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对正常皮肤、泛发性银屑病无症状皮肤和皮损处皮肤表皮亚群和增殖的评估

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世界核心医学期刊文摘（皮肤病学分册） 2006年第12期2卷 10-11页

作者： Krver J.E.m. van duijnhoven m.w.f.m. Pasch m.C. 周少娜 Department of Dermatology Radboud University Nijmegen Medical Centre PO Box 9101 6500 HB Nijmegen Netherlands

Background: The margin zone in spreading psoriatic lesions has frequently been used as a model to study the changes in epidermal proliferation, keratinization and inflammation during the transition from symptomless to lesional skin. However, the dynamics of the changes in the epidermal subpopulations-basal cells, transit amplifying cells and differentiated cells -have not been studied in the transition between symptomless and lesional skin. Objectives: To quantify in a dynamic model of the margin zone in psoriasis the characteristics of these subpopulations with respect to epidermal proliferation and differentiation. methods: from seven patients with active psoriasis, biopsies were taken from the distant uninvolved skin, outer margin, innermargin and centre of a spreading psoriatic plaque. frozen sections were labelled immunofluorescently using direct immunofluorescence for Ki-67 and β1 integrin and the Zenon labelling technique for keratin 6, 10 and 15. Digital photographs of the stained sections were quantitatively analysed. Results: In the distant uninvolved skin the expression of β1 integrin was decreased and keratin 15 expression was lost. In this area supra basal cells expressed β1 integrin and in the outer margin supra basal cells expressed Ki-67. from the outer to the inner margin of the psoriasis plaque, which coincided with the appearance of the clinical lesion, there was a significant change in the various markers. The patchy expression of keratin 6 in the innermargin became homogeneous in the centre of the psoriasis plaque and here was also coexpression of keratin 6 and keratin 10 in a single cell. Conclusions: The present study provides additional evidence that the distant uninvolved skin has a prepsoriatic phenotype, which is the first step in a psoriatic cascade. The cascade between symptomless and lesional skin comprises first an abnormality in inflammation with involvement of β1 integrin-dim cells (transit amplifying cells) subsequently eliciting an

关键词：银屑病白疮皮损表皮细胞泛发性无症状亚群皮肤解剖部位

联合Zenon标签技术和显微映像分析研究正常人和银屑病患者表皮细胞

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世界核心医学期刊文摘（皮肤病学分册） 2005年第6期1卷 32-33页

作者： van duijnhoven m.w.f.m. van De Kerkhof P.C.m. Pasch m.C. 李政霄 Department of Dermatology University Medical Centre Nijmegen Nijmegen Netherlands

Background: In order to better characterize epidermal cell populations in psoriatic vs. normal skin, fluorescent immunohistochemical techniques were extended with a new labeling technique. The Zenon technique conjugates primary antibodies rapidly and quantitatively after which they are used in the same manner as covalently labeled primary antibodies. Digital microscopic images of epidermal expression of keratin 10 and keratin 6 (differentiation), Ki-67 antigen (proliferation), and keratin 15 and β- 1 integrin (basal layer) were analyzed in a standardized way. Co-expression of different proteins was demonstrated. methods: Sections of normal skin and psoriatic lesions were compared immunohistochemically. Antibodies against keratin 6, 10, and 15 were labeled with the Zenon technique. Antibodies against the Ki-67 antigen and β 1 integrin were covalently fluorescein isothiocyanate- labeled. Using standardized image analysis, intensity and positive surface area of the different antibodies in the epidermis were measured. Results: The number of Ki-67-antigen positive cells was significantly increased in lesional psoriatic skin. Intensity and positive surface area of keratin 10 and β -1 integrin were significantly decreased in comparison to normal epidermis. Differential expression of keratin 6 and keratin 15 was demonstrated. Conclusions: Using Zenon technology and image analysis, a description of morphology, co- expression, and quantification of representative markers for epidermal cell populations is possible.

关键词：银屑病 Zenon 表皮细胞标签技术角蛋白皮损区抗原表达整联蛋白共价结合基底层

Enabling low-cost decentralized power reserves adopting carbon dioxide for green methane exchange in stabilized clathrate adsorbent

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Journal of Energy Chemistry 2024年第10期97卷 438-443页

作者： Lucas Hanssens maarten Houlleberghs C.Vinod Chandran Geert watson Sambhu Radhakrishnan Pascal van Der Voort Joeri f.m.Denayer Christine E.A.Kirschhock Johan A.martens Eric Breynaert Centre for Surface Chemistry and Catalysis-Characterization and Application Team (COK-KAT) NmR/X-Ray Platform for Convergence Research (NmRCoRe) Centre for Ordered materials Organometallics and Catalysis (COMOC) Department of Chemistry Ghent University Department of Chemical Engineering Vrije Universiteit Brussel

*** circular methane energy systems In recent decades,methane-based energy systems have rapidly gained traction across the globe because of the increasing availability of low-cost methane production ***,fossil methane... 详细信息

关键词： Long duration energy storage Green methane Carbon neutrality Confined clathrate hydrates CH4 /CO2 exchange Direct gas exchange ENERGY-STORAGE CONfINED NANOSPACE TO-mETHANE GAS mECHANISmS ADSORPTION HYDROGEN

Analysis of the Impact of the Blazhko Effect Both on the van Hoof Effect and Radial Velocity Amplitude in the Star RR Lyr

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Research in Astronomy and Astrophysics 2024年第6期24卷 253-272页

作者： Y.El jariri f.L.Sefyani A.Benhida Z.Benkhaldoun K.Kolenberg K.Chafouai A.Habib m.Sabil Observatoire de l'Oukaimeden LPHEAFSSMUniversitéCadi AyyadMarrakech2390Morocco Observatoire de l'Oukaimeden LPHEAFSTGUniversitéCadi AyyadMarrakech549Morocco Département de physique Universitéd'Anvers Avenue Groenenborger 171Anvers2020Belgium LICPm ENSA-BMUniversitéSultan Moulay SlimaneBeni-Mellal23020Morocco

The van Hoof effect is a phase shift existing between the radial velocity curves of hydrogen and metallic lines within the atmosphere of pulsating *** this article,we present a study of this phenomenon through the spectra of the brightest pulsating star RR Lyr of RR Lyrae stars recorded for 22 *** based ourselves,on the one hand,on 1268 spectra(41 nights of observation)recorded between the years 1994 and 1997 at the Observatory of Haute Provence(OHP,france)previously observed by Chadid and Gillet,and on the other hand on 1569 spectra(46nights of observation)recorded at our Oukaimeden Observatory(morocco)between 2015 and *** this study,we have detected information on atmospheric dynamics that had not previously been ***,the van Hoof effect which results in a clear correlation between the radial velocities of hydrogen and those of the metallic lines has been observed and analyzed at different Blazhko phases.A correlation between the radial velocities of different metallic lines located in the lower atmosphere has been observed as *** the first time,we were able to show that the amplitude of the radial velocity curves deduced from the lines of hydrogen and that of feⅡ(λ4923.921?)increases toward the minimum of the Blazhko cycle and decreases toward the maximum of the same Blazhko ***,we found that the van Hoof effect is also modulated by the Blazhko ***,toward the minimum of the Blazhko cycle the van Hoof effect is more visible and at the maximum of the Blazhko cycle,this effect is *** also observed the temporal evolution of the amplitudes of the radial velocities of the lower and upper *** observed over a long time,we can interpret it as a function of the Blazhko phases.

关键词： stars:atmospheres stars:variables:RR Lyrae shock waves techniques:spectroscopic techniques:radial velocities stars:individual(RR Lyr)

The germline genetics of mild-to-moderate penetrance:An intriguing role of PRAmE in multiple carcinogenesis

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Genes & Diseases 2024年第3期11卷 7-10页

作者： Diaddin Hamdan van Tai Nguyen Justine Paris Christophe Leboeuf morad El Bouchtaoui marc Espie Anne Janin Geraldine falgarone melanie Di Benedetto Guithem Bousquet Universite de Paris Cite INSERMUMR_S942MASCOTParis F-75006France Hopital La Porte Verte Versailles F-78004France National Cancer Hospital Cancer Research and Clinical Trials CenterHaNoi100000VietNam AP-HP-Hopital Saint Louis Centre de Maladies du SeinParisF-75010France Universite Sorbonne Paris Nord Bobigny F-93000France AP-HP-Hopital Avicenne Unite de Medecine AmbulatoireBobigny F-93000France

Germline genetics of high penetrance such as BRCA genes,mutations might be sufficient for carcinogenesis,but this only explains fewer than 10%of *** assume that most cancers are the result of germline mutations of low to moderate penetrance,combined with acquired mutations due to external carcinogenic *** their accumulation over time,aging is associated with an increased risk of multiple cancer development in a given *** decades,germline genetics have been based on familial linkage studies enabling most high-penetrance genes to be *** recently,population-wide studies have led to the identification of considerable numbers of polymorphisms associated with cancer ***,most of them are of unknown functional value,thus limiting their translational application.

关键词： carcinogenesis BRCA linkage

Realizing High Thermoelectric Performance in n-Type Se-free Bi2Te3 materials by Spontaneous Incorporation of feTe2 Nanoinclusions

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Energy & Environmental materials 2024年第4期7卷 344-354页

作者： Jamil Ur Rahman woo Hyun Nam Yong-Jae Jung Jong Ho won Jong-min Oh Nguyen van Du Gul Rahman Víctor m.García-Suárez Ran He Kornelius Nielsch Jung Young Cho won-Seon Seo Jong wook Roh Sang-il Kim Soonil Lee Kyu Hyoung Lee Hyun Sik Kim weon Ho Shin Leibniz Institute for Solid State and materials Research Advanced materials Convergence R&D Division Korea Institute of Ceramic Engineering & Technology Department of Electronic materials Engineering Kwangwoon University Department of Energy Engineering Dankook University faculty of fundamental Science Phenikaa University Department of Physics Quaid-i-Azam University Departamento de física Universidad de Oviedo Nanomaterials and Nanotechnology Research Center-CINN Department of materials Science and Engineering Yonsei University School of Nano & materials Science and Engineering Kyungpook National University Department of materials Science and Engineering University of Seoul School of materials Science and Engineering Changwon National University

Bi2Te3-based materials have drawn much attention from the thermoelectric community due to their excellent thermoelectric performance near room ***,the stability of existing n-type Bi2（Te,Se）3materials is still low due to the evaporation energy of Se (37.70 kJ mol-1) being much lower than that of Te (52.55 kJ mol-1).The evaporated Se from the material causes problems in interconnects of the module while degrading the efficiency.

关键词： Bi2Te3 energy harvesting feTe2 nanoinclusion n-type materials thermoelectric

Low-Cost and Biodegradable Thermoelectric Devices Based on van der waals Semiconductors on Paper Substrates

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Energy & Environmental materials 2024年第1期7卷 205-210页

作者： Gulsum Ersu Carmen munuera federico J.mompean Daniel Vaquero Jorge Quereda Jo?o Elias f.S.Rodrigues Jose A.Alonso Eduardo flores Jose R.Ares Isabel J.ferrer Abdullah m.Al-Enizi Ayman Nafady Sruthi Kuriakose Joshua O.Island Andres Castellanos-Gomez materials Science factory Instituto de Ciencia de Materiales de Madrid (ICMM-CSIC) Nanotechnology Group USAL–Nanolab Univesidad de Salamanca GISC Departamento de Física de Materiales Universidad Complutense de Madrid Departamento de física Aplicada Centro de Investigación y Estudios Avanzados mIRE Group Departamento de Física de Materiales Universidad Autónoma de Madrid Instituto Nicolás Cabrera Universidad Autónoma de Madrid Department of Chemistry College of Science King Saud University Department of Physics and Astronomy University of Nevada Las Vegas

we present a method to fabricate handcrafted thermoelectric devices on standard office paper *** devices are based on thin films of wS2,Te,and BP（P-type semiconductors） and TiS3and TiS2（N-type semiconductors）,depo... 详细信息

关键词： paper-based electronics Seebeck effect semiconductors thermoelectrics van der waals materials

CT影像组学模型在结直肠癌肝转移中的独立验证：预测肿瘤消融后局部进展

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国际医学放射学杂志 2024年第4期 500-501页

作者： D.J.van der Reijd C.Guerendel f.C.R.Staal m.P.Busard m.de Oliveira Taveira E.G.Klompenhouwer 刘晓彤

摘要目的对3种既往报道的基于CT预测结直肠癌肝转移（CRLm）病变热消融后局部肿瘤进展（LTP）的影像组学模型进行独立内部及外部验证。方法从2个机构收集接受

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli m.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik m.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad f. Ahmadov w.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot m. Ait Tamlihat B. Aitbenchikh I. Aizenberg m. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt m. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos f. Alfonsi m. Algren m. Alhroob B. Ali H.m.J. Ali S. Ali S.w. Alibocus m. Aliev G. Alimonti w. Alkakhi C. Allaire B.m.m. Allbrooke J.f. Allen C.A. Allendes flores P.P. Allport A. Aloisio f. Alonso C. Alpigiani m. Alvarez Estevez A. Alvarez fernandez m. Alves Cardoso m.G. Alviggi m. Aly Y. Amaral Coutinho A. Ambler C. Amelung m. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel m.T. Anthony E. Antipov m. Antonelli f. Anulli m. Aoki T. Aoki J.A. Aparisi Pozo m.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-f. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin m. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu f. Backman A. Badea P. Bagnaia m. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.m. Baldin P. Balek E. Ballabene f. Balli L.m. Baltes w.K. Balunas J. Balz E. Banas m. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak m. Barakat E.L. Barberio D. Barberis m. Barbero m.Z. Barel K.N. Barends T. Barillari m-S. Barisits T. Barklow P. Baron D.A. Baron mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING