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国外医学（皮肤性病学分册） 1994年第1期20卷 33-37页

作者： van der sluis jj 龚匡隆

对梅毒免疫血清学试验和分子生物学方法等梅毒的实验室诊断技术进行了文献复习。着重比较了梅毒血清学试验与分子生物学技术诊断梅毒的敏感性和特异性。认为多聚酶链式反应诊断先天性和神经性梅毒具有一定的敏感性和特异性。

关键词：梅毒实验室诊断

An unusual cause of hematemesis:Goiter

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World Journal of Gastroenterology 2006年第33期12卷 5412-5415页

作者： Astrid AM van der Veldt Mohammed Hadithi Marinus A Paul Fred G van den Berg Chris jj Mul-der Mikael E Craanen Department of Gastroenterology VU University Medical Center Amsterdam The Netherlands Department of Surgery VU University Medical Center Amsterdam The Netherlands Department of Radiology VU University Medical Center Amsterdam The Netherlands

Downhill varices are located in the upper part of the esophagus and are usually related to superior vena cava obstruction. Bleeding from these varices is extremely rare. We describe a 77-year-old patient with hematemesis due to downhill varices as a result of recurrent goiter. A right lobe thyroidectomy was carried out with disappearance of the varices.

关键词： Downhill Esophageal Varices Goiter Hematemesis

Double balloon endoscopy associated pancreatitis:A description of six cases

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World Journal of Gastroenterology 2008年第5期14卷 720-724页

作者： Soeresh VA Jarbandhan Stijn JB van Weyenberg Willem M van der Veer Dimitri GN Heine Chris jj Mulder Maarten AJM Jacobs Small Bowel Unit Department of Gastroenterology VU University Medical Center Amsterdam The Netherlands

AIM:To perform a single-center analysis of all double balloon endoscopy (DBE) related cases of pancreatitis identified prospectively from a recorded DBE-complication database. METHODS:From November 2003 until January 2007, 603 DBE procedures were performed on 412 patients, with data on complications recorded in a database. The setting was a tertiary care center offering DBE. DBE was performed from the antegrade or retrograde route. Out-come measurements included age, gender, medication, indication, DBE-endoscope type, insertion depth, proce-dure duration, findings, interventions, post-procedural abdominal pain, and post-procedural hospitalization. RESULTS:This is the largest single-center study report-ing on post-DBE pancreatitis prospectively. Six patients (1.0%) developed post-DBE pancreatitis, all after antegrade DBE. There was no association with gender, duration of the procedure or type of endoscope. The mean age was 51.9 years (range 25-78). Four patients had severe pancreatitis. Of these, two had inflammatory signs in the body-tail region, one had pancreatitis in the tail region, and the total pancreas was involved in one. CONCLUSION:The incidence of post-DBE pancreatitis in our series is higher than previously reported. We found no relation with DBE-endoscope type. The inflammatory changes occurred in the body-tail region of the pancreas, suggesting that post-DBE pancreatitis is caused by repetitive mechanical strain on the pancreas.

关键词： Double balloon endoscopy Small intestine Adverse events Complications Pancreatitis Enteroscopy

Surgery in (pre)malignant celiac disease

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World Journal of Gastroenterology 2015年第43期21卷 12403-12409页

作者： Jolanda MW van de Water Petula Nijeboer Laura R de Baaij Jessy Zegers Gerd Bouma Otto J Visser Donald L van der Peet Chris jj Mulder Wilhelmus JHJ Meijerink Department of Gastroenterology and Hepatology Coeliac Center AmsterdamVU University Medical Center Department of Haematology Coeliac Center AmsterdamVU University Medical Center Department of Surgery Coeliac Center Amsterdam VU University Medical Center

AIM: To report the outcome of surgery in patients with(pre)malignant conditions of celiac disease(CD) and the impact on ***: A total of 40 patients with(pre)malignant conditions of CD,ulcerative jejunitis(n = 5) and enteropathy associated T-cell lymphoma(EATL)(n = 35),who underwent surgery between 2002 and 2013 were retrospectively evaluated. Data on indications,operative procedure,post-operative morbidity and mortali ty,adjuvant therapy and overal l survival(OS) were collected. Eleven patients with EATL who underwent chemotherapy without resection were included as a control group for survival analysis. Patients were followed-up every three months during the first year and at 6-mo intervals ***: Mean age at resection was 62 years. The majority of patients(63%) underwent elective laparotomy. Functional stenosis(n = 1 3) and perforation(n = 12) were the major indications for surgery. In 70% of patients radical resection wasperformed. Early postoperative complications,mainly due to leakage or sepsis,occurred in 14/40(35%) of patients. Eight patients required reoperation. More patients who underwent resection in the acute setting(n = 3,20%) died compared to patients treated in the elective setting. With a median follow-up of 20 mo,seven patients(18%) required reoperation due to long-term complications. Significantly more patients who underwent acute surgery could not be treated with adjuvant chemotherapy. Patients who first underwent surgical resection showed significantly better OS than patients who received chemotherapy without ***: Although the complication rate is high,the preferred first step of treatment in(pre)malignant CD consists of local resection as early as possible to improve survival.

关键词： Enteropathy associated T-cell lymphoma Ulcerative

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World Journal of Gastroenterology 2012年第38期18卷 5397-5403页

作者： Sietze T van Turenhout Leo GM van Rossum Frank A Oort Robert JF Laheij Anne F van Rijn Jochim S Terhaar sive Droste Paul Fockens René WM van der Hulst Anneke A Bouman Jan BMJ Jansen Gerrit A Meijer Evelien Dekker Chris jj Mulder Department of Gastroenterology and Hepatology VU University Medical Center1081 HV Amsterdam The Netherlands Department of Epidemiology Biostatistics and HTA Radboud University Nijmegen Medical Center6500 HB Nijmegen The Netherlands Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Center6500 HB Nijmegen The Netherlands Department of Gastroenterology and Hepatology Academic Medical Center1105 AZ Amsterdam The Netherlands Department of Gastroenterology and Hepatology Kennemer Gasthuis 2035 RC Haarlem The Netherlands Clinical Chemistry VU University Medical Center 1081 HV Amsterdam The Netherlands Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Center 6500 HB Nijmegen The Netherlands Department of Pathology VU University Medical Center 1081 HV Amsterdam The Netherlands Department of Gastroenterology and Hepatology Academic Medical Center 1105 AZ Amsterdam The Netherlands Department of Gastroenterology and Hepatology VU University Medical Center 1081 HV Amsterdam The Netherlands

AIM: To improve the interpretation of fecal immunochemical test (FIT) results in colorectal cancer (CRC) cases from screening and referral cohorts. METHODS: In this comparative observational study, two prospective cohorts of CRC cases were compared. The first cohort was obtained from 10 322 average risk subjects invited for CRC screening with FIT, of which, only subjects with a positive FIT were referred for colonoscopy. The second cohort was obtained from 3637 subjects scheduled for elective colonoscopy with a positive FIT result. The same FIT and positivity threshold (OC sensor; ≥ 50 ng/mL) was used in both cohorts. Colonoscopy was performed in all referral subjects and in FIT positive screening subjects. All CRC cases were selected from both cohorts. Outcome measurements were mean FIT results and FIT scores per tissue tumor stage (T stage). RESULTS: One hundred and eighteen patients with CRC were included in the present study: 28 cases obtained from the screening cohort (64% male; mean age 65 years, SD 6.5) and 90 cases obtained from the referral cohort (58% male; mean age 69 years, SD 9.8). The mean FIT results found were higher in the referral cohort (829 ± 302 ng/mLvs 613 ± 368 ng/mL,P = 0.02). Tissue tumor stage (T stage) distribution was dif-ferent between both populations [screening population: 13 (46%) T1, eight (29%) T2, six (21%) T3, one (4%) T4 carcinoma; referral population: 12 (13%) T1, 22 (24%) T2, 52 (58%) T3, four (4%) T4 carcinoma], and higher T stage was significantly associated with higher FIT results (P < 0.001). Per tumor stage, no significant difference in mean FIT results was observed (screening vs referral: T1 498 ± 382 ng/mL vs 725 ± 374 ng/mL, P = 0.22; T2 787 ± 303 ng/mL vs 794 ± 341 ng/mL, P = 0.79; T3 563 ± 368 ng/mLvs 870 ± 258 ng/mL,P = 0.13; T4 not available). After correction for T stage in logistic regression analysis, no significant differences in mean FIT results were observed between both types of cohorts (P = 0.10). CONCLUSION

关键词： Screening population Referral cohort Fecal immunochemical test Tumor stage distribution Colorectal cancer

Colonoscopic yield of colorectal neoplasia in daily clinical practice

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World Journal of Gastroenterology 2009年第9期15卷 1085-1092页

作者： Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris jj Mulder Department of Gastroenterology and Hepatology VU University Medical CentrePO Box 70571007 MBAmsterdamThe Netherlands Gastroenterology and Hepatology Kennemer Gasthuis2000 AKHaarlemThe Netherlands Gastroenterology and Hepatology Academic Medical Centre1100 DDAmsterdamThe Netherlands Epidemiology and Biostatistics VU University Medical Centre1007 MBAmsterdamThe Netherlands Pathology VU University Medical Centre1007 MBAmsterdamThe Netherlands Gastroenterology and Hepatology Slotervaart Hospital1006 BKAmsterdamThe Netherlands Gastroenterology and Hepatology Medical Centre Alkmaar1800 AMAlkmaarThe Netherlands Gastroenterology and Hepatology Sint Lucas Andreas Hospital1061 AEAmsterdamThe Netherlands

AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per ***:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or ***:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients.

关键词： Colorectal cancer Screening Advanced neoplasia Colonoscopy Adenoma

Imaging the initial condition of heavy-ion collisions and nuclear structure across the nuclide chart

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Nuclear Science and Techniques 2024年第12期35卷 438-454页

作者： Jiangyong Jia Giuliano Giacalone Benjamin Bally James Daniel Brandenburg Ulrich Heinz Shengli Huang Dean Lee Yen‑Jie Lee Constantin Loizides Wei Li Matthew Luzum Govert Nijs Jacquelyn Noronha‑Hostler Mateusz Ploskon Wilke van der Schee Bjoern Schenke Chun Shen Vittorio Somà Anthony Timmins Zhangbu Xu You Zhou Stony Brook University Stony BrookNY 11794USA Brookhaven National Laboratory UptonNY 11973USA CERN CH‑1211 Geneve 23Switzerland IRFU CEAUniversitéParis-Saclay91191 Gif‑sur‑YvetteFrance The Ohio State University ColumbusOH 43210‑1117USA Michigan State University East LansingMI 48824USA Massachusetts Institute of Technology CambridgeMA 02139USA Rice University HoustonTX 77005USA Instituto de Física Universidade de São PauloR.do Matão 1371São Paulo 05508‑090Brazil University of Illinois at Urbana-Champaign ChampaignIL 61801USA Lawrence Berkeley National Laboratory BerkeleyCA 94720USA Wayne State University DetroitMI 48201USA RIKEN BNL Research Center Brookhaven National LaboratoryUptonNY 11973USA University of Houston HoustonTX 77204USA Physics Department Kent State UniversityKentOH 44242USA Niels Bohr Institute University of CopenhagenBlegdamsvej 172100 CopenhagenDenmark

High-energy nuclear collisions encompass three key stages:the structure of the colliding nuclei,informed by low-energy nuclear physics,the initial condition,leading to the formation of quark-gluon plasma(QGP),and the hydrodynamic expansion and hadronization of the QGP,leading to fnal-state hadron distributions that are observed *** advances in both experimental and theoretical methods have ushered in a precision era of heavy-ion collisions,enabling an increasingly accurate understanding of these ***,most approaches involve simultaneously determining both QGP properties and initial conditions from a single collision system,creating complexity due to the coupled contributions of these stages to the fnal-state *** avoid this,we propose leveraging established knowledge of low-energy nuclear structures and hydrodynamic observables to independently constrain the QGP's initial *** conducting comparative studies of collisions involving isobar-like nuclei—species with similar mass numbers but diferent ground-state geometries—we can disentangle the initial condition's impacts from the QGP *** approach not only refnes our understanding of the initial stages of the collisions but also turns high-energy nuclear experiments into a precision tool for imaging nuclear structures,ofering insights that complement traditional low-energy *** for carrying out such comparative experiments at the Large Hadron Collider and other facilities could signifcantly advance both highenergy and low-energy nuclear ***,this approach has implications for the future electron-ion *** the possibilities are extensive,we focus on selected proposals that could beneft both the high-energy and low-energy nuclear physics *** prepared as input for the long-range plan of *** physics,this white paper refects the status as of September 2022,with a brief update on developments sinc

关键词： Nuclear structure Heavy-ion collisions Collective behavior Quark-gluon plasma

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主动脉弓僵硬与高血压患者早期脑损伤相关

中华高血压杂志 2016年第10期24卷 998-998页

作者： Sala M van den Berg-Huysmans A van der Grond J Huis man M Brandts A Westenberg jj de Roos A 陈云叶鹏

已证明在高血压患者中可以检测到脑组织微结构损伤，但是潜在的机制还没有被完全了解。该研究旨在无脑血管病临床表现的高血压患者中探讨扩散张量成像（diffusion tensor imaging，DTI）测量的脑损伤和主动脉弓脉搏波传导速度（pulse wa... 详细信息

已证明在高血压患者中可以检测到脑组织微结构损伤，但是潜在的机制还没有被完全了解。该研究旨在无脑血管病临床表现的高血压患者中探讨扩散张量成像（diffusion tensor imaging，DTI）测量的脑损伤和主动脉弓脉搏波传导速度（pulse wave velocity，PwV）的关系。

关键词：高血压患者早期脑损伤主动脉弓脉搏波传导速度僵硬扩散张量成像结构损伤临床表现