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Larvicidal efficacy of plant extracts and isolated compounds from Annonaceae and Piperaceae against Aedes aegypti and Aedes albopictus

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Asian Pacific Journal of Tropical Medicine 2020年第9期13卷 384-396页

作者： Alzeir M.Rodrigues Victor Emanuel P.Martins Selene M.morais Departamento de Ensino Instituto Federal de EducaçãoCiência e Tecnologia do Ceará(IFCE)Rodovia CE 060km 332Vila Martins63.560-000 AcopiaraCearáBrazil Programa de Pós-Graduação em Biotecnologia RENORBIOUniversidade Estadual do CearáAvenida Doutor Silas Munguba170060741-000 FortalezaCearáBrazil Instituto de Ciências Exatas e da Natureza Universidade da Integração Internacional da Lusofonia Afro-Brasileira(Unilab)Campus das AurorasRua JoséFranco de Oliveira s/n62790-970 RedençãoCearáBrasil Departamento de Química Universidade Estadual do CearáAvenida Doutor Silas Munguba170060741-000 FortalezaCearáBrazil

The Aedes(Ae.)aegypti and *** mosquitoes are vectors of epidemiologically relevant arboviruses in the public health context,such as the dengue,Zika and chikungunya *** the alternatives to synthetic insecticides for the control of these vectors,the use of natural plant products deserves *** review summarizes findings on the larvicidal potential of plant extracts on *** and ***,as well as the potential of isolated compounds from plants of the Annonaceae and Piperaceae families against these *** related to larvicidal activity of plant extracts and isolated compounds in Aedes *** the Web of Science database were used,for plant extracts considering publications between 2000 and 2019.A total of 859 articles were analyzed for plant extracts and estimates of lethal concentration values(LC50 and LC90).In the end,95 articles that presented the larvicidal potential of 150 plant species from 52 families were *** two families most studied for this activity were Fabaceae and Asterace *** plant families with the best LC50 values against mosquitoes were Piperaceae and *** activity of 50 acetogenins has already been identified on ***,and 29 of them presented LC50 below 10μg/mL,as well as the larvicidal activity of 8 compounds isolated from ***,plants of these two families are promising for the development of commercial botanical larvicides in the form of extracts and isolated substances,as well as the production via organic synthesis of the most active compounds.

关键词： Larvicidal activity Plant extracts Acetogenins Aedes

Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension

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World Journal of Gastroenterology 2007年第38期13卷 5065-5070页

作者： Francisco X Eizayaga Omar Aguejouf vanessa Desplat Philippe Belon Christian Doutremepuich CEBBAD Universidad Maimónides Buenos Aires Argentina France Laboratoire d'Hématologie Université Victor Segalen Bordeaux 2 Bordeaux 146 Rue Léo Saignat 33076 Bordeaux Cedex France Laboratoires Boiron Sainte-Foy-les-Lyons France

AIM: To study the mechanism involved in the potentially beneficial effect of ultra low dose aspirin (ULDA) in prehepatic portal hypertension, rats were pretreated with selective COX 1 or 2 inhibitors (SC-560 or NS-398 respectively), and subsequently injected with ULDA or placebo. METHODS: Portal hypertension was induced by portal vein ligation. Platelet activity was investigated with an in-vivo model of laser induced thrombus production in mesenteric circulation and induced hemorrhagic time (IHT). Platelet aggregation induced by ADP and dosing of prostanoid products 6-keto-PGF1α, TXB2, PGE2 and LTB4 were also performed. RESULTS: The portal hypertensive group receiving a placebo showed a decreased in vivo platelet activity with prolonged IHT, an effect that was normalized by ULDA. SC-560 induced a mild antithrombotic effect in the normal rats, and an unmodified effect of ULDA. NS-398 had a mild prothrombotic action in portal hypertensive rats, similar to ULDA, but inhibited a further effect when ULDA was added. An increased 6-keto-PGF1α was observed in portal hypertensive group that was normalised after ULDA administration. TXA2 level after ULDA, remained unchanged. CONCLUSION: These results suggest that the effect of ULDA on platelet activity in portal hypertensive rats, could act through a COX 2 pathway more than the COX 1, predominant for aspirin at higher doses.

关键词： Ultra Low Dose Aspirin Portal hypertension COX 1 COX 2 COX selective inhibition

Understanding how environmental heterogeneity and elevation drives the distribution of woody communities across vegetation types within the campo rupestre in South America

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Journal of Mountain Science 2021年第5期18卷 1192-1207页

作者： Marcelo Leandro BUENO vanessa Leite REZENDE Luiza Fonseca A.DE PAULA João Augusto Alves MEIRA-NETO JoséRoberto Rodrigues PINTO Andreza Viana NERI vanessa PONTARA State University of Mato Grosso do Sul Laboratory of Macroecology and EvolutionMundo Novo79980-000Mato Grosso do SulBrazil Federal University of Lavras Department of BiologyEcology and Conservation SectorLavras37200-000Minas GeraisBrazil Federal University of Minas Gerais Department of GeneticsEcology and EvolutionBelo Horizonte31270-901PampulhaMinas GeraisBrazil Federal University of Viçosa Department of Plant BiologyLaboratory of Ecology and Evolution of PlantsCampus Universitário36570-900ViçosaMinas GeraisBrazil University of Brasília Department of Forest EngineeringBrasília70910-900Federal DistrictBrazil

The campo rupestre sensu lato is a vegetation type that occurs in South American mountains,supports a distinctive flora characterized by high rates of endemism,high herbaceous species richness and often-neglected but also species-rich of the arboreal *** aimed to investigate how environmental factors and elevation are associated with the distribution and diversity of woody species in different rupestrian vegetation types across South *** a database of 2,049 woody species from 185 sites across four vegetation types within the campo rupestre,we assessed how the vegetation types were grouped according to their floristic composition and number of shared indicator species,as well as by using different beta diversity *** most important variables from a set of 27 variables(***,geo-edaphic and climatic)explaining species distribution were identified using redundancy analysis(RDA)and variation partitioning *** distribution of vegetation types was related to both environmental and spatial fractions,with a set of 17 variables retained(***,grass cover and temperature seasonality as the most important variables).There was an association between the floristic composition of each vegetation type and the elevation *** the identified vegetation types are floristically related,they are distinguished by exclusive and habitat-specialist woody *** uniqueness of vegetation types should be considered in terms of complementarity for the conservation of campos rupestres.

关键词： Beta diversity Campo rupestre Elevational gradient Rupestrian vegetation Tropical mountain Variation partitioning

Targeting mRNA translation aberrations:A novel approach for therapy in chronic lymphocytic leukemia

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Cancer Communications 2023年第12期43卷 1373-1376页

作者： vanessa Klapp Jerome Paggetti Anne Largeot Etienne Moussay Tumor Stroma Interactions Department of Cancer Research Luxembourg Institute of Health Luxembourg Luxembourg Faculty of Science Technology and Medicine University of Luxembourg Esch-sur-Alzette Luxembourg

1 mRNA TRANSLATION IS AFFECTED IN CHRONIC LYMPHOCYTIC LEUKEMIA(CLL)AT VARIOUS LEVELS mRNA translation dynamics enable tight regulation of protein expression and rapid stress adaptation;however,its contribution to oncogenesis is overlooked compared to genetic and epigenetic *** in mRNA translation are a common feature of cancer and are established as a therapeutic *** is growing evidence of dysregulated protein synthesis in CLL.

关键词： lymphocytic leukemia translation

Experiment meets biogeography:plants of river corridor distribution are not more stress tolerant but benefit less from more benign conditions elsewhere

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Journal of Plant Ecology 2010年第3期3卷 149-155页

作者： Markus Fischer Michael Burkart vanessa Pasqualetto Mark van Kleunen Institute for Biochemistry and Biology University of PotsdamMaulbeerallee 1D-14469 PotsdamGermany Institute of Plant Sciences and Oeschger Centre University of BernAltenbergrain 21CH-3013 BernSwitzerland

Aims Factors limiting distributions of species are fundamental to ecology and evolution but have rarely been addressed experimentally for multiple *** conspicuous linear distribution patterns of plant species confined to river corridors in the Central European lowlands constitute an especially long-standing distribution *** experimentally tested our novel hypothesis that the tolerance of species to river corridor conditions is independent of the degree of confinement to river corridor habitats,but that species not confined to river corridors are better able to take advantage of the more benign non-river corridor *** We grew 42 herbaceous species differing in their confinement to river corridors in a common garden experiment on loamy soil typical for river corridor areas and sandy soil typical for non-river corridor areas,and with and without a flooding *** a subset of species,we grew plants of both river corridor and non-river corridor origin to test for adaptation to river corridor *** findings Species more confined to river corridor areas benefited less from the more benign non-flooded and non-river corridor soil conditions than species of wider distributional range *** subsets of 7 and 12 widespread species,the response to flooding and soil origin,respectively,did not differ between plants from river corridor sites and plants from other sites,suggesting that the habitat tolerance of widespread species is due to phenotypic plasticity rather than to local ***,we found clear support for our novel hypothesis that species not confined to river corridors are more able to take advantage of the more benign non-river corridor *** study provides a general hypothesis on differences between species confined to stressful habitats and widespread species out for test in further multispecies comparative experiments.

关键词： distributional patterns edaphic factors environmental tolerance flooding local adaptation multispecies experiment phenotypic plasticity

Settlement predictions of footings on sands using probabilisticanalysis

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Journal of Rock Mechanics and Geotechnical Engineering 2016年第2期8卷 198-203页

作者： felipe carvalho bungenstab kátia vanessa bicalho federal university of espirito santo VitóriaBrazil

The design of footings on sands is often controlled by settlement rather than bearing ***,settlement predictions are essential in the design of shallow ***,predicted settlements of footings are highly dependent on the chosen elastic modulus and the used *** paper presents the use of probabilistic analysis to evaluate the variability of predicted settlements of footings on sands,focusing on the load curve(predicted settlements)*** methodologies,the first-and second-order second-moment(FOSM and SOSM),and Monte Carlo simulation(MCS),for calculating the mean and variance of the estimated settlements through Schmertmann(1970)’s equation,are presented and *** soil beneath the footing is treated as an uncorrelated layered material,so the total settlement and variance are found by adding up the increments of the *** deformability modulus(ESi)is considered as the only independent random *** an example of application,a hypothetical case of a typical subsoil in the state of Espirito Santo,southeast of Brazil,is *** results indicate that there is a significant similarity between the SOSM and MCS methods,while the FOSM method underestimates the results due to the non-consideration of the high-order terms in Taylor’s *** contribution of the knowledge of the uncertainties in settlement prediction can provide a safer design.

关键词： Footings Settlements Probabilities Deformability modulus

Medical management of metabolic and cardiovascular complications after liver transplantation

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World Journal of Gastroenterology 2020年第18期26卷 2138-2154页

作者： Chiara Becchetti Melisa Dirchwolf vanessa Banz Jean-Francois Dufour Hepatology Department of Visceral Surgery and MedicineInselspitalUniversity Hospital BernBern CH-3008Switzerland Department of Biomedical Research University of BernBern CH-3008Switzerland Hepatology Hepatobiliary Surgery and Liver Transplant UnitHospital Privado de RosarioRosario S2000GAPSanta FeArgentina Department of Visceral Surgery and Medicine InselspitalUniversity Hospital BernBern CH-3008Switzerland Department of Clinical Research University of BernBern CH-3008Switzerland

Liver transplantation represents the only curative option for patients with endstage liver disease,fulminant hepatitis and advanced hepatocellular *** though major advances in transplantation in the last decades have achieved excellent survival rates in the early post-transplantation period,long-term survival is hampered by the lack of improvement in survival in the late post transplantation period(over 5 years after transplantation).The main etiologies for late mortality are malignancies and cardiovascular *** latter are increasingly prevalent in liver transplant recipients due to the development or worsening of metabolic syndrome and all its components(arterial hypertension,dyslipidemia,obesity,renal injury,etc.).These comorbidities result from a combination of pre-liver transplant features,immunosuppressive agent side-effects,changes in metabolism and hemodynamics after liver transplantation and the adoption of a sedentary *** this review we describe the most prevalent metabolic and cardiovascular complications present after liver transplantation,as well as proposing management strategies.

关键词： Solid organ transplantation Hypertension New-onset diabetes after transplantation Obesity Orthotopic liver transplantation Post-transplantation metabolic syndrome

Mencius' View on Human Nature and its Contemporary Meaning

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Mencius' View on Human Nature and its Contemporary Meaning

作者： Lucy vanessa Kuchera 陕西师范大学

学位级别：硕士

孟子的人性论讨论了人类的所有行为品质,包括人们如何在一开始就正确开展各类仪式,以及在这些仪式中如何正确发挥情感。所谓人性,是指来自各方面的人类行为的集合,这些行为被各种研究人员和哲学家所考查,以便得出结论。对于这项研究,孟... 详细信息

孟子的人性论讨论了人类的所有行为品质,包括人们如何在一开始就正确开展各类仪式,以及在这些仪式中如何正确发挥情感。所谓人性,是指来自各方面的人类行为的集合,这些行为被各种研究人员和哲学家所考查,以便得出结论。对于这项研究,孟子的人性论伴随着他的全部教导。研究回顾了孟子的背景,包括他的生平,他所支持和参与的活动。我认为他是一个真正的老师,他教会人们重要的生活方式。他的生活充满挑战,例如他从小由单身母亲抚养长大,这其实是当今世界很多人都会遇到的挑战。在他的一生中,他试图探讨各种他所注意到的社会问题,而这些古代社会的问题似乎与今天的社会面临的问题类似。例如人民治理和贫困有关的问题。他强调教育的价值,他试图让社会在人性养成的过程中得到稳定。他认为教育是为了确保所有人类都能为他们的同胞开发他们天生的善良。他发现他所处的社会中有许多问题,如糟糕的治理和其他种类的剥削。这种问题触动了他,因为这些行动与理想相反。这种情况迫使他从一个邦国到另一个邦国以传播他的教导,因为他发现社会中有太多需要解决的问题和需要团结的人群,他希望使人们正直。但令人惊讶的是,由于各种原因,错误的事情仍然会困扰着社会。孟子设计了许多教导,并希望将其传递到下一代,让其他人了解人的本质,即使他遇到了很多反对的哲学观点,他也要坚持自己的结论,思考人性的起源和与之相关的价值。此外,文章还将考察孟子所理解的人们的感性活动与人性的关系,以及人们多拥有的美德对人们相互间交往的影响文章将考察当代社会的管理机构是否可能通过遵循孟子的论说以正确地进行的治理。孟子多次关注管理者的品质,所有这些内容对我们当前全世界的社会都很有意义。他认为政府的行为应始终反映管理者们的善良,并更好地实现对人性养成的引导。他的哲学讨论了天,天被描述为一个最高的权力,天与人的美德直接相关,并支持具有良好美德君主的治理,天通过选择支持那些它所认可的治理类型来向人们展示它的存在。孟子强调人要通过自我来实现人性养成。他自信地支持人性本善的学说,并通过使用“牛山”的比喻来解释他的教导。他认为外在环境会影响我们的生活,包括好的影响和坏的影响,进而改变我们的“材”,不过我们的人性是善良的。另一个例子是关于井和儿童的。这个例子是为了支持他的人性善的哲学。当一个人看到一个孩子将要掉进井里,他将毫不犹豫地实施救助,这说明为孩子提供保护是人的本性。这些教导长期以来一直被儒者们所继承,并且仍然适用于今天的社会。我们可以想象,除了这个例子以外,世界上还有很多情况下人类能够以某种方式在某种程度上互相帮助,即使我们互不相识。这是因为当前的世界是一个全球社会。人类只有互相帮助才能更好地面对外界的挑战,才能变得更加强大。本文将结合中国文化关于人性的传统理解来看看孟子的哲学是如何与传统的人性论观念相联系的。孟子提出了一组中间观念,以汇通传统关于人性的理解和他的学说。这就是四端之心。他们包括仁慈,礼仪,智慧以及正义。当这四端之心彼此相互作用时,人性完美地体现着善。如果一个人向他的伙伴施善,无论老幼,人们都会认同他。这说明人们其实都遵循并服从天的律法,比如孩子们都希望服从父母和有着良好社会行为的长辈。孟子认为教育应该从社会的最小单位,也就是家庭开始。在家庭中,孩子们可以了解更多关于他们的社会结构,以及四端之心,包括四端之心是什么意思,如何行使其付诸实践等等方面。如果四端之心得到了完全的理解,那么人类活动的各个方面的美德,包括谦卑,合作以及慈善行动都将得到实现。本文还将思考人性问题与当今世界的关系,并将讨论孟子人性论全方面的现代意义,包括孟子人性论与现代教育和实践的意义。例如,世界已经发展成为一个全球社区,尽管生活中处处充满挑战,但有总有人仍在行使他们的善良。尽管有不同的比赛,但世界上的各种体育活动都有一个目标,那就是无论人们的种族、民族、宗教信仰如何,都可以在体育活动中彼此欣赏、提高社会间的相互理解,并消除人类之间的不安全感。由于善良的天性,预计人类预计将获得相互信任。当今世界需要有一种努力,要发挥人们天生的善良本性,摧毁那些正在侵蚀着人类的外部负能量,它们毁灭了人们的善良。因此,需要以各种方式克服自我的弱点,使得世界越来越好。而在孟子的哲学中,这需要全社会的努力。我们当前的社会有很大的变化,时刻威胁着人类内在的善良本性,比如说负极能量时刻威胁着人类相互间的善意。按照孟子的教导,克服负能量的努力包括了很多方面,比如提升治理模式等,而最重要的是要了解,如果想要改变外部的环境,人们首先必须对自我进行修正,今天的世界试图通过外在法律来进行改变不美好的一面,但尚未意识到更重要的是完善人的先天的善性。孟子通过他的哲学为当今世界提供了积极的引导。

关键词：孟子论证人性

Innovative Benthic Lander for Macroalgae Monitoring in Shallow-Water Environments

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Journal of Marine Science and Application 2020年第1期19卷 133-147页

作者： João Pedro Santana Nuno Mathias Richelle Hoveling Hugo Alves Tiago morais INEGI-Institute of Science and Innovation in Mechanical and Industrial Engineering Rua Dr.Roberto Frias 400 Campus FEUP4200-465 PortoPortugal Quest Innovations BV Industrieweg 411775 PW MiddenmeerThe Netherlands

The colonization of underwater environments by exotic seaweeds is causing major ecological problems around the *** project,referred to AMALIA,aims to transform this current ocean threat into an opportunity by adding value to the macroalgae present off the northwest of the Iberian *** do so and to observe the presence of seaweeds in situ,an ocean modular submersible platform was *** platform was designed to be capable of detecting and surveying surges of invasive seaweeds while withstanding sea *** designs followed by a screening process were performed,taking into consideration criteria such as operational range and *** open-frame lander was considered and further developed using buckling *** parallel,a state-of-the-art monitoring system was created using spectral imaging,allowing for the future creation of a macroalgae identification *** addition,sensorial systems for characterizing growth conditions were *** trials were executed to assess the capability of the system,and sea trials are currently being *** simulations and laboratory trials indicate that the structure is fully capable of being deployed for shallow-water environments with a state-of-the-art invasive seaweed monitoring system while maintaining a high degree of modularity.

关键词： Benthic landers Ocean surveillance Environmental protection Ocean technology Marine instrumentation