检索结果-南通市图书馆

世界核心医学期刊文摘(心脏病学分册) 2007年第6期 16-17页

作者： van Beeumen k Duytschaever m Tavernier R 郭俊 Department of Cardiology University HospitalGhentBelgium Dr.

心力衰竭(HF)与心房传导延迟相关。使用彩色组织多普勒成像评价HF患者、无HF的器质性心脏病患者以及对照者的心房内和心房间不同步。研究对象包括

关键词：不同步心房房间心力衰竭患者

CT中自动钙化评分的深度学习：用多个心脏CT和胸部CT参数进行验证

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2020年第3期 362-363页

作者： S.G.m.van Velzen N.Lessmann B.k.Velthuis I E.m.Bank D.H.J.G.van den Bongard T.Leiner 姜文蓁 Image Sciences Institute University Medical Center Utrecht

摘要尽管多种基于深度学习(DL)的钙化评分方法在特定CT参数中具有优异的性能,但在多种CT检查中其性能尚不清楚。目的对一种DL方法在多种CT检查中进行自动

关键词：

SATB1 Protein Is Associated with a more Aggressive Phenotype of Sporadic Colorectal Cancer

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Pathology 2013年第4期3卷 156-165页

作者： Akueni L. Davelaar Agnieszka m. Rygiel margriet R. Timmer Liudmila L. kodach Carel J. m. van Noesel Paul Fockens kausilia k. krishnadath Center for Experimental and molecular medicine Academic Medical Center Amsterdam The Netherlands

Background: Experimental studies have shown that cyclo-oxygenase-2 (Cox2) is related to the development and progression of tumors, since this enzyme is induced and expressed by cells such as macrophages, osteoblasts, “activated” endothelial cells, and tumor cells. The activity in tumors includes proliferation, cell transformation, tumor growth, invasion and metastasis and may play an important role in carcinogenesis of the canine osteosarcoma, since it has high expression in tissue fragments. The combination of selective Cox2 inhibitors and other treatment modalities is the basis for a new anti-cancer therapy strategy. This in vitro study exposed primary cells of five different canine osteosarcoma cultures to selective Cox2 inhibitor at increasing concentrations and times. Results: For Cox2 negative cultures, despite the absence of differences, greater sensitivity of cells to treatment was observed. For Cox2 positive cultures, a higher number of necrotic cells were observed (P ≤ 0.05), when compared with negative cultures. For exposure times with Celecoxib doses, no difference (P > 0.05) was found between the three times analyzed for living, apoptotic and apop- totic/necrotic cells. There are similarities in the values of 24 h and 48 h, with slight reduction of living cells, increasing those undergoing apoptosis and apoptosis/necrosis. There was significance for necrosis (P ≤ 0.05). In 72 hours, a significant difference was observed between the other two previous values (P ≤ 0.05). It was found for the group of 100 μm?L?1, that there was a numerically greater signaling for apoptosis and lower (P = 0.08) for necrosis, and this point was the onset of the pharmacodynamic phenomenon, with drop in the values for living cells and increased number of necrotic cells, with a tendency (P = 0.08) for reducing the percentage of necrotic cells for the group of 100 μm?L?1 when compared to that of 10 μm?L?1. Conclusions: For Cox2 positive and negative cultures, there was differenc

关键词： SATB1 Biomarker Sporadic Colorectal Cancer

Which psychosocial factors are associated with return to sport following concussion? A systematic review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2022年第4期11卷 438-449页

作者： Jacqueline van Ierssel kaleigh Ferdinand Pennock.m.rgaret Sampson Roger Zemek Jeffrey G.Caron Children’s Hospital of Eastern Ontario Research Institute OttawaON K1H 8L1Canada Faculty of kinesiology and Physical Education University of TorontoTorontoON M5S 2W6Canada Department of Pediatrics Faculty of MedicineUniversity of OttawaOttawaON K1H 8M5Canada Faculty of medicine University of MontrealMontrealQC H3T 1J4Canada Center for Interdisciplinary Research in Rehabilitation MontrealQC H3S 1M9Canada

Background:Psycho social factors predict recurrent inj ury and return to preinjury level of performance following orthopedic injury but are poorly understood following *** management protocols prioritize physical measures of ***,the objective of this study was to describe the psychosocial factors associated with return to sport(RTS) and how they are measured in athletes who sustained a ***:mEDLINE,Embase,APA PsycINFO,CINAHL,and SPORTDiscus were searched through February 2,*** studies included original peer-reviewed publications describing psychosocial factors associated with RTS following a diagnosed *** primary outcome was scales or measures employed and/or key thematic ***:Of the 3615 studies identified,10 quantitative cohort studies(Oxford Centre for Evidence-Based medicine Level-3) representing 2032 athletes(85% male;high-school and collegiate collision/contact athletes) and 4 qualitative studies representing 66 athletes(74% male;70% American football;aged 9-28 years) were *** identified 3 overarching themes and 10 outcome measures related to psychosocial factors associated with RTS following concussion:(a) fear(e.g,of recurrent concussion,of RTS,of losing playing status);(b) emotional factors(e.g,depression,anxiety,perceived stress,mental health,disturbance mood);and(c) contextual factors(e.g,social support,pressure,sense of identity).Conclusion:Although current medical clearance decisions prioritize physical measures of recovery,evidence suggests diverse psychosocial factors influence RTS following *** remains unclear which psychosocial factors contribute to a successful RTS,including the influence of sex/gender and *** studies should evaluate the association of psychological readiness with physical measures of recovery at medical clearance,preinjury level of performance,and risk of recurrent concussion to support RTS clinical decision-making.

关键词： Concussion Recovery Rehabilitation Sport psychology Sporting injuries

米卡芬净与脂质体两性霉素B在德国治疗念珠菌血症和侵袭性念珠菌病的药物经济学分析

在线全文

学校读者我要写书评

暂无评论

中国药物经济学 2009年第3期4卷 69-82页

作者： O A Cornely m Sidhu I Odeyemi A k van Engen J m van der Waal O Schoeman 杨莉

目的:旨在探索米卡芬净(mICA)治疗侵袭性念珠菌病和念珠菌血症(系统性念珠菌感染)的经济学影响,比较米卡芬净与脂质体两性霉素B(L-AmB)的成本-效果。研究设计和方法:本研究的模型是基于对米卡芬净和两性霉素B进行比较的一项Ⅲ期、随机... 详细信息

目的:旨在探索米卡芬净(mICA)治疗侵袭性念珠菌病和念珠菌血症(系统性念珠菌感染)的经济学影响,比较米卡芬净与脂质体两性霉素B(L-AmB)的成本-效果。研究设计和方法:本研究的模型是基于对米卡芬净和两性霉素B进行比较的一项Ⅲ期、随机双盲临床试验所建立的决策模型。采用14～20周的治疗时间并从德国医院的角度进行观察。主要观察指标:主要观察指标被定义为在初始治疗后取得临床和真菌学疗效并在研究结束时(EOS)仍然存活的病人百分比,以及整个研究期间的治疗相关总费用。结果:卫生经济学分析显示,米卡芬净能使52.9%的病人得到成功治疗并且在研究结束时仍然存活,而脂质体两性霉素B的治疗成功率仅49.1%。米卡芬净和脂质体两性霉素B治疗每例病人平均所需的相关费用分别为43243欧元和49216欧元,米卡芬净治疗所需相关费用低于脂质体两性霉素B。与脂质体两性霉素B相比,米卡芬净的费用较低且疗效更好,因此具有更好的成本-效果。但是概率敏感度分析的结果显示,由于方差大而不能认为该差异具有显著性,即使米卡芬净在单因素敏感度分析中是最具有成本-效果的选择方案。结论:本研究结果提示,米卡芬净与脂质体两性霉素B相比是治疗侵袭性念珠菌病和念珠菌血症的更具成本-效果的治疗方法。

关键词：念珠菌病经济学模型脂质体两性霉素B 米卡芬净药物经济学

An Empirical Assessment of marine Debris, Seawater Quality and Littering in Ghana

在线全文

学校读者我要写书评

暂无评论

Journal of Geoscience and Environment Protection 2016年第5期4卷 21-36页

作者： Irene P. van Dyck Francis k. E. Nunoo Elaine T. Lawson Institute for Environment and Sanitation Studies University of Ghana Accra Ghana Department of marine & Fisheries Sciences University of Ghana Accra Ghana

A baseline survey was carried out at four beaches along Ghana’s Accra-Tema coastline over a period of sixteen weeks to determine beach quality, seawater quality and the perception of beach users towards littering. A total of 18,241 items of marine debris which weighed 297.59 kg were collected. Plastic materials were the dominant debris, accounting for 63.72% of total debris. Land-based marine debris formed the largest proportion of debris collected (93% of items/m2 and 85 kg/m2). Water quality analysis revealed high mean levels of coliforms and E. coli above World Health Organization (WHO) levels on all four beach locations. A social survey that targeted beach users and some stakeholders revealed a habit of littering and beach users as the main source of litter generation on Ghana’s beaches. Intensive education, continuous monitoring and the enforcement of appropriate policy initiatives remain vital to addressing beach and water quality issues along Ghana’s coastline.

关键词： marine Debris Accra-Tema Coastline Ghana Plastics Seawater Quality Littering Perception

Importance of charge self-consistency in first-principles description of strongly correlated systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational materials 2021年第1期7卷 1949-1956页

作者： Swagata Acharya Dimitar Pashov Alexander N.Rudenk.m.lte Rösner mark van Schilfgaarde mikhail I.katsnelson Institute for molecules and materials Radboud UniversityNijmegen 6525 AJThe Netherlands Theory and Simulation of Condensed matter King's College LondonThe StrandLondon WC2R2LSUK National Renewable Energy Laboratory Golden80401 ColoradoUSA

First-principles approaches have been successful in solving many-body Hamiltonians for real materials to an extent when correlations are weak or *** the electronic correlations become stronger often embedding methods based on first-principles approaches are used to better treat the correlations by solving a suitably chosen many-body Hamiltonian with a higher level *** success of such embedding theories,often referred to as second-principles,is commonly measured by the quality of self-energy E which is either a function of energy or momentum or ***,E should,in principle,also modify the electronic eigenfunctions and thus change the real space charge *** such practices are not prevalent,some works that use embedding techniques do take into account these *** such cases,choice of partitioning,of the parameters defining the correlated Hamiltonian,of double-counting corrections,and the adequacy of low-level Hamiltonian hosting the correlated subspace hinder a systematic and unambiguous understanding of such ***,for a large variety of correlated systems,strong correlations are largely confined to the charge *** an adequate non local low-order theory is important,and the high-order local correlations embedding contributes become *** we study the impact of charge self-consistency within two example cases,TiSez and CrBrs,and show how real space charge re-distribution due to correlation effects taken *** within a first-principles Green's function-based many-body perturbative approach is key in driving qualitative changes to the final electronic structure of these materials.

关键词： theory charge principles

Differential molecular profiles and associated functionalities characterize connective tissue grafts obtained at different locations and depths in the human palate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral Science 2023年第4期15卷 701-717页

作者： maria B.Asparuhova Xiaoqing Song Dominic Riedwyl Geert van Geest Dieter D.Bosshardt Anton Sculean Laboratory of Oral Cell Biology School of Dental MedicineUniversity of BernBernSwitzerland Department of Periodontology School of Dental MedicineUniversity of BernBernSwitzerland Interfaculty Bioinformatics Unit University of BernBernSwitzerland Robert k.Schenk Laboratory of Oral Histology School of Dental MedicineUniversity of BernBernSwitzerland

The present study aimed to assess the molecular profiles of subepithelial connective tissue grafts(CTGs)obtained at different locations and depths in the human ***-four CTGs belonging to anterior deep(AD),anterior superficial(AS),posterior deep(PD),and posterior superficial(PS)groups were subjected to RNA-Sequencing and their transcriptomes were analyzed *** correlations characterizing the CTG groups were validated by cell biological experiments using primary human palatal fibroblasts(HPFs)extracted from the CTGs.A clearly more pronounced location-dependent than depth-dependent difference between the grafts,with a minimal number of genes(4)showing no dependence on the location,was ***,endothelial,and monocytic cell migration was strongly(Pmotif chemokine ligands as well as significantly(Pmmunomodulatory phenotype for AD-and *** growth factor gene expression and significantly activated(Pk and Akt signaling in HPFs originating from A-CTGs implied their involvement in cell survival,proliferation,and *** collagen-rich expression profile contributing to high mechanical stability,increased osteogenesis-related gene expression,and strongly activated(Pmad1/5/8 signaling characterized HPFs originating from *** present data indicate that in humans,differences between palatal CTGs harvested from different locations and depths appear to be location-rather than *** findings provide the basis for future personalization of the therapeutic strategy by selecting an optimal graft type depending on the clinical indications.

关键词： selecting characterizing showing

Biomarkers in precision therapy in colorectal cancer

在线全文

学校读者我要写书评

暂无评论

Gastroenterology Report 2013年第3期1卷 166-183页

作者： marlies S.Reimers Eliane C.m.Zeestraten Peter J.k.kuppen Gerrit Jan Liefers Cornelis J.H.van de Velde Department of Surgery Leiden University Medical CenterLeidenThe Netherlands

Colorectal cancer(CRC)is the most commonly diagnosed cancer in *** CRC is also a major cause of cancerrelated deaths worldwide,a lot of research has been focused on the discovery and development of biomarkers to improve the diagnostic process and to predict treatment *** till now only a few biomarkers are recommended by expert *** TNm criteria,however,cause substantial under-and overtreatment of CRC ***,there is a growing need for new and efficient biomarkers to ensure optimal treatment *** ideal biomarker should be easily translated into clinical practice,to identify patients who can be spared from treatment or benefit from therapy,ultimately resulting in precision medicine in the *** this review we aim to provide an overview of a number of frequently studied biomarkers in CRC and,at the same time,we will emphasize the challenges and controversies that withhold the clinical introduction of these *** will discuss both prognostic and predictive markers of chemotherapy,aspirin therapy as well as overall therapy ***,only mutant kRAS,mutant BRAF,mSI and the Oncotype DXColon Cancer Assay are used in clinical *** biomarker studies showed insufficient evidence to be introduced into clinical *** patient selection criteria,absence of validation studies and a large number of single biomarker studies are possibly *** therefore recommend that future studies focus on combining key markers,rather than analysing single markers,standardizing study protocols,and validate the results in independent study cohorts,followed by prospective clinical trials.

关键词： colorectal cancer biomarkers treatment prognosis

胆管支架阻塞机制:共聚焦激光扫描和扫描电镜的研究结果

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 26-27页

作者： van Berkel A.m. van marle J. Groen A.k. Bruno m.J. 尹勇 Dept. of Gastroenterology and Hepatology Academic Medical Center Meibergdreef 9 1105 AZ AmsterdamNetherlandsDr.

Background and study aims: Endoscopic insertion of plastic biliary endoprostheses is a well-established treatment for obstructive jaundice. The major limitation of this technique is late stent occlusion. In order to compare events involved in biliary stent clogging and identify the distribution of bac-teria in unblocked stents, confocal laser scanning (CLS) and scanning electron microscopy (SEm) were carried out on two different stent materials - polyethylene (PE) and hydrophilic polymer-coated polyurethane (HCPC). Patien-ts and methods: Ten consecutive patients with postoperative benign biliary strictures were included in the study. Two 10-Fr stents 9 cm in length, one made of PE and the other of HCPC, were inserted. The stents were electively exchanged after 3 months and examined using CLS and SEm. Results: No differences were seen between the two types of stent. The inner stent surface was covered with a uniform amorphous layer. On top of this layer, a biofilm of living and dead bacteria was found, which in most cases was unstructured. The lumen was filled with free-floating colonies of bacteria and crystals, surrounded by mobile laminar structures of mucus. An open network of large dietary fibers was seen in all of the stents. Conclusions: The same clogging events occurred in both PE and HCPC stents. The most remarkable observation was the identification of networks of large dietary fibers, resulting from duodenal reflux, acting as a filter. The build-up of this intraluminal framework of dietary fibers appears to be a major factor contributing to the multifactorial process of stent clogging.

关键词：胆管支架扫描电镜激光扫描支架材料胆管狭窄阻塞性黄疸食物纤维细菌菌落自由漂浮内支架