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Artemisia vulgaris Induces Tumor-Selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) Signaling

Chinese Journal of Integrative Medicine 2024年第6期30卷 525-533页

作者： Lucas dos Santos Zamarioli Michele Rosana Maia Santos Adolfo Garcia Erustes vanessa marques meccatti Thais Cristine Pereira Soraya S Smaili Maria Cristina Marcucci Carlos Rocha Oliveira Gustavo JS Pereira Claudia Bincoletto Department of Pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on Phytocomplexes and Cell Signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(MCF-7 and SKBR-3),chronic myeloid leukemia(K562)and NIH/3T3 *** Phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HPLC)*** and cell death studies were performed using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BAPTA-AM)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of MCF-7,SKBR-3 and K562 cells(P<0.05).The viability of HEAV-treated K562 cells was reduced compared to HEAV-exposed fibroblasts(P<0.05).Treatment of K562 cells with HEAV induced cell death primarily by late apoptosis and necrosis in assays using annexin V-FITC/7-AAD(P<0.05).The use of Nec-1 and Fer-1 increased the viability of K562 cells treated with HEAV relative to cells exposed to HEAV alone(P<0.01).HEAV-induced Ca^(2+)release mainly from lysosomes in K562 cells(P<0.01).Furthermore,BAPTA-AM,an intracellular Ca^(2+)chelator,decreased the number of non-viable cells treated with HEAV(P<0.05).Conclusions HEAV is cytotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).These effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

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Genotoxic Effect of Phenol on the Cells of Onion (Allium cepa) Roots

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生态毒理学报 2013年第4期8卷 609-615页

作者： Gisele Pigatto Regildo Marcio Gonalves da Silva Gian Luigi Mariottini vanessa marques de Oliveira Mauri Sergio Alves Palma Attilio Converti Department of Pharmaceutical and Biochemical Technology Universidade de So PauloSao Paulo SP Brasil Department of Civil Chemical and Environmental Engineering University of GenoaGenova Italy Department of Biology Universidade Estadual PaulistaAssis SP Brasil Department of Earth Environment and Life Sciences University of GenoaGenova Italy

The roots of onion (Allium cepa) stand out for having cells with large size and small number of *** characteristics make them useful in bioassays for the measurement of a variety of cytogenetic and morphological parameters , in which they can be used as toxicity indicators of the induction and formation of micronuclei and chromosomal *** on this background , the potential genotoxic effect of phenol concentration on cells of *** was investigated either in terms of induced aberrations or micronuclei *** results demonstrated that the higher the concentration of phenol , the higher the incidence of abnormalities , thus confirming the genotoxicity of this pollutant.

关键词：摘要编辑部编辑工作读者

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Analysis of Forging Dies Coated with Tungsten Carbide through HVOF Processing

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Journal of Mechanics Engineering and Automation 2016年第7期6卷 373-378页

作者： vanessa Moura de Souza Angela Selau marques Jorge Antoenio Huff Alexandre da Silva Rocha Luciano Kempski GES (Group of Engineering Surface) Federated University of Rio Grande do Sul Porto Alegre Brazil

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Major Approaches on the Piezoelectric Device, Drills and Saws to Orthognathic Surgery: A Systematic Review

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Health 2019年第6期11卷 783-791页

作者： Diego César marques vanessa Gabriela Gonzáles Pinto Rogério Luiz de Araújo Vian Regis Manzini Leandro Aparecido Irrazabal Priscilla Janaína de Lima Borelli Bovo Idiberto José Zotarelli Filho Elias Naim Kassis University Center North Paulista (Unorp) S&#227 o José do Rio Preto (SP) Brazil Post Graduate and Continuing Education (Unipos) S&#227 o José do Rio Preto (SP) Brazil Cristo Redentor Hospital Iporá Goáis Brazil Santa Casa de Misericórdia Hospital Servi&#231 o de Cirurgia e Traumatologia Bucomaxilofacial Ribeir&#227 o Preto (SP) Brazil Universida de Federal do Pampa (Unipampa) Campus Uruguaiana (RS) Brazil

Introduction: The incidence of lesions of sensory and motor nerves associated with oral and maxillofacial surgery is often underestimated, representing around 32.0% of all lesions, and orthognathic surgery contributes 12.3% to these lesions. Thus, the use of piezosurgery (PiZCi) has been indicated in several procedures within oral and maxillofacial surgery due to a number of advantages over conventional drill and saw techniques. Objective: to analyze the main literature on the use of the piezoelectric device in relation to the use of drills and to orthognathic surgery in dentistry. Methods: A total of 41 articles were found involving Orthognathic Surgery, Piezoelectric Device, Drills Device, Saws Device, and Efficiency. Initially, it was held the exclusion existing title and duplications following the interest described this work. After this process, the summaries were evaluated, and a new exclusion was held. 29 articles were included and discussed in this study. Initially, the keywords were determined by searching the DeCS tool (Descriptors in Health Sciences, BIREME base) and later verified and validated by MeSh system (Medical Subject Headings, the US National Library of Medicine). Results and conclusion: It was concluded that the piezoelectric device has excelled with an effective surgical technique, being able to be indicated in the most diverse areas of the oral surgery, providing accurate, clean and minimally traumatic osteotomies for the soft tissues, intraoperative bleeding, when compared to conventional surgery using drills and/or saws.

关键词： Orthognathic Surgery Piezoelectric Device Drills Device Saws Device Efficiency

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