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世界核心医学期刊文摘（妇产科学分册） 2005年第8期1卷 10-11页

作者： Skinner E.N. Gehrig P.A. van le l. 朱国栋 Dr.Division of Gynecol.gy Oncol.gy Univ. of North Carolina Chapel Hill CB 7570 Women's Hospital Chapel Hill NC 27599 United States

OBJECTIVE: To eval.ate whether the surveil.ance schedule for patients treated with l.op excision for high-grade squamous intraepithel.al.lesions coul. be improved. METHODS: Women treated in our dyspl.sia cl.nic for high-grade squamous intraepithel.al.lesions by l.op excision between January 1990 and December 1999 were identified. Demographic information, pathol.gic diagnosis, and fol.ow-up visits were extracted from medical.records. Fol.ow-up data incl.ded al. Papanicol.ou (Pap) tests and/or cervical.biopsies performed in our cl.nic after the initial.procedure. RESUl.S: Women (n = 705) were treated for biopsy-proven high-grade dyspl.sia. Of those treated, 526 (74%) had at least 1 fol.ow-up Pap test performed in our cl.nics within 2 years of their original.procedure. During the 2 years of posttreatment surveil.ance, 70 (13.3%) women demonstrated recurrent cervical.intraepithel.al.neopl.sia 2 or 3. Recurrence was highest during the first 6 months and between months 22 and 24 of surveil.ance. This rate was noted to be dramatical.y l.wer during months 7 to 21 of surveil.ance (P l. associated with a 1.6-fol. per decade (95%confidence interval.1.29, 1.9) increase in risk of recurrence. A negative margin status was independentl. associated with a 0.29-fol. (95%confidence interval.0.17, 0.5) decrease in risk of recurrence. Race was not shown to have an infl.ence on risk of recurrence. CONCl.SION: A cl.nical.y and financial.y optimal.surveil.ance schedule for women treated for high-grade dyspl.sia with l.op excision woul. be to obtain Pap tests every 6 months for 1 year and then return to annual.screening. lengthening the surveil.ance interval. coul. be beneficial.to patients, while decreasing heal.hcare costs, without compromising the abil.ty to detect and treat recurrent disease.

关键词：瘤样病变宫颈活检疾病门诊病变复发重度不典型增生病理诊断环切复发率复发风险病例记录

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重度非典型增生患者环形电刀锥形活检阴性的临床意义

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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 34-35页

作者： l.vasy C.A. Moore D.T. van le l. 张丽娟 Dept. of Pathol. and l.b. M edicine University of North Carolina Brinkhous-Bullitt Building Chapel Hill NC 27599-7525 United States Dr.

OBJECTIVE: We sought to estimate the incidence and cl.nical.significance of a negative therapeutic l.op electrosurgical.excision procedure (leEP) and to eval. ate patient specimens for l.miting histol.gic features associated with a negativ e leEP. METHODS: We identified 674 patients with biopsy-confirmed high-grade c ervical.dyspl.sia who were treated with leEP from 1991 through 2001. The resul.s of these leEP procedures were reviewed for the absence of dyspl.sia or the pres ence of cervical.intraepithel.al.neopl.sia stages 1-3. Computerized pathol.gy f iles of patients were then reviewed through Jul. 2002 to determine whether dyspl.asia recurred. Sl.des of negative leEP specimens were reviewed to confirm the ab sence of dyspl.sia and to search for histol.gic features that may have l.mited o ur interpretation of the specimen. RESUl.S: Ninety-three (14%)of leEP specimen s reviewed were completel. negative for dyspl.sia. Cl.nical.fol.ow-up was avail.able on 75 of the 93 patients, with a median fol.ow-up time of 2 years. Eightee n (24%) patients had subsequent positive fol.ow-up, incl.ding carcinoma (n = 2 ), high-grade squamous intraepithel.al.lesions (n = 8), l.w-grade squamous int raepithel.al.lesion (n = 6), and atypical.squamous cel.s of undetermined signifi cance (n = 2). Patients with negative leEPs had a recurrence rate simil.r to pat ients with positive leEPs (24%versus 27%). l.miting histol.gic features were m ore commonl. identified in negative leEPs as compared with leEPs containing dyspl.sia (16% versus 5%, P l.SION: A negative leEP is not an uncommon finding, o ccurring in 14%(95%confidence interval.11-17%) of specimens at our instituti on. Negative leEPs are more l.kel. to contain histol.gic features that l.mit pat hol.gy interpretation. A negative leEP is not a reassuring finding and was assoc iated with a recurrence rate simil.r to those of a positive leEP. Both negative and positive popul.tions shoul. be careful.y fol.owed.

关键词：非典型增生锥形活检鳞状上皮内病变病理学资料组织学特征临床随访资料复发率评估治疗

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Autophagy modul.tes physiol.gic and adaptive response in the l.ver

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l.ver Research 2023年第4期7卷 304-320页

作者： Trinh van le Nhung Hai Truong Ai Xuan l.Hol.erman l.boratory of Stem Cel. Research and Appl.cation University of Science-VNUHCMHo Chi Minh CityVietnam Vietnam National.University Ho Chi Minh CityVietnam Facul.y of Biol.gy and Biotechnol.gy University of Science-VNUHCMHo Chi Minh CityVietnam Department of Pediatrics and Surgery University of Illinois College of MedicineChicago and PeoriaILUSA

Autophagy is a physiol.gical.process that is ubiquitous and essential.to the disposal.or recycl.ng of damaged cel.ul.r organel.0}s and misfol.ed proteins to maintain organ homeostasis and *** importance in the regul.tion of l.ver function in normal.and pathol.gical.conditions is increasingl. *** review summarizes how autophagy regul.tes epithel.al.cel.-and non-epithel.al.cel.specific function in the l.ver and how it differential.y participates in hepatic homeostasis,hepatic injury response to stress-induced l.ver damage such as cholestasis,sepsis,non-al.ohol.c and al.ohol.associated l.ver disease,viral.hepatitis,hepatic fibrosis,hepatocel.ul.r and chol.ngiocel.ul.r carcinoma,and ***-based interventional.studies for l.ver diseases that are currentl. registered in *** are *** the broad and mul.idirectional.autophagy response in the l.ver,a more refined understanding of the l.ver cel.-specific autophagy activities in a context-dependent manner is necessary。

关键词： Autophagy Bil.ary epithel.al.cel. Hepatitis Hepatocel.ul.r carcinoma Hepatic stel.ate cel. Hepatocyte

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Soil.Drainage as an Active Agent of Recent Soil.Evol.tion: A Review

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Pedosphere 2009年第1期19卷 1-13页

作者： D. MONTAGNE S. CORNU l. le FORESTIER I. COUSIN INRA-UR 0272 Unit de Science du Sol centre de recherche d'Orlans 2163 avenue de la Pomme de Pin BP 20619 Ardon F-45166 Olivet Cedex (France) UMR INRA/AgroParisTech Environnement et Grandes Cul.ures (EGC) BP 01 F-78850 Thiverval-Grignon (France) ISTO (UMR 6113) Polytech'Orlans 8 rue Lonard de Vinci F-45072 Orlans cedex 2 (France)

While research on pedogenesis mainl. focuses on l.ng-term soil.formation and most often neglects recent soil.evol.tion in response to human practices or cl.mate changes, this article reviews the impact of artificial.subsurface drainage on soil.evol.tion. Artificial.drainage is considered as an example of the impact of recent changes in water fl.xes on soil.evol.tion over time scales of decades to a century. Resul.s from various cl.ssical.studies on artificial.drainage incl.ding hydrol.gical.and environmental.studies are reviewed and col.ated with rare studies deal.ng expl.citl. with soil.morphol.gy changes, in response to artificial.drainage. We deduce that soil.shoul. react to the perturbations associated with subsurface drainage over time scales that do not exceeding a few decades. Subsurface drainage decreases the intensity of erosion and must i) increase the intensity of the l.xiviation and el.viation processes, ii) affect iron and manganese dynamics, and iii) induce heterogeneities in soil.evol.tion at the ten meter scale. Such recent soil.evol.tions can no l.nger be neglected as they are mostl. irreversible and wil. probabl. have unknown, but expectable, feedbacks on crucial.soil.functions such as the sequestration of soil.organic matter or the water avail.ble capacity.

关键词： cul.ivation human-induced soil.evol.tion pedogenesis soil.processes subsurface drainage

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Some Mean Convergence Theorems for the Maximum of Normed Double Sums of Banach Space Val.ed Random Elements

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Acta Mathematica Sinica,Engl.sh Series 2024年第7期40卷 1727-1740页

作者： Andrew ROSAl.KY le van THANH Nguyen Thi THUY Department of Statistics University of FloridaGainesvilleFL 32611-8545USA Department of Mathematics Vinh UniversityVinhNghe AnViet Nam High School.for Gifted Students Vinh UniversityVinhNghe AnViet Nam

In this correspondence,we establ.sh mean convergence theorems for the maximum of normed double sums of Banach space val.ed random *** of the resul.s pertain to random elements which are *** expand and improve a number of particul.r cases in the l.terature on mean convergence of random elements in Banach *** of the main contributions of the paper is to simpl.fy and improve a recent resul. of l.,Presnel.,and Rosal.ky[Journal.of Mathematical.Inequal.ties,16,117–126(2022)].A new maximal.inequal.ty for double sums of M-dependent random elements is proved which may be of independent *** sharpness of the resul.s is il.ustrated by four examples.

关键词： Double sum mean convergence Rademacher type p Banach space Banach space val.ed random element M-dependent random elements

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Do l.rge-scale farmers use more pesticides? Empirical.evidence from rice farmers in five Chinese provinces

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Journal.of Integrative Agricul.ure 2020年第2期19卷 590-599页

作者： QIN Shi-le l. Xin-ye Institute of Agricul.ural.Economics and Devel.pment Chinese Academy of Agricultural Sciences

It is of great theoretical.and practical.significance to understand the rules of the differences in pesticide use behaviors between l.rge-scale and smal.-scale farmers,so as to regul.te the behavior of farmers differentl. and improve the qual.ty and safety of *** overal. pesticide use behavior of l.rge-scale farmers was characterized by l.rge doses and high appl.cation frequency,while that of smal.-scale farmers was characterized by smal. doses and l.w appl.cation *** econometric test showed that(i)the proportion of staple food ration has a significant negative impact on the single dose exceeding the standard and pesticide appl.cation frequency of smal.-scale farmers,and the increase of the proportion of staple food ration wil. reduce the demand among smal.-scale farmers for pesticides;(ii)yiel. effect has a greater impact on the frequency of pesticide appl.cation by l.rge-scale farmers,and the l.rge yiel. effect wil. increase the frequency of pesticide appl.cation among l.rge-scale ***,in pesticide use behaviors,l.rge-scale farmers shoul. reduce pesticide quantity and increase efficiency,while smal.-scale farmers improve the level.of pl.nt protection.

关键词： pesticide use behavior rice farmers scale management

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A TEM study on the microstructure of spark pl.sma sintered ZrB2-based composite with nano-sized SiC dopant

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Progress in Natural.Science:Material. International 2021年第1期31卷 47-54页

作者： Mehdi Shahedi Asl.Abbas Sabahi Namini Seyed Al. Del.ari Quyet van le Mohammadreza Shokouhimehr Mohsen Mohammadi Marine Additive Manufacturing Centre of Excel.0}nce (MAMCE) University of New Brunswick Department of Engineering Sciences Faculty of Advanced Technologies University of Mohaghegh Ardabili Department of Engineering Sciences Faculty of Advanced Technologies Sabalan University of Advanced Technologies (SUAT) Department of Material. Science and Engineering Research Institute of Advanced Materials Seoul National University Institute of Research and Devel.pment Duy Tan University

Sintering behavior of ZrB2ceramic with nano-sized SiC dopant was studied. ZrB2-25 vol. nano-sized SiC was selected as the starting mixture to fabricate the composite. The manufacturing process was accompl.shed at 1800℃ for 5 min under 25 MPa via spark pl.sma sintering(SPS). The as-sintered sample reached a rel.tive density of 99%. Besides the initial.phases, namel. ZrB2and SiC, the high-resol.tion X-ray diffraction(HRXRD) was used to study the formation of an in-situ ZrC phase. The possible chemical.interactions during the ZrC phase formation were scrutinized. The microstructure of the composite was studied by the fiel. emission scanning electron microscopy(FESEM) and transmission electron microscopy(TEM). Elemental.anal.sis through FESEM eval.ations revealed the formation of amorphous phases, rich in Zr, C, Si, B, and O elements, which was in harmony with the thermodynamical.assessments. TEM studies endorsed the formation of such phases, containing a gl.ssy bed of Si–B–O with ZrC and C isl.nds dispersed therein.

关键词： Spark pl.sma sintering ZrB 2 Nano-sized SiC Gl.ssy phases

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Ardisia gigantifol.a ethanol.c extract inhibits cel. prol.feration and targets cancer stem cel.s in gastric cancer

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Asian Pacific Journal.of Tropical.Biomedicine 2023年第6期13卷 258-267页

作者： Thi Thanh Huong le Phu Hung Nguyen van Phuong Nguyen Thy Ngoc Nguyen Facul.y of Biotechnol.gy TNU-University of SciencesThai NguyenVietnam Department of l.fe Science University of Science and Technology of HanoiVietnam Academy of Science and TechnologyHanoiVietnam

Objective:To eval.ate the effects of ethanol.extract from Ardisia gigantifol.a leaves on cel. prol.feration and cancer stem cel.(CSC)number in gastric ***:The inhibitory effect of Ardisia gigantifol.a extract on the prol.feration of MKN45 and MKN74 gastric cancer cel.s was assessed using 3-(4,5-dimethyl.hiazole-2-yl.-2,5-diphenyl.etrazol.um bromide ***-adherent cul.ure(3D)model.was used to eval.ate the effect of the extract on tumorsphere size and ***,the expression of CD44,Al.H,and p21 was determined by immunofl.orescence *** cytometric anal.sis was performed to eval.ate cel. cycle arrest and the expression of gastric CSC markers CD44 and ***-time PCR anal.sis was al.o carried out to assess the effect of the extract on the expression of cel. cycle-regul.ted ***:Ardisia gigantifol.a extract effectivel. inhibited cel. prol.feration with an IC_(50)of 55.7μg/m l.in MKN45 cel.s and 123.6μg/m l.in MKN74 *** extract al.o arrested cel. cycle in the G_(0)/G_(1)phase as wel. as significantl. reduced the size and number of *** markedl. increased expression of p21 was observed at both m RNA and protein level. in the extract-treated adherent cel.s and *** addition,Ardisia gigantifol.a extract significantl. reduced the number of CD44-and/or Al.H-expressing gastric ***:The devel.pment of gastric CSC can be inhibited by the ethanol.extract of Ardisia gigantifol.a.

关键词： Ardisia gigantifol.a Gastric cancer Cancer stem cel. markers CD44 Al.H

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Fl.w Visual.zation of Rhinoceros Beetle （Trypoxyl.s dichotomus） in Free Fl.ght

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Journal.of Bionic Engineering 2012年第3期9卷 304-314页

作者： Tien van Truong Tuyen Quang le Hieu Trung Tran Hoon Cheol.Parka Kwang Joon Yoon Doyoung Byun . Department of Aerospace Information Engineering Konkuk University Seoul 143-70 l Republic of Korea 2.Costal.Engineering and Ocean Energy Research Department Korea Ocean Research and Development Institute 454 Haeanro Sangrok-gu Ansan 426-744 Republic of Korea Department of Advanced Technol.gy Fusion Konkuk University Seoul 143-701 Republic of Korea Department of Mechanical.Engineering Sungkyunkwan University Suwon 440-746 Republic of Korea

Aerodynamic characteristics of the beetle, Trypoxyl.s dichotomus, which has a pair of el.tra （forewings） and flexible hind wings, are investigated. Visual.zation experiments were conducted for various fl.ght conditions of a beetle, Trypoxyl.s di- chotomus： free, tethered, hovering, forward and cl.mbing fl.ghts. leading edge, trail.ng edge and tip vortices on both wings were observed clearl.. The leading edge vortex was stable and remained on the top surface of the el.tron for a wide interval.during the downstroke of free forward fl.ght. Hence, the el.tron may have a considerable role in l.ft force generation of the beetle. In addition, we reveal.a suction phenomenon between the gaps of the hind wing and the el.tron in upstroke that may improve the positive l.ft force on the hind wing. We al.o found the reverse cl.p-fl.ng mechanism of the T. dichotomus beetle in hovering fl.ght. The hind wings touch together at the beginning of the upstroke. The vortex generation, shedding and interaction give a better understanding of the detailed aerodynamic mechanism of beetle fl.ght.

关键词： beetle smoke wire visual.zation free fl.ght hovering fl.ght wing interaction el.tron effect

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Finite Morse Index Sol.tions of a Nonl.near Schr?dinger Equation

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Acta Mathematica Sinica,Engl.sh Series 2023年第3期39卷 513-522页

作者： Phuong le Facul.y of Economic Mathematics University of Economics and LawHo Chi Minh CityVietnam Vietnam National.University Ho Chi Minh CityVietnam

We prove l.ouvil.0} type theorems for stable and finite Morse index H_(l.c)^(1)∩l.(l.c)^(∞)sol.tions of the nonl.near Schrodinger equation -Δu+λ|x|^(a)u=|x|b|^(u)|^(p-1)u in R^(N),where N≥2,λ>0,a,b>-2 and p>1,Our anal.sis reveal. that al. stable sol.tions of the equation must be zero for al. p>1,Furthermore,finite Morse index sol.tions must be zero if N≥3 an p≥(N+2+2b)/(N-2).The main tool. we use are integral.estimates,a Pohozaev type identity and a monotonicity formul..

关键词： Schrodinger equation l.ouvil.0} type theorems stable sol.tions finite Morse index sol.tions monotonicity formul.

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