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dietary copper triggers onset of fulminant hepatitis in the Long-Evans cinnamon rat model

World Journal of Gastroenterology 2012年第39期18卷 5542-5550页

作者： Ramsi Siaj vanessa Sauer Sandra Stppeler Hans-Ullrich Spiegel Gabriele Khler Andree Zibert Hartmut HJ Schmidt Klinik und Poliklinik für Transplantationsmedizin Universittsklinikum MünsterD-48149 MünsterGermany Abteilung Chirurgische Forschung Klinik und Poliklinik für Allgemein-und ViszeralchirurgieUniversittsklinikum MünsterD-48149 MünsterGermany Gerhard-domagk-Institut für Pathologie Universittsklinikum MünsterD-48149 MünsterGermany

AIM： To investigate the impact of dietary copper given at different time points on the onset of fulminant hepatitis. METHOdS： The Long-Evans cinnamon （LEC） rat mod- el of Wilson＇s disease （Wd） was used to study the im- pact of high dietary copper （hCu） on the induction of fulminant hepatitis at early or late time points of life. High Cu diet was started in rat pups or in adults （month 5） for three months. Animals that received reduced di- etary copper （rCu） throughout their lifetime served as a control. Hepatitis-associated serum markers （alanine aminotransferase, aspartate transaminase, bilirubin） were analyzed in animal groups receiving hCu or rCu. Liver copper content and liver histology were revealed at sacrifice. A set of 5 marker genes previously found to be affected in injured liver and which are related to angiogenesis （Vegfa）, fat metabolism （Srebf1）, ex- tracellular matrix （Timp1）, oxidative stress （Hmox1）, and the cell cycle （Cdknla） were analyzed by real-time polymerase chain reaction. RESULTS： Regardless of the time point when hCu was started, LEC rats （35/36） developed fulminant hepati- tis and died. Animals receiving rCu （36/36） remained healthy, did not develop hepatitis, and survived long term without symptoms of overt disease, although liver copper accumulated in adult animals （477 ± 75 μg/g）. With regard to start of hCu, onset of fulminant hepatitis was significantly （P 〈 0.001） earlier in adults （35±9 d） that showed pre-accumulation of liver copper as com- pared to the pup group （77±15 d）. Hepatitis-associ- ated serum markers, liver copper and liver histology, as well as gene expression, were affected in LEC rats re- ceiving hCu. However, except for early and rapid onset of hepatitis, biochemical and molecular markers were similar at the early and late time points of disease. CONCLUSION： Rapid onset of fulminant hepatitis in asymptomatic LEC rats with elevated liver copper sug- gests that there is a critical threshold of liver copper which is imp

关键词： Wilson's disease Fulminant hepatitis Acuteliver failure dietary copper Long-Evans cinnamon rat A TP7B

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How well are families doing?A description of family well-being in South Africa

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Family Medicine and Community Health 2016年第3期4卷 9-18页

作者： Nicolette vanessa Roman Serena Ann Isaacs Charl davids Xin-Cheng Sui department of Social Work University of the Western CapeBellvilleSouth Africa department of Psychology University of the Western CapeBellvilleSouth Africa

Objective:The purpose of this study was to describe the well-being of a sample of families from low socioeconomic communities in the Western Cape South Africa in terms of family resil-ience,family satisfaction,parenting styles,family structure and family ***:The study used a descriptive survey design and sampled 358 adult family ***:The results indicate that although family functioning is challenged,parents are per-ceived to be using an authoritative parenting style and having a father present enhances family *** results also describe families as displaying low-to-average levels of family ***:This study provides a descriptive study of a sample of families in the Western Cape,South *** the families in this study are not doing very *** implications and significance of these findings are further explained.

关键词： Family functioning family resilience family satisfaction family well-being parenting styles South Africa

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The Euro’s Nemesis

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Beijing Review 2010年第26期53卷 12-14页

作者： vanessa ROSSI the London-based Royal Institute of International Affairs

Greece’s debt crisis underlines the need for tougher and smarter governance for the euro zone Since the news from Greece of an unexpectedly large surge in its government deficit and debt broke at the end of 2009。

关键词： s Nemesis The Euro Greek GdP ESM

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THAT ISN'T PROJECT-BASEd LEARNING

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城市漫步（上海版、英文） 2022年第3期 62-63页

作者： vanessa Jencks 不详

Out of the following scenarios,which is genuinely project-based learning(PBL)?A student must create a website about her favorite aquatic species found within the neighboring waters of *** test different potted vegetab... 详细信息

关键词： favorite learning(PBL) neighboring

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Gender specific medicine in liver diseases:a point of view

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World Journal of Gastroenterology 2014年第9期20卷 2127-2135页

作者： Marilena durazzo Paola Belci Alessandro Collo vanessa Prandi Erika Pistone Maria Martorana Roberto Gambino Simona Bo department of Medical Sciences University of Turin 10126 Turin Italy

Gender medicine focuses on the patho-physiological, clinical, prevention and treatment differences in diseases that are equally represented in men and women. The purpose of gender medicine is to ensure that each individual man and woman receives the best treatment possible based on scientific evidence. The concept of “gender” includes not only the sexual characteristics of individuals but also physiological and psychological attributes of men and women, including risk factors, protective/aggravating effects of sexual hormones and variances linked to genetics and corporal structures that explain biological and physiological differences between men and women. It is very important to consider all the biological, physiological, functional, psychological, social and cultural characteristics to provide patients with individualized disease management. Herein, we critically analyze the literature regarding gender differences for diseases and acquired conditions of the most representative hepatic pathologies: primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis, non alcoholic fatty liver disease and alcoholic liver disease, and viral chronic hepatitis B and C. The last section addresses hemochromatosis, which is a prevalent iron overload disorder in the Caucasian population. This review aims to describe data from the literature concerning viral chronic hepatitis during pregnancy, management during pregnancy and delivery, and new effective drugs for the prevention of maternal infection transmission without significant adverse effects or complications.

关键词： Gender Liver disease Primary biliary cirrhosis Autoimmune hepatitis Viral chronic hepatitis B Viral chronic hepatitis C Non alcoholic fatty liver disease Alcoholic liver disease

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Expat Pregnancy Rights

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城市漫步（上海版、英文） 2022年第3期 64-66页

作者： vanessa Jeneks 不详

A dirty secret in the education industry is the lengths some private schools will go to to avoid fulfilling pregnancy and maternity rights laws・Though these schools claim to be for children,when they fail to provide women with their legal right to maternity leave and benefits,they exemplify that they are only about the bottom line of profits・due to a language barrier,fewer social conn ections and an often inadequate understanding of Chinese Labor Law,inter national female employees are a particularly vulnerable group to such ***'s spoke with *** who have first-ha nd experience of such practices and followed up with a lawyer who told us how to avoid being taken advantage of by such schools.

关键词： legal education schools

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Parenting Tips for Hectic Holidays

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城市漫步（GBA版） 2021年第12期 46-47页

作者： vanessa Jeneks 不详

For roany families,the win ter holiday seas on is the most wonderful time of the year with n cookies,festive decoratio ns and delightfully well-man nered *** n there re some families who simply need to survive・It's enough to make those parents want to burn their trees and block out their calendars until the New Year bounces into spring・Rebecca Archer,certified positive-discipline educator,took scenarios we threw at her and responded with positive principles you can apply for calmer,more cheerful celebrations.

关键词： apply enough simply

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THAT ISN'T PROJECT-BASEd LEARNING Examining School Projects with Kyle Wagner

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城市漫步（GBA版） 2022年第3期 62-63页

作者： vanessa Jencks 不详

Out of the following scenarios,which is genuinely pr oject-based learning(PBL)?A student must create a website about her favorite aquatic species found within the neighboring waters of Hainan.

关键词： favorite learning(PBL) neighboring

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Hepatic structural enhancement and insulin resistance amelioration due to AT1 receptor blockade

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World Journal of Hepatology 2017年第2期9卷 74-79页

作者： vanessa Souza-Mello Biomedical Centre Institute of BiologyDepartment of AnatomyState University of Rio de Janeiro20551-030Brazil

Over the last decade, the role of renin-angiotensin system (RAS) on the development of obesity and its comorbidities has been extensively addressed. Both circulating and local RAS components are up-regulated in obesity and involved in non-alcoholic fatty liver disease onset. Pharmacological manipulations of RAS are viable strategies to tackle metabolic impairments caused by the excessive body fat mass. Renin inhibitors rescue insulin resistance, but do not have marked effects on hepatic steatosis. However, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ARB) yield beneficial hepatic remodeling. ARBs elicit body mass loss and normalize insulin levels, tackling insulin resistance. Also, this drug class increases adiponectin levels, besides countering interleukin-6, tumoral necrosis factor-alpha, and transforming growth factor-beta 1. The latter is essential to prevent from liver fibrosis. When conjugated with peroxisome proliferator-activated receptor (PPAR)-alpha activation, ARB fully rescues fatty liver. These effects might be orchestrated by an indirect up-regulation of MAS receptor due to angiotensin II receptor type 1 (AT1R) blockade. These associations of ARB with PPAR activation and ACE2-angiotensin (ANG) (1-7)-MAS receptor axis deserve a better understanding. This editorial provides a brief overview of the current knowledge regarding AT1R blockade effects on sensitivity to insulin and hepatic structural alterations as well as the intersections of AT1R blockade with peroxisome proliferator-activated receptor activation and ACE2-ANG (1-7) - MAS receptor axis.

关键词： Non-alcoholic fatty liver disease Insulin resistance Angiotensin receptor blockers MAS receptor Renin-angiotensin system

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Sharing Culture and Belonging Through Cross-Cultural Collaborative Painting

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Journal of Literature and Art Studies 2014年第6期4卷 483-488页

作者： vanessa Maree Barbay Australian National University Canberra Australia

The topic of this paper is animals in painting and the investigative process undertaken by the artist vanessa Barbay during her practice--led Ph.d.. Her aim was to discover a way to present deceased animals that retained their agency as individuals by challenging the objectifying nature of representation. The foundation of this method was the collaboration between artist and dead animal subjects through harnessing the natural decomposition of the subject in order to generate their image. A related stream of Barbay＇s research was learning about the art and culture of Kunwinjku speaking artists living in Kunbarlanja Western Amhem Land where artists have painted images of animals on rock shelters and on bark from ancient through to contemporary times. The significance of their form of animal representation is a mythopoeic relationship between locally found pigments and animal bodies. Paintings are considered as collaboration between matter, subject, and artist, which Barbay extends in her current work centred on collaborative painting involving more than one artist.

关键词： painting animals pigments Kunwinjku shroud decomposition

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