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Controllable Transdermal Drug Delivery of Theobroma cacao Extract Based Polymeric Hydrogel against Dermal Microbial and Oxidative Damage

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Food and Nutrition Sciences 2019年第10期10卷 1212-1235页

作者： Shriya Agarwal vandana tyagi Mugdha Agarwal Arushi Pant Harleen Kaur Rachana Manisha Singh Department of Biotechnology Jaypee Institute of Information Technology Noida India Amity Institute of Biotechnology Amity University Noida India.

Human dermal layers are directly bared to the external environmental adversities like pollution, radiation, dust along with various chemical and mechanical stress conditions which constantly lead to the oxidative stress, eventually forming free radicals. These conditions also support the dermal microbial infections by invading the cutaneous layers. Therefore, the most efficient approach accepted globally to combat these complications is to opt for transdermal application of exogenous antioxidants which helps in reducing the ill effects of oxidative stress and promotes the DNA repair. However, many scientific findings exhibited the potential role of Theobroma cacao for providing efficient skin protection. Theobroma cacao known for its vital procyanidin flavonoids, phenolic compounds, methylxanthines, catechin and epicatechin phytoconstituents with numerous health benefits, besides helping in smoothening and softening the damaged skin. These therapeutic benefits of cocoa phytocompounds are attributed to its anti-inflammatory and antioxidative characteristics. This study addresses the fabrication and optimizations of Theobroma cacao extract loaded carbopol hydrogel system for increased antioxidative and antimicrobial effects. It was found in the studies that the hydrogel-based T. cacao extract (TCHG) has significantly improved the therapeutic index of the extract, making it more suitable for transdermal application. The optimized hydrogel was further characterized by physicochemical parameters, SEM analysis and in-vitro release kinetics. The reported findings showed the sustained compound release with comparatively significant antimicrobial activity of TCHG against microbial (Pseudomonas fluorescens, Bacillus licheniformis, Micrococcus luteus, Aspergillus niger, Trichoderma harzianum, Rhizopus oryzae) infections. Also, the higher ROS quenching ability of TCHG as compared to T. cacao extract promises to be an effective transdermal formulation.

关键词： Theobromine Hydrogel Oxidative Stress Release Kinetics Transdermal

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Congenital anomalies of coronary artery misdiagnosed as coronary dilatations in Kawasaki disease:A clinical predicament

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World Journal of Clinical Pediatrics 2025年第1期14卷 93-100页

作者： Rakesh Kumar Pilania Pallavi L Nadig Suprit Basu Reva tyagi Abarna Thangaraj Ridhima Aggarwal Munish Arora Arun Sharma Surjit Singh Manphool Singhal Pediatric Allergy Immunology Unit Department of PediatricsAdvanced Pediatrics CenterPost Graduate Institute of Medical Education and ResearchChandigarh 160012ChandīgarhIndia Department of Radiodiagnosis and Imaging Postgraduate Institute of Medical Education and ResearchChandigarh 160012ChandīgarhIndia

BACKGROUND 2D-echocardiography(2DE)has been the primary imaging modality in children with Kawasaki disease(KD)to assess coronary *** To report the presence and implications of incidental congenital coronary artery anomalies that had been misinterpreted as coronary artery abnormalities(CAAs)on *** Records of children diagnosed with KD,who underwent computed tomography coronary angiography(CTCA)at our center between 2013-2023 were *** identified 3 children with congenital coronary artery anomalies in this cohort on *** of CTCA and 2DE were compared in these 3 *** Of the 241 patients with KD who underwent CTCA,3(1.24%)had congenital coronary artery anomalies on CTCA detected *** all 3 patients,baseline 2DE had identified *** was then performed for detailed evaluation as per our unit ***(11-year-boy)amongst the 3 patients had complete KD,while the other two(3.3-year-boy;4-month-girl)had incomplete *** revealed separate origins of left anterior descending artery and left circumflex from left sinus[misinterpreted as dilated left main coronary artery(LCA)on 2DE],single coronary artery(interpreted as dilated LCA on 2DE)and dilated right coronary artery on 2DE in case of anomalous origin of LCA from the main pulmonary *** latter one was subsequently operated *** CTCA is essential for detailed assessment of coronary arteries in children with KD especially in cases where there is suspicion of congenital coronary artery *** solely on 2DE may not be sufficient in such cases,and findings from CTCA can significantly impact therapeutic decision-making.

关键词： Coronary artery abnormalities Congenital coronary artery anomalies Computed tomography coronary angiography Kawasaki disease 2-dimensional echocardiography

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Locally Rotationally Symmetric Bianchi Type-II Magnetized String Cosmological Model with Bulk Viscous Fluid in General Relativity

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Chinese Physics Letters 2011年第8期28卷 364-367页

作者： Atul tyagi Keerti Sharma Department of Mathematics and Statistics University College of ScienceMLS UniversityUdaipur 313001(Raj.)India Department of Mathematics Medi-caps Institute of Technology and ManagementIndore(MP)India

The locally rotationally symmetric Bianchi type-II magnetized string cosmological model with bulk viscous fluid is *** magnetic field is due to an electric current produced along the x−*** the magnetic field is in the y–z plane and F23 is the only non−vanishing component of electromagnetic field tensor *** obtain the deterministic model in terms of cosmic time t,we have assumed the conditionξθ=const,whereξis the coefficient of bulk viscosity andθis the expansion in the model.

关键词： Bianchi string Cosmo

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Bianchi Type-V Magnetized String Cosmological Model with Variable Magnetic Permeability for Viscous Fluid distribution

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Chinese Physics Letters 2010年第8期27卷 275-278页

作者： Atul tyagi Keerti Sharma Department of Mathematics and Statistics College of Science MLS University Udaipur 313001 India Department of Mathematics Medi-Caps Institute of Technology and Management A.B. Road Pigdambar Indore 453331 India

We investigate the Bianchi type-V magnetized string cosmological model with variable magnetic permeability for viscous fluid distribution. The magnetic field is due to an electric current produced along the x-axis. Thus the magnetic field is in yz-plane and F23 is the only non-vanishing component of electromagnetic field tensor Fij. To obtain the deterministic model in terms of cosmic time t, we assume the condition ξθ const where ξ is the coefficient of bulk viscosity and θ the expansion in the model.

关键词： Magnetic fields Viscosity Cosmological models

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Artificial neural network based modeling of liquid membranes for separation of dysprosium

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Journal of Rare Earths 2023年第3期41卷 440-445,I0005页

作者： Jawad Iqbal Arjun tyagi Manish Jain Department of Applied Chemistry Delhi Technological UniversityDelhi110042India

In recent years,the liquid membrane process has been widely investigated to remove rare earth ***,transport modeling of this process requires the accurate values of several parameters,which are difficult to ***,the accurate simulation of this process is a challenging *** this study,the artificial neural network(ANN)based approach is used to model the liquid membrane process for removing *** results from a previous study were used to train the ***,the number of neurons in the hidden layer was *** minimum mean squared error between experimental results and model predictions is found with ten *** predictions were successfully validated with experimental results with correlation factor(R)of 0.9987,which confirms the authenticity of the trained *** ANN was then used to study the effects of different operating parameters on transport *** higher volume ratio of membrane solution to feed solution(3-4)with 50-60 min of operation,higher feed pH(5),HCl concentration in stripping solution of 2 mol/L,and moderate concentration of carrier species(0.5 mol/L)with 0.5×10^(-4) mol/L dysprosium initial concentration are found to be optimum values of operating conditions for maximizing the transport rate.

关键词： Rareearth metal separation Artificial neural network Dysprosium separation Liquid membranes

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Bianchi Type-IX String Cosmological Models for Perfect Fluid Distribution in General Relativity

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Chinese Physics Letters 2010年第7期27卷 299-301页

作者： Atul tyagi Keerti Sharma Payal Jain Department of Mathematics and Statistics College of Science MLS University Udaipur-313001 India Department of Mathematics Techno India NJR Institute of Technology Udaipur-313004 India

The present study deals with Bianchi type-IX string cosmological models for perfect fluid distribution. We consider two cases：（i） ρ ＋ λ = 0, （ii） ρ - λ = 0, where ρ and λ are the rest energy density and the tension density of a string cloud, respectively. The physical and geometrical properties of the models are discussed.

关键词： Clouds Cosmological models Relativity theory

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Application of Fractional Order PID Controller for AGC Under Deregulated Environment

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International Journal of Automation and computing 2018年第1期15卷 84-93页

作者： Nagendra Kumar Barjeev tyagi Vishal Kumar Department of Electrical Engineering Indian Institute of Technology

In this paper, a fractional order proportional integral derivative （FOPID） controller for multiarea automatic generation control （AGC） scheme has been designed. FOPID controller has five parameters and provides two additional degrees of flexibility in comparison to a proportional integral derivative （PID） controller. The optimal values of parameters of FOPID controller have been determined using Big Bang Big Crunch （BBBC） search algorithm. The designed controller regulates real power output of generators to achieve the best dynamic response of frequency and tie-line power on a load perturbation. The complete scheme for designing of the controllers has been developed and demonstrated on multiarea deregulated power system. The performance of the designed FOPID controllers has been compared with the optimally tuned PID controllers. It is observed from the results that the FOPID controller shows a considerable improvement in the performance as compared to the conventional PID controller.

关键词： Automatic generation control (AGC) deregulation Big Bang Big Brunch (BBBC) algorithm fractional order propor-tional integral derivative (FOPID) controller optimization.

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Metalloproteinases as mediators of inflammation and the eyes： molecular genetic underpinnings governing ocular pathophysiology

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International Journal of Ophthalmology(English edition) 2017年第8期10卷 1308-1318页

作者： Mahavir Singh Suresh C tyagi Eye and Vision Science Laboratory Department of Physiology University of Louisville School of Medicine Louisville KY 40202 USA

There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases （MMPs）; the Zn （2＋）-dependent endoproteases in eye health along with pathogenesis of prominent ocular diseases such as macular degeneration, diabetic retinopathy, and glaucoma via understanding MMPs regulation in affected patients, interactions of MMPs with their substrate molecules, and key regulatory functions of tissue inhibitor of metalloproteinases （TIMPs） towards maintaining overall homeostasis.

关键词： age-related macular degeneration choroidal neovascularization diabetes glaucoma metalloproteinases tissue inhibitors of metalloproteinases

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Genes and genetics in eye diseases: a genomic medicine approach for investigating hereditary and inflammatory ocular disorders

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 117-134页

作者： Mahavir Singh Suresh C tyagi Eye and Vision Science Laboratory Department of Physiology University of Louisville School of Medicine

Past 25 y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can influence vision and health of our eyes. Based on these findings, it is becoming clear that an early diagnosis employing genetic testing can help evaluate patients＇ conditions for instituting treatment plan（s） and follow-up care to avoid vision complications later. For example, knowing family history becomes crucial for inherited eye diseases as it can benefit members in family who may have similar eye diseases or predispositions. Therefore, gathering information from an elaborate examination along with complete assessment of past medical illness by ophthalmologists followed by consultation with geneticists can help create a roadmap for making diagnosis and treatment precise and beneficial. In this review, we present an update on ocular genomic medicine that we believe has tremendous potential towards unraveling genetic implications in ocular diseases and patients＇ susceptibilities. We also discuss translational aspects of genetic ophthalmology and genome engineering that may help advance molecular diagnostics and therapeutics.

关键词： CRISPR/Cas9 precision medicine genetic ophthalmology genome engineering inflammation single nucleotide polymorphism

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Investigation of Weakly Relativistic Ponderomotive Effects on Self-Focusing During Interaction of High Power Elliptical Laser Beam with Plasma

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Communications in Theoretical Physics 2017年第8期67卷 245-249页

作者： Keshav Walia Deepak Tripathi Yachna tyagi Department of Physics DAV University Jalandhar Department of Physics AIAS Amity University Noida

This paper presents an investigation of weakly relativistic ponderomotive effects on self-focusing during interaction of high power elliptical laser beam with plasma. The nonlinear differential equations for the beam width parameters of elliptical laser beam have set up by using Wentzal–Krammers–Brillouin(WKB) and paraxial approximations. These equations have been solved numerically by using fourth order Runge–Kutta method to study the variation of these beam width parameters against normalized distance of propagation. Effects of variation in laser beam intensity,plasma density and electron temperature on the beam width parameters are also analyzed.

关键词： self-focusing elliptical laser beam weakly relativistic ponderomotive effects plasma density elec-tron temperature

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