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Insights fr.m.an academic endeavor into central nervous system drug discovery

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Neural regeneration research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An m.Voets Tim vanmierlo rudy Schreiber BIOmED Biomedical research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Depar.m.nt of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University mS Center(UmSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery r&D ***,in modern times their.m.nagement reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by gover.m.nts and patient-organizations and a shift of research to academia(mazzucato,2013).

关键词： academic approval consequences

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.r.Groh moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.r.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Depar.m.nt of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity fr.m.temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics pr.m.se a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Nuclear radiation shielding effectiveness and corrosion behavior of some steel alloys for nuclear reactor systems

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Defence Technology（防务技术） 2019年第4期15卷 621-628页

作者： m.m. Sadawy r.m. El Shazly mining and Petroleum Engineering Depar.m.nt Al-Azhar University Nasr City Cairo 11371 Egypt Physics Depar.m.nt Faculty of Science Al-Azhar University Nasr City Cairo 11884 Egypt

Different types of nuclear par.m.ters and corrosion behavior were deduced for carbon steel(AISI 1018),austenitic(304 SS),and duplex(2507 SS)stainless steel *** types of neutron energies as well as nine gamma ray energy lines(121.78-1407.92 keV)were used to evaluate the macroscopic neutron cross-sections(∑,cm^-1)and mass attenuation coefficients[σ,cm^2·g^-1)of gamma ray *** corrosion behavior was investigated using different electrochemical *** results showed that the stainless-steel alloys had a good attitude than that of carbon steel alloy for neutron and gamma ray par.m.ters,especially the duplex stainless *** calculated values of mass attenuation coefficient using WinXcom computer progr.m.Version 3.1),exhibited a very good agreement with the exper.m.ntal values of that ***,the results indicated that duplex stainless-steel exhibited corrosion resistance higher than 304 SS and AISI 1018 steel alloys.

关键词： Steel alloys macroscopic cross-section mass attenuation coefficient Passive film Pitting

EXACT EVALUATIONS OF FINITE TrIGONOmETrIC SUmS BY SAmPLING THEOr.m.

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Acta mathematica Scientia 2011年第2期31卷 408-418页

作者： m.H. Annaby r.m. Asharabi Depar.m.nt of mathematics Faculty of Science Cairo University Depar.m.nt of mathematics Faculty of Education Al-MahweetSana'a University

We use the sampling representations associated with Sturm-Liouville difference operators to derive generalized integral-valued trigonometric sums. This extends the known results where zeros of Chebyshev polynomials of the first kind are involved to the use of the eigenvalues of difference operators, which leads to new identities. In these identities Bernoulli＇s numbers play a role similar to that of Euler＇s in the old ones. Our technique differs fr.m.that of Byrne-Smith （1997） and Berndt-Yeap （2002）.

关键词： Trigonometric sums difference equations sampling theorem

GIS-based analysis of fault patterns in urban areas： A case study of Irkutsk city, russia

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Geoscience Frontiers 2016年第2期7卷 287-294页

作者： r.m. Lobatskaya I.P. Strelchenko Irkutsk research Technological University Irkutsk Russia

The capabilities of GIS in modeling fault patterns are explored for Irkutsk city in East Siberia with implications for ground stability. The neotectonic structure of the area is visualized in three dimension （3D） taking into account fault dips, using the ArcGIS, Globalmapper and Paradigm Geophysical packages. The study area is divided into blocks of different size classes according to the length-based ranks of the bounding faults, which are of five classes distinguished with the equal interval method. The blocks show different deformation patterns, with different densities and strikes of crossing and bounding faults. The data are statistically processed using GIS to estimate the deformation degrees of blocks in arbitrary units per square kilometer using the attributes of rank and crossing/bounding position of faults and the size of blocks. The deformation degrees are then compared with available estimates of ground stability measured as a score of points corresponding to destabilizing factors. Although the comparison generally confirms some linkage between the deformation degree of blocks and their ground stability, the correlation is intricate and ambiguous. In order to enhance the advantages of GIS in building and analyzing 3D models of fault patterns for estimating ground stability and mitigating geological hazards, it is expected in the future to proceed fr.m.the reported initial step of visualization to more advanced analysis.

关键词： GIS 3D modeling Fault pattern Faults Blocks Ground stability

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural regeneration research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Depar.m.nt of Psychology and Neuroscience Duke UniversityDurhamNCUSA Depar.m.nt of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit r.m.deling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions r.m.ins a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating fr.m.cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Guava extract (Psidium guajava) alters the labelling of blood constituents with technetium-99m

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第6期7卷 429-435页

作者： ABrEU P.r.C. ALmEIDA m.C. BErNArDO r.m. BErNArDO L.C. BrITO L.C. GArCIA E.A.C. FONSECA A.S. BErNArDO-FILHO m. Depar.m.nt of Biophysics and Biometry Institute of Biology Roberto Alcantara Gomes University of Estate of Rio de Janeiro Rio de Janeiro 20551030 Brazil Depar.m.nt of Physiology Biological Sciences and Health Center Federal University of Sergipe So Cristóvo Sergipe 49100000 Brazil Depar.m.nt of Pharmacology and Psychobiology Institute of Biology Roberto Alcantara Gomes University of Estate of Rio de Janeiro Rio de Janeiro 20551030 Brazil

Psidium guajava (guava) leaf is a phytotherapic used in folk medicine to treat gastrointestinal and respiratory dis-turbances and is used as anti-inflammatory medicine. In nuclear.m.dicine, blood constituents (BC) are labelled with techne-tium-99m (99mTc) and used to image procedures. However, data have demonstrated that synthetic or natural drugs could modify the labelling of BC with 99mTc. The aim of this work was to evaluate the effects of aqueous extract of guava leaves on the labelling of BC with 99mTc. Blood samples of Wistar rats were incubated with different concentrations of guava extract and labelled with 99mTc after the percentage of incorporated radioactivity (%ATI) in BC was determined. The results suggest that aqueous guava extract could present antioxidant action and/or alters the membrane structures involved in ion transport into cells, thus decreasing the radiolabelling of BC with 99mTc. The data showed significant (Pration of ATI in BC fr.m.blood incubated with guava extract.

关键词： Antioxidant Blood constituents Psidium guajava Technetium-99m

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural regeneration research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes fr.m.the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting fr.m.stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor.m.metics: HEr-096 as a disease-modifying therapy for Parkinson’s disease

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Neural regeneration research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmstr.m.Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic