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Clinical profile and outcomes in very elderly patients with atrial fibrillation anticoagulated with rivaroxaban: data from the EMIR study

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Journal of geriatric Cardiology 2024年第7期21卷 723-732页

作者： Francisco Marín Manuel Anguita Sánchez Iñaki Lekuona Marcelo Sanmartín Fernán-dez Vivencio Barrios Carlos Perez Muñoz Juan Cosín-Sales Alejandro IPérez Cabeza vanesa roldán schi.li.g Carles Rafols Priu Esteban Orenes-Piñero María Asunción Es-teve-Pastor Department of Cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of Cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital galdakao-Usansolo BizkaiaSpain Department of Cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of Cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Center La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of Cardiology Hospital Arnau de VilanovaValenciaSpain Department of Car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of Medical Affairs Bayer HispaniaBarcelonaSpain Department of Biochemistry and Molecular Biology-A University of MurciaMurciaSpain

Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial fibrillation(AF),taking rivaroxaban in clinical *** Observational and non-interventional study that included AF adults recruited from 79 Spanish centers,anticoagulated with rivaroxaban ≥ 6 months before being *** were analyzed according to age(≥ 80 vs.nts,453(31.6%) were octogenarians at *** to younger patients,octogenarians had more comorbidities,higher CHA2DS2-VASc(4.5 ± 1.3 vs.3.0 ± 1.4;P nd HAS-BLED scores(2.0 ± 1.0 vs.1.4 ± 1.0;P n was adequately prescribed in 83.4% of patients,but more frequently in the younger population(71.1% vs.89.1%;P = 0.039).After a mean follow-up of 2.2 ± 0.6 years,annual rates of stroke + systemic embolism + transient ischemic attack,MACE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03% and 1.75%,respectively,in octogenarian *** for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar compared to younger *** octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with MACE,and higher HAS-BLED score with major *** In clinical practice,around one third of patients taking rivaroxaban are *** patients have many comorbidities and a high thromboembolic *** that,rates of adverse events remain *** is adequately prescribed in the majority of octogenarians.

关键词： patients atrial bleeding

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Impacts of brood parasitism by shiny cowbird Molothrus bonariensis on the breeding success of a small host, the black-backed water tyrant Fluvicola albiventer

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Current Zoology 2024年第4期70卷 539-547页

作者： Lorena vanesa Sovrano Evelina Jesica Leon Rodrigo Ezequiel Lorenzón Pamela Fernanda Olguin Adolfo Héctor Beltzer Alejandro Raúl giraudo Laboratorio de Biodiversidad y Conservacion de Tetrapodos Instituto Nacional de Limnologia(INALICONICET-UNL)Paraje El Pozo s/nSanta Fe(3000)Argentina Departamento de Biologia Universidad Autonoma de Entre RiosKm 10.5 RP 11Oro Verde(3100)Entre RiosArgentina Departamento de Biologia Universidad Nacional del LitoralFacultad de Humanidades y CienciasParaje Ei Pozo s/nSanta Fe(3000)Argentina

The shiny cowbird Molothrus bonariensis parasitizes many species with different life-history traits and has a detrimental effect on the survival of the progeny of the *** response,hosts have developed numerous antiparasitic ***,we examined the effects of brood parasitism by shiny cowbird on the clutch and brood sizes(83 nests)in a small host,the black-backed water tyrant Fluvicola *** also studied whether the death of parasite nestlings was related to the care of the foster parents and whether the host had any antiparasitic defense against the shiny *** results indicate that brood parasitism significantly decreased the host hatching and fledging *** majority of nest failures(57%)were caused by brood *** cowbird parasitism occurred in 52%of nests and the intensity of parasitism was 1.23±0.53 eggs per parasitized *** the total host eggs,54%were *** the incubation stage,20 nests(47%)were abandoned because of egg punctures by shiny cowbirds *** two parasitic fledglings were recorded,while the remaining nestlings either died from starvation(n=12)or predation(n=3).Foster parents abandoned parasitic nestlings between 5 and 10 days *** findings demonstrate that the shiny cowbird has very low rates of fledging success when parasitizing black-backed water ***,parasitism had a high reproductive cost in the black-backed water tyrant because a very low proportion(7%)of the parasitized nests(n=43)were successful.

关键词： brood parasitism host defenses nest desertion shiny cowbird small host.

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Compression properties of cost-efficient porous expanded clay reinforced AA7075 syntactic foams fabricated by industrial-oriented die casting technology

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China Foundry 2024年第1期21卷 60-70页

作者： İsmail Cem Akgün Çağın Bolat Ali gökşenli Faculty of Mechanical Engineering Istanbul Technical University34437İstanbulTurkey Faculty of Engineering Samsun University55420SamsunTurkey

In today’s manufacturing industries,hard competition between rival firms makes it compulsory for researchers to design lighter and cheaper machine components due to the megatrends of cost-effectiveness and *** this point,aluminum syntactic foams(ASFs)are new-generation engineering composites and come into the upfront as a *** to their features like low density,sufficient elongation,and perfect energy absorption ability,these advanced foams have been considerably seductive for many industrial sectors *** this study,an industrial-oriented automatic die casting technology was used for the first time to manufacture the combination of AA7075/porous expanded clay(PEC).Micro evaluations(optical and FESEM)reveal that there is a homogenous particle distribution in the foam samples,and inspections are compatible with the other ASF ***,T6 aging heat treatment was operated on one half of the produced foams to explore the probable impact of aging on the compressive *** results show that PEC particles can be an alternative to expensive hollow spheres used in the previous ***,a favorable relationship is ascertained between the aging treatment and mechanical properties such as compression strength and plateau strength.

关键词： die casting porous materials metal matrix sytanctic foams expanded clay compressive deformation

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Commentary on“Desialylated Platelets Maintain Immune Quiescence through Regulating Kupffer Cells”

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Research 2024年第3期6卷 621-623页

作者： Chen li Craig n.Morrell Aab Cardiovascular Research Institute University of Rochester School of Medicine and DentistryRochesterNYUSA Department of Pharmacology and Physiology University of Rochester School of Medicine and DentistryRochesterNYUSA Department of Medicine University of Rochester School of Medicine and DentistryRochesterNYUSA Department of Microbiology and Immunology University of Rochester School of Medicine and DentistryRochesterNYUSA Department of Pathology and Laboratory Medicine University of Rochester School of Medicine and DentistryRochesterNYUSA.

Platelets have long been studied for their roles in hemostasis and vascular injury repair. However, there is a continually evolving and deepening understanding that platelets initiate and regulate responses to tissue injury and pathogens, leading to platelets now being considered immune modulatory cells [1]. Platelets actively participate in host immune responses directly through pathogen engulfing and killing, or by regulating both innate and adaptive immune responses to infection or tissue injury [2]. Activated platelets promote inflammatory responses to tissue injury or infection by direct contact dependent interactions with immune cells and through indirect interactions via released soluble factors. However, mice that are deficient in platelets have skewed T helper cell differentiation [3] and increased vascular permeability [4], implying poorly defined roles for platelets in maintaining healthy immune homeostasis.

关键词： Platelet homeostasis Immune

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Coke behavior with H_(2)O in a hydrogen-enriched blast furnace:A review

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 959-976页

作者： Feng Zhou Daosheng Peng Kejiang li Alberto n.Conejo Haotian liao Zixin Xiong Dongtao li Jianliang Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Chemical Engineering The University of QueenslandSt LuciaQLD 4072Australia Baosteel Central Research Institute(R&D Center of Wuhan Iron&Steel Co. Ltd.)Wuhan 430080China Shougang Research Institute of Technology Shougang Group Corporation Ltd.Beijing 100043China Beijing Key Laboratory of green Recyclable Process for Iron and Steel Production Technology Beijing 100043China

Hydrogen-enriched blast furnace ironmaking has become an essential route to reduce CO_(2)emissions in the ironmaking ***,hydrogen-enriched reduction produces large amounts of H_(2)O,which places new demands on coke quality in a blast *** a hydrogen-rich blast furnace,the presence of H_(2)O promotes the solution loss *** result improves the reactivity of coke,which is 20%-30%higher in a pure H_(2)O atmosphere than in a pure CO_(2)*** activation energy range is 110-300 kJ/mol between coke and CO_(2)and 80-170 kJ/mol between coke and H_(2)***_(2)and H_(2)O are shown to have different effects on coke degradation *** review provides a comprehensive overview of the effect of H_(2)O on the structure and properties of *** exploring the interactions between H_(2)O and coke,several unresolved issues in the field requiring further research were *** review aims to provide valuable insights into coke behavior in hydrogen-rich environments and promote the further development of hydrogen-rich blast furnace ironmaking processes.

关键词： hydrogen ironmaking coke behavior blast furnace gasification microstructure kinetics

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Performances of fissured red sandstone after thermal treatment with constant-amplitude and low-cycle impacts

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Journal of Rock Mechanics and geotechnical Engineering 2024年第2期16卷 561-587页

作者： Yongjun Chen Tubing Yin P.g.Ranjith Xibing li Qiang li Dengdeng Zhuang School of Resources and Safety Engineering Central South UniversityChangsha410083China Department of Civil Engineering Monash UniversityMelbourne3800Australia Oulu Mining School University of OuluOuluFI-90014Finland

In the engineering practices,it is increasingly common to encounter fractured rocks perturbed by temperatures and frequent dynamic *** this paper,the dynamic behaviors and fracture characteristics of red sandstone considering temperatures(25℃,200℃,400℃,600℃,and 800℃)and fissure angles(0°,30°,60°,and 90°)were evaluated under constant-amplitude and low-cycle(CALC)impacts actuated by a modified split Hopkinson pressure bar(SHPB)***,fracture morphology and second-order statistics within the grey-level co-occurrence matrix(gLCM)were examined using scanning electron microscopy(SEM).Meanwhile,the deep analysis and discussion of the mechanical response were conducted through the synchronous thermal analyzer(STA)test,numerical simulations,one-dimensional stress wave theory,and material *** multiple regression models between response variables and interactive effects of independent variables were established using the response surface method(RSM).The results demonstrate the fatigue strength and life diminish as temperatures rise and increase with increasing fissure angles,while the strain rate exhibits an inverse ***,the peak stress intensification and strain rate softening observed during CALC impact exhibit greater prominence at increased fissure *** failure is dominated by tensile damage with concise evolution paths and intergranular cracks as well as the compressor-crushed zone which may affect the failure mode after 400℃.The second-order statistics of gLCM in SEM images exhibit a considerable dependence on the ***,thermal damage dominated by thermal properties controls the material structure and wave impedance and eventually affects the incident wave *** tensile wave reflected from the fissure surface is the inherent mechanism responsible for the angle effect exhibited by the fatigue strength and ***,the peak stress intensification and strain rate softening during impact are determ

关键词： Red sandstone Temperature Fissure Constant-amplitude and low-cycle(CALC) impact Fatigue failure Response surface method(RSM)

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Effect of Al_(2)O_(3)on the Mechanical Properties of(B_(4)C+Al_(2)O_(3))/Al neutron Absorbing Materials

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Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1411-1420页

作者： J.X.Cai B.M.Shi n.li Y.liu Z.g.Zhang Y.n.Zan Q.Z.Wang B.L.Xiao Z.Y.Ma Shi‑Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Key Laboratory of nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China nuclear Equipment Division Beijing Institute of Nuclear EngineeringChina Nuclear Power Engineering Co.Ltd.Beijing 100840China Department of Materials Science School of Mechanical EngineeringShenyang UniversityShenyang 110044China

B_(4)C/Al composites are widely utilized as neutron absorbing materials for the storage and transportation of spent nuclear *** order to improve the high-temperature mechanical properties of B_(4)C/Al composites,in-situ nano-Al_(2)O_(3)was introduced utilizing oxide on Al powder *** this study,the Al_(2)O_(3)content was adjusted by utilizing spheroid Al powder with varying diameters,thereby investigating the impact of Al_(2)O_(3)content on the tensile properties of(B_(4)C+Al_(2)O_(3))/Al *** was found that the pinning effect of Al_(2)O_(3)on the grain boundaries could hinder the recovery of dislocations and lead to dislocation accumulation at high *** the result,with the increase in Al_(2)O_(3)content and the decrease in grain size,the high-temperature strength of the composites increased *** finest Al powder used in this investigation had a diameter of 1.4μm,whereas the resultant composite exhibited a maximum strength of 251 MPa at room temperature and 133 MPa at 350℃,surpassing that of traditional B_(4)C/Al composites.

关键词： Al matrix composites neutron absorbing materials (B_(4)C+Al_(2)O_(3))/Al composites High-temperature strength

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Anthropogenic mineral generation and its potential resource supply:The case of niobium

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Science China Earth Sciences 2024年第8期67卷 2583-2591页

作者： Xianlai ZEng Moisés gómez Mahmoud BAKRY Yong gEng Jinhui li School of Environment Tsinghua UniversityBeijing 100084China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of International and Public Affairs Shanghai Jiao Tong UniversityShanghai 200030China

The strategy of carbon neutrality is reshaping the global landscape of resource flow and *** the final sink of geological minerals,the proliferated anthropogenic minerals,also called secondary resources,play an increasingly important role in resource supply *** is a critical metal that lacks full concern for its *** fundamental principle of niobium circularity is to recycle and maintain the material as close to the manufacturing process as *** we estimate the niobium-containing applications lost at their end-of-life,underscoring the imperative to minimize such ***,we elucidate the extraction processes for scrap and alloy quantities throughout the industry's *** from anticipated waste generated by the majority of niobium applications,a forecast indicates a potential loss of approximately 168 kt by 2090 in the absence of ***,with a recycling efficiency of 90%for niobium,the projected loss diminishes to approximately 16 *** delve into the significance of niobium's circular economy and explore various aspects that demand further investigation for a seamless transition from linear to circular practices.

关键词： niobium Anthropogenic mineral Circular economy Recycling Sustainability

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Structural changes in the obese brain

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neural Regeneration Research 2024年第12期19卷 2561-2562页

作者： Anna R.R.Da Conceicao Marcelo n.n.Vieira Fernanda g.De Felice D’Or Institute for Research and Education Rio de JaneiroBrazil Institute of Medical Biochemistry Leopoldo De Meis Federal University of Rio de JaneiroRio de JaneiroBrazil Centre for neuroscience Studies Department of Biomedical and Molecular Sciences&Department of PsychiatryQueen’s UniversityKingstonONCanada

Obesity represents a major global health concern,with widespread growing prevalence and severe consequences for the quality of life and life expectancy of affected individuals and for the economic burden of healthcare systems(Prospective Studies Collaboration,2009).Obesity is a well-established risk factor for a variety of conditions including metabolic,vascula r,and heart diseases,and seve ral types of cancer(Prospective Studies Collaboration,2009).

关键词： diseases consequences prevalence

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Enhanced heavy and extra heavy oil recovery: Current status and new trends

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PETROLEUM 2024年第3期10卷 399-410页

作者： gomaa, Sayed Salem, Khalaf g. El-hoshoudy, A. n. Al Azhar Univ Fac Engn Min & Petr Engn Dept Cairo Egypt South Valley Egyptian Petr Holding Co gAnOPE Dept Reservoir Engn Cairo Egypt Egyptian Petr Res Inst PVT Lab Prod Dept Cairo 11727 Egypt Egyptian Petr Res Inst EPRI PVT Serv Ctr Cairo 11727 Egypt

Due to the increased demand for energy resources these days, especially due to the Russian-Ukrainian war, the focus of the major countries is turning strongly towards improving oil production, especially heavy and extra heavy oil, which represents 40% of the world oil reserve. Steam-based and thermal (EOR) procedures are promising techniques for recovering heavy oil reservoirs, but they suffer from a sequence of problems and complications that arise after long-term application. These complications comprise steam breakthrough, steam overlap, and steam/rock interactions. This research presents the currently applied techniques to maximize the productivity of heavy oil, such as steam injection, cyclic steam stimulation, in-situ combustion, and steam-assisted gravity drainage. Thermal technologies face numerous obstacles, as they are energy and water-intensive processes that are not environmentally friendly. The research also presents future trends in energy-saving and environmentally friendly techniques that enhance heavy oil recovery through vapor extraction (VAPEX) steam-solvent hybrid techniques, electromagnetic energy, sonication, and nanotechnology. The findings of this review reported that all the presented techniques focus on how to reduce the oil viscosity and in-situ upgrade the crude oil properties. In turn, these enhance both the productivity rate and oil recovery and minimize the production cost. This article can be considered a comprehensive review of thermal recovery methods in heavy and extra-heavy oil, in addition to screening criteria used for each method. (c) 2023 Southwest Petroleum University. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-nC-nD license (http:// ***/licenses/by-nc-nd/4.0/).

关键词： Enhanced oil recovery Heavy crude oil Steam flood Hybrid techniques nanotechnology In-SITU-COMBUSTIOn ASSISTED gRAVITY-DRAInAgE CYCliC-STEAM-STIMULATIOn ROCK WETTABIliTY VAPOR EXTRACTIOn InJECTIOn PERFORMAnCE BITUMEn SAgD EOR

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