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Antenatal use of bosentan and/or sildenafil attenuates pulmonary features in rats with congenital diaphragmatic hernia

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World Journal of Pediatrics 2014年第4期10卷 354-359页

作者： María de Lourdes Lemus-Varela Amed Soliz Belinda Claudia Gómez-Meda Ana Lourdes Zamora-Perez José Manuel Ornelas-Aguirre valery melnikov Blanca Miriam Torres-Mendoza Guillermo Moisés Zúñiga-González Division of Neonatology High Specialty Medical UnitPediatric HospitalWestern National Medical CenterMexican Social Security InstituteGuadalajaraJaliscoMéxico Neonatal Intensive Care Unit Division of NeonatologyMiami Children's HospitalMiami FLDUSA Molecular Biology in Medicine Institute Molecular Biology and Genomic DepartmentHealth Sciences University CenterUniversity of GuadalajaraGuadalajaraJaliscoMéxico Odontology Research Institute Integrated Odontology Clinic DepartmentHealth Sciences University CenterUniversity of GuadalajaraGuadalajaraJaliscoMéxico Pathology Department High Specialty Medical UnitNorth-western National Medical CenterMexican Social Security InstituteCiudad ObregónSonoraMéxico School of Medicine University of ColimaColimaMéxico Division of Neurosciences Western Biomedical Research CenterMexican Social Security Institute and Department of ClinicsHealth Sciences University CenterUniversity of GuadalajaraGuadalajaraJaliscoMéxico Mutagenesis Laboratory Western Biomedical Research CenterMexican Social Security InstituteGuadalajaraJaliscoMéxico

Background:Lung hypoplasia,pulmonary persistent hypertension of the newborn and its morphological changes are the main features in congenital diaphragmatic hernia(CDH).This study was undertaken to investigate if antenatal use of sildenafil and/or bosentan attenuates vascular remodeling,promotes branching,and improves alveolarization in experimental nitrofeninduced ***:Nitrofen(100 mg)was gavage-fed to pregnant rats at post conception day(PCD)9 to induce *** rats were randomized to 5 groups:1)control;2)nitrofen;3)nitrofen+sildenafil 100 mg/kg per day at PCD 16-20;4)nitrofen+bosentan 30 mg/kg per day,at PCD 16-20,and 5)nitrofen+bosentan+sildenafil,same doses and administration *** cesarean delivery,the offsprings were sacrifi *** diaphragmatic defect and pulmonary hypoplasia were identified,and the lungs were *** wall thickness,bronchiolar density and alveolarization were ***:The offsprings with CDH were characterized by severe pulmonary hypoplasia(lung weight-to-body weight ratio:0.0263[95%confidence interval(CI)0.0242-0.0278)]in the nitrofen group versus 0.0385(95%CI 0.0355-0.0424)in the control group(P=0.0001).Pulmonary arterial wall thickness was decreased to 3.0(95%CI 2.8-3.7)μm in the nitrofen+sildenafil group versus 5.0(95%CI 4.1-4.9)μm in the nitrofen group(P=0.02).Terminal bronchioles increased to 13.7(95%CI 10.7-15.2)μm in the nitrofen+bosentan group in contrast to 8.7(95%CI 7.2-9.4)μm in the nitrofen group(P=0.002).More significant differences(P=0.0001)were seen in terminal bronchioles in the nitrofen+sildenafil+bosentan group than in the nitrofen group[14.0(95%CI 12.5-15.4)μm versus 8.5(95%CI 7.1-9.3)μm].Pulmonary arterial wall thickness was also decreased in the former ***:In this rat model,antenatal treatment with sildenafil attenuates vascular *** promotes the development of terminal bronchioles in nitrofen-induced CDH.

关键词： antenatal treatment bosentan congenital diaphragmatic hernia pulmonary hypoplasia sildenafil

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命运的连环画

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传媒评论 2021年第6期 F0003-F0003页

作者：徐斌 [俄罗斯]valery melnikov(摄影) 不详

谁能坐在着了火的自家房子台阶上泰然地黯然?他做到了,因为点火的就是他自己(图一)。谁会用步枪保护自己的一棵果树?他做了,因为这棵树的后面是他倾注了劳力和心血的果园(图二)。谁会把一颗炸弹从空中扔下,插进昔日同胞的土地?他们都做... 详细信息

谁能坐在着了火的自家房子台阶上泰然地黯然?他做到了,因为点火的就是他自己(图一)。谁会用步枪保护自己的一棵果树?他做了,因为这棵树的后面是他倾注了劳力和心血的果园(图二)。谁会把一颗炸弹从空中扔下,插进昔日同胞的土地?他们都做了,因为这是别人家的土地(图三)。

关键词：连环画果树果园土地

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Phase-matched third-harmonic generation via doubly resonant optical surface modes in 1D photonic crystals

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Light(Science & Applications) 2016年第1期5卷 424-429页

作者： valery N Konopsky Elena V Alieva Sergey Yu Alyatkin Alexey A melnikov Sergey V Chekalin Vladimir M Agranovich Institute of Spectroscopy Fizicheskaya5TroitskMoscow 142190Russia Moscow Institute of Physics and Technology Institutskiy per.9Dolgoprudny 141700Russia

Efficient nonlinear conversion requires that interacting optical waves maintain a consistent phase relationship when traveling in a medium despite its *** phase-matching,which is often used to compensate for the dispersion,is not applicable to optically isotropic nonlinear ***,we present a one-dimensional photonic crystal structure that allows the propagation of optical surface waves,both at the fundamental and third-harmonic frequencies,as an efficient medium for phasematched third-harmonic generation.A unique advantage of this structure is that the effective refractive indices for the surface waves are similar to the refractive index of air at both *** allows phase-matching between the first and third harmonics,and a visible collinear beam of the third harmonic is produced at the prism-coupled ***,these optical surface waves propagate over long distances even if a lossy nonlinear nanofilm is deposited onto the photonic crystal *** provide experimental results for third-harmonic generation at a wavelength of 410 nm for a bare dielectric Ta2O5/SiO2 multilayer structure and for the same structure coated with a 15-nm GaAs film.

关键词： nonlinear optics optical surface waves photonic crystals

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