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Burns in the elderly:a nationwide study on management and clinical outcomes

Burns & Trauma 2020年第1期8卷 71-81页

作者： Harold Goei margriet e.van Baar Jan Dokter J Vloemans Gerard I.J.m.Beerthuizen esther middelkoop Kees H.van der Vlies the Dutch Burn Repository group Association of Dutch Burn Centres Burn CentreMaasstad HospitalRotterdamthe Netherlands Department of Plastic Reconstructive and Hand SurgeryAmsterdam Movement SciencesVU University Medical CentreAmsterdamthe Netherlands Burn Centre.m.asstad Hospital Rotterdamthe Netherlands Burn Centre Red Cross Hospital Beverwijkthe Netherlands Burn Centre Martini HospitalGroningenthe Netherlands Association of Dutch Burn Centres Burn Centre Red Cross HospitalBeverwijkthe Netherlands Department of Public Health Erasmus Medical CentreRotterdamthe Netherlands 不详

Background:In modern-day burn care,advanced age remains an important predictor for mortality among burn *** this study,we compared the complete treatment trajectory(including prehospital and surgical treatment)and the outcomes between an elderly burn population and a younger adult burn ***:In this nationwide study,data from the Dutch Burn Repository were *** is a uniform national registration for Dutch specialized burn *** adult patients that were admitted to one of the three Dutch burn centres from the period 2009 to 2015 were included in the *** patients were considered as elderly when≥65 years of age,and were then further subdivided into three age categories:65–74,75–85 and 85+*** adults in the age category 18–64 years were used as the reference *** managementwas studied comprehensively and included timing of surgery,the number of procedures and details on the surgical technique,especially the technique used for debridement and the grafting technique that was *** the comparison of clinical outcome,the following parameters were included:mortality,wound infections,length of stay/TBSA(total body surface area)burned,discharge disposition and secondary ***:During the study period,3155 adult patients were included(elderly,n=505).Burn severity,reflected by the.m.dian TBSA,varied between 3.2–4.0%and was comparable,but aetiology and pre-hospital care were different between elderly and the younger adult reference *** treatment was initiated significantly faster in elderly burn patients(pess selective techniques for surgical debridement were used in the elderly burns patients(hydrosurgery,42.0%vs 23.5–22.6%),and on the other hand more avulsion(5.3%vs 7.3–17.6%)and primary wound closure(6.7%vs 24.5%).The.m.st frequently used grafting technique was meshed skin grafts(79.2–88.6%);this was not related to *** increased rapidly with a higher age and showed a h

关键词： Burns Nationwide study elderly Surgical management Clinical outcomes

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蛛网膜下腔出血后CT检查:脑灌注与迟发性脑缺血的关系

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世界核心医学期刊文摘(神经病学分册) 2006年第11期 61-62页

作者： van der Schaaf I We.m.r m.J van der Graaf Y 郭俊 Department of Radiology e132 University Medical Center Utrecht PO Box 85500 3508 GA Utrecht Netherlands Dr.

BACKGROUND: Delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is difficult to predict. The authors studied the relation between several parameters of brain perfusion at admission and development of DCI. meTHODS: The authors analyzed the admission CT perfusion (CTP) scans of 46 patients scanned within 72 hours after SAH. They assessed cerebral blood volume (CBV) and flow (CBF), mean transit time (mTT), and time to peak (TTP) for eight predefined regions of interest. For patients with and without DCI, the authors compared perfusion quantitatively and semiquantitatively. With receiver-operator characteristic (ROC) curves, the authors assessed the relationship between DCI and perfusion parameters. To assess the potential prognostic value, they calculated sensitivity and specificity of optimal threshold values for the semiquantitative data. ReSULTS: DCI was not significantly related with quantitative perfusion values. For the semiquantitative data, patients with DCI had significantly more asymmetry in perfusion, and ROC curves indicated a good relation (0.75 to 0.81). Optimal threshold values distinguishing between patients with and without DCI were 0.77 for CBV and 0.72 for CBF ratios, and 0.87 seconds for mTT and 1.0 second for TTP differences. The corresponding sensitivity was 0.75 for all parameters; the specificity was 0.70 for CBV, 0.93 for CBF, 0.70 for mTT, and 0.90 for TTP. CONCLUSIONS: Delayed cerebral ischemia (DCI) is related to perfusion asymmetry on admission CT perfusion (CTP). The cerebral blood flow ratio (comparing contralateral regions of interest) se.m. the best prognosticator for development of DCI. Further studies are needed to investigate the additional value of CTP to other prognosticators for DCI and to validate the chosen threshold values.

关键词：迟发性脑缺血患者蛛网膜下腔出血 DCI CT

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红细胞多态性的基因分型

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国际输血及血液学杂志 2010年第5期33卷 473-478页

作者： van der Schoot e de Haas m engelfriet CP(et al) 郑小凡(节译) 不详浙江省血液中心杭州310006

红细胞多态性在DNA水平的分型是输血医学的重大进展,其将对输血服务产生重大影响.最近,国际输血协会和国际血液学标准化委员会就此问题组织三次研讨会结果表明,可为分子血型基因分型设定非常高的标准.随着基因分型用于红细胞多态性研究... 详细信息

红细胞多态性在DNA水平的分型是输血医学的重大进展,其将对输血服务产生重大影响.最近,国际输血协会和国际血液学标准化委员会就此问题组织三次研讨会结果表明,可为分子血型基因分型设定非常高的标准.随着基因分型用于红细胞多态性研究的报道迅速增加,引起了＂国际论坛＂对其进展评价的关注.为了获得必要的信息,该领域的专家被问及以下问题：

关键词：基因分型多态性红细胞国际论坛 DNA水平输血医学输血服务输血协会

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LIGHT INTeRCePTION AND USe eFFICIeNCY DIFFeR WITH mAIZe PLANT DeNSITY IN mAIZe-PeANUT INTeRCROPPING

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Frontiers of Agricultural Science and engineering 2021年第3期8卷 432-446页

作者： Qi WANG Zhanxiang SUN Wei BAI Dongsheng ZHANG Yue ZHANG Ruonan WANG Wopke van der WeRF Jochem B.eVeRS Tjeerd-Jan STOmPH Jianping GUO Lizhen ZHANG State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological ScienceBeijing 100081China China Agricultural University College of Agricultural Resources and Environmental SciencesBeijing 100193China Wageningen University Centre for Crop Systems Analysis(CSA)Droevendaalsesteeg 16708 PB Wageningenthe Netherlands Tillage and Cultivation Research Institute Liaoning Academy of Agricultural SciencesShenyang 110161China Shanxi Agricultural University College of AgricultureTaigu 030800China

Intercropping increases crop yields by optimizing light interception and/or use *** intercropping combinations and metrics have been reported,the effects of plant density on light use are not well ***,we examined the light interception and use efficiency in maize-peanut intercropping with different maize plant densities in two row configurations in semiarid dryland agriculture over a two-year *** field experiment comprised four cropping systems,i.e.,monocropped maize.m.nocropped peanut,maize-peanut intercropping with two rows of maize and four rows of peanut,intercropping with four rows of maize and four rows of peanut,and three.m.ize plant densities(3.0,4.5 and 6.0 plants m^(-1) row)in both monocropped and intercropping *** mean total light interception in intercropping across years and densities was 779 mJ·m^(-2),5.5%higher than in monocropped peanut(737 mJ·m^(-2))and 7.6%lower than in monocropped maize(843 mJ·m^(-2)).Increasing maize density increased light interception in monocropped maize but did not affect the total light interception in the *** years the LUe of maize was 2.9 g·mJ–1 and was not affected by cropping system but increased with maize plant *** LUe of peanut was enhanced in intercropping,especially in a wetter *** yield advantage of maize-peanut intercropping resulted mainly from the LUe of *** results will help to optimize agronomic management and system design and provide evidence for system level light use efficiency in intercropping.

关键词： dryland agriculture light interception light use efficiency maize-peanut intercropping semiarid

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以往有先兆子痫的非孕妇女血小板反应性增强造成血管损伤的亚临床症状

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世界核心医学期刊文摘（妇产科学分册） 2006年第6期2卷 9-10页

作者： Spaande.m.n m.e.A. Schippers m. van der Graaf F. 张新艳 Department of Obstetrics and Gynecology Radboud University Nijmegen Medical Center NijmegenNetherlandsDr.

Objective: In nonpregnant formerly preeclamptic women, the prevalence of occult cardiovascular abnormalities is increased. These high- risk women mildly benefit from low- dose aspirin in the prevention of recurrent disease. How this effect is mediated, either by affecting platelet or vascular function, is still unsettled. In this study, we tested the hypothesis that in these nonpregnant women, enhanced platelet responsiveness is common and related to microvascular damage. Study design: At least 6 months’ postpartum we evaluated in 66 formerly preeclamptic women platelet count, volume, and in vitro response to low- dose ADP (0.5 μ g/mL). Peripheral levels of fibronectin (μ g/mL), vonWillebrand factor antigen (% ), C- reactive protein (high- sensitive CRP, mg/L), urinary albumin, and protein (24- hour collection, g/mol creatinine) served as markers of vascular damage. Hemodynamic function was dete.m.ned by plasma volume (iodine I 125 HSA indicator dilution method, mL/kg lean body mass), cardiac index (Doppler, mL/min/m2), blood pressure and heart rate (Dinamap [Critikon, Tampa, FL], mm Hg and beats/min, respectively). Thereafter, we subdivided these 66 women into 2 subgroups either with (n = 10, 15% ) or without increased platelet responsiveness (n = 56, 85% ). Both groups were compared nonparametrically. Results: Groups were comparable with respect to age, blood pressure, body mass index, parity, plasma volume, and cardiac index. Women with enhanced platelet responsiveness had higher levels of circulation fibronectin and CRP, and displayed more often albuminuria and proteinuria. In addition, even though platelet count was comparable between groups, the.m.an platelet volume was higher among women with enhanced platelet responsiveness. Conclusion: Fifteen percent of formerly preeclamptic women had enhanced platelet responsiveness, which was associated with elevated levels of various markers for (micro) vascular damage. We speculate that in these women platelets are pre

关键词：血小板反应性微血管损伤高危妇女先兆子痫亚临床症状血小板平均体积纤维结合蛋白 24h尿蛋白血浆容量心脏指数

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Design and the.m.dynamic analysis of a pathway enabling anaerobic production of poly-3-hydroxybutyrate in escherichia coli

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Synthetic and Systems Biotechnology 2023年第4期8卷 629-639页

作者： Karel Olavarria marco V.Becker Diana Z.Sousa mark C.m.van Loosdrecht S.Aljoscha Wahl Laboratory of microbiology Wageningen University and ResearchStippenenweg 46708 WEWageningenThe Netherlands Centre for Living Technologies Eindhoven-Wageningen-Utrecht AlliancePrincetonlaan 63584 CBUtrechtThe Netherlands Department of Biotechnology Applied Sciences FacultyDelft University of Technologyvan der Maasweg 92629 HZDelftThe Netherlands Lehrstuhl für Bioverfahrenstechnik Friedrich-Alexander-Universit¨atPaul-Gordan-Strasse 391052ErlangenGermany

Utilizing anaerobic metabolisms for the production of biotechnologically relevant products presents potential advantages,such as increased yields and reduced energy ***,lower energy dissipation may indicate that certain reactions are operating closer to their the.m.dynamic *** stoichiometric analyses and genetic modifications are frequently employed in metabolic engineering,the use of the.m.dynamic tools to evaluate the feasibility of planned interventions is less *** this study,we propose a novel metabolic engineering strategy to achieve an efficient anaerobic production of poly-(R)-3-hydroxybutyrate(PHB)in the.m.del organism escherichia *** approach involves re-routing of two-thirds of the glycolytic flux through non-oxidative glycolysis and coupling PHB synthesis with NADH *** complemented our stoichiometric analysis with various the.m.dynamic approaches to assess the feasibility and the bottlenecks in the proposed engineered *** to our calculations,the.m.in the.m.dynamic bottleneck are the reactions catalyzed by the acetoacetyl-CoAβ-ketothiolase(eC 2.***.1.9)and the acetoacetyl-CoA reductase(eC 1.***.1.36).Furthe.m.re,we calculated the.m.dynamically consistent sets of kinetic parameters to dete.m.ne the enzyme amounts required for sustaining the conversion *** the case of the engineered conversion route,the protein pool necessary to sustain the desired fluxes could account for 20%of the whole cell dry weight.

关键词： Pathway feasibility analysis Protein cost Anaerobic metabolism engineered pathways metabolite concentrations

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煤浆管线系统的设计技术条件

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油气储运 1981年第1期 66-72页

作者： R.L.Gandhi P.e.snoek m.D.Weston 辛未然美国Bechtel公司管道部分浆液系统工程处

一、引言用浆液管道输送各种固体物质,在现代已公认是经济、可靠的方法。任何一个观察家在纵观有关文献之后,可能会认为这方面的工艺技术已经完全明了,并能借此所有关系将其编制程序,再运用一系列计算技术,就可直接得到系统最佳条件的... 详细信息

一、引言用浆液管道输送各种固体物质,在现代已公认是经济、可靠的方法。任何一个观察家在纵观有关文献之后,可能会认为这方面的工艺技术已经完全明了,并能借此所有关系将其编制程序,再运用一系列计算技术,就可直接得到系统最佳条件的选配。遗憾的是,尽管近十年来技术情况有了巨大进展,而这样的理想却仍未成为现实。一条浆液管线系统的设计,包括三个截然不同的系统:浆液制备系统、管道输送系统和应用系统。所

关键词：管线长度摩阻损失细颗粒摩擦损失管输费用煤浆油气输送管道输送管线系统设计技术

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通过内窥镜螺旋钉钉器将止血海绵固定于骶骨对骶前出血进行填塞治疗:两例病例报道

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 21-22页

作者： van der Vurst T.J. Bodegom m.e. Rakic S. 李康 Department of Surgery Twenteborg Hospital Zilvermeeuw 1 7600 SZ Almelo NetherlandsDr.

Presacral venous hemorrhage is a severe complication in low rectal surgery. Th is complication was encountered in 5 of 165 patients (3 percent) who underwent a presacral dissection for rectal mobilization. Conventional hemostatic measures often are ineffective to arrest this hemorrhage, and a number of alternative hem ostatic techniques have been proposed. We report the successful tamponade of pre sacral hemorrhage with absorbable hemostatic sponges fixed to the sacrum with en doscopic helical tackers.

关键词：填塞治疗螺旋钉直肠切除直肠手术骶前静脉止血措施

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非残疾老年人的中央颞叶萎缩和白质高信号与轻度认知功能障碍相关:LADIS研究

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 37-38页

作者： van der Flier W.m. van Straaten e.C.W. Barkhof F. 赵天智 Department of Neurology and Alzhe.m.r Centre Vrije Universiteit Medical Centre PO Box 7057 1007 MB Amsterdam Netherlands.Prof

Objective: To assess the associations of medial temporal lobe atrophy (mTA) and white.m.tter hyperintensities (WmH) with cognitive function in a large group of independently functioning elderly people. methods: Data were drawn from the.m.lticentre, multinational leukoaraiosis and disability (LADIS) project which is s tudying prospectively the role of WmH as an independent predictor of the transit ion to disability in non-disabled elderly people. In all, 639 participants were enrolled in the LADIS study. For the present analysis, data on 581 subjects wer e available. Cognitive function was assessed by the.m.nimental state examination (mmSe). Visual ratings of WmH and mTA were undertaken on magnetic resonance ima ges (mRI). Results: The presence of either severe WmH or mTA was associated with a modest but non-significant increase in frequency of mild cognitive deficits (severe WmH: odds ratio (OR) = 1.9 (95%confidence interval (CI), 1.0 to 3.7); mTA present: OR = 1.5 (95%CI, 1.8 to 2.8)). However, subjects with the combination of mTA and se vere WmH had a more than fourfold increase in frequency of mild cognitive defici ts (OR = 4.1 (95%CI, 2.3 to 7.4)). Analysis of variance with post hoc Bonferron i t tests showed that subjects with both mTA and severe WmH performed worse on m mSe than those with either no mRI abnormality or a single.m.I abnormality (p ese results provide further evidence for the combined invol vement of both Alzhe.m.r type pathology and vascular pathology in the earliest s tages of cognitive decline and suggest an additive effect of WmH and mTA.

关键词：轻度认知功能障碍高信号 LADIS 颞叶大脑皮质白质髓质残疾老年人

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electrochemically-stimulated nanoscale.m.chanochemical wear of silicon

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摩擦:英文版 2023年第11期11卷 2142-2152页

作者： Chen XIAO Stefan van VLIeT Roland BLIem Bart WeBeR Steve FRANKLIN Advanced Research Center for Nanolithography(ARCNL) Amsterdam 1098XGthe Netherlands van der Waals–Ze.m.n Institute Institute of PhysicsUniversity of Amsterdam(UvA)Amsterdam 1098XGthe Netherlands Department of materials Science and engineering The University of SheffieldSheffield S13JDUK

mechanochemical reactions at the sliding interface between a single-crystalline silicon(Si)wafer and a silica(SiO2)microsphere were studied in three environmental conditions:humid air,potassium chloride(KCl)solution,and KCl solution with an applied *** to that from humid air,mechanochemical material removal from the silicon surface increased substantially in the KCl-immersed condition,and further increased when electrochemistry was introduced into the tribological *** measuring the load dependence of the.m.terial removal rate and analyzing the results using a mechanically assisted Arrhenius-type kinetic model,the activation energy(e_(a))and the.m.chanical energy(e_(m)),by which this energy is reduced by mechanical activation,were compared qualitatively under different environmental *** the KCl-immersed condition,mechanochemistry may decrease the required effective energy of reactions(e_(eff)=e_(a)−e_(m))and promote.m.terial removal mainly through improved catalysis of the.m.chanochemical reactions facilitated by greater availability of water molecules compared to the humid air ***,the effectiveness of the.m.chanochemistry is *** the electrochemical condition,electrochemically-accelerated oxidation of the silicon surface was confirmed by the X-ray photoelectron spectroscopy(XPS)*** results strongly suggest that electrochemistry further stimulates mechanochemical reactions primarily by increasing the initial energy state of the surface via the facilitated formation of interfacial bonding bridges,i.e.,a surface oxidation/hydroxylation process.

关键词： spherical contact adhesive wear normal loading power law

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