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Elucidating regulatory processes of intense physical activity by multi-omics analysis

Military Medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko Young-Mo Kim Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie Munoz Kathleen M.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa M.Bramer Fernando Montes Kathleen A.Clark Grant Tietje Justin Teeguarden Kristin E.Burnum-Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and Molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and Molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

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A comparative study of semi-active control strategies for base isolated buildings

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Earthquake Engineering and Engineering Vibration 2015年第3期14卷 487-502页

作者： Oliveira F. morais P. Suleman A. National Laboratory for Civil Engineering (LNEC) Av. do Brasil 101 1700-066 Lisbon Portugal Scholarship HolderPh D CandidateMSc National Laboratory for Civil Engineering (LNEC) Av. do Brasil 101 1700-066 Lisbon Portugal Researcher Ph D University of Victoria Dep. Mechanical Engineering PO Box 1700 Stn CSC Victoria BC V8W 2Y2 Canada Professor Ph D PEng

A comparative analytical study of several control strategies for semi-active(SA) devices installed in baseisolated buildings aiming to reduce earthquake induced vibrations is *** force tracking schemes comprising a linear controller plus a 'clipped' algorithm and a nonlinear output feedback controller(NOFC) are considered to tackle this *** controllers include the integral controller(I),the linear quadratic regulator(LQR) and the model predictive controller(MPC).A single degree-of-freedom system subjected to input accelerograms representative of the Portuguese seismic actions are first used to validate and evaluate the feasibility of these *** obtained results show that structural systems using SA devices can in general outperform those equipped with passive devices for lower fundamental frequency structural systems,namely base-isolated *** effectiveness of the proposed strategies is also evaluated on a 10 storey base-isolated dual frame-wall *** force tracking scheme with an integral controller outperforms the other three as well as the original structure and the structure equipped with passive devices.

关键词： semi-active control integral controller linear qua

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Epidemiological, Clinical and Evolutionary Aspects of Human African Trypanosomiasis in Children in Nola

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Open Journal of Pediatrics 2024年第2期14卷 344-358页

作者： Brice Olivier Bogning Mejiozem Gaspard Tékpa Synthia Ningatoloum Nazita Jocelyn Tony Nengom Danebera Lydie Verlaine Carine Judith Kiteze Nguinzanémou Rostand Juste Koyangboi Kombaya Iris vanessa Gaspiet Sonny Jean Chrysostome Gody Complexe Hospitalier Pédiatrique de Bangui Bangui République Centrafricaine Service des Maladies Infectieuses H&#244pital de l’Amitié Bangui République Centrafricaine Faculté des Sciences de la Santé de l’Université de Bangui Bangui République Centrafricaine Centre Hospitalo Universitaire Communautaire de Bangui Bangui République Centrafricaine Faculté de Médecineet des Sciences Biomédicales Université de Yaoundé 1 Yaoundé Cameroun

Background: Human African trypanosomiasis (HAT) occurs in three historical foci in the Central African Republic. Objective: To describe the morbi-mortality of childhood HAT in rural Central African Republic with the aim of early management. Methods: Descriptive and analytic cross-sectional study conducted from January 1, 2017 to March 30, 2018 at Nola prefectural hospital. This study was included all children seen as outpatients and/or hospitalized in the pediatric wards, in whom the diagnosis of HAT was confirmed. Statistical analysis was performed using Epi-info software. Results: Forty children were included from Bilolo (60%), Nola (30%) and Salo (10%). The sex ratio was 0.66 with a median age of 8.65 ± 12.48 years. Fever (82.5%), nocturnal insomnia (75%), daytime somnolence (67.5%), headache (65%), polyarthralgia (62.5%), convulsions 52.5% (n = 21), tremor (27.5%), trypanidism (7.5%) and delirium (2.5%) were the main functional signs. Examination signs were adenopathy (52.5%), paresthesia (30%), decreased cutaneous-abdominal reflexes (25%) and osteoarticular reflexes (17.5%), hyperesthesia (20%), extrapyramidal hypertonia (15%) and depression (2.5%). The children were in the lymphatic-blood phase in 65% of cases, and meningoencephalitis in 35%. Pentamidine was administered in 65% of cases. Four children died and 6 had neurological sequelae. There was an association between age under 5, Bilolo’s focus, the children’s history and the severity of the disease. Age under 5, gender, household, children’s activity, history and occurrence of sequelae were also associated. Conclusion: HAT remains a permanent threat to Central African children. Any clinical presentation combining long-term infectious signs and unexplained neurological or neuropsychological disorders must be treated with caution.

关键词： Morbidity-Mortality Child HAT Nola CAR

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重症监护室护士限制治疗努力的能力:整合性综述

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International Journal of Nursing Sciences 2024年第1期11卷 143-154,I0003页

作者： Elvia R.Lopez-Panza vanessa C.Pacheco-Roys Kelly J.Fernandez-Ahumada Diana C.Díaz-Mass María Y.Exposito-Concepcion Elizabeth Villarreal-Cantillo Cesar I.Aviles Gonzalez Nursing Department Universidad del NorteBarranquillaColombia Nursing Program Faculty of Health SciencesUniversidad Popular del CesarValleduparColombia Clínica Valledupar ValleduparColombia Hospital Universidad del Norte SoledadColombia Department of Medical Sciences and Public Health University of CagliariCittadella Universitaria di MonserratoCagliariItaly

目的在重症监护病房(IntensiveCareUnit,ICU),护土难免会遇到需要限制治疗努力(limiting therapeutie efort,LTE)的患者,尽管多数护士还缺乏为这些临终患者及其家庭提供支持的准备。本综述旨在描述ICU护士在LTE中需要具备的能力。方法对... 详细信息

目的在重症监护病房(IntensiveCareUnit,ICU),护土难免会遇到需要限制治疗努力(limiting therapeutie efort,LTE)的患者,尽管多数护士还缺乏为这些临终患者及其家庭提供支持的准备。本综述旨在描述ICU护士在LTE中需要具备的能力。方法对2010年--2023年发表的文献进行综述。系统检索了5个数据库:Medline、Wiley Online Library、SciELO、ScienceDirect和Web of Science。使用关键评估项目工具西班牙语版(Critical Appraisal Skills Programme in Spanish,CASPe)作为评判性阅读工具。使用牛津循证医学中心(Center for Evidence-Based Medicine.,CEBM)评估工具确定证据级别和推荐强度。结果共纳入25篇文献。ICU护士LTE护理的能力包括对患者的直接护理、以家庭为中心的护理以及护士在团队中的作用。该综述确定了3个类别的能力:作为患者、家庭与跨学科团队之间维护者的能力,在LTE方面的决策能力,在患者生命末期治疗和护理干预的能力。结论ICU护士在LTE方面需要具备相应的能力,这对患者的生活质量死亡尊严以及患者家庭应对悲伤的全面支持至关重要。

关键词：重症监护家庭支持重症监护病房护士的作用安宁疗护专业能力

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What can a heavy U(1)B-L Z'boson do to the muon(g-2)u anomaly and to a new Higgs boson mass?

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Chinese Physics C 2021年第1期45卷 32-46页

作者： Antonio P.morais Roman Pasechnik J.Pedro Rodrigues Departamenlo de Fisica da Universidade de Aveiro and CIDMA Campus de Santiago 3810-183 AveiroPortugal Department of Astronomy and Theoretical Physics Lund UniversitySE 223-62 LundSweden Nuclear Physics Institute ASCR 25068 RezCzech Republic Departamento de Fisica CFMUniversidade Federal de Santa CatarinaC.P.476CEP 88.040-900FlorianopolisSCBrazil

The minimal U(1)B_L extension of the Standard Model(B-L-SM)offers an explanation for neutrino mass generatio n via a seesaw mechanism;it also offers two new physics states,namely an extra Higgs bos on and a new Z'gauge *** emerge nee of a second Higgs particle as well as a new Z'gauge boson,both lin ked to the breaking of a local U(1)B_L symmetry,makes the B-L-SM rather constrained by direct searches in Large Hadron Collider(LHC)*** investigate the phenomenological status of the B-L-SM by confr on ting the new physics predictions with the LHC and electroweak precision *** into account the current bounds from direct LHC searches,we demonstrate that the prediction for the muon(g-2)u anomaly in the B-L-SM yields at most a contribution of approximately 8.9×10^-12,which represents a tension of 3.28 standard deviations,with the current 1σuncertainty,by means of a Z'boson if its mass is in the range of 6.3 to 6.5 TeV,within the reach of future LHC *** means that the B-L-SM,with heavy yet allowed Z‘bos on mass range,in practice,does not resolve the tension between the observed anomaly in the muon(g-2)u and the theoretical prediction in the Standard *** a heavy Z'boson also implies that the minimal value for the new Higgs mass is of the order of 400 GeV.

关键词： beyond Standard Model Higgs physics gauge extensions of the Standard Model Z'boson

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Mixed-method study on medicinal herb collection in relation to wildlife conservation:the case of giant pandas in China

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Integrative Zoology 2019年第6期14卷 604-612页

作者： Yichao ZENG Jindong ZHANG vanessa HULL Department of Wildlife Ecology and Conservation University of FloridaGainesvilleFloridaUSA Key Laboratory of Southwest China Wildlife Resources Conservation China West Normal UniversityMinistry of EducationNanchongChina

Medicinal herb collection has historical and cultural roots in many rural communities in developing *** where herb collection occurs may overlap with biodiversity hotspots and crucial habitat of endangered and threatened ***,impacts of such practices on wildlife are unknown and possibly underestimated,perhaps due to the elusive nature of such *** examined this phenomenon in Wolong Nature Reserve,China,a protected area in the South-Central China biodiversity hotspot that also supports a community of Tibetan,Qiang and Han people who use herb collection as a supplementary source of *** adopted a participatory approach in which we engaged local people in outlining spatial and temporal dynamics of medicinal herb collection *** found that the overall spatial extent of herb collection increased in the past two *** then overlaid herb collection maps with localities of giant panda(Ailuropoda melanoleuca)feces collected over two time points in the *** a Bayesian parameter estimation,we found evidence for declined giant panda occurrence in the areas most recently impacted by emerging medicinal herb *** methodology demonstrates the potential power of integrating participatory approaches with quantitative methods for processes like herb collection that may be difficult to examine *** discuss future directions for improving explanatory power and addressing uncertainty in this type of mixed-method,interdisciplinary re*** work has implications for future attempts to understand whether and how prevalent but subtle human activities may affect wildlife conservation.

关键词： Bayesian parameter estimation medicinal herb collection participatory mapping wildlife conservation

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Telemetry research on elusive wildlife: A synthesis of studies on giant pandas

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Integrative Zoology 2016年第4期11卷 295-307页

作者： Thomas CONNOR vanessa HULL Jianguo LIU Center for Systems Integration and Sustainability Michigan State UniversityEast LansingUSA

Telemetry studies that track animals through space and time can lead to advances in scientific understanding that are vital in conservation *** example,telemetry studies of the giant panda(Ailuropoda melanoleuca)have shed light on many aspects of panda biology,but small sample sizes in each separate study make it difficult to draw broad *** overcome this problem we conducted the first synthesis of all 5 panda telemetry studies conducted to *** these data we investigated patterns in 6 main topics:home range,space-use interactions,core areas,movement patterns,seasonal migration and natal *** found that panda home range sizes do not vary between 2 main mountain ranges(Qionglai and Qinling),as was previously *** results also suggest that female pandas increase their movement in the mating season:a behavior typically attributed only to *** found and summarized telemetry and genetic evidence for female natal dispersal in the giant *** synthesis highlights the need for additional research relating panda behavior to human disturbance factors,and can aid future studies on giant pandas as well as other species.

关键词： giant panda home range natal dispersal synthesis wildlife telemetry

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Structural and optical properties of pillared Eu^(3+)-containing layered double hydroxides intercalated by 2-to 12-carbon aliphatic dicarboxylates

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Journal of Rare Earths 2022年第2期40卷 260-267,I0003页

作者： Alexandre Candido Teixeira Ivan Guide Nunes Silva Alysson Ferreira.morais Danilo Mustafa Physics Institute.University of Sao Paulo 05508-090Sao PauloSPBrazil

While the versatile composition of layered double hydroxides(LDHs)allows the introduction of almost any polyvalent cation in their structure,the exchangeable negatively charged ions intercalated between the plates increase their vast range of *** we report on the preparation and optical properties of pillared Eu^(3+)-substituted ZnAl LDHs intercalated by aliphatic dicarboxylates:-OOC-(CH_(2))_(n-2)-COO-.The basal distance in these materials is dependent on the size and packing of the intercalated *** varying the number(n)of carbon atoms in the aliphatic chain from 2 to 12,the interlayer gallery of these ZnAlEu LDHs is considerably expanded from 0.9 to 2.1 *** the interlayer gallery,the aliphatic dicarboxylates form a monolayer,with the aliphatic chain inclined by an angleα≈63°with the hydroxide *** carbon atom in the COO-group is 0.43 nm far from the metal plane,showing that these carboxylates are not grafted in the brucite-like *** LDHs are thermally stable up to around 150℃,after which dehydroxylation of the hydroxide layers is *** Judd-Ofelt intensity parameters were obtained and compared to the Eu^(3+)-containing complexes with the same ligand series indicating a more symmetrical and less polarizable chemical environment around the rare earth ion.

关键词： Europium Layered double hydroxides Carboxylate ligands Luminescence Rare earths

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Recent Progress on Electrode Characteristics of Mg and Mg-Based Hydrogen Storage Alloys

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Journal of Rare Earths 2005年第S1期23卷 358-362页

作者：王仲民 Chi Ying vanessa Li Department of Information Material Science and Engineering Guilin University of Electronic Technology Guilin 541004 China School of Materials Science and Engineering University of New South Wales Sydney UNW 2052 Australia

Recent development of Mg and Mg-based hydrogen storage alloys used in Ni-MH battery was discussed extensively. The results obtained from recent studies prove that these alloys with nanocrystalline/amorphous structure formed by mechanical alloying (MA) or mechanical grinding (MG) have good electrode characteristics. In general, MA or MG, and elemental substitution alloying are regarded as the effective means to seek new system of Mg-based alloys and nano-composite with improved electrode characteristics. However, until now, the currently known improvement in these electrode characteristics is still far from reach to that required for commercial application.

关键词： Mg and Mg-based Ni-MH battery Electrode characteristics mechanical alloying (MA)

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Extracellular vesicle fingerprinting:the next generation for cancer diagnosis?

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Signal Transduction and Targeted Therapy 2020年第1期5卷 294-296页

作者： vanessa Sandim Robson Q.Monteiro Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de JaneiroRio de JaneiroBrazil

In a recent report,Hoshino and colleagues from several institutions around the world demonstrated that large-scale proteomic analysis of extracellular vesicles(EVs)and particles comprising exomeres and two distinct subpopulations of small and large exosomes(which were named as EVPs)might constitute the next generation for cancer diagnosis.

关键词： diagnosis cancer constitute

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