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Progress in Natural Science:Materials International 2020年第5期30卷 661-668页

作者： Dieu Linh tran Phuong Le thi Thai Thanh Hoang thi Ki Dong Park Department of Molecular Science and Technology Ajou University Biomaterials and Nanotechnology Research Group Faculty of Applied Sciences Ton Duc Thang University

The impairment of regenerative processes induced by high blood-glucose level(hyperglycemia) and excessive reactive oxygen species(ROS) contributes to the diabetic complication progression and development. In this study, an injectable, in situ crosslinkable chitosan hydrogel with ROS-scavenging capability was developed by conjugating gallic acid onto the chitosan backbone(CGA). We hypothesized that gallic acid serves as both antioxidant and crosslinking moieties to form hydrogel in situ by means of enzymatic crosslinking with horseradish peroxidase(HRP). The rapid gelation(from 30 s) was observed by vial tilting. The mechanical properties and microstructures of CGA hydrogels can be well controlled by varying the concentrations of H2O2. The ROSscavenging ability of these CGA hydrogels was demonstrated against DPPH radical, hydroxyl radical, and total reducing power. Notably, in an in vitro hyperglycemia environment, CGA hydrogels significantly improved the proliferation and migration of human dermal fibroblast cells, which are closely related to diabetic wound healing. These results suggest that CGA hydrogels have potential as advanced materials for the treatment of diabetes-related diseases via attenuating the excessive ROS production and improving cellular behaviors.

关键词： Chitosan Gallic acid Injectable hydrogel Hyperglycemia Free-radical-scavenging

Successful containment of a COVID-19 outbreak in Bach Mai Hospital by prompt and decisive responses

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Asian Pacific Journal of Tropical Medicine 2021年第5期14卷 234-235页

作者： van Minh Hoang thi Phuong Thao tran thi Ngoc Phuong Nguyen thi Hai Yen Nguyen Quang Tuan Nguyen Hanoi University of Public Health HanoiVietnam Bach Mai Hospital HanoiVietnam

In low-and middle-income countries,tertiary care hospitals frequently face an extremely heavy workload and shoulder an even heavier burden during the COVID-19 *** Mai Hospital(BMH),one of the leading tertiary hospitals in Vietnam,is on the frontline in the fierce battle against *** letter aims to describe how BMH tackles the COVID-19 outbreak in the hospitallevel battle,which could support policymakers in time-management and well-preparation for this unpredictable pandemic.

关键词： prompt income policy

Properties of poly（1-naphthylamine）/Fe3O4 composites and arsenic adsorption capacity in wastewater

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Frontiers of Materials Science 2016年第1期10卷 56-65页

作者： Minh thi tran thi Huyen trang NGUYEN Quoc Trung VU Minh Vuong NGUYEN Faculty of Physics Hanoi National University of Education 136-Xuanthuy Street Caugiay District Hanoi Vietnam Faculty of Chemistry Hanoi National University of Education 136-Xuanthuy Street Caugiay District Hanoi Vietnam Department of Physics Quynhon University 170 An Duong Vuong Quynhon Vietnam

The research results of poly（1-naphthylamine）lFe3O4 （PNA/Fe3O4） nanocomposites synthesized by a chemical method for As（Ⅲ） wastewater treatment are presented in this paper. XRD patterns and TEM images showed that the Fe3O4 grain size varied from 13 to 20 nm. The results of Raman spectral analysis showed that PNA participated in part of the PNA/Fe3O4 composite samples. The grain size of PNA/Fe3O4 composite samples is about 25-30 nm measured by SEM. The results of vibrating sample magnetometer measurements at room temperature showed that the saturation magnetic moment of PNA/Fe3O4 samples decreased from 63.13 to 43.43 emu/g, while the PNA concentration increased from 5% to 15%. The nitrogen adsorption-desorption isotherm of samples at 77 K at a relative pressure PIPo of about 1 was studied in order to investigate the surface and porous structure of nanoparticles by the BET method. Although the saturation magnetic moments of samples decreased with the polymer concentration increase, the arsenic adsorption capacity of the PNA/Fe3O4 sample with the PNA concentration of 5% is better than that of Fe3O4 in a solution with pH = 7. In the solution with pH 〉 14, the arsenic adsorption of magnetic nanoparticles is insignificant.

关键词： poly(1-naphthylamin)/Fe3O4 nanocomposite magnetization arsenic adsorption

Synthesis and characterization of NaYF4:Yb3+,Er3+@silica-N=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells

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Journal of Rare Earths 2019年第11期37卷 1183-1187页

作者： Ha thi Phuong tran Thu Huong Le thi Vinh Hoang thi Khuyen Do thi Thao Nguyen Thanh Huong Pham thi Lien Le Quoc Minh Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietCau GiayHanoiViet Nam Graduate University of Science and Technology-Vietnam Academy of Science and Technology 18 Hoang Quoc VietCau GiayHanoiViet Nam Department of Chemistry Hanoi Medical University1-Ton That TungDong DaHanoiViet Nam Department of Chemistry Hanoi University of Mining and Geology18-Pho LienBac Tu LiemHanoiViet Nam Institute of Biotechnology Vietnam Academy of Science and Technology18-Hoang Quoc VietCau GiayHanoiViet Nam Duy Tan University K7/25 Quang TrungDa NangViet Nam

Upconversion nanophosphors are new promising nanomaterials to be used as biolabels for detection and imaging of cancer *** nanophosphors absorb long-wavelength excitation radiation in the infrared or near infrared region and emit shorter wavelength,higher energy radiation from ultraviolet to *** this paper,we studied the hydrothermal method and optical properties of the functionalized NaYF4:Yb^3+,Er^3+for biomedical *** synthesis,these NaYF4:Yb^3+,Er^3+nanophosphors were functionalized with aminosilanes and folic *** acid binds to the folate receptor on the surface of MCF-7 breast cancer cells and this binding promotes internalization of the nanophosphors via *** sizes of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA(folic acid)nanophosphors can be controlled with length of the rod about 300-800 nm and diameter of the rod about 100-200 *** structure of NaYF4:Yb^3+,Er^3+is in hexagonal crystal *** photo luminescence(PL)spectra of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA nanophosphors were *** nanophosphors emit in red color with the strongest band at 650 nm under 980 nm *** result can provide NaYF4:Er^3+,Yb^3+@silica-N=FA complex for developing fluorescence label and image tool in cancer biology and medicine.

关键词： Upconversion luminescence NaYF4:Yb^3+,Er^3+ Nanophosphors Bioimaging Cancer cell Rare earths

Incorporation of hydroxyapatite in crosslinked gelatin/chitosan/poly(vinyl alcohol) hybrids utilizing as reinforced composite sponges, and their water absorption ability

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Progress in Natural Science:Materials International 2021年第5期31卷 664-671页

作者： thi Sinh Vo tran thi Bich Chau Vo Truong Sinh Nguyen Nhan Duy Pham School of Mechanical Engineering Sungkyunkwan University Department of Chemistry Memorial University of Newfoundland Department of Industrial Management Can Tho University

The crosslinked gelatin/chitosan/poly(vinyl alcohol)/hydroxyapatite(GEL/CTS/PVA/HAp, GCPH) sponges were fabricated by a freeze-drying method to yield the reinforced composite sponges with proper features. The porosity value and pore size of the crosslinked GCPH sponges reached ～80% and 50–100 μm, respectively, which can be an appropriate range to allow cells to migrate into the reinforced composite sponges in the tissue engineering technology. Besides, the proper bonding presence between HAp particles and the crosslinked polymeric matrix or the crosslinked network formation between the polymers were also proved through fourier-transform infrared spectroscopy(FTIR), X-ray diffraction(XRD) and thermal gravimetric(TG/DTG) analysis. Owing to incorporation of HAp particles and good distribution of HAp particles inside the crosslinked polymeric matrix, their mechanical properties were improved through the determination of compression tests. Concomitantly, their water absorption ability reached effectively in both the distilled water and Na Cl solution, and their recovery also maintained well for 10 absorbing–squeezing cycles to be considered as an effective reusability for the crosslinked sponge ***, the crosslinked GCPH sponge prepared in the present study can become a potential candidate to apply especially in the biomedical/medical applications and tissue engineering technology.

关键词： Reinforced composite sponge Gelatin Chitosan Poly(vinyl alcohol) Hydroxyapatite Water absorption ability Reusability

Ecoregional variations of aboveground biomass and stand structure in evergreen broadleaved forests

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Journal of Forestry Research 2020年第5期31卷 1713-1722页

作者： tran van Do Mamoru Yamamoto Osamu Kozan Vo Dai Hai Phung Dinh Trung Nguyen Toan Thang Lai Thanh Hai Vu Thanh Nam Trieu Thai Hung Hoang van Thang tran Duc Manh Cao Chi Khiem Vu Tien Lam Nguyen Quang Hung tran Hoang Quy Pham Quang Tuyen Trinh Ngoc Bon Nguyen thi Thu Phuong Ninh Viet Khuong Nguyen van Tuan Dang thi Hai Ha tran Hai Long Dang van Thuyet Dang thinh Trieu Nguyen van thinh tran Anh Hai Duong Quang Trung Nguyen van Bich Dinh Hai Dang Pham Tien Dung Nguyen Huy Hoang Le thi Hanh Phan Minh Quang Nguyen thi Thuy Huong Hoang Thanh Son Nguyen Thanh Son Nguyen thi van Anh Nguyen thi Hoai Anh Pham Dinh Sam Hoang thi Nhung Hoang van Thanh Nguyen Huu thinh tran Hong van Ho Trung Luong Bui Kieu Hung Research Institute for Sustainable Humanosphere Kyoto UniversityUjiKyotoJapan Silviculture Research Institute Vietnamese Academy of Forest SciencesNorth Tu LiemHanoiVietnam Center for Southeast Asian Studies Kyoto UniversityKyotoJapan Vietnamese Academy of Forest Sciences North Tu LiemHanoiVietnam Vietnam Administration of Forestry No.2 Ngoc HaBa DinhHanoiVietnam

Biotic and abiotic factors control aboveground biomass(AGB)and the structure of forest *** study analyses the variation of AGB and stand structure of evergreen broadleaved forests among six ecoregions of Vietnam.A data set of 1731-ha plots from 52 locations in undisturbed old-growth forests was *** results indicate that basal area and AGB are closely correlated with annual precipitation,but not with annual temperature,evaporation or hours of *** area and AGB are positively correlated with trees>30 cm *** areas surveyed(52.6%)in these old-growth forests had AGB of 100–200 Mg ha^-1;5.2%had AGB of 400–500 Mg ha^-1,and 0.6%had AGB of>800 Mg ha^-*** percent of the areas surveyed had stand densities of 300–600 ***^-1,and 64%had basal areas of 20–40 m^2 ha^-*** is an important factor influencing the AGB of old-growth,evergreen broadleaved forests in *** causing the loss of large-diameter trees(e.g.,>100 cm DBH)affects AGB but may not seriously affect stand density.

关键词： Aboveground biomass Carbon storage Climatic variables Ecoregion Edaphic variables Oldgrowth forest

Anti-inflammatory effects of alkaloid enriched extract from roots of Eurycoma longifolia Jack

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Asian Pacific Journal of Tropical Biomedicine 2019年第1期9卷 18-23页

作者： Dao thi Thanh Hien tran Phi Long tran Phuong Thao Jeong-Hyung Lee Duong Thu trang Nguyen thi Thu Minh Pham van Cuong Do thi Ngoc Lan Nguyen Hai Dang Nguyen Tien Dat Deparment of Traditional Pharmacy Hanoi University of Pharmacy Department of Biochemistry College of Natural Sciences Kangwon National University Advanced Center for Bio-organic Chemistry Institute of Marine Biochemistry Vietnam Academy of Science and Technology National Institute of Drug Quality Control Center for Research and Technology transfers

Objective: To examine the in vitro and in vivo anti-inflammatory effects of the alkaloid enriched extract(ELA) from the roots of Eurycoma longifolia. Methods: The in vitro antiinflammatory effects of ELA were evaluated by examining its inhibitory activities against nitric oxide(NO) production and inducible nitric oxide synthase(iN OS) and cyclooxygenase2(COX-2) expressions in lipopolysaccharide(LPS)-stimulated RAW264.7 cells. The level of NO produced in the culture media was determined by Griess method. The i NOS and COX-2 protein expressions were analyzed by Western blot. The in vivo effect of ELA was evaluated on LPS-induced septic shock in mice model. Mice mortality was monitored for5 days after injection of LPS. The chemical contents of the ELA were determined by using various chromatographic and spectroscopic techniques. Results: The ELA was found to exhibit a significant anti-inflammatory effect in both in vitro and in vivo models. The results demonstrated that ELA dose-dependently inhibited LPS-induced NO production as well as the protein iN OS and COX-2 expressions. In the septic shock model, ELA dose-dependently protected mice from LPS-induced mortality. Further study on the isolated components of ELA indicated that 9,10-dimethoxycanthin-6-one may contribute significantly to the antiinflammatory effects of the extract. Conclusions: These results suggest that ELA exhibits the anti-inflammatory activity via suppression of pro-inflammatory mediators such as NO, iN OS,and COX-2 and protects mice from LPS-induced mortality in septic shock model.

关键词： Eurycoma longifolia Anti-inflammation Alkaloid 9,10-dimethoxycanthin-6-one

Simultaneous Quantitative Analysis of Five Components in Angelica sinensis and Angelica acutiloba Acclimatized Growing in Vietnam by High-Performance Liquid Chromatography with Photodiode Array Detector

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World Journal of Traditional Chinese Medicine 2021年第1期7卷 6-10页

作者： thi Minh Tam Pham thi Thu Cuc Le van Thanh Nguyen Viet Hung tran Departments of Microbiology Institute of Drug Quality ControlHo Chi Minh City Departments of Instrumental Analysis Institute of Drug Quality ControlHo Chi Minh City Institute of Drug Quality Control Ho Chi Minh City Faculty of Pharmacy Nguyen Tat Thanh UniversityHo Chi Minh CityVietnam

Background:Chinese Danggui(Angelica sinensis)and Japanese Danggui(Angelica acutiloba)are evaluated as the same in using and critical of quality control in Vietnamese *** Vietnam,Japanese Danggui were acclimatized and cultivated in several regions in recent *** the huge climatic difference between Vietnam and Japan,Japanese Danggui grows very well in ***,there are no studies to assess the overall quality of this medicinal *** and Objectives:The aim of this study is to develop a method to identify and assay simultaneously 5 component compounds of these crude herbs:chlorogenic acid,ferulic acid,scopoletin,xanthotoxin and ligustilide by high-performance liquid chromatography with photodiode array detector(HPLC-PDA).Materials and Methods:The procedure was optimized by using column Phenomenex Gemini 5μm PR C18,15 x 4,6 mm with the detection wavelength set at 321 nm for detector PDA and mobile phase was composed of(A)ACN and(B)aqueous solution 1%of acid acetic using a gradient *** were performed at 30°C with a flow rate of 1.0 mL/***:The developped method were fully validated for linearity,accuracy,recovery and met the validation requirements,proved practical applicability for the quality control of these herbs and related ***:The method was successfully applied to the quantification of five markers simultaneously from collected samples.

关键词： Chlorogenic acid Danggui ferulic acid ligustilide scopoletin xanthotoxin

Fabrication and characterization of YVO_4:Eu^(3+) nanomaterials by the microwave technique

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Journal of Rare Earths 2011年第12期29卷 1137-1141页

作者： tran Thu Huong Vu Duc Tu tran Kim Anh Le thi Vinh Le Quoc Minh Institute of Materials Science Vietnamese Academy of Science and Technology University of Engineering and Technology National University Hanoi Departments of Chemistry Hanoi University of Mining and Geology

Fabrication and characterization of YVO4：Eu^3＋ nanophosphors prepared by microwave （MW） irradiation assisted soft template synthesis were reported. The effects of synthesis conditions such as different powers of MW irradiation, pH values and concentration of reac- tion materials on properties of nanophosphor were also investigated to obtain the controllable size, morphology and high luminescence efficiency. Morphology, crystalline structure, and optical properties were characterized by field emission scanning electron microscopy （FE-SEM）, X-ray diffraction （XRD） and fluorescence spectroscopy, respectively. The results showed that YVOa：Eu^3＋ nanophosphors were obtained by using diethyleneglycol （DEG） as soft template, with pH values in the range of 4 to 12, upon microwave irradiation from 300 to 900 W, at temperature of 80 ℃. The high fluorescent YVOa：Eu^3＋ nanocrystals obtained with size from 15 nm down to 8 nm are more effective to develop an ultrahigh sensitive fluorescent label for biomolecule, cell and tissue.

关键词： microwave synthesis method DEG soft template YVO4:Eu^3+ nanophosphor luminescence rare earths

Multi-clustering study on the association between human leukocyte antigen-DP-DQ and hepatitis B virus-related hepatocellular carcinoma and cirrhosis in Viet Nam

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World Journal of Gastroenterology 2024年第46期30卷 4880-4903页

作者： Thuy Thu Nguyen Tu Cam Ho Huong thi Thu Bui van-Khanh tran Tue Trong Nguyen Center for Gene and Protein Research Hanoi Medical UniversityHanoi 116177Viet Nam Institute of Virology TUM School of MedicineTechnical University of MunichMunich 81675Germany Department of Biochemistry Thai Nguyen University of Medicine and PharmacyThai Nguyen 251540Viet Nam Medical Technology Department Hanoi Medical UniversityHanoi 116177Viet Nam Clinical Laboratory Hanoi Medical University HospitalHanoi 116177Viet Nam

BACKGROUND Human leukocyte antigen(HLA)class II molecules are cell surface receptor proteins found on antigen-presenting *** and mutations in the HLA gene can affect the immune system and the progression of hepatitis *** To study the relation between rs2856718 of HLA-DQ,rs3077,and rs9277535 of HLA-DP,hepatitis B virus(HBV)-related cirrhosis,and hepatocellular carcinoma(HCC).METHODS In this case-control study,the genotypes of these single nucleotide polymorphisms(SNPs)were screened in 315 healthy controls,471 chronic hepatitis B patients,250 patients with HBV-related liver cirrhosis,and 251 patients with HCC using TaqMan real-time *** conducted Hardy-Weinberg equilibrium and linkage disequilibrium tests on the genotype distributions of rs2856718,rs3077,and rs9277535 before hierarchical clustering analysis to build the complex interaction between the markers in each patient *** The physical distance separating these SNPs was 29816 kB with the disequilibrium(D’)values ranging from 0.07 to *** close linkage between rs3077 and rs9277535 was attributed to a distance of 21 *** D’value decreased from moderate in the healthy control group(D’=0.50,P<0.05)to weak in the hepatic disease group(D’<0.3,P<0.05).In a combination of the three variants rs2856718,rs3077,and rs9277535,the A allele decreased hepatic disease risk[A-A-A haplotype,risk ratio(RR)=0.44(0.14;1.37),P<0.05].The G allele had the opposite effect[G-A/G-G haplotype,RR=1.12(1.02;1.23),P<0.05].In liver cancer cases,the A-A-A/G haplotype increased the risk of HCC by 1.58(P<0.05).CONCLUSION Rs9277535 affects liver fibrosis progression due to HBV infection,while rs3077 is associated with a risk of HBVrelated *** link between rs2856718,rs3077,and rs9277535 and disease risk was determined using a multiclustering analysis.

关键词： Human leukocyte antigen Multi-clustering study Hepatitis B virus Hepatocellular carcinoma Cirrhosis