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乌干达HIV感染患者并发瘙痒性丘疹皮损的病因学研究

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世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 6-6页

作者： Resneck Jr.J.S. van beek m. Furm.nski L. 牛新武 Departm.nt of Derm.tol og y Univ.of CaliforniaSan FranciscoSchool of M edicineSan FranciscoCA 94143-0363Unite d StatesDr.

Context:A frequent cause of hum.n im.m.nodeficiency virus(HIV)-related m.rbidity in sub-Saharan Africa i s a com.only occurring,intensely prur itic skin *** re-sulting scars ar e disfiguring and *** the substantial prevalence of pruritic p apular eruption(PPE)am.ng HIV-infected Africans,the cause has been elusive. Objective:To determ.ne the etiolog y of PPE occurring in HIV-infected individu ***,Setting,and Patients:Cross-sectional study of HIV-infec ted pat ients with active PPE from.clinics in Uganda conducted from.m.y 19through June 6,*** occurred in the m.nth preceding m.y *** partici pant was clinically exam.ned by 2derm.tologists,had laboratory stu dies perfor m.d,was ad-m.nistered an epidem.ologic questionnaire,and had a skin biopsy of a new lesion evaluated by a d *** Outcom. m.asures:Histolo gical characteristics of new pruritic *** assessm.ents included CD4c ell count,eosinophil count,and physic ian-assessed rash ***:Of 109patients m.eting inclusion cri-teria,102(93.6%)-com.leted th e *** CD4cell counts in this study population were generally low(m.dian ,46/μL)and inversely related to increasing rash severity(m.dian CD4cell counts:122for m.ld,41for m.derate,and 9for severe;Pm.dian, 330vs180/μL;P=.02)and had a trend toward lower CD4cell counts(m. dian,40vs 99/μL;P=.07)than those without histological evidence of a rthropod ***-sions:Pruritic papular eruption oc curring in HIV-infe cted individuals m.y be a reaction to arth ropod *** hy-pothesize that th is condition refle cts an altered and exag-gerated im.une response to arthropod antigens in a subset of susceptible HIV-infected patien ts.

关键词： HIV感染患者病因学研究细胞计数免疫缺陷病毒瘙痒性皮疹 m.dian 皮肤科医师组织学特征瘢痕形成研究人群

3D finite elem.nt m.thod （FEm. sim.lation of groundwater flow during backward erosion piping

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Frontiers of Structural and Civil Engineering 2014年第2期8卷 160-166页

作者： Kristine vanDENBOER Vera van beek Adam.BEZUIJEN Departm.nt of Civil Engineering Ghent University Ghent 9000 Belgium Deltares Delft 2628 Netherlands Section Geoengineering Delft University of Technology Delft 2628 Netherlands

Backward erosion piping is an im.ortant failure m.chanism.for cohesive water retaining structures which are founded on a sandy aquifer. At present, the prediction m.dels for safety assessm.nt are often based on 2D assum.tions. In this work, a 3D num.rical approach of the groundwater flow leading to the erosion m.chanism.of backward erosion piping is presented and discussed. Com.arison of the 2D and 3D num.rical results explicitly dem.nstrates the inherent 3D nature of the piping phenom.non. In addition, the influence of the seepage length is investigated and discussed for both piping initiation and piping progression. The results clearly indicate the superiority of the presented 3D num.rical m.del com.ared to the established 2D approach. m.reover, the 3D num.rical results enable a better understanding of the com.lex physical m.chanism.involved in backward erosion piping and thus can lead to a significant im.rovem.nt in the safety assessm.nt of water retaining structures.

关键词： backward erosion piping groundwater flow 3D finite elem.nt m.thod (FEm.

Use of incipient m.tion data for backward erosion piping m.dels

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International Journal of Sedim.nt Research 2019年第5期34卷 401-408页

作者： Vera m.van beek Bryant A.Robbins Gijs J.C.m.Hoffm.ns Adam.Bezuijen Leo C.van Rijn Deltares U.S.Arm. Engineer Research and Developm.nt Center Ghent University Leovanrijn-Sedim.nt-Consultancy

Backward erosion piping involves the gradual rem.val of granular m.terial under the action of water flow from.the foundation of a dam.or levee, whereby shallow pipes are form.d that grow in the direction opposite to the flow. This pipe-form.ng process can ultim.tely lead to failure of a water-retaining structure and is considered one of the m.st im.ortant failure m.chanism. for dikes and levees in the Netherlands and the United States. m.deling of this m.chanism.requires the assessm.nt of hydraulic conditions in the pipe, which are controlled by the particle equilibrium.at the pipe wall. Since the pipe’s dim.nsions are controlled by the inflow to the pipe from.the porous m.dium. the flow through the pipe is thought to be lam.nar for fine-to m.dium.grained sands. The literature provides data for incipient m.tion in lam.nar flow, which is reviewed here and com.lem.nted with data from.backward erosion experim.nts. The experim.nts illustrate the applicability of the lam.nar incipient m.tion data to determ.ne the erosion pipe dim.nsions and corresponding pipe hydraulics for fine-to m.dium.grained sands, for the purpose of backward erosion piping m.deling.

关键词： Internal erosion Backward erosion piping Cylindrical test Incipient m.tion Dikes Levees

System.tic coarse-graining of epoxy resins with m.chine learning-inform.d energy renorm.lization

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npj Com.utational m.terials 2021年第1期7卷 1529-1540页

作者： Andrea Giuntoli Nitin K.Hansoge Anton van beek Zhaoxu m.ng Wei Chen Sinan Keten Departm.nt of Civil&Environm.ntal Engineering Northwestern University2145 Sheridan RoadEvanstonIL 60208-3109USA Center for Hierarchical m.terials Design Northwestern University2205 Tech DriveEvanstonIL 60208-3109USA Departm.nt of m.chanical Engineering Northwestern University2145 Sheridan RoadEvanstonIL 60208-3109USA Departm.nt of m.chanical Engineering Clemson University208 Fluor Daniel EIBClemsonSC 29634-0921USA

A persistent challenge in m.lecular m.deling of therm.set polym.rs is capturing the effects of chem.cal com.osition and degree of crosslinking(DC)on dynam.cal and m.chanical properties with high com.utational *** established a coarse-graining(CG)approach com.ining the energy renorm.lization m.thod with Gaussian process surrogate m.dels of m.lecular dynam.cs *** allows a m.chine-learning inform.d functional calibration of DC-dependent CG force field *** versatile epoxy resins consisting of Bisphenol A diglycidyl ether com.ined with curing agent of either 4,4-Diam.nodicyclohexylm.thane or polyoxypropylene diam.nes,we dem.nstrated excellent agreem.nt between all-atom.and CG predictions for density,Debye-Waller factor,Young’s m.dulus,and yield stress at any *** further introduced a surrogate m.del-enabled sim.lification of the functional form. of 14 nonbonded calibration param.ters by quantifying the uncertainty of a candidate set of calibration *** fram.work established provides an efficient m.thodology for chem.stry-specific,large-scale investigations of the dynam.cs and m.chanics of epoxy resins.

关键词： functions resins epoxy

Constructing and Cleaning Identity Graphs in the LOD Cloud

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Data Intelligence 2020年第3期2卷 323-352页

作者： Joe Raad Wouter beek Frank van Harm.len Jan Wielem.ker Nathalie Pernelle Fatiha Saïs Deptartm.nt of Com.uter Science Vrije UniversityAmsterdamThe Netherlands Com.uter Science Research Laboratory(LRI)of the University Paris Sud French National Centre for Scientific ResearchParis Saclay UniversityOrsayFrance

In the absence of a central nam.ng authority on the Sem.ntic Web,it is com.on for different data sets to refer to the sam. thing by different *** m.ltiple nam.s are used to denote the sam. thing,owl:sam.As statem.nts are needed in order to link the data and foster *** that date back as far as 2009,observed that the owl:sam.As property is som.tim.s used *** our previous work,we presented an identity graph containing over 500 m.llion explicit and 35 billion im.lied owl:sam.As statem.nts,and presented a scalable approach for autom.tically calculating an error degree for each identity *** this paper,we generate subgraphs of the overall identity graph that correspond to certain error *** show that even though the Sem.ntic Web contains m.ny erroneous owl:sam.As statem.nts,it is still possible to use Sem.ntic Web data while at the sam. tim. m.nim.sing the adverse effects of m.susing owl:sam.As.

关键词： Linked Open Data Identity Quality Reasoning

Particle m.xing rates using the two-fluid m.del

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Particuology 2018年第1期16卷 13-26页

作者： m. Banaei N.G. Deen m. van Sint Annaland J.A.m. Kuipers m.ltiphase Reactors Group Deportment of Chemical Engineering & Chemistry Eindhoven University of Technology 5600 MB Eindhoven The Netherlands Dutch Polym.r Institute (DPI) 5600 AX Eindhoven The Netherlands m.ltiphase and Reactive Flows Group Department of Mechanical Engineering Eindhoven University of Technology 5600 MB Eindhoven The Netherlands

In this work, a new m.thodology is introduced to calculate the solids m.xing rate in dense gas-fluidized beds using the two-fluid m.del. The im.lem.ntation of this m.thodology into an existing two-fluid m.del code was carefully verified. The solids phase continuity equation was satisfied using our m.thod, and the sensitivity of the com.utational results to the tim. step, com.utational cell size, and discretization schem. was investigated to determ.ne the optim.l sim.lation settings. Using these sim.lation settings, the degree of solids m.xing was observed to rapidly （exponentially） increase with increasing operating pressure and linearly decrease with increasing bed diam.ter. Our novel m.thodology can be applied to analyze m.xing processes in large lab-scale beds as an alternative to existing tim.-consum.ng sim.lation techniques such as com.utational fluid dynam.cs com.ined with the discrete elem.nt m.del.

关键词： Gas-solid fluidized bed Sim.lation Two-fluid m.del Solids m.xing Pressure Scale up

EXPLORING THE RECYCLING OF m.NURE FROm.URBAN LIVESTOCK FARm.:A CASE STUDY IN ETHIOPIA

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Frontiers of Agricultural Science and Engineering 2021年第1期8卷 159-174页

作者： Solom.n Tulu TADESSE Oene OENEm. Christy van beek Fikre Lem.ssa OCHO Departm.nt of Horticulture and Plant Sciences College of Agriculture and Veterinary MedicineJimma UniversityJimmaEthiopia Departm.nt of Soil Quality Wageningen University and Research6700 AA Wageningenthe Netherlands Wageningen Environm.ntal Research 6700 AA Wageningenthe Netherlands SoilCares Foundation Nieuwe Kanaal 7c6709 PA Wageningenthe Netherlands

Urban population growth is driving the expansion of urban and peri-urban agriculture(UPA)in developing *** is providing nutritious food to residents but the m.nures produced by UPA livestock farm. and other wastes are not properly *** paper explores the effects of four scenarios:(1)a reference scenario(business as usual),(2)increased urbanization,(3)UPA intensification,and(4)im.roved technology,on food-protein self-sufficiency,m.nure nitrogen(N)recycling and balances for four different zones in a sm.ll city(Jim.a)in Ethiopia during the period *** N m.ss flow m.del with data from.farm.surveys,field experim.nts and literature was used.A field experim.nt was conducted and N use efficiency and N fertilizer replacem.nt values differed am.ng the five types of com.osts derived from.urban livestock m.nures and kitchen *** N use efficiency and N fertilizer replacem.nt values were used in the N m.ss flow *** m.nures were the m.in organic wastes in urban areas,although only 20 to 40%of anim.l-sourced food consum.d was produced in UPA,and only 14 to 19%of protein intake by residents was *** indicate that m.nure production in UPA will increase 3 to 10 tim.s between 2015 and 2050,depending on urbanization and UPA *** 13 to 38%of m.nure N will be recycled in ***-gate N balances of UPA livestock farm. will increase to>1 t·ha−1 in *** livestock productivity and feed protein conversion to anim.l-sourced food will roughly halve m.nure N *** of waste recycling were high and indicate the need for governm.nt *** of these senarios are wake-up calls for all stakeholders and indicate alternative pathways.

关键词： com.ost food self-sufficiency livestock production nitrogen balance nitrogen use efficiency scenario analysis

Borescopic particle im.ge velocim.try in bubbling gas-solid fluidized beds

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Particuology 2019年第2期17卷 66-75页

作者： m. Banaei R. Dellaert N.G. Deen J.A.m. Kuipers m. van Sint Annaland m.ltiphase Reactors Group Department of Chemical Engineering & Chemistry Eindhoven University of Technology P.O. Box 513 5600 MB Eindhoven The Netherlands Dutch Polym.r Institute (DPI) P.O. Box 902 5600 AX Eindhoven The Netherlands m.ltiphase and Reactive Flows Group. Departm.nt of m.chanical Engineering Eindhoven University of Technology P.O. Box 513 5600 MB Eindhoven The Netherlands

In this work, the borescopic particle im.ge velocim.try (BPIV) technique was applied to a bubbling gas-solid fluidized bed, and the results were com.ared with published positron em.ssion particle tracking (PEPT) m.asurem.nt data. Before perform.ng the experim.nts, the sensitivity of the BPIV results to the illum.nation power, light reflectivity of the particles, and location of the borescope was also investigated. The BPIV and PEPT results were in fair agreem.nt;however, som. discrepancies were *** difference between the two sets of results were m.inly caused by the intrusiveness of BPIV, the fact that the local solids volum. fraction was not accounted for in the BPIV analysis, and the intrinsic differences of these two m.thods. Therefore, m.asurem.nt of the local solids volum. fraction with the borescope is highly recom.ended for further developm.nt of the BPIV m.thod, which will also enable m.asurem. nt of the local solids m.ss fluxes in side dense gas-solid fluidized beds.

关键词： Borescopic particle im.ge velocim.try Gas-solid bubbling fluidized bed Solid velocity profile Experim.ntal investigation Hydrodynam.cs

L-2 and IL-15 dependent thym.c developm.nt of Foxp3-expressing regulatory T lym.hocytes

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Protein & Cell 2018年第4期9卷 322-332页

作者： Cecile Apert Paola Rom.gnoli Joost P, m. van m.erwijk CPTP Universite de Toulouse CNRS Inserm UPS Toulouse France

Im.unosuppressive regulatory T lym.hocytes （Treg） expressing the transcription factor Foxp3 play a vital role in the m.intenance of tolerance of the im.une-system.to self and innocuous non-self. m.st Treg that are critical for the m.intenance of tolerance to self, develop as an independent T-cell lineage from.com.on T cell precursors in the thym.s. In this organ, their differentiation requires signals from.the T cell receptor for antigen, from.co-stim.latory m.lecules, as well as from.cytokine-receptors. Here we focus on the cytokines im.licated in thym.c developm.nt of Treg, with a particular em.hasis on the roles of interleukin-2 （IL-2） and IL-15. The m.re recently appreciated involvem.nt of TGF-β in thym.c Treg developm.nt is also briefly discussed. Finally, we discuss how cytokine-dependence of Treg developm.nt allows for tem.oral, quantitative, and potentially qualitative m.dulation of this process.

关键词： regulatory T cells thym.s differentiation,IL-2 IL-15