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Dietary encapsulated essential oils and organic acids mixture improves gut health in broiler chickens challenged with necrotic enteritis

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Journal of Animal Science and Biotechnology 2020年第3期11卷 866-883页

作者： van hieu pham Liugang Kan Jinyu Huang Yanqiang Geng Wenrui Zhen Yuming Guo Waseem Abbas Zhong Wang State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Faculty of Animal Science and Veterinary Medicine Thai Nguyen University Agriculture and ForestryThai NguyenVietnam Menon Animal Nutrition Technology Co.Ltd. ShanghaiChina

Background:The poultry industry is in need of effective antibiotic alternatives to control outbreaks of necrotic enteritis(NE)due to Clostridium *** the present study,we investigated the effects of dietary supplementation with a blend of encapsulated essential oils and organic acids(BLJ)on growth performance and gut health using a coinfection model of NE in broiler ***:Two hundred and eighty-eight one-day-old male Arbor Acres broiler chicks were randomly assigned using a 2×2 factorial design into two groups fed either 0 or 500 mg/kg dietary BLJ and co-challenged(or not challenged for the control)with Eimeria spp./***:Infected birds fed the BLJ-supplemented diet exhibited an improved feed conversion ratio throughout the trial(P<0.01),a higher villus height and villus height/crypt depth ratio,and reduced intestinal *** counts,liver *** carriage,gut lesion scores and serum fluorescein isothiocyanate dextran(FITC-D)concentrations at 7 d postinfection compared with those of birds without BLJ supplementation(P<0.05).NE-infected birds fed BLJ exhibited significantly upregulated claudin-1 and IGF-2 mRNA levels(P<0.05),increased A20 mRNA expression and significantly downregulated TRAF-6,TNFSF15 and TOLLIP mRNA levels in the jejunum at 7 d post-infection compared with those in birds without BLJ supplementation(P<0.05).Compared with the uninfected and untreated birds,the uninfected birds fed BLJ displayed increased relative abundances of Lactobacillus and Coprococcus but reduced Rikenellaceae *** with the unsupplemented NE-challenged birds,infected birds fed BLJ showed an increased relative abundance of Unclassified_Lachnospiraceae and a significantly decreased relative abundance of ***:BLJ supplementation improved growth performance and gut health in NE-infected broiler chickens by strengthening the intestinal barrier function,positively modulating the gut microbiota community

关键词： Broiler chickens Clostridium perfringens Essential oils and organic acids Gut health

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Dietary coated essential oil and organic acid mixture supplementation improves health of broilers infected with avian pathogenic Escherichia coli

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Animal Nutrition 2023年第1期12卷 245-262页

作者： van hieu pham Waseem Abbas Jinyu Huang Fangshen Guo Kaichen Zhang Linhua Kong Wenrui Zhen Yuming Guo Zhong Wang State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China Faculty of Animal Science and Veterinary Medicine Thai Nguyen University Agriculture and ForestryThai NguyenViet Nam Menon Animal Nutrition Technology Co.Ltd. Shanghai201807China Tengzhou Heyi Food Co.Ltd. Zaozhuang277000China

Colibacillosis caused by avian pathogenic Escherichia coli(APEC)is a very prevalent disease in poultry farms in *** exploration of effective non-antibiotic substances is of great significance for the control of APEC *** experiment evaluated the efficacy of coated essential oil and organic acid(EOA)supplementation to prevent *** O78 infection in broiler chickens.A total of 288 one-day-old male broiler chicks were randomly distributed into 4 groups with 6 replicates per *** were fed a diet either supplemented with EOA(500 mg/kg feed)or not,and either uninfected or infected with *** O78 *** showed that *** O78 infection reduced body weight gain,increased mortality and the ratio of feed to gain along with cecal and liver *** load,damaged gut mucosa,induced local and systemic inflammation,and altered cecal microbial composition,diversity and function(P<0.05).Supplemental EOA improved feed conversion efficiency,lowered gross lesion scores and cecal *** population,enhanced intestinal goblet cells and serum IgG concentration,and tended to decrease serum IL-12 production(P<0.05).Essential oil and organic acid addition downregulated IFN-γmRNA,tended to decrease mucin-2 mRNA levels while upregulating IL-10 mRNA,and tended to increase ZO-1 gene expression in the jejuna of infected birds at 7 d after *** O78 challenge(P<0.05).The 16S rRNA gene sequencing indicated that both EOA addition and *** O78 challenge altered the diversity and composition of the cecal microbiota ***,infected birds fed EOA showed decreased Bacteroidetes and genus Lactobacillus abundance compared with the infected *** analysis showed that Firmicutes,Ruminococcaceae,Clostridiales,Clostridia,Lactobacillus,Lactobacilaceae,and cc-115 were enriched in the non-infected but EOA-treated group(P<0.05).Collectively,dietary EOA supplementation could mildly alleviate ***-induced gut injury and inflammation.

关键词： Encapsulated essential oil and organic acid mixture Avian pathogenic Escherichia coli Health Broiler chicken

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循环三轴试验加载频率和压实度对重塑砂土液化行为的影响

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岩土力学 2024年第6期45卷 1813-1823页

作者： THUY Do van TIEP pham Duc hieu Nguyen van THANG pham Cao 勒奎东技术大学特殊工程技术研究所越南河内越南航空科技协会越南河内

通过对各向同性固结不排水试样进行循环三轴试验,研究了饱和重塑砂土的液化行为。试验采用恒幅正弦载荷,通过测量剪切模量、阻尼比、轴向应变和超孔隙水压力比的变化,评估了加载频率(分别为0.1、0.5、1.0 Hz)和压实度(分别为0.95、0.90... 详细信息

通过对各向同性固结不排水试样进行循环三轴试验,研究了饱和重塑砂土的液化行为。试验采用恒幅正弦载荷,通过测量剪切模量、阻尼比、轴向应变和超孔隙水压力比的变化,评估了加载频率(分别为0.1、0.5、1.0 Hz)和压实度(分别为0.95、0.90和0.80)对砂土液化行为的影响。试验结果表明,对于压实度为0.95的砂样,在5000次加载循环中,0.1 Hz的加载频率对液化过程影响甚微;而对于压实度为0.90和0.80的砂样,此频率的影响显著。对于压实度为0.80的砂样,当频率增加到0.5 Hz时几乎一加载就直接发生液化。这表明增加加载频率会加快液化速度,而增加压实度则会减慢液化速度。因此,通过一系列的试验可以模拟现场砂土在不同频率下的动荷载条件。试验结果表明,饱和砂土的液化行为由以下因素决定:(1)试样的压实度越低,液化越容易发生;(2)加载频率越高,液化越容易发生;(3)循环轴向应变越大,发生液化所需的循环次数越少;(4)超孔隙水压力随加载循环次数增加,直至试样完全液化。

关键词：液化行为加载频率循环三轴试验饱和固结不排水条件重塑砂土压实度

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Predicting 3D Radiotherapy Dose-Volume Based on Deep Learning

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Intelligent Automation & Soft Computing 2024年第2期39卷 319-335页

作者： Do Nang Toan Lam Thanh Hien Ha Manh Toan Nguyen Trong Vinh pham Trung hieu Institute of Information Technology Vietnam Academy of Science and TechnologyHanoi10072Vietnam Faculty of Information Technology Lac Hong UniversityBien HoaDong Nai76120Vietnam

Cancer is one of the most dangerous diseaseswith *** of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill from doctors and *** our study,we focused on the 3D dose prediction problem in radiotherapy by applying the deeplearning approach to computed tomography(CT)images of cancer *** image data has more complex characteristics than normal image data,and this research aims to explore the effectiveness of data preprocessing and augmentation in the context of the 3D dose prediction *** proposed four strategies to clarify our hypothesis in different aspects of applying data preprocessing and *** strategies,we trained our custom convolutional neural network model which has a structure inspired by the U-net,and residual blocks were also applied to the *** output of the network is added with a rectified linear unit(Re-Lu)function for each pixel to ensure there are no negative values,which are absurd with radiation *** experiments were conducted on the dataset of the Open Knowledge-Based Planning Challenge which was collected from head and neck cancer patients treatedwith radiation *** results of four strategies showthat our hypothesis is rational by evaluating metrics in terms of the Dose-score and the Dose-volume histogram score(DVH-score).In the best training cases,the Dose-score is 3.08 and the DVH-score is *** addition,we also conducted a comparison with the results of another study in the same context of using the loss function.

关键词： CT image 3D dose prediction data preprocessing augmentation

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越南昆嵩地体早古生代花岗岩地球化学特征及对三岐–福山洋俯冲的响应

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大地构造与成矿学 2024年

作者：赖宗婷张玉芝余小清钱鑫 pham Trung hieu 徐畅王岳军中山大学地球科学与工程学院广东省地球动力作用与地质灾害重点实验室南方海洋科学与工程广东省实验室(珠海) University of Science VNU-HCM 227Nguyen Van Cu Street

昆嵩地体位于印支陆块东部,广泛发育早古生代岩浆作用,是了解东南亚原特提斯洋演化的关键地区。但长久以来此地区原特提斯洋的俯冲极性与时间争议较大。本文对该地体的一套早古生代花岗岩进行了岩相学、锆石U-Pb年代学、锆石原位Hf同位... 详细信息

昆嵩地体位于印支陆块东部,广泛发育早古生代岩浆作用,是了解东南亚原特提斯洋演化的关键地区。但长久以来此地区原特提斯洋的俯冲极性与时间争议较大。本文对该地体的一套早古生代花岗岩进行了岩相学、锆石U-Pb年代学、锆石原位Hf同位素以及全岩主微量和Sr-Nd-Pb同位素研究。年代学结果显示该套花岗岩的结晶年龄为446～440Ma。花岗岩样品的K2O为2.14%～5.92%, Na2O+K2O为5.49%～8.25%,显示高钾钙碱性特征。其A/CNK值为1.03～1.18,为过铝质S型花岗岩。样品均显示明显的大离子亲石元素（如Rb、Th和U等）富集以及高场强元素（如Nb、Ta、Sr和Ti等）亏损,并具有强烈的Eu负异常（Eu/Eu*=0.23～0.69）。样品呈现变化范围较大的锆石原位Hf同位素组成(εHf（t）=-19.84～+1.99)以及新太古代-中元古代的Hf二阶模式年龄(tDM2=2.70～1.28 Ga),且具有富集的全岩Nd同位素组成(εNd（t）=-10.3～-6.5)。本文研究显示该套早古生代花岗岩是古老变沉积岩和基性变火成岩部分熔融的产物。结合区域地质研究表明,越南中部昆嵩地块早古生代花岗岩形成于俯冲作用下的岛弧背景,响应于区域上印支陆块内部原特提斯三岐–福山洋的南向俯冲过程。

关键词：昆嵩地体早古生代 S型花岗岩原特提斯洋三岐–福山洋俯冲作用

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Deep learning long short-term memory combined with discrete element method for porosity prediction in gravel-bed rivers

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International Journal of Sediment Research 2023年第1期38卷 128-140页

作者： Duong Tran Anh Ahad Hasan Tanim Daniel Prakash Kushwaha Quoc Bao pham van hieu Bui HUTECH University Center for River Harbor and Landslide Research Chittagong University of Engineering & Technology Govind Ballabh Pant University of Agriculture and Technology Institute of Applied Technology Thu Dau Mot University Faculty of Mechanical Engineering Thuyloi University

The porosity of gravel riverbed material often is an essential parameter to estimate the sediment transport rate, groundwater-river flow interaction, river ecosystem, and fluvial geomorphology. Current methods of porosity estimation are time-consuming in simulation. To evaluate the relation between porosity and grain size distribution(GSD), this study proposed a hybrid model of deep learning Long Short-Term Memory(LSTM) combined with the Discrete Element Method(DEM). The DEM is applied to model the packing pattern of gravel-bed structure and fine sediment infiltration processes in threedimensional(3D) space. The combined approaches for porosity calculation enable the porosity to be determined through real time images, fast labeling to be applied, and validation to be done. DEM outputs based on the porosity dataset were utilized to develop the deep learning LSTM model for predicting bed porosity based on the GSD. The simulation results validated with the experimental data then segregated into 800 cross sections along the vertical direction of gravel pack. Two DEM packing cases, i.e., clogging and penetration are tested to predict the porosity. The LSTM model performance measures for porosity estimation along the z-direction are the coefficient of determination(R~2), root mean squared error(RMSE), and mean absolute error(MAE) with values of 0.99, 0.01, and 0.01 respectively, which is better than the values obtained for the Clogging case which are 0.71, 0.14, and 0.03, respectively. The use of the LSTM in combination with the DEM model yields satisfactory results in a less complex gravel pack DEM setup, suggesting that it could be a viable alternative to minimize the simulation time and provide a robust tool for gravel riverbed porosity prediction. The simulated results showed that the hybrid model of the LSTM combined with the DEM is reliable and accurate in porosity prediction in gravel-bed river test samples.

关键词： Numerical modeling Discrete element method LSTM Bed porosity Gravel-bed river

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A hierarchical system to predict behavior of soil and cantilever sheet wall by data-driven models

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Frontiers of Structural and Civil Engineering 2022年第6期16卷 667-684页

作者： Nang Duc BUI hieu Chi PHAN Tiep Duc pham Ashutosh Sutra DHAR Institute of Techniques for Special Engineering Le Quy Don Technical UniversityHanoi 100000Vietnam Faculty of Engineering and Applied Science Memorial University of NewfoundlandSt.John’sNL A1B 3X5Canada

The study proposes a framework combining machine learning(ML)models into a logical hierarchical system which evaluates the stability of the sheet wall before other *** study uses the hardening soil(HS)model to develop a 200-sample finite element analysis(FEA)database,to develop the ML ***,a system containing three trained ML models is proposed to first predict the stability status(random forest classification,RFC)followed by 1)the cantilever top horizontal displacement of sheet wall(artificial neural network regression models,RANN1)and 2)vertical settlement of soil(RANN2).The uncertainty of this data-driven system is partially investigated by developing 1000 RFC models,based on the application of random sampling technique in the data splitting *** on the distribution of the evaluation metrics reveals negative skewed data toward the 1.0000 *** implies a high performance of RFC on the database with medians of accuracy,precision,and recall,on test set are 1.0000,1.0000,and 0.92857,*** regression ANN models have coefficient of determinations on test set,as high as 0.9521 for RANN1,and 0.9988 for RANN2,*** parametric study for these regressions is also provided to evaluate the relative insight influence of inputs to output.

关键词： finite element analysis cantilever sheet wall machine learning artificial neural network random forest

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Evolutionary Fixed Potential Agronomic Traits in Polysomic Polyploidy Plants with Special Reference to Potato

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American Journal of Plant Sciences 2023年第7期14卷 793-811页

作者： pham van hieu Biotechnology Center of Ho Chi Minh Ho Chi Minh City Vietnam

It is commonly known that polyploidization has become one of major forces for a speciation and evolution, especially with evolutionary fixed potential agronomic traits in plants. Although several studies demonstrate that allopolyploid plants were successful in developing novel crops, autopolyploid ones are also more substantial and worth exploring. Obviously, autopolyploid development via sexual or asexual pathways can lead to advantages in biomass, changing process of development, and lots of benefits on coping with climate changes do not comprehend as a whole. This review shed light on 1) gaining gigantic effect and increasing phytochemical content;2) enhancing biotic and abiotic tolerance to adapt to climate change;3) changing in process of development;4) adapting ecology. Based on these benefits, this review provides breeders with several choices when they need in the breeding strategies. Also further review on prospects of polyploidy potato in food security is concerned.

关键词： Polyploidisation Evolution Agronomic Trait Potato

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Polyploid Gene Expression and Regulation in Polysomic Polyploids

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American Journal of Plant Sciences 2019年第8期10卷 1409-1443页

作者： pham van hieu Graduate School of Life and Environmental Sciences University of Tsukuba Tsukuba Japan Biotechnology Center of Ho Chi Minh City Ho Chi Minh City Vietnam

Polyploidization is one of the most crucial pathways in introducing speciation and broadening biodiversity, especially in the Plant Kingdom. Although the majority of studies have focused only on allopolyploid or disomic polyploids, polysomic polyploid species have occurred frequently in higher plants. Due to the occurrence of the capabilities of more copies of alleles in a locus which can have additive dosage effects and/or allelic interactions, polysomic polyploids can lead to unique gene regulations to silence or adjust the expression level to create variations in organ size, metabolic products, and abiotic stress tolerance and biotic stress resistance, etc. This review aims to comprehensively summarize the contemporary understanding and findings concerning the molecular mechanisms of gene expression as well as gene regulation in natural typed and resynthesized polysomic polyploid plants. The review investigates the molecular level of phenomena in polysomic polyploid plants such as 1) typically enlarging organ size and stabilizing meiosis, 2) increasing phytochemical content and metabolic products, 3) enhancing the ability to adapt with biotic and abiotic stress, and 4) changing in gene regulation to silence or adjust the expression levels involve in sequence elimination, methylation, gene suppression, subfunctionalization, neo-functionalization, and transposon activation.

关键词： Polysomic Polyploids Allelic Interactions Gene Expression and Regulation Evolution

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Towards a systematic understanding of blockchain governance in proposal voting: A dash case study

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Blockchain(Research and Applications) 2022年第3期3卷 89-99页

作者： Lawrence Mosley hieu pham Xiaoshi Guo Yogesh Bansal Eric Hare Nadia Antony Omni Analytics Group AmesIA50014USA College of Business The University of Alabama in HuntsvilleHuntsvilleAL35899USA Department of Industrial and Manufacturing Systems Engineering Iowa State UniversityAmesIA50014USA Omni Analytics Innovative Technologies Initiative AmesIA50014USA

The transparent and immutable nature of blockchain provides incentives for organizations wishing to create and implement an open,decentralized governance *** members exercise their voting rights,a fault-tolerant record accumulates on the blockchain that can be analyzed to diagnose and intercept potential threats to the governing *** date,there has not been a systematic study of on-chain governance with respect to *** this paper,we provide an analysis of blockchain governance through a case study of the first cryptocurrency to adopt on-chain voting,*** analysis introduces the key characteristics of blockchain governance,steps through a data-driven exploration of Dash's on-chain voting system,and highlights exploitable attack vectors and vulnerabilities for the subversion of Dash's on-chain voting system via a novel network analysis *** then conclude with guidelines for other organizations looking to implement similar blockchain governance solutions while maintaining integrity in their operations.

关键词： Decentralized governance Blockchain Voting systems Data mining Network analysis

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