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Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy

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World Journal of Methodology 2025年第2期15卷 137-144页

作者： vandana Tayal Akash Mandal Ijasul Haque M Akhilesh Mishra Bhupinder S Kalra vandana roy Department of Pharmacology Maulana Azad Medical CollegeNew Delhi 110002India Department of Pharmacology MES Medical CollegePerintalmanna 679338KeralaIndia Department of Central Animal Facility Maulana Azad Medical CollegeNew Delhi 110002India

BACKGROUND Epilepsy impacts millions of people,with many not responding to existing *** evidence links neuroinflammatory processes to *** exhibit anti-inflammatory and neuroprotective properties,potentially offering antiepileptic *** To evaluate the anticonvulsant effects of rosuvastatin in animal models of *** Ninety-six albino mice were divided into 16 *** the maximal electroshock seizure(MES)model,eight groups received intraperitoneal vehicle,carbama-zepine,rosuvastatin,or a *** measured included seizure protection[tonic hind limb extension(THLE)],duration of THLE,seizure duration,and *** the pentylenetetrazol(PTZ)model,eight groups were pretreated with vehicle,valproate,rosuvastatin,or a combination,with outcomes measured as seizure latency,seizure duration,and *** In the MES model,rosuvastatin exhibited protection against THLE in a small percentage of *** shortens the duration of THLE in a dose-dependent ***,none of these were statistically significant com-pared to the control *** combination of rosuvastatin 10 mg/kg with carbamazepine 4 mg/kg resulted in a significant reduction in seizure duration compared to the control group,better than carbamazepine alone at 4 mg/kg and 6 mg/*** the PTZ model,rosuvastatin alone showed no significant effects on latency,duration of seizure,or ***,rosuvastatin 10 mg/kg combined with valproate 100 mg/kg significantly delayed the onset of seizures,seizure duration and mortality percentage,better than valproate alone at 100 mg/*** Rosuvastatin enhanced the anticonvulsant effects of carbamazepine and *** studies are required to explore the antiepileptic potential of rosuvastatin at various doses,durations,dosage forms,routes and models.

关键词： Antiepileptic Anticonvulsant Statins Rosuvastatin Maximal electroshock seizure Pentylenetetrazol

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Awareness,practice and views about integrating AYUSH in allopathic curriculum of allopathic doctors and interns in a tertiary care teaching hospital in New Delhi,India

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Journal of Integrative Medicine 2018年第2期16卷 113-119页

作者： Shubha Singhal vandana roy Department of Pharmacology Maulana Azad Medical College

Objective： To assess the knowledge, attitude, perception and practice of Ayurveda, yoga, Unani, Siddha, homeopathy and naturopathy （AYUSH） among allopathic doctors and interns and determine their opin- ion regarding integration of AYUSH education within the allopathic curriculum. Methods： This prospective, cross sectional study was conducted in a tertiary care teaching Hospital, New Delhi, India, from March 2016 to March 2017. A survey of 500 aUopathic doctors and 150 interns was performed using a structured questionnaire. Results： A majority of doctors （95.2%） were aware of the term AYUSH and had knowledge of yoga （70.6%）, homeopathy （55.6%）, Ayurveda （50.3%）, Siddha （47.8%）, naturopathy （32.9%） and Unani （28.9%）. Most of the participants （63.0%） felt that therapies under AYUSH are effective. A majority （84.0%） of the doctors were of the view that more research is required in the field of AYUSH. While homeopathy （44.0%） was the most common system used by doctors for themselves, yoga was the therapy most commonly （60.0%） recommended to patients. Nearly half of the doctors （46.7%） recommended AYUSH to their patients, mainly for chronic illness （74.0%）. A majority （77.5%） of the respondents agreed that students of allopathic med- icine should be familiarized with AYUSH. The modes of incorporation of AYUSH into the medical curriculum most commonly suggested by respondents were optional courses （54.5%） and introductory lectures （42.3%）. Conclusion： Doctors and interns ofallopathic medicine are aware of AYUSH systems. They use it for them- selves and recommend it to patients. They believe that familiarization of Bachelor of Medicine and Bachelor of Surgery students with AYUSH therapies and their integration with allopathic medicine may help in improving patient care.

关键词： Ayurveda Yoga Unani Siddha Homeopathy Naturopathy Allopathic doctors Complementary therapies Ayurvedic medicine

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Practice patterns among ophthalmic surgeons in treating concomitant oculoplastic conditions in preoperative period:A questionnaire-based study

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World Journal of Clinical Cases 2025年第1期13卷 29-37页

作者： Bijnya Birajita Panda Chitaranjan Mishra Bhagabat Nayak Avik Kumar roy Logesh Balakrishnan Priyadarshini Mishra Department of Ophthalmology All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia Department of Vitreo-Retina Trilochan NetralayaSambalpur 768004India Department of Glaucoma Services LV Prasad Eye InstituteBhubaneswar 751013India Department of Statistics Apollo HospitalsChennai 823104India

BACKGROUND Addressing oculoplastic conditions in the preoperative period ensures both the safety and functional success of any ophthalmic *** oculoplastic conditions,like nasolacrimal duct obstruction,have been extensively studied,whereas others,like eyelid malposition and thyroid eye disease,have received minimal or no *** To investigate the current practice patterns among ophthalmologists while treating concomitant oculoplastic conditions before any subspecialty ophthalmic *** A cross-sectional survey was disseminated among ophthalmologists all over *** survey included questions related to pre-operative evaluation,anaesthetic and surgical techniques preferred,post-operative care,the use of adjunctive therapies,and patient follow-up *** A total of 180 ophthalmologists responded to the *** practitioners(89%)felt that the ROPLAS test was sufficient during pre-operative evaluation before any subspecialty surgery was *** most common surgical techniques employed were lacrimal drainage procedures(Dacryocystorhinostomy)(63.3%),eyelid malposition repair(36.9%),and ptosis repair(58.7%).Post-operatively,47.7%of respondents emphasized that at least a 4-week gap should be maintained after lacrimal drainage procedures and eyelid ***-seven percent of ophthalmologists felt that topical anaesthetic procedures should be preferred while performing ocular surgeries in thyroid eye disease *** Approximately 50%of ophthalmologists handle prevalent oculoplastic issues themselves,seeking the expertise of an oculoplastic surgeon under particular *** ophthalmologists still favor using ROPLAS as a preliminary screening method before proceeding with cataract *** conditions and thyroid eye disease are not as commonly addressed before subspecialty procedures compared to issues like nasolacrimal duct obstruction and periocular infections.

关键词： Oculoplasty Ophthalmic plastic surgery Nasolacrimal duct obstruction Practice patterns Survey

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A Review on Thermophysical Properties and Nusselt Number Behavior of Al2O3 Nanofluids in Heat Exchangers

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Journal of Thermal Science 2021年第2期30卷 418-431页

作者： ISSA roy Jean College of Engineering West Texas A&M UniversityCanyonTexas 79016USA

During the last several years,the increase in cooling power requirements for heat exchangers have led to an escalation in heat transfer studies being performed on the use of nanofluids as heat transfer ***,limited effort has been attempted to relate and interpret these findings or the anomalies associated with *** paper compiles test data from several studies conducted on different types of heat *** this review,a concentrated effort is spent to clarify the ambiguities regarding the effect of nanoparticle size on the nanofluid thermal conductivity and Nusselt *** show that the nanofluid thermal conductivity is not influenced by the nanoparticle size,but by the clustering of the particles *** less compact the structure of the nanoparticle clustering is,the greater the enhancement in the nanofluid thermal conductivity *** were also compiled to interpret the relation between the nanofluid flow pattern,nanoparticles volume fraction in the base fluid,and the convective heat *** results from the majority of the heat exchanger studies show an increase in the heat transfer coefficient with the increase in nanoparticle volume ***,studies conducted on plate heat exchanges display some *** the majority of the heat exchanger studies with the exception of few,the decrease in the nanoparticle size is shown to result in an enhancement of the bulk fluid Nusselt *** test data also reveal that the effectiveness of the alumina nanoparticles is dependent on the flow *** increase in the nanoparticles concentration is shown to result in an increase in the nanofluid heat transfer enhancement as the fluid is transitioning from laminar to turbulent *** general,the smaller the nanoparticle size is,the greater the enhancement in the fluid Nusselt number is.

关键词： heat exchanger Nusselt number alumina nanofluid

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An Estimation of the Geometrical Structure of Polar Cap and Emission Property of Radio Pulsar:A Treatment from an Analytical Approach

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Research in Astronomy and Astrophysics 2023年第4期23卷 44-55页

作者： Tridib roy Indian Institute of Astrophysics Sarjapur Main RoadKoramangala 2nd BlockBangalore 560034India SN Bose National Cenre for Basic Science SaltlakeSector 3JD BlockKolkata 700106India

Pulsars are believed to be one of the most interesting objects in the *** emission mechanism of pulsars is still a conundrum to physicists,as there is no completely acceptable theory that can establish a consensus between theory and *** possess a gigantic magnetic field,to the order of 10^(12)Gauss,and generate a very powerful radio beam from the magnetic ***,the powerful radio beam is generated by some complicated coherent plasma processes and acceleration in the pulsar *** location of the origin of the radio waves has been predicted to come out exclusively from the polar cap zone,whose boundary is defined by the footprint of the last open field ***,in this paper,we mainly try to generate the shape of the polar cap structure from an analytical solution and discuss how it gets distorted for different geometrical parameters due to the presence of perturbation such as polar cap current ***,apart from that,we try to emphasize understanding the variation of radio emission height and polarization angle with respect to different geometryrelated parameters as well as with frequency.

关键词： (stars:)pulsars general-stars neutron-radiation mechanisms non-thermal

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A synchronous duty-cycled reservation based MAC protocol for underwater wireless sensor networks

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Digital Communications and Networks 2021年第3期7卷 385-398页

作者： Alak roy Nityananda Sarma Department of Information Technology Tripura UniversityWest TripuraIndia Department of Computer Science and Engineering Tezpur UniversityAssamIndia

To design an energy-efficient Medium Access Control(MAC)protocol for the Underwater Wireless Sensor Networks(UWSNs)is an urgent research issue since depleted batteries cannot be recharged or replaced in the underwater ***,the underwater acoustic channels are affected by hindrances such as long propagation delay and limited bandwidth,which appear in the design of the MAC protocol for the *** available MAC protocols for the terrestrial wireless sensor networks exhibit low performance in energy efficiency,throughput and reliability in the UWSNs,and cannot be used in the UWSNs directly because of their unique *** paper proposes a synchronous duty-cycled reservation-based MAC protocol named Ordered Contention MAC(OCMAC)*** basic mechanism of this protocol is to schedule data transmission by transmitters through the scheduling of Ready To Send(RTS)*** protocol eliminates the possible collision during data transmission and improves communication *** paper analyzes the performance in energy efficiency,throughput and reliability of the protocol by modeling the queuing behavior of OCMAC with a Markov Chain ***,the analytical model is validated through a simulation *** analysis results demonstrated that while providing good throughput and reliability,OCMAC can achieve energy saving.

关键词： Underwater wireless sensor networks MAC protocol Energy efficiency Throughput Reliability Acoustic communication OCMAC

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Structural,optical,electrical,and dielectric relaxation properties of rare earth containing sodium bismuth titanate Na_(0.5)Bi_(0.5)TiO_(3) perovskite:Effect of ionic radius

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Journal of Rare Earths 2024年第2期42卷 383-391,I0006页

作者： Rajdip roy Abhigyan Dutta Department of Physics The University of BurdwanBurdwan713104India

The main focus of this work is to study the effect of the ionic radius of different rare earth dopant cations RE^(3+)(RE=La,Sm,Dy,and Ho) on structural and various physical properties of sodium bismuth titanate(Na_(0.5)B_(0.5)TiO_(3),NBT) based perovskite *** X-ray diffraction data indicate the successful formation of the rhombohedral phase(space group R3c) of NBT nano perovskite incorporated with various rare earth ions in *** lattice parameters were found to increase linearly with the ionic radius of the dopant *** ionic radii and atomic mass of rare earth dopants appear to be essential factors in the grain growth of the prepared *** grain growth results in better crystallinity of the sample by reducing the microstrain with the increase of dopant ionic *** emission scanning electron microscopy and energy-dispersive X-ray spectra confirm the prepared compositions' phase purity and *** UV-Vis spectra reveal that La-doped NBT composition exhibits the lowest optical band gap,which unfolds the application of NBT-based perovskite as photoactive *** ac conductivity and complex impedance spectra unveil that the composition with the largest ionic radius,i.e.,La-doped NBT compound,exhibits the highest dc and bulk conductivity with the lowest activation *** frequency-dependent dielectric data follows Havriliak-Negami(HN) formalism and non-Debye type relaxation *** also indicate that La-doped NBT composition exhibits the highest dielectric strength ***,this study first elaborates that the increasing ionic radius of the rare earth dopant cation in the Bi-site of NBT perovskite improves its microstructural,optical,and electrical properties.

关键词： Rare earth doped NBT Microstructural analysis Optical band gap AC Conductivity Dielectric relaxation Rare earths

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Time evolution of the matter content of the expanding universe in the framework of Brans-Dicke gravity

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Research in Astronomy and Astrophysics 2019年第4期19卷 137-150页

作者： Sudipto roy Department of Physics St.Xavier's College30 Mother Teresa Sarani (Park Street)

A cosmological model has been constructed in the framework of Brans-Dicke(BD) gravity,based on an inter-conversion between matter and dark energy, for a spatially flat universe in the era of pressureless dust. To account for the non-conservation of the matter content, a function of time f(t) has been arbitrarily put into the expression for the density of matter(ρa^3= f(t)ρ_0 a_0~3). By definition, f(t) is proportional to the matter content of the universe. Using suitable ansatzes for the scale factor and scalar field, the functional form of f(t) has been determined from the BD field equations. The scale factor has been so chosen that it would cause a signature flip in the deceleration parameter with time. The function f(t) decreases monotonically with time, indicating a transformation of matter into dark energy. The time dependence of the proportions of matter and dark energy in the universe has been determined. The effect of non-conservation of the matter content upon various cosmological parameters has been explored in the present study. Two models of matter-energy interaction have been proposed and f(t) has been expressed as a function of their interaction term. The dark energy equation-of-state(EoS) parameter has been expressed and analyzed in terms of f(t).

关键词： cosmology:cosmological parameters dark energy Brans-Dicke theory

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Hybrid optimization algorithm for modeling and management of micro grid connected system

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Frontiers in Energy 2014年第3期8卷 305-314页

作者： Kallol roy Kamal Krishna MANDAL Faculty of Electrical Engineering University Institute of Technology University of Burdwan Burdwan 713104 India

In this paper, a hybrid optimization algorithm is proposed for modeling and managing the micro grid （MG） system. The management of distributed energy sources with MG is a multi-objective problem which consists of wind turbine （WT）, photovoltaic （PV） array, fuel cell （FC）, micro turbine （MT） and diesel generator （DG）. Because, perfect economic model of energy source of the MG units are needed to describe the operating cost of the output power generated, the objective of the hybrid model is to minimize the fuel cost of the MG sources such as FC, MT and DG. The problem formulation takes into consideration the optimal configuration of the MG at a minimum fuel cost, operation and maintenance costs as well as emissions reduction. Here, the hybrid algorithm is obtained as artificial bee colony （ABC） algorithm, which is used in two stages. The first stage of the ABC gets the optimal MG configuration at a minimum fuel cost for the required load demand. From the minimized fuel cost functions, the operation and maintenance cost as well as the emission is reduced using the second stage of the ABC. The proposed method is implemented in the Maflab/ Simulink platform and its effectiveness is analyzed by comparing with existing techniques. The comparison demonstrates the superiority of the proposed approach and confirms its potential to solve the problem.

关键词： micro grid (MG) multi-objective function,artificial bee colony (ABC) fuel cost operation andmaintenance cost

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Heat Transfer Optimization for Air-Mist Cooling between a Stack of Parallel Plates

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Journal of Thermal Science 2010年第3期19卷 253-260页

作者： roy J.Issa Mechanical Engineering Division Department of Engineering and Computer Science West Texas A&M University CanyonTexas 79016USA

A theoretical model is developed to predict the upper limit heat transfer between a stack of parallel plates subject to multiphase cooling by air-mist *** model predicts the optimal separation distance between the plates based on the development of the boundary layers for small and large separation distances,and for dilute mist *** results show the optimal separation distance to be strongly dependent on the liquid-to-air mass flow rate loading ratio,and reach a limit for a critical *** these dilute spray conditions,complete evaporation of the droplets takes *** results also show the optimal separation distance decreases with the increase in the mist flow *** proposed theoretical model shall lead to a better understanding of the design of fins spacing in heat exchangers where multiphase spray cooling is used.

关键词： Air-mist Multiphase Heat transfer Liquid-to-air loading

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