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RACE研究中持续性孤立性房颤的临床特征

世界核心医学期刊文摘（心脏病学分册） 2005年第7期1卷 52-53页

作者： Rienstra M. Hagens V.E. van veldhuisen d.j. I.C. van Gelder 苏畅 dr. department of Cardiology Thoraxcenter University Hospital P.O. Box 30.001 9700 RB Groningen Netherlands

In the RAte Control versus Electrical cardioversion for persistent atrial fibrillation(RACE) study, 522 patients were randomized to either rate or rhythm control therapy. Lone atrial fibrillation(AF) was present in 89 patients. demographics, cardiovascular mortality and morbidity, and quality of life were compared between patients with lone AF and those with underlying structural heart disease. Patients with lone AF were significantly younger(65±10 vs 69±8 years) and had fewer complaints of fatigue(p=0.01) and dyspnea(p=0.005). With lone AF, quality-of-life scoreswere higher on almost all 8 Medical Outcomes Study Short-Form health survey questionnaire subscales, and comparable to healthy, age-and gender-matched controls. Mean follow-up was 2.3±0.6 years. Cardiovascular end points occurred in 9 patients with lone AF(10%),consisting of death(all bleedings) 3%, thromboembolic complications in 3%, nonfatal bleeding in 2%, and pacemaker implantation in 2%, but no heart failure and severe adverse effects due to antiarrhythmic drugs occurred. End points occurred in 95 patients(22%) with underlying diseases. Heart failure and severe adverse effects from drugs did not occur in patients with lone AF in this study. despite the absence of demonstrable cardiovascular and cerebrovascular disease, lone AF is associated with bleeding and thromboembolism.

关键词：孤立性房颤 RACE 持续性房颤心脏电复律抗心律失常药起搏器植入术血栓栓塞心血管疾病呼吸困难健康问卷调查

医生和护士主导的心力衰竭门诊的额外价值:来自deventer-Alkmaar心力衰竭研究的结果

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世界核心医学期刊文摘（心脏病学分册） 2007年第10期3卷 47-48页

作者： Bruggink-André de La Porte P.W.F. Lok d.j.A. van veldhuisen d.j. 朱冰坡 Cardiology department deventer Hospital Fesevurstraat 7 7415 CM deventer Netherlands

目的:明确在心力衰竭(HF)门诊中由临床医生和心血管科护士(均接受过HF方面的培训)对NYHA分级Ⅲ/IV级的患者施行强化干预,能否减少因HF恶化住院和(或)全因死亡(主要终点)

关键词：心力衰竭心血管科 deventer-Alkmaar 护士门诊

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首次心肌缺血性事件对肾功能的影响

世界核心医学期刊文摘（心脏病学分册） 2007年第11期3卷 25-页

作者： Eijkelkamp W.B.A. de Graeff P.A. van veldhuisen d.j. 马超 department of Clinical Pharmacology Division of Nephrology University Medical Center Groningen Groningen Netherlands Dr.

心血管功能障碍对肾功能的影响尚未明确。因此,作者对来自PREVENd研究的普通人群中首次心脏缺血事件与远期肾功能改变之间的关系进行了探讨。纳入6360例受试者,总随访期为27017人年。

关键词：心脏缺血血清肌酐肾功能

在高血压患者中对持续性房颤的节律控制治疗使心血管病的发病率和死亡率增加:来自RACE研究的资料

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世界核心医学期刊文摘（心脏病学分册） 2007年第8期3卷 38-38页

作者： Rienstra M. van veldhuisen d.j. Crijns H.j.G.M. van Gelder I.C. 王海玲 department of Cardiology University Medical Center Groningen University of Groningen PO Box 30.001 9700 RB Groningen Netherlands

目的:调查在对持续性房颤(AF)患者进行心率控制和节律控制治疗期间,高血压对发病率和死亡率的影响。方法和结果:在心率控制与电转复比较(RACE)研究中,522例患者(其中256例患高血压)被随机分配到心率控制组或节律控制组。比较高血压患者... 详细信息

目的:调查在对持续性房颤(AF)患者进行心率控制和节律控制治疗期间,高血压对发病率和死亡率的影响。方法和结果:在心率控制与电转复比较(RACE)研究中,522例患者(其中256例患高血压)被随机分配到心率控制组或节律控制组。比较高血压患者和非高血压患者的心血管病发病率和死亡率。高血压患者的年龄较大(69±8岁vs67±9岁,P=0.01)、女性较多(PdS2评分较高(2.2±1.0vs1.0±0.9,P<0.001)、

关键词：持续性房颤心血管病 RACE 心率控制电转复合并糖尿病者控制组终点事件植入起搏器抗心律

Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： daniella da Silva Madeleen jansen van Rensburg Anine Crous Heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 j/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

Evolving management of colorectal cancer

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World.j.urnal of Gastroenterology 2008年第25期14卷 3956-3967页

作者： jochem van der Voort van Zijp Harald.j.Hoekstra Marc d Basson department of Radiation Oncology Leiden University Medical Center department of Surgery University of Groningen Medical Center john d. dingell VA Medical Center and Wayne State University

This article reviews recent advances in surgical techniques and adjuvant therapies for colorectal cancer, including total mesorectal excision, the resection of liver and lung metastasis and advances in chemoradiation and foreshadows some interventions that may lie just beyond the frontier. In particular, little is known about the intracellular and extracellular cascades that may influence colorectal cancer cell adhesion and metastasis. Although the phosphorylation of focal adhesion kinases and focal adhesion associated proteins in response to integrin-mediated cell matrix binding ("outside in integrin signaling") is well described, the stimulation of cell adhesion by intracellular signals activated by pressure prior to adhesion represents a different signal paradigm. However, several studies have suggested that increased pressure and shear stress activate cancer cell adhesion. Further studies of the pathways that regulate integrin-driven cancer cell adhesion may identify ways to disrupt these signals or block integrin-mediated adhesion so that adhesion and eventual metastasis can be prevented in the future.

关键词： Adhesion Colorectal Signaling Cancer Surgery

Impact of systems modelling on agronomic research and adoption of new practices in smallholder agriculture

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journal of Integrative Agriculture 2015年第8期14卷 1478-1489页

作者： d.j.Connor H van Rees P S Carberry The University of Melbourne Crop Facts Mandurang South 3551 Australia Commonwealth Scientific and Industrial Research Organization

An analysis of the impact of simulation modelling in three diverse crop-livestock improvement projects in Agricultural Research for development（AR4d） reveals benefits across a range of aspects including identification of objectives, design and implementation of experimental programs, effectiveness of participatory research with smallholder farmers, implementation of system change and scaling-out of *** planning change, farmers must consider complex interactions within both biophysical and socioeconomic aspects of their crop and animal production *** this, whole-farm models that include household models of food, workload and financial requirements have the most utility and *** analysis also proposes improvements in design and implementation of AR4 d projects to improve the utility of simulation modelling for securing positive agronomic and livestock outcomes and lasting legacies.

关键词： agricultural systems animal production crop production modelling research for development

Surveillance for hepatocellular carcinoma in chronic liver disease:Evidence and controversies

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World.j.urnal of Gastroenterology 2013年第40期19卷 6744-6756页

作者： Suzanne van Meer Robert A de Man Peter d Siersema Karel j van Erpecum department of Gastroenterology and Hepatology University Medical Center Utrecht3508 GA UtrechtThe Netherlands department of Gastroenterology and Hepatology Erasmus Medical Center3015 CE RotterdamThe Netherlands

Primary liver cancer is the sixth most common cancer in the world and the third cause of cancer-related *** carcinoma(HCC)represents more than90%of primary liver cancers and generally occurs in patients with underlying chronic liver disease such as viral hepatitis,hemochromatosis,primary biliary cirrhosis and non-alcoholic *** cirrhotic patients are at risk of HCC and regular surveillance could enable early detection and therapy,with potentially improved *** here summarize existing evidence for surveillance including ultrasound,other radiological modalities and various serum biomarkers,and current international guideline recommendations for *** andα-fetoprotein(alone or in combination)are most frequently used for surveillance,but their sensitivities and specificities are still far from perfect,and evidence for surveillance remains weak and *** other potential surveillance tools have been tested,including serum markers as des-carboxyprothrombin,lectin-boundα-fetoprotein,and(most recently)circulating TIE2-expressing monocytes,and radiological investigations such as computed tomographyscan or magnetic resonance *** early results appear promising,these tools have generally been tested in diagnostic rather than surveillance setting,and in most cases,no detailed information is available on their *** the near future,it remains important to define those patients with highest risk of HCC and most benefit from surveillance,and to restrict surveillance to these categories.

关键词： Hepatocellular carcinoma Surveillance Chronic liver disease

Impacts of climate gradients on the vegetation phenology of major land use types in Central Asia （1981-2008）

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Frontiers of Earth Science 2012年第2期6卷 206-225页

作者： jahan KARIYEVA Willem j.d. van LEEUWEN Connie A. WOOdHOUSE School of Geography and development The University of Arizona Tucson AZ 85721 USA School of Natural Resources and the Environment - Office of Arid Lands Studies - Arizona Remote Sensing Center The University of Arizona Tucson AZ 85721 USA

Time-series of land surface phenology （LSP） data offer insights about vegetation growth patterns. They can be generated by exploiting the temporal and spectral reflectance properties of land surface components. Inter- annual and seasonal LSP data are important for under- standing and predicting an ecosystem＇s response to variations caused by natural and anthropogenic drivers. This research examines spatio-temporal change patterns and interactions between terrestrial phenology and 28 years of climate dynamics in Central Asia. Long-term （1981-2008） LSP records such as timing of the start, peak and length of the growing season and vegetation productivity were derived from remotely sensed vegetation greenness data. The patterns were analyzed to identify and characterize the impact of climate drivers at regional scales. We explored the relationships between phenologi- cal and precipitation and temperature variables for three generalized land use types that were exposed to decade- long regional drought events and intensified land and water resource use： rainfed agriculture, irrigated agriculture, and non-agriculture. To determine whether and how LSP dynamics are associated with climate patterns, a series of simple linear regression analyses between these two variables was executed. The three land use classes showed unique phenological responses to climate variation across Central Asia. Most of the phenological response variables were shown to be positively correlated to precipitation and negatively correlated to temperature. The most substantial climate variable affecting phenological responses of all three land use classes was a spring temperature regime. These results indicate that future higher temperatures would cause earlier and longer growing seasons.

关键词： phenology land use climate variability