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journal of Modern Power systems and Clean Energy 2018年第2期6卷 268-280页

作者： j.prada j.R.DORRONsORO Universidad Autonoma de Madrid

General noise cost functions have been recently proposed for support vector regression(sVR). When applied to tasks whose underlying noise distribution is similar to the one assumed for the cost function, these models should perform better than classical -sVR. On the other hand, uncertainty estimates for sVR have received a somewhat limited attention in the literature until now and still have unaddressed problems. Keeping this in mind,three main goals are addressed here. First, we propose a framework that uses a combination of general noise sVR models with naive online R minimization algorithm(NORMA) as optimization method, and then gives nonconstant error intervals dependent upon input data aided by the use of clustering techniques. We give theoretical details required to implement this framework for Laplace, Gaussian, Beta, Weibull and Marshall–Olkin generalized exponential distributions. second, we test the proposed framework in two real-world regression problems using data of two public competitions about solar energy. Results show the validity of our models and an improvement over classical -sVR. Finally, in accordance with the principle of reproducible research, we make sure that data and model implementations used for the experiments are easily and publicly accessible.

关键词： support vector regression General noise model Naive online R minimization algorithm(NORMA) Uncertainty intervals Clustering solar energy Reproducible research

DIFFERENTIAL OPERATORs OF INFINITE ORDER IN THE sPACE OF RAPIDLY DECREAsING sEQUENCEs

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Acta Mathematica scientia 2016年第2期36卷 325-333页

作者： M.MALDONADO j.prada M.j.sENOsIAIN Department of Mathematics Salamanca University

We consider the space of rapidly decreasing sequences s and the derivative operator D defined on it. The object of this article is to study the equivalence of a differential operator of infinite order; that is φ（D） =^∞∑k=0φkD^k.φk constant numbers an a power of ***, meaning, is there a isomorphism X （from s onto s） such that Xφ（D） = D^nX？. We prove that if φ（D） is equivalent to Dn, then φ（D） is of finite order, in fact a polynomial of degree n. The question of the equivalence of two differential operators of finite order in the space s is addressed too and solved completely when n = 1.

关键词： Ordinary differential operators sequence spaces operators on function spaces

Left Ventricle Postinfarction Pseudoaneurysm: Anatomical Forms and surgical Management

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surgical science 2014年第4期5卷 138-145页

作者： j. M. Garrido A. Ferreiro j. F. Rodríguez-Vázquez P. prada s. Verdugo j. silva s. López-Checa I. sánchez-Montesinos Departamento de Anatomía y Embriología Humana II Facultad de Medicina Universidad Complutense de Madrid Madrid Spain Departamento de Anatomía y Embriología Humana Facultad de Medicina Universidad de Granada Granada Spain servicio de Cirugía Cardiovascular HU Ramón y Cajal Departamento de Ciencias Morfológicas Universidad Europea de Madrid Madrid Spain servicio de Cirugía Cardiovascular HU Ramón y Cajal Madrid Spain servicio de Cirugía Cardiovascular HU Virgen de las Nieves Granada Spain

Introduction: Left Ventricle Postinfarction Pseudoaneurysm (LVPs)—false aneurysm occurs after a free-wall rupture contained by the adjacent pericardium. LVPs lacks the normal structure of the ventricular wall and disrupts the normal chamber anatomy. However, the natural history, clinical presentation and surgical outcome are still unclear. For that reason, it is necessary to describe the most relevant anatomical characteristics of LVPs and the appropriate surgical strategies currently applied. Methods: We reviewed the anatomical characteristics of several patients diagnosed of LVPs and the surgical technique performed. In this work two different anatomical types of LVPs are described in detail, with the surgical and structural implications for left ventricle reconstruction. Results: There are two different anatomical forms of LVPs: 1) Typical pseudoaneurysm, with a small gateway neck between the Left Ventricle and the false aneurysm chamber (Figure 1(A));2) Atypical pseudoaneurysm, in which the anatomical defect is bigger, without well-defined edges, extends over a large segment of infarcted and thinned myocardial tissue. In both cases, the therapeutics targets and the surgical techniques used were directed to restore the normal geometry of Left Ventricle, keeping the optimal mitral valve function. Conclusions: The surgical key-step is to preserve or to remodel the ventricular chamber anatomy. This fact restores the ventricular geometry, not only removing the wall discontinuity that generated the pseudoaneurysm. Nevertheless, final prognosis depends on the underlying ischemic cardiomyopathy and mechanical complications, such us mitral regurgitation or ventricular septal defect.

关键词： Ventricular Anatomy Left Ventricle Pseudoaneurysm surgical Treatment Ventricular Remodelling Restore of Left Ventricle Morphology and Function of Left Ventricle Ischemic Cardiomyopathy

Neurophysics Assessment of the Muscle Bioenergy Generated by Transcranial Magnetic stimulation

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Research 2019年第1期2019卷 1077-1085页

作者： Fidias E.Leon-sarmiento Alexander Gonzalez-Castaño Carlos V.Rizzo-sierra juan Aceros Daniel s.Leon-Ariza juan s.Leon-Ariza Diddier G.prada William Bara-jimenez Zeng Y.Wang smell and Taste Center Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA Human Motor Control section NINDSNational Institutes of HealthBethesdaMDUSA Mediciencias Research Group LouisvilleKYUSA Universidad Internacional de la Rioja Spain Neurophysics Unit Corporacion Universitaria Minuto de Dios-UNIMINUTOColombia Charity Association for Person Centered Medicine Moral EntityItaly school of Engineering University of North FloridaJacksonvilleFLUSA Faculty of Health sciences Santander UniversityUDESColombia Department of Neurosurgery Johns Hopkins UniversityBaltimoreMAUSA Harvard T.H.Chan school of Public Health Harvard UniversityBostonMAUSA Unidad de Investigacion Biomedica en Cancer Instituto Nacional de CancerMexico DFMexico Neuromuscular Division Department of NeurologyUniversity of LouisvilleLouisvilleKYUSA

Te content of the rectifed motor evoked potential(MEP)induced by transcranial magnetic stimulation(TMs)has ambiguously been assessed without the precision that energy calculation *** fact has misled data interpretation and misguided biomedical *** defnitively fll the gap that exits in the neurophysics processing of these signals,we computed,in Walls(̂�),the bioenergy within the rectifed MEP recorded from the human frst digitorum index(FDI)muscle at rest and under isometric *** also gauged the biowork exerted by this *** we show that bioenergy and biowork can accurately and successfully be assessed,validated,and determined in̂�from MEP signals induced by TMs,regardless of knowing the mathematical expression of the function of the *** novel neurophysics approach represents a dramatic paradigm shif in analysis and interpretation of the content of the MEP and will give a true meaning to the content of rectifed ***,this innovative approach allowed unveiling that women exerted more bioenergy than men at the magnetic stimulations used in this *** of conclusions drawn from studies published elsewhere assessing rectifed EMG signals that have used ambiguous units is strongly recommended.

关键词： stimulation gauge allowed

Cryopreservation of seeds and Embryos of jatropha curcas L.

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American journal of Plant sciences 2015年第1期6卷 172-180页

作者： julián Andrés prada María Elena Aguilar Ana Abdelnour-Esquivel Florent Engelmann Egresado Escuela de Posgrado del CATIE Cartago Costa Rica Laboratorio de Biotecnología Centro Agronómico Tropical de Investigación y Ense&ntildeanza (CATIE) Cartago Costa Rica Centro de Investigación en Biotecnología Instituto Tecnológico de Costa Rica (ITCR) Cartago Costa Rica IRD UMR DIADE Montpellier France

jatropha curcas is a species with a variety of uses. It is grown primarily for oil for biodiesel, but also has agronomic and medicinal applications. Two methods were evaluated for cryopreservation of seeds and zygotic embryos of j. curcas: desiccation followed by rapid immersion of seeds and embryos in liquid nitrogen (LN, -196°C), and vitrification of zygotic embryos. Prior to cryo-preservation, seeds were manually scarified and the moisture content (MC) of seeds and embryos was determined. Explants were disinfected after cryopreservation. seed germination after LN exposure was 100%. Plantlet development was better in sand substrate than that in vitro. survival of zygotic embryos after cryopreservation was also 100%, without significant differences between treatments. Optimal development (100%) and plantlet length (51.77 mm) were observed with embryos dried for 60 min to 9.4% MC under laminar flow prior to cryopreservation. Zygotic embryos subjected to the vitrification procedure did not withstand LN exposure. survival data for non-cryopreserved embryos after each step of the vitrification procedure provided information about embryo tolerance to cryoprotectants.

关键词： Cryopreservation seeds Embryos Dehydration Vitrification Desiccation

Maize Gene Regulatory Network for Phenolic Metabolism

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Molecular Plant 2017年第3期10卷 498-515页

作者： Fan Yang Wei Li Nan jiang Haidong Yu Kengo Morohashi Wilberforce Zachary Oumal Daniel E. Morales-Mantilla Fabio Andres Gomez-Canol Eric Mukundi Luis Daniel prada-salcedo Roberto Alers Velazquez jasmin Valentin Maria Katherine Mejia-Guerra john Gray Andrea I. Doseff Erich Grotewold Center for Applied sciences (CAPs) Department of Molecular Genetics Department of Physiology and Cell Biology Heart and Lung Research Institute Molecular Cellular and Developmental Biology (MCDB) Graduate Program success in Graduate Education (siGuE) Program The Ohio state University Columbus OH 43210 USA Department of Biological sciences University of Toledo Toledo OH 43560 USA

The translation of the genotype into phenotype, represented for example by the expression of genes encod- ing enzymes required for the biosynthesis of phytochemicals that are important for interaction of plants with the environment, is largely carried out by transcription factors （TFs） that recognize specific cis-regulatory elements in the genes that they control. TFs and their target genes are organized in gene regulatory net- works （GRNs）, and thus uncovering GRN architecture presents an important biological challenge necessary to explain gene regulation. Linking TFs to the genes they control, central to understanding GRNs, can be car- ried out using gene- or TF-centered approaches. In this study, we employed a gene-centered approach uti- lizing the yeast one-hybrid assay to generate a network of protein-DNA interactions that participate in the transcriptional control of genes involved in the biosynthesis of maize phenolic compounds including gen- eral phenylpropanoids, lignins, and flavonoids. We identified 1100 protein-DNA interactions involving 54 phenolic gene promoters and 568 TFs. A set of 11 TFs recognized 10 or more promoters, suggesting a role in coordinating pathway gene expression. The integration of the gene-centered network with informa- tion derived from TF-centered approaches provides a foundation for a phenolics GRN characterized by in- terlaced feed-forward loops that link developmental regulators with biosynthetic genes.

关键词： phenylpropanoid flavonoid yeast one-hybrid chromatin immunoprecipitation

交通相关的空气污染与血压和线粒体丰度的关系

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中华高血压杂志 2015年第11期23卷 1099-1099页

作者： Zhong j Cayir A Trevisi L sanchez-Guerra M Lin X Peng C Bind MA prada D Laue H Brennan Kj Dereix A sparrow D Vokonas P schwartz j Baccarelli AA 刘莉叶鹏

该文研究线粒体丰度（一种代偿细胞氧化还原失衡的自适应机制）在黑色碳（车辆交通污染的示踪剂）和血压关系中的作用。方法：纳入标准老龄化研究中的675名老年男性进行一次或多次随访，评估定点监视器中的每日环境黑色碳与血压水平。

关键词：血压水平交通污染线粒体空气污染丰度适应机制氧化还原老年男性

新生儿舌部先天性黑素斑和皮脂腺迷芽瘤:表皮迷芽瘤

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 16-16页

作者： Azorin D. Enriquez De salamanca j. De prada I. 李政霄 servicio de Anatomia Patologica Hosp. Inf. Universitario Nino Jesus Avda. Mené ndezPelayo65Madrid 28009 Spain

Oral hyperpigmentation is a common event in older individuals, however, is exceptional in neonates (congenital melanotic macules). Conversely, 70- 80% of people have sebaceous glands in the oral mucosa, with the tongue representing an ectopic location and termed sebaceous choristoma by some authors. We report a case that fulfills both conditions in a tongue lesion. A 1-month-old boy presented with a pigmented macula on his tongue noted at birth. An excisional biopsy was performed showing a lesion lined by an epidermal-like epithelium with basal pigmentation, under which, sebaceous glands, abortive hair follicles and ductal structures mimicking apocrine glands were found. seven cases of congenital melanotic macules of the tongue have been reported, however, none of them showed sebaceous glands under the lesion. Furthermore, there has not been a reported case of sebaceous choristoma of the tongue present at birth. We present a case that shares clinical and histological features of both conditions and propose the name ‘ epidermal choristoma’ .

关键词：迷芽瘤黑素斑基底样细胞黑色素斑色素沉着活组织检查生时基底层

承受轴向、弯曲、剪切和扭曲组合荷载的钢筋混凝土和预应力混凝土的三维数值模型

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钢结构 2008年第6期23卷 91-91页

作者： j. Navarro Gregori P. Miguel sosa M.A. Fernández prada Filip C. Filippou

提出了钢筋混凝土和预应力混凝土承受组合荷载下的分析模型,荷载包括轴力、双向弯矩、扭矩和双向剪力。所提出的模型基于Timoshenko梁理论的简单动力假设,保持了任意截面尺寸情况下的三维框架的形状。框架的控制截面被细分为一维,二维... 详细信息

提出了钢筋混凝土和预应力混凝土承受组合荷载下的分析模型,荷载包括轴力、双向弯矩、扭矩和双向剪力。所提出的模型基于Timoshenko梁理论的简单动力假设,保持了任意截面尺寸情况下的三维框架的形状。框架的控制截面被细分为一维,二维和三维材料响应。钢筋混凝土和预应力混凝土构建的材料模型遵循用切线刚度公式表示的改进压缩场理论的基本假设。通过其结果与文献中几个著名的试验相比较验证了模型的正确性。这些模拟包括弯曲、剪力和扭矩一系列变化的荷载组合。分析结果显示,试件的极限强度以及从初始裂缝到最终荷载的局部应变响应与试验结果十分吻合。

关键词：双向弯曲双向剪力混凝土有限元改进压缩场理论扭矩