs) are well established. Highlights of recent research on AAs include mechanisms of AA intrarenal transport and metabolism and vigorous debate on whether AAs may also cause liver cancers. Many other botanicals may also cause renal injury, but a generalized framework for diagnosing botanical-induced kidney injury(BIKI) is lacking. Based on what we have learnt about the wide spectrum of phenotypes of BIKI attributed to AAs and a recently published standardized phenotypic framework of drug-induced kidney disease, we propose that BIKI may be categorized into six phenotypes(acute kidney injury, tubular dysfunction, glomerular disorders, nephrolithiasis, chronic kidney disease, and neoplasms) and four mechanistic types(A, predictable;B, idiosyncratic;C, chronic;and D, delayed). We call for international cooperation assembling a task force to develop, refine, and regularly appraise an online BIKI database, documenting botanical use, phenotypes, mechanisms, and levels of evidence. Once established, such a database may be linked with electronic patient records and pharmacovigilance channels to generate alerts, guide clinical decision-making, direct future research, and support evidence-based regulation of herbal medicines and education of healthcare professionals and the public. Finally, to prevent BIKI, we propose that a proactive approach integrating the triad of botanicals, users, and stakeholders will be needed.

关键词： Adverse effects database herbal kidney mechanisms phenotypes prevention

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Performance evaluation of laterite soil embankment stabilized with bottom ash,coir fiber,and lime

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Journal of Mountain Science 2024年第7期21卷 2334-2351页

作者： Yunusa Hamdanu SANI amin EISAZADEH School of Civil Engineering and Technology Sirindhorn International Institute of TechnologyThammasat UniversityPathum Thani 12120Thailand

In tropical regions,heavy rainfall induces erosion and shallow landslides on road ***-based stabilization methods,common in these regions,contribute to climate change due to their high carbon *** study explored the potential application of coir fiber-reinforced laterite soil-bottom ash mixtures as embankment materials in the *** objective is to enhance engineered embankment slopes'erosion resistance and stability while offering reuse options for industrial *** study examined various mix designs for unconfined compressive strength(UCS)and permeability,utilizing 30%bottom ash(BA)and 1%coir fiber(CF)with varying sizes ranging from 10 to 40 mm,6%lime,and laterite soil(LS),followed by microstructural *** results demonstrate that the compressive strength increases as the CF length increases to 25 *** contrast,permeability increases continuously with increasing CF ***-treated mixtures exhibit superior short-and long-term strength and reduce permeability owing to the formation of cementitious materials,as confirmed by microstructural analyses.A lab-scale slope box was constructed to evaluate the surface erosion of the stabilized laterite soil *** on the rainfall simulation results,the LS-BA-CF mixtures show better resistance to erosion and deformation compared to untreated LS,especially when lime is added to the top *** study provides insights into a sustainable and cost-effective approach for slope stabilization using BA and CF,offering a promising solution for tropical regions susceptible to surface erosion and landslides.

关键词： Lateritic soil Bottom ash Coir fiber lime Unconfined compressive strength Permeability FESEM/EDS Rainfall simulation tests

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Analysis and Modeling of Mobile Phone Activity Data Using Interactive Cyber-Physical Social System

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Computers, Materials & Continua 2024年第9期80卷 3507-3521页

作者： Farhan amin Gyu Sang Choi School of Computer Science and Engineering Yeungnam UniversityGyeongsan38541Republic of Korea

Mobile networks possess significant information and thus are considered a gold mine for the researcher’s *** call detail records(CDR)of a mobile network are used to identify the network’s efficacy and the mobile user’s *** is evident from the recent literature that cyber-physical systems(CPS)were used in the analytics and modeling of telecom *** addition,CPS is used to provide valuable services in smart *** general,a typical telecom company hasmillions of subscribers and thus generatesmassive amounts of *** this aspect,data storage,analysis,and processing are the key *** solve these issues,herein we propose a multilevel cyber-physical social system(CPSS)for the analysis and modeling of large internet *** proposed multilevel system has three levels and each level has a specific ***,raw Call Detail Data(CDR)was collected at the first ***,the data preprocessing,cleaning,and error removal operations were *** the second level,data processing,cleaning,reduction,integration,processing,and storage were ***,suggested internet activity record measures were *** proposed system initially constructs a graph and then performs network *** proposed CPSS system accurately identifies different areas of internet peak usage in a city(Milan city).Our research is helpful for the network operators to plan effective network configuration,management,and optimization of resources.

关键词： Cyber-physical social systems big data cyber-physical systems pervasive computing smart city big data management techniques

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Numerical study of flow and thermal characteristics of pulsed impinging jet on a dimpled surface

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Theoretical & Applied Mechanics Letters 2024年第2期14卷 106-117页

作者： amin Bagheri Kazem Esmailpour Morteza Heydari Renewable Energy Research Center Damavand BranchIslamic Azad UniversityDamavandIran

This research comprehensively investigates the flow and thermal characteristics of a pulsating impinging jet over a dimpled *** analyzes the impact of key parameters(e.g.,inlet velocity pulsation functions,pulsation frequency,amplitude,dimple pitch,dimple depth,Reynolds number)on flow patterns and heat *** computational fluid dynamics and the Re-normalization group turbulence model are employed to accurately simulate complex turbulent flow *** and average heat transfer coefficients are calculated and compared to steady impingement cases,revealing the potential benefits of pulsation for heat transfer *** study also examines how pulsation-induced flow modulation and thermal mixing affect heat transfer *** indicate that combining fluctuating flow with a dimpled surface can improve heat transfer *** summary,increasing pulsation amplitude consistently enhances heat transfer,while the effect of frequency varies between impinging and wall jet zones.

关键词： Pulsating impinging jet Dimpled surface Heat transfer enhancement Pulsation frequency and amplitude Coherent structures

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Dual PPAR delta/gamma agonist offer therapeutic potential for Alzheimer's disease

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Neural Regeneration Research 2024年第6期19卷 1175-1176页

作者： Ian Steinke Meenakshi Singh Rajesh amin Department of Drug Discovery and Development Auburn UniversityAuburn AlabamaALUSA

The increasing incidence of Alzheimer's disease(AD)in the aging population,indicates the critical need for the development of novel targeted molecular therapies for ameliorating AD ***,clinical and preclinical evidence demonstrates that peroxisomal proliferator activating receptors(PPAR)agonists regulate energy and lipid homeostasis in models of diabetes,as well as improve spatial memory in animal models of AD(Khan et al.,2019).

关键词： Alzheimer clinical homeostasis

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TFN-FICFM:sEMG-Based Gesture Recognition Using Temporal Fusion Network and Fuzzy Integral-based Classifier Fusion

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Journal of Bionic Engineering 2024年第4期21卷 1878-1891页

作者： Fo Hu Kailun He Mengyuan Qian Mohamed amin Gouda College of Information Engineering Zhejiang University of TechnologyHangzhou310023China Department of Mechanical Engineering and Automation Northeastern UniversityShenyang110819China

Surface electromyography(sEMG)-based gesture recognition is a key technology in the field of human–computer ***,existing gesture recognition methods face challenges in effectively integrating discriminative temporal feature representations from sEMG *** this paper,we propose a deep learning framework named TFN-FICFM comprises a Temporal Fusion Network(TFN)and Fuzzy Integral-Based Classifier Fusion method(FICFM)to improve the accuracy and robustness of gesture ***,we design a TFN module,which utilizes an attention-based recurrent multi-scale convolutional module to acquire multi-level temporal feature representations and achieves deep fusion of temporal features through a feature pyramid ***,the deep-fused temporal features are utilized to generate multiple sets of gesture category prediction confidences through a feedback ***,we employ FICFM to perform fuzzy fusion on prediction confidences,resulting in the ultimate *** study conducts extensive comparisons and ablation studies using the publicly available datasets Ninapro DB2 and *** demonstrate that the TFN-FICFM model outperforms state-of-the-art methods in classification *** research can serve as a benchmark for sEMG-based gesture recognition and related deep learning modeling.

关键词： Gesture recognition sEMG Deep learning Temporal fusion Fuzzy fusion

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Geyser Inspired Algorithm:A New Geological-inspired Meta-heuristic for Real-parameter and Constrained Engineering Optimization

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Journal of Bionic Engineering 2024年第1期21卷 374-408页

作者： Mojtaba Ghasemi Mohsen Zare Amir Zahedi Mohammad-amin Akbari Seyedali Mirjalili Laith Abualigah Department of Electronics and Electrical Engineering Shiraz University of TechnologyShirazIran Department of Electrical Engineering Faculty of EngineeringJahrom UniversityJahromFrasIran Department of Electrical and Computer Engineering Tarbiat Modares UniversityTehranIran Department of Electrical and Computer Engineering University ofCyprusNicosiaCyprus Centre for Artificial Intelligence Research and Optimisation Torrens University AustraliaBrisbaneQLD 4006Australia University Research and Innovation Center Obuda University1034 BudapestHungary Department of Electrical and Computer Engineering Lebanese American UniversityByblos 13-5053Lebanon Hourani Center for Applied Scientific Research Al-Ahliyya Amman UniversityAmman 19328Jordan MEU Research Unit Middle East UniversityAmman 11831Jordan Applied Science Research Center Applied Science Private UniversityAmman 11931Jordan

Over the past years,many efforts have been accomplished to achieve fast and accurate meta-heuristic algorithms to optimize a variety of real-world *** study presents a new optimization method based on an unusual geological phenomenon in nature,named Geyser inspired Algorithm(GEA).The mathematical modeling of this geological phenomenon is carried out to have a better understanding of the optimization *** efficiency and accuracy of GEA are verified using statistical examination and convergence rate comparison on numerous CEC 2005,CEC 2014,CEC 2017,and real-parameter benchmark ***,GEA has been applied to several real-parameter engineering optimization problems to evaluate its *** addition,to demonstrate the applicability and robustness of GEA,a comprehensive investigation is performed for a fair comparison with other standard optimization *** results demonstrate that GEA is noticeably prosperous in reaching the optimal solutions with a high convergence rate in comparison with other well-known nature-inspired algorithms,including ABC,BBO,PSO,and *** that the source code of the GEA is publicly available at https://***/projects/gea.

关键词： Nature-inspired algorithms Real-world and engineering optimization Mathematical modeling Geyser algorithm(GEA)

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Er_(2)TiO_(5)@Ag nanocomposites:Enhanced photocatalysis and bacteria inactivation,and cytotoxicity

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Journal of Rare Earths 2024年第5期42卷 851-858,I0002页

作者： Mehdi Nazeri Hossein Sedaghat Reza Rafiei Mohammad amin Farzin Seyed Mostafa Hosseinpour Mashkani Department of Parasitology and Mycology Kashan University of Medical SciencesKashanIran Department of Microbiology Kashan University of Medical SciencesKashanIran General Medicine Student School of MedicineKashan University of Medical SciencesKashanIran Student Research Committee Kashan University of Medical SciencesKashanIran Institute for Biomedical Materials and Devices School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneyNSW2007Australia

In this study,we successfully synthesized Er_(2)TiO_(5)@Ag nanocomposites(NCPs) using the ultrasonicmediated sol-gel technique to create a multifunctional material with enhanced photocatalytic and antibacterial *** visible light photocatalytic activities of Er_(2)TiO_(5) nanoparticles(NPs) and Er_(2)TiO_(5)@Ag NCPs were systematically evaluated under various conditions,including different concentrations of Basic Blue 41(BB 41) dye and *** results reveal a remarkable improvement in the photocatalytic degradation efficiency of Er_(2)TiO_(5)@Ag NCPs(95%) compared to Er_(2)TiO_(5) NPs(80%).Furthermore,the antibacterial efficacy of Er_(2)TiO_(5) NPs and Er2TiO_5@Ag NCPs were extensively examined against Gram-positive and Gram-negative ***,Er_(2)TiO_(5)@Ag NCPs exhibit significantly higher minimum bactericidal concentration(MBC) values compared to Er_(2)TiO_(5) *** antibacterial effect of Er_(2)TiO_(5)@Ag NCPs is particularly pronounced against *** and Pseudomonas aeruginosa,while demonstrating moderate effects on Escherichia coli and Enterococcus *** assess the biocompatibility of the synthesized materials,we investigated their internalization by MCF-7 ***,both Er_(2)TiO_(5) NPs and Er_(2)TiO_(5)@Ag NCPs are found to be effectively internalized by the cells,suggesting their potential application in biomedical ***,our study unveils the exceptional potential of Er_(2)TiO_(5)@Ag NCPs as a dual-action solution,simultaneously possessing enhanced photocatalytic efficiency and potent antibacterial *** multifunctional nanocomposite not only outperforms Er_(2)TiO_(5) and Ag but also paves the way for innovative applications in sustainable environmental remediation and advanced biomedical technologies,promising a brighter and cleaner future.

关键词： Rare earth catalysis Nanocomposite Er_(2)TiO_(5)@Ag Antibacterial activity Photocatalysis Cytotoxicity

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Electrospun Aloe Vera Extract Loaded Polycaprolactone Scaffold for Biomedical Applications:A Promising Candidate for Corneal Stromal Regeneration

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Journal of Bionic Engineering 2024年第4期21卷 1949-1959页

作者： amin Orash Mahmoud Salehi Mohammad Rafienia Narsimha Mamidi Saeed Heidari Keshel Alireza Baradaran-Rafii Department of Chemistry and Nanotechnology School of Engineering and ScienceTecnologico de MonterreyMonterreyNuevo Leon64849Mexico Biosensor Research Center Isfahan University of Medical SciencesIsfahan81746-73461Iran Wisconsin Center for NanoBioSystems School of PharmacyUniversity of Wisconsin-MadisonMadisonWisconsin53705USA Medical Nanotechnology Research Center Shahid Beheshti University of Medical SciencesTehran19857-17443Iran Department of Ophthalmology Ophthalmic Research CenterLabbafinejad Medical CenterShahid Beheshti University of Medical SciencesTehran19395-4631Iran Department of Ophthalmology Morsani College of MedicineUniversity of South FloridaTampaFL33612USA Department of Tissue Engineering and Applied Cell Science School of Advanced Technologies in MedicineShahid Beheshti University of Medical SciencesTehran19857-17443Iran

Corneal diseases,the second leading cause of global vision loss affecting over 10.5 million people,underscores the unmet demand for corneal tissue *** the scarcity of fresh donor corneas and the associated risks of immune rejection,corneal tissue engineering becomes *** nanofibrous scaffolds that mimic the natural corneal structure is crucial for creating transparent and mechanically robust corneal equivalents in tissue ***,Aloe Vera Extract(AVE)/Polycaprolactone(PCL)nanofibrous scaffolds were primed using *** electrospun AVE/PCL fibers exhibit a smooth,bead-free morphology with a mean diameter of approximately 340±95 nm and appropriate light *** measurements reveal Young’s modulus and ultimate tensile strength values of around 3.34 MPa and 4.58 MPa,respectively,within the range of stromal *** addition,cell viability of AVE/PCL fibers was measured against Human Stromal Keratocyte Cells(HSKCs),and improved cell viability was *** cell-fiber interactions were investigated using scanning electron *** conclusion,the incorporation of Aloe Vera Extract enhances the mechanical,optical,hydrophilic,and biological properties of PCL fibers,positioning PCL/AVE fiber scaffolds as promising candidates for corneal stromal regeneration.

关键词： Corneal stromal regeneration Aloe vera extract Polycaprolactone Electrospinning

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Tuning structural,electrical,dielectric and magnetic properties of Mg-Cu-Co ferrites via dysprosium(Dy^(3+))doping

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Journal of Rare Earths 2024年第1期42卷 137-146,I0005页

作者： Maria Akhtar M.S.Hasan Nasir amin N.A.Morley Muhammad Imran Arshad Department of Physics Government College UniversityFaisalabad38000Pakistan Department of Physics The University of Lahore53700Pakistan Department of Materials Science and Engineering The University of SheffieldS13JDUK Department of Physics&Astronomy University College LondonUK

In current research work,Dy3+substituted Mg0.5Cu0.25Co0.25Fe2-xDyxO4(0.0≤x≤0.04 with the step interval of 0.01)soft ferrites were synthesized by the sol-gel auto combustion *** prepared samples were characterized by the techniques using X-ray diffraction(XRD),scanning electron microscopy(SEM),energy dispersive X-ray spectroscopy(EDS),Fourier transform infrared(FTIR)spectroscopy,curre nt-voltage(Ⅰ-Ⅴ)measurement,LCR meter,vibrating sample magnetometer(VSM)and *** data reveal that the average crystallite size is 49.71 nm and the lattice constant is 0.83703 nm for sample x=*** non-uniform grain growth was demonstrated by micrographs and impurity-free elemental composition was observed from EDX *** DC resistivity has an increasing and decreasing trend in ferromagnetic and paramagnetic regions with an increase in ***,the high resistivity is observed with the order of 1010Ω·cm,and the activation energy is 0.944 eV for samples x=*** dielectric parameters including dielectric constant,dielectric losses,and impedance gradually decrease with the increase in frequency from 8 Hz to 8 *** minimum dielectric loss at high frequency is found for sample x=*** coercivity(Hc)and saturation magnetization(Ms)are found in the ranges of 520.82-544.02 Oe and 20.5841-21.1473 emu/g,*** observations confirm that dysprosium(x=0.03)doped MCC-soft ferrites may be applicable in transformer cores,microwave absorbance,and telecommunication devices.

关键词： Soft ferrites DC resistivity Dielectric loss Impedance Coercivity Rare earths

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