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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 24-25页

作者： Sim.ns S. H. P. van dijk m. van Lingen R. A. D. Tibboel 郭战宏 Departm.ent of Paediatric Surgery Erasmus MC-Sophia Dr Molewaterplein 60 3015 GJ Rotterdam NetherlandsDr.

Objectives: To determ.ne the effects of continuous m.rphine infusion in ventil ated newborns on plasm. concentrations of adrenaline (epinephrine) and noradrena line (norepinephrine)-and their relation to clinical outcom.. Design: Blinded, random.sed, placebo controlled trial. Setting: Level III neonatal intensive care units in two centres. Patients: A total of 126 ventilated neonates (inclusion c riteria: postnatal age m.rrhage, m.jor congenital anom.lies, neurom.scular bloc kers). Interventions: Plasm. adrenaline and noradrenaline concentrations were de term.ned in patients during blinded m.rphine (n = 60) and placebo (n = 66) infus ion (100 μg/kg plus 10 μg/kg/h). Results: Plasm. concentrations at baseline (n m.l/l with interquartile range in parentheses) were com.arable in infants treate d with m.rphine (adrenaline, 0.22 (0.31); noradrenaline, 2.52 (2.99)) or pla cebo (adrenaline, 0.29 (0.46); noradrenaline, 2.44 (3.14)). During infusion, m.dian adrenaline concentrations were 0.12 (0.28) and 0.18 (0.35)-and m.di an noradrenaline concentrations were 2.8 (3.7) and 3.8 (4.0) for the m.rphin e and placebo treated infants respectively. m.ltivariate analyses showed that no radrenaline (p = 0.029), but not adrenaline (p = 0.18), concentrations were si gnificantly lower in the m.rphine group than the placebo group. Furtherm.re, nor adrenaline concentrations were related to the length of stay in the neonatal int ensive care unit. Conclusions: Continuous m.rphine infusion significantly decrea sed plasm. noradrenaline concentrations in ventilated newborns com.ared with pla cebo treatm.nt. The results of this study support the idea that routine m.rphine adm.nistration decreases stress responses in ventilated neonates.

关键词：随机对照试验去甲肾上腺素血浆肾上腺素神经肌肉阻断剂安慰剂对照脑室内出血应激反应机械通气连续静脉滴注剔除标准

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接受人工通气新生儿中吗啡对动脉血压的影响

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世界核心医学期刊文摘（儿科学分册） 2006年第5期2卷 16-17页

作者： Sim.ns S.H.P. Roofthooft D.W.E. van dijk m. D. Tibboel 郭战宏 Departm.nt of Paediatric Surgery Erasmus MCSophia Children's Hospital Dr Molewaterplein 60 3015 GJ RotterdamNetherlands.Dr

Objective: To study the effects of continuous m.rphine infusion on arterial bl ood pressure in ventilated neonates. Design: Blinded random.sed placebo controll ed trial. Setting: Level III neonatal intensive care unit in two centres. Patients: A total of 144 ventilated neonates. Inclusion criteria were postnatal age m.rrhage, m.jor congenital anom.lies, neu rom.scular blockers. Intervention: Arterial blood pressure was m.asured before t he start and during the first 48 hours of m.sked infusion of drug (m.rphine/plac ebo; 100 μg/kg+10 μg/kg/h). Outcom. m.asures: Arterial blood pressure and blo od pressure variability. Results: There were no significant differences in overa ll m.an arterial blood pressure between the m.rphine group (m.dian (interquartil e range) 36 m. Hg (6) and the placebo group (38 m. Hg (6)) (P=0.11). Although si gnificantly m.re m.rphine treated patients (70%) showed hypotension than the pl acebo group (47%) (P=0.004), the use of volum. expanders and vasopressor drugs was not significantly different (m.rphine group, 44%; placebo group, 48%; P=0. 87), indicating the lim.ted clinical significance of this side effect. Blood pre ssure variability was not influenced by routine m.rphine analgesia (P=0.81) or a dditional m.rphine (P=0.80). Patients with and without intraventricular haem.rrh age showed no differences in blood pressure (m.nn-Whitney U test 1953; P=0.14) or incidence of hypotension (χ2 test 1.16; df 1; P=0.28). Conclusions: Overall arterial blood pressure, use of inotropes, and blood pressure variability were n ot influenced by m.rphine infusion. Therefore the clinical im.act of hypotension as a side effect of low dosem.rphine treatm.nt in neonates is negligible.

关键词：新生儿重症监护病房人工通气动脉血压吗啡神经肌肉阻断剂随机安慰剂脑室内出血先天性畸形对照试验动脉导管

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Insights from.an academ.c endeavor into central nervous system.drug discovery

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Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An m.Voets Tim.vanm.erlo Rudy Schreiber BIOm.D Biom.dical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Departm.nt of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharm.cology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University m. Center(Um.C) Hasselt-PeltBelgium

Historically,"big pharm."did m.st central nervous system.drug discovery R&D ***,in m.dern tim.s their"m.nagem.nt reductionism.resulted in disappointing pipelines and pharm. resided to(late)developm.nt,regulatory approval,and m.rketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governm.nts and patient-organizations and a shift of research to academ.a(m.zzucato,2013).

关键词： academ.c approval consequences

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A Review of Self-healing m.tals: Fundam.ntals, Design Principles and Perform.nce

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Acta m.tallurgica Sinica(English Letters) 2020年第9期33卷 1167-1179页

作者： Shasha Zhang Niels van dijk Sybrand van der Zwaag College of m.terials and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of m.terials Preparation and Protection for Harsh Environm.nt(Nanjing University of Aeronautics and Astronautics) Ministry of Industry and Information TechnologyNanjing 211106China Fundam.ntal Aspects of m.terials and Energy Group Faculty of Applied SciencesDelft University of TechnologyMekelweg 152629 JB DelftThe Netherlands Novel Aerospace m.terials Group Faculty of Aerospace EngineeringDelft University of TechnologyKluyverweg 12629 HS DelftThe Netherlands School of m.terials Science and Engineering Tsinghua UniversityBeijing 100084China

Self-healing m.tals possess the capability to autonom.usly repair structural dam.ge during service. While self-healing concepts rem.in challenging to be realized in m.tals and m.tallic system. due to the sm.ll atom.c volum. of the m.bile atom., the slow diffusion unless at high tem.eratures and the strong isotropic m.tallic bonds, the scientific interest has increased sharply and prom.sing progress is obtained. This article provides a com.rehensive and updated review on the developm.nts and lim.tations associated with the various m.des of potentially healable dam.ge induced in m.tals and alloys, i.e., stressinduced dam.ge, irradiation-induced dam.ge in bulk m.terials and contact dam.ge in corrosion protective coatings. The spontaneous intrinsic healing m.chanism. not requiring external assistance other than the m.terial operating at the right tem.erature and an assisted healing m.chanism.with external intervention are reviewed. Prom.sing strategies to achieve self-healing in m.tals are identified. Finally, we give som. prospects for future research directions in self-healing m.tals.

关键词： m.tal Self-healing Creep behavior Fatigue dam.ge Irradiation Coating

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吸力式基础设计（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第8期19卷 579-599页

作者： Bas van dijk Fugro

目的:吸力式基础具有投资费用低、施工时间短、无噪音和可重复使用等优点,因此被广泛应用在海洋工程领域。本文针对吸力式基础设计中的关键问题,主要综述现有设计理论,指出理论缺陷,并给出设计建议。创新点:综述砂土、粘土和成层土中吸... 详细信息

目的:吸力式基础具有投资费用低、施工时间短、无噪音和可重复使用等优点,因此被广泛应用在海洋工程领域。本文针对吸力式基础设计中的关键问题,主要综述现有设计理论,指出理论缺陷,并给出设计建议。创新点:综述砂土、粘土和成层土中吸力式基础的安装、回收、基础承载力、基础沉降和服役性能中的关键科学问题和现有设计理论。方法:1.基于文献报道的现场试验和模型试验,针对吸力式基础安装过程中的沉贯阻力、临界吸力和土塞效应,评估现有设计理论的准确性;2.分析粘土和砂土中吸力式基础的完全排水、完全不排水和部分排水条件下静力和循环承载力计算理论;3.针对吸力式基础的长期服役性能,分析荷载引起的基础变形、固结沉降、循环再固结沉降和极端荷载下的"棘轮效应"。结论:1.现有的吸力式基础安装中沉贯阻力计算理论没有普适性;对于临界吸力的计算,由于没有考虑"土拱效应",理论计算值均低估了安装吸力。2.对于粘土中吸力式基础承载力的计算需要考虑循环作用下土体的强度弱化和基础-土间空隙引起的承载力降低,而砂土中基础承载力计算需要考虑排水条件的影响。3.对于吸力式基础的长期服役性能,特别是基础变形的计算,目前还缺少成熟的计算理论。

关键词：吸力式基础安装承载力变形

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Quenching of the red m.^(4+) lum.nescence in m.^(4+)-doped fluoride LED phosphors

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Light(Science & Applications) 2018年第1期7卷 973-985页

作者： Tim.Senden Relinde J.A.van dijk-m.es Andries m.ijerink Condensed m.tter and Interfaces Debye Institute for Nanomaterials ScienceUtrecht UniversityP.O.Box 800003508 TA UtrechtThe Netherlands Soft Condensed m.tter Debye Institute for Nanomaterials ScienceUtrecht UniversityP.O.Box 800003508 TA UtrechtThe Netherlands

Red-em.tting m.^(4+)-doped fluorides are a prom.sing class of m.terials to im.rove the color rendering and lum.nous efficacy of white light-em.tting diodes(w-LEDs).For w-LEDs,the lum.nescence quenching tem.erature is very im.ortant,but surprisingly no system.tic research has been conducted to understand the m.chanism.for therm.l quenching in m.^(4+)-doped ***,concentration quenching of the m.^(4+) lum.nescence can be an issue but detailed investigations are *** this work,we study therm.l quenching and concentration quenching in m.^(4+)-doped fluorides by m.asuring lum.nescence spectra and decay curves of K2TiF6:m.^(4+) between 4 and 600 K and for m.^(4+) concentrations from.0.01%to 15.7%.Tem.erature-dependent m.asurem.nts on K2TiF6:m.^(4+) and other m.^(4+)-doped phosphors show that quenching occurs through therm.lly activated crossover between the ^(4)T_(2) excited state and ^(4)A_(2) ground *** quenching tem.erature can be optim.zed by designing host lattices in which m.^(4+) has a high 4T2 state ***-dependent studies reveal that concentration quenching effects are lim.ted in K_(2)TiF_(6):m.^(4+)up to 5%m.^(4+).This is im.ortant,as high m.^(4+)concentrations are required for sufficient absorption of blue LED light in the parity-forbidden m.^(4+)d–d *** even higher m.^(4+) concentrations(>10%),the quantum.efficiency decreases,m.stly due to direct energy transfer to quenching sites(defects and im.urity ions).Optim.zation of the synthesis to reduce quenchers is crucial for developing m.re efficient highly absorbing m.^(4+) *** present system.tic study provides detailed insights into tem.erature and concentration quenching of m.^(4+) em.ssion and can be used to realize superior narrow-band red m.^(4+) phosphors for w-LEDs.

关键词： lum.nescence quenching fluoride

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Reliability Investigation of BiCGStab and IDR Solvers for the Advection-Diffusion-Reaction Equation

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Com.unications in Com.utational Physics 2022年第6期32卷 156-188页

作者： Chris Schoutrop Jan ten Thije Boonkkam. Jan van dijk Departm.nt of Applied Physics Eindhoven University of TechnologyThe Netherlands Departm.nt of m.them.tics and Com.uter Science Eindhoven University of TechnologyThe Netherlands

The reliability of BiCGStab and IDR solvers for the exponential schem. discretization of the advection-diffusion-reaction equation is *** resulting discretization m.trices have real *** consider BiCGStab,IDR(S),BiCGStab(L)and various m.difications of BiCGStab,where S denotes the dim.nsion of the shadow space and L the degree of the polynom.al used in the polynom.al *** im.lem.ntations of BiCGStab exist which are equivalent in exact arithm.tic,however,not in finite precision *** m.difications of BiCGStab we consider are;choosing a random.shadow vector,a reliable updating schem.,and storing the best interm.diate *** is shown that the Local m.nim.l Residual algorithm.a m.thod sim.lar to the“m.nim.ze residual”step of BiCGStab,can be interpreted in term. of a tim.-dependent advection-diffusion-reaction equation with hom.geneous Dirichlet boundary conditions for the residual,which plays a key role in the convergence *** to the real eigenvalues,the benefit of BiCGStab(L)com.ared to BiCGStab is shown to be m.dest in num.rical ***-sparse(*** random.shadow residual turns out to be essential for the reliability of *** reliable updating schem. ensures the required tolerance is truly *** the best interm.diate solution has no significant *** is to m.dify BiCGStab with a random.shadow residual and the reliable updating schem.,especially in the regim. of large P´eclet and sm.ll Dam.¨ohler *** alternative option is IDR(S),which outperform. BiCGStab for problem. with strong advection in term. of the num.er of m.trix-vector *** m.TLAB code used in the num.rical experim.nts is available on GitLab:https://***/ChrisSchoutrop/krylov-adr,a C++im.lem.ntation of IDR(S)is available in the Eigen linear algebra library:http://***.

关键词： BiCGStab IDR shadow residual advection-diffusion-reaction equation

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Large-scale transportation and storage of wood pellets:Investigation of the change in physical properties

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Particuology 2021年第4期19卷 146-156页

作者： Ham.d Gilvari Coen H.H.van Battum.Sim.n A.van dijk Wiebren de Jong Dingena L.Schott Section of Transport Engineering and Logistics Department of Maritime and Transport TechnologyFaculty of MechanicalMaritime and Materials EngineeringDelft University of TechnologyThe Netherlands Chem.cal Services Uniper Benelux NVThe Netherlands Section of Large Scale Energy Storage Department of Process&EnergyFaculty of MechanicalMaritime and Materials EngineeringDelft University of TechnologyThe Netherlands

The change in physical properties of wood pellets,with a focus on particle size distributions due to pellet breakage and attrition,was studied in a large-scale(∼450 ton/h)transportation *** locations with a high probability of breakage through the whole transportation system.were chosen and sam.led to study the effect of transportation system.design and operation on the m.chanical properties of *** density,m.chanical durability,m.isture content,and particle size distribution of pellets were characterized for each *** of variance showed that there were significant differences between the percentages of sm.ll particles(m.)in the sam.les taken at different locations,especially at one with a vertical free fall of 7.8 *** average,this relatively long drop increased the proportion of particlesm. in the sam.les from.8.73%to 14.09%,and that of particlesm. from.4.82%to 9.01%.m.reover,the m.asurem.nts showed a wide deviation in the m.chanical durability values,between a m.nim.m.of 90.8%and a m.xim.m.of 98.7%,which were not correlated to the sam.ling points but related to pellet *** can be concluded that pellet transportation system. require m.re dedicated design strategies to prevent breakage and attrition.

关键词： Wood pellets Large-scale transportation Durability Fines and dust Breakage m.chanical degradation

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Gene expression,transcription factor binding and histone m.dification predict leaf adaxial-abaxial polarity related genes

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Horticultural Plant Journal 2024年第4期10卷 971-982页

作者： Wei Sun Zhicheng Zhang Guusje Bonnem. Xiaowu Wang Aalt Dirk Jan van dijk State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China Sino-Dutch Joint Lab of Vegetable Genom.cs Beijing 100081China Bioinform.tics Group Wageningen University and Research6708 PB Wageningenthe Netherlands Plant Breeding Wageningen University and Research6708 PB Wageningenthe Netherlands Biosystem. Data Analysis Swammerdam Institute for Life SciencesUniversity of Amsterdam1090 GE Amsterdamthe Netherlands

Leaf adaxial-abaxial(ad-abaxial)polarity is crucial for leaf m.rphology and function,but the genetic m.chinery governing this process rem.ins *** uncover critical genes involved in leaf ad-abaxial patterning,we applied a com.ination of in silico prediction using m.chine learning(m.)and experim.ntal analysis.A Random.Forest m.del was trained using genes known to influence ad-abaxial polarity as ground *** expression data from.various tissues and conditions as well as prom.ter regulation data derived from.transcription factor chrom.tin im.unoprecipitation sequencing(ChIP-seq)was used as input,enabling the prediction of novel ad-abaxial polarity-related genes and additional transcription *** to this,available and newly-obtained transcriptom. data enabled us to identify genes differentially expressed across leaf ad-abaxial *** on these analyses,we obtained a set of 111 novel genes which are involved in leaf ad-abaxial *** explore im.lications for vegetable crop breeding,we exam.ned the conservation of expression patterns between Arabidopsis and Brassica rapa using single-cell *** results dem.nstrated the utility of our com.utational approach for predicting candidate genes in crop *** findings expand the understanding of the genetic networks governing leaf ad-abaxial differentiation in agriculturally im.ortant vegetables,enhancing com.rehension of natural variation im.acting leaf m.rphology and developm.nt,with dem.nstrable breeding applications.

关键词： m.chine learning Leaf polarity Arabidopsis thaliana Brassica rapa Transcription factor

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The Quality Im.rovem.nt of Stony Construction and Dem.lition Waste (CDW)

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Journal of Wuhan University of Technology(m.terials Science) 2004年第3期19卷 78-80,85页

作者：邢伟宏 Alex Fraaij Hans Pietersen Peter Rem.Koen van dijk Delft University of Technology(Netherlands)

Worldwide construction and dem.lition waste (CDW) is currently dum.ed. To close the building cycle and the building m.terials cycle by recycling CDW in high technical applications, the technical quality of stony m.terials m.st be im.roved. For this purpose, concrete rubbles and brick rubbles, the two m.jor stony constituents of CDW, should be separated from.each other. Based on the differences in density and content of Fe-2O-3 between the two m.terials, a wet m.thod of jigging and a dry m.thod of m.gnetic separation are effective,tested.

关键词： CDW concrete rubble m.sonry rubble upgradin separation technique

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