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Stereoselective recognition of morphine enantiomers by μ-opioid receptor

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National Science Review 2024年第3期11卷 183-191页

作者： Yibo Wang van A.ngo Xiaohui Wang Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of Sciences Advanced Computing for Life Sciences and Engineering Group Science Engagement Section National Center for Computational Sciences Oak Ridge National Lab School of Applied Chemistry and Engineering University of Science and Technology of China Beijing National Laboratory for Molecular Sciences

Stereospecific recognition of chiral molecules plays a crucial role in biological systems. The μ-opioid receptor（MOR） exhibits binding affinity towards（-）-morphine, a well-established gold standard in pain management, while it shows minimal binding affinity for the（+）-morphine enantiomer, resulting in a lack of analgesic activity. Understanding how MOR stereoselectively recognizes morphine enantiomers has remained a puzzle in neuroscience and pharmacology for over half-a-century due to the lack of direct observation techniques. To unravel this mystery, we constructed the binding and unbinding processes of morphine enantiomers with MOR via molecular dynamics simulations to investigate the thermodynamics and kinetics governing MOR's stereoselective recognition of morphine enantiomers. Our findings reveal that the binding of（-）-morphine stabilizes MOR in its activated state, exhibiting a deep energy well and a prolonged residence time. In contrast,（+）-morphine fails to sustain the activation state of ***, the results suggest that specific residues, namely D1142.50and D1473.32, are deprotonated in the active state of MOR bound to（-）-morphine. This work highlights that the selectivity in molecular recognition goes beyond binding affinities, extending into the realm of residence time.

关键词： stereoselective recognition thermodynamics and kinetics residence time morphine enantiomers μ-opioid receptor

Marketing Strategies Evaluation and Selection for Supply Chain Management Under Uncertainty

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Computers, Materials & Continua 2022年第12期73卷 6535-6546页

作者： ngo Quang Trung Nguyen van Thanh Faculty of Commerce Van Lang UniversityHo Chi Minh City70000Vietnam

Sustainable marketing,often known as green marketing,has grown in popularity over the last two *** is currently putting pressure to encourage firms to become environmentally aware in multiple aspects like human and financial utilization,advertisement,and product *** types of companies are including many environmental campaigns into their own products to take advantage of the *** many scholars have addressed the relevance of green marketing as well as theory development,this study is unique in that it examines both techniques in a fuzzy *** integrated Fuzzy Multicriteria Decision Making Model(MCDM)of the analytical hierarchy process(AHP)and a Portuguese-acronymous MCDM method(TODIM)are used to select the best marketing strategy from five alternatives:(i)Green Design,(ii)Green Positioning,(iii)Green Pricing,(v)Green Packaging,and(iv)Green *** on criteria such as the scale of the green market,price parity,and the commitment of top *** for evaluating green marketing strategies was established in the study as contributions for decisionmakers in this field under unclarified *** research also a useful guideline for ranking alternatives in others industry.

关键词： Green marketing MCDM model sustainable marketing strategy

Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da Silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

Insights from an academic endeavor into central nervous system drug discovery

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Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An M.Voets Tim vanmierlo Rudy Schreiber BIOMED Biomedical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Department of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University MS Center(UMSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery R&D ***,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(Mazzucato,2013).

关键词： academic approval consequences

Added Resistance Acting on Hull of a Non Ballast Water Ship

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Journal of Marine Science and Application 2014年第1期13卷 11-22页

作者： ngo van He Yoshiho Ikeda Marine System Engineering Osaka Prefecture University Department of Ship Engineering and Fluid Mechanics Hanoi University of Science and Technology

In this paper, added resistances acting on a hull of non ballast water ship(NBS) in high waves is discussed. The non ballast water ships were developed at the laboratory of the authors at Osaka Prefecture University, Japan. In the present paper, the performances of three kinds of bow shapes developed for the NBS were theoretically and experimentally investigated to find the best one in high waves. In previous papers, an optimum bow shape for the NBS was developed in calm water and in moderated waves. For a 2 m model for experiments and computations, the wave height is 0.02 m. This means that the wave height is 15% of the draft of the ship in full load conditions. In this paper, added resistances in high waves up to 0.07 m for a 2 m model or 53% of the full load draft are investigated. In such high waves linear wave theories which have been used in the design stage of a ship for a long time may not work well anymore, and experiments are the only effective tool to predict the added resistance in high waves. With the computations for waves, the ship is in a fully captured condition because shorter waves, λ/Lpp<0.6, are assumed.

关键词： added resistance non ballast water ship hull optimum bow shape

Offshoring and Reshoring： The Roles of Incomplete Contracts and Relative Bargaining Power

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2018年第1期13卷 32-51页

作者： ngo van Long Maxwell Tuuli Department of Economics McGill University Montreal Quebec H3A 2T7 Canada Peter B. Gustavson School. of Business University of Victoria Victoria BC V8P 5C2 Canada

This paper demonstrates that an increase in bargaining power of Northern firms relative to that of their Southern contractors can trigger reshoring if the North- South wage differential is moderate, such that only industries with a high share of unskilled labor find outsourcing profitable. However, such an increase in Northern bargaining power can increase offshoring if the wage differential is so high that even industries with a low share of unskilled labor also offshore.

关键词： incomplete contracts bargaining power offshoring reshoring

Formal verification of synchronous data-flow program transformations toward certified compilers

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Frontiers of Computer Science 2013年第5期7卷 598-616页

作者： van Chan ngo Jean-Pierre TALPIN Thierry GAUTIER Paul Le GUERNIC Loic BESNARD INRIA Rennes-Bretagne Atlantique Rennes 35042 France IRISA/CNRS Rennes 35042 France

Translation validation was invented in the 90＇s by Pnueli et al. as a technique to formally verify the correctness of code generators. Rather than certifying the code generator or exhaustively qualifying it, translation validators attempt to verify that program transformations preserve semantics. In this work, we adopt this approach to formally verify that the clock semantics and data dependence are preserved during the compilation of the Signal compiler. Translation valida- tion is implemented for every compilation phase from the initial phase until the latest phase where the executable code is generated, by proving the transformation in each phase of the compiler preserves the semantics. We represent the clock semantics, the data dependence of a program and its trans- formed counterpart as first-order formulas which are called clock models and synchronous dependence graphs （SDGs）, respectively. We then introduce clock refinement and depen- dence refinement relations which express the preservations of clock semantics and dependence, as a relation on clock mod- els and SDGs, respectively. Our validator does not require any instrumentation or modification of the compiler, nor any rewriting of the source program.

关键词： formal verification translation validation certi-fied compiler multi-clocked synchronous programs embed-ded systems.

Fuzzy Decision Model: Evaluating and Selecting Open Banking Business Partners

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Computers, Materials & Continua 2022年第9期72卷 4557-4570页

作者： ngo Quang Trung Nguyen van Thanh Nguyen Viet Tinh Syed Tam Husain Faculty of Commerce Van Lang UniversityHo Chi Minh City70000Vietnam

The finance supply chain has always been a different supply chain compared to product supply chain being a service supply *** Banking(OB)is one of the most important milestones since the beginning of financial technology innovation and service supply *** these are activities provided by traditional banks,non-bank financial institutions also provide financial service with access to consumer banking,transactional and other financial data to develop financial applications and services tailored to their *** development of financial technology,“Open banking”,promotes financial services to begin this ***,evaluating and selecting open banking business partners from multiple perspectives for banks are ***,the authors in this research proposed a hybrid multicriteria decision-making model which includes a Spherical Fuzzy Analytical Hierarchy Process(SF-AHP)model and a Multi-Attributive Ideal-Real Comparative Analysis(MAIRCA)model with supports from seasoned domain *** contribution of this research is a proposition of a fuzzy decision model for evaluating and selecting open banking business *** model successfully determined a suitable open bank provider in order to assist decision makers decide objectively.

关键词： Open banking MCDM SF-AHP MAIRCA fuzzy theory

Photodiode-Based Chua＇s Circuit with Light Controllability

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Chinese Physics Letters 2014年第6期31卷 24-28页

作者： NAM sang Guk NGUYEN van Ha SONG Hanjung Department of Nanoseience and Engineering lnje University Gimhae 621-749 Korea Center for Nano Manufacturing Inje University Gimhae 621-749 Korea

We present a photodiode-based Chua＇s chaotic circuit that is controllable by light. The proposed circuit consists of an inductor, two passive capacitors, a photodiode-based variable resistor, and a positive feedback trans- conductor with negative nonlinearity. The chaotic dynamics of the circuit were verified by using the simulation program with integrated circuit emphasis analysis using the 0.35 #m complementary metal-oxide-semiconductor process parameters. The gain results （such as the time waveform~ frequency analysis, three-dimensional attractor, bifurcation and Lyapunov exponents diagrams） confirm that the chaotic behavior of the circuit could be controlled by light intensity via the photodiode-based variable resistor.

关键词： REDUCED instruction set computers INTEGRATED circuits SEMICONDUCTOR industry COMPUTER simulation ENERGY storage SEMICONDUCTOR doping