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modern methods of underground hydromechanics with applications to reservoir engineering

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Journal of Hydrodynamics 2016年第6期28卷 937-946页

作者： Hua XIAnG valery v.KADET Department of Petroleum and Underground Hydromechanics Gubkin Russian State University of Oil and Gas

In the report the basic principles of new approach to the study of transport processes in porous medium are represented. The ＂percolation＂ approach has arisen as an attempt to overcome the traditional phenomenological approach in the underground hydromechanics, based on the assumption of continuity of saturated porous media, which does not allow to explain and to model a number of effects arising from the fluids flow in porous media. The results obtained are very interesting not only from the scientific point of view but as the scientific basis for a number of enhanced oil recovery technologies.

关键词： fluid flow in porous media percolation theory relative phase permeability oil field development low salinity waterflooding

OPTICAL PROPERTIES OF SKIn,SUBCUTAnEOUS,AnD mUSCLE TISSUES:A REvIEW

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Journal of Innovative Optical Health Sciences 2011年第1期4卷 9-38页

作者： ALEXEY n.BASHKATOv ELInA A.GEnInA valery v.TUCHIn Institute of Optics and Biophotonics Saratov State University Saratov 410012Russia Institute of Precise mechanics and Control of RAS Saratov 410028Russia

The development of optical methods in modern medicine in the areas of diagnostics,therapy,and surgery has stimulated the investigation of optical properties of various biological tissues,since the efficacy of laser treatment depends on the photon propagation and fluence rate distribution within irradiated *** this work,an overview of published absorption and scattering properties of skin and subcutaneous tissues measured in wide wavelength range is *** principles of measurements of the tissue optical properties and techniques used for processing of the measured data are outlined.

关键词： Absorption coefficient scattering coefficient anisotropy factor reduced scattering coefficient refractive index

Glycerol effects on optical,weight and geometrical properties of skin tissue

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Journal of Innovative Optical Health Sciences 2021年第5期4卷 64-74页

作者： vadim D.Genin Elina A.Genina valery v.Tuchin Alexey n.Bashkatov Saratov State University(national Research University) 83Astrakhanskaya Str.Saratov 410012Russia Tomsk State University(national Research University) 36Lenina Av.Tomsk 634050Russia Institute of Precise mechanics and Control of RAS 24Rabochaya Str.Saratov 410028Russia

Complex study of glycerol effects on the skin tissue was *** change in optical,weight and geometrical parameters of the rat skin under the action of the glycerol solutions was studied ex *** mechanisms of the skin optical clearing under the action of glycerol solutions of different concentrations were *** results can be helpful for refinement of models developed to evaluate the effective diffusion coefficients of glycerol in tissues.

关键词： Glycerol solutions skin optical clearing collimated transmittance dehydration

Evolution of metabolic scaling among the tetrapod:effect of phylogeny,the geologic time of class formation,and uniformity of species within a class

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Integrative Zoology 2022年第5期17卷 904-917页

作者： valery m.GAvRILOv Tatiana B.GOLUBEvA Andrey v.BUSHUEv Department of vertebrate Zoology M.V.Lomonosov Moscow State UniversityMoscowRussia Zvenigorod Biological Station M.V.Lomonosov Moscow State UniversityMoscowRussia

The metabolic scaling in the animal has been discussed for over 90 years,but no consensus has been *** analysis of 2126 species of vertebrates reveals a signiﬁcant allometric exponent *** show that classes of terrestrial vertebrates exhibit the evolution of metabolic *** the allometric coefﬁcient“a”and the allometric exponent“b”change naturally,but differently depending on the geological time of group *** allometric coefﬁcient“a”shows the measure of the evolutionary development of systems that forms resting metabolism in *** classes,such as birds and mammals,have a metabolic rate that is in an order of magnitude higher than that in ectothermic classes,including amphibians and *** the terrestrial vertebrate phylogeny,weﬁnd that the metabolic scaling is characterized by 3 main allometric exponent values:b=3/4(mammals),b>3/4(ectotherms,such as amphibians and reptiles),and bneity of the allometric exponent is a natural phenomenon associated with the general evolution of *** scaling factor decreases depending on both the external design and the size(birds vs mammals)of the *** metabolic rate and uniformity of species within a class increase as the geological start date of for-mation of the class approaches the present *** higher the mass-speciﬁc standard metabolic rate in the class,the slower metabolic rate grows with increasing body size in this *** results lay the groundwork for further exploration of the evolutionary and ecological aspects of the development of metabolic scaling in animals.

关键词： geological time metabolic rate scaling

Optical clearing mechanisms characterization in muscle

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Journal of Innovative Optical Health Sciences 2016年第5期9卷 82-100页

作者： Luís Oliveira m.Inês Carvalho Elisabete nogueira valery v.Tuchin Physics Department–Polytechnic Institute of Porto School of Engineering Rua Dr.Antonio Bernardino de Almeida 4314200-072 PortoPortugal FEUP–University of Porto Rua Dr.Roberto Frias 4200-465 PortoPortugal CIETI–Centre of Innovation in Engineering and Industrial Technology ISEP Rua Dr.Antonio Bernardino de Almeida4314200-072 PortoPortugal DEEC/FEUP and InESC TEC University of Porto Rua Dr.Roberto Frias 4200-465 PortoPortugal Research-Education Institute of Optics and Biophotonics Saratov national Research State University 83 Astrakhanskaya street Saratov 410012Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision mechanics and Control RAS 24 Rabochaya street Saratov 410028Russia Interdisciplinary Laboratory of Biophotonics Tomsk national Research State University 36 Lenin's avenue Tomsk 634050Russia

Optical immersion clearing is a technique that has been widely studied for more than two decades and that is used to originate a temporary transparency effect in biological *** applied in cooperation with clinical methods it provides optimization of diagnosis and treatment *** technique turns biological tissues more transparent through two main mechanisms-tissue dehydration and refractive index(RI)matching between tissue *** matching is obtained by partial replacement of interstit ial water by a biocompat ible agent that presents higher RI and it can be completely rever sible by natural rehydration in vrivo or by assisted rehydration in ex vivo *** data to characterize and discriminate between the two mechanisms and to find new ones are *** a simple method,based on collimated transmittance and thickness measurements made from muscle samples under treatment,we have estimated the diffusion properties of glucose,ethylene glycol(EG)and water that were used to perform such char acterization and *** these properties with data from literature that characterize their diffusion in water we have observed that musde cell membrane permeability limits agent and water diffusion in the *** same experi-mental data has allowed to calculate the optical dearing(OC)eficiency and make an inter-pretation of the internal changes that occurred in muscle during the *** same methodology can now be used to perform similar studies with other agents and in other tissues in order to solve engineering problems at design of inexpensive and robust technologies for a *** improvement of optical tomogr aphic techmiques with better contrast and in depth imaging.

关键词： Collimated transmittance agent diffusivity tissue dehydration thickness variation refractive index matching glucose ethylene glycol

Advances in small animal mesentery models for in vivo flow cytometry,dynamic microscopy,and drug screening

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World Journal of Gastroenterology 2007年第2期13卷 192-218页

作者： Ekaterina I Galanzha valery v Tuchin vladimir P Zharov Philips Classic Laser Laboratories University of Arkansas for Medical Sciences (UAMS) Little Rock AR United States Department of Optics and Biomedical Physics Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov Russia Department of Optics and Biomedical Physics Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov Russia Philips Classic Laser Laboratories University of Arkansas for Medical Sciences (UAMS) Little Rock AR United States

Using animal mesentery with intravital optical microscopy is a well-established experimental model for studying blood and lymph microcirculation in vivo. Recent advances in cell biology and optical techniques provide the basis for extending this model for new applications, which should generate significantly improved experimental data. This review summarizes the achievements in this specific area, including in vivo label-free blood and lymph photothermal flow cytometry, super-sensitive fluorescence image cytometry, light scattering and speckle flow cytometry, microvessel dynamic microscopy, infrared (IR) angiography, and high-speed imaging of individual cells in fast flow. The capabilities of these techniques, using the rat mesentery model, were demonstrated in various studies; e.g., real-time quantitative detection of circulating and migrating individual blood and cancer cells, studies on vascular dynamics with a focus on lymphatics under normal conditions and under different interventions (e.g. lasers, drugs, nicotine), assessment of lymphatic disturbances from experimental lymphedema, monitoring cell traffic between blood and lymph systems, and high-speed imaging of cell transient deformability in flow. In particular, the obtained results demonstrated that individual cell transportation in living organisms depends on cell type (e.g., normal blood or leukemic cells), the cell’s functional state (e.g., live, apoptotic, or necrotic), and the functional status of the organism. Possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo- and radio-sensitivity tests, and drug screening, are also discussed.

关键词： Lymph microcirculation Transmission digital microscopy Rat mesentery Flow cytometry Photothermal technique

COmPARATIvE TREATmEnT OF ACnE vULGARIS USInG PALOmAR LUX APPLIQU´E TECHnIQUE AnD DIRECT InTRALESIOnAL InJECTIOn

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Journal of Innovative Optical Health Sciences 2009年第3期2卷 279-287页

作者： ELInA A.GEnInA ALEXEY n.BASHKATOv valery v.TUCHIn GEORGY v.SImOnEnKO vERA n.SHERSTnEvA ILYA v.YAROSLAvSKY GREGORY B.ALTSHULER Department of Optics and Biophotonics Saratov State University 83 Astrakhanskaya str. Saratov 410012Russia Saratov State medical University 112 B.Kazachya str. Saratov 410012Russia Palomar medical Technologies Inc. 82 Cambridge St.Burlington 01803MAUSA

Intralesional injection of triamcinolone(TmC)preparations is an effective therapy for cystic acne ***,invasive delivery techniques limit the use of this modality to a relatively narrow class of *** permeability can be enhanced through creating a lattice of microzones(islets)of light-induced limited thermal damage in the upper layers of *** this paper,we directly compared safety and efficacy of delivering TmC acetonide with this novel technique versus conventional intralesional injection for treatment of inflammatory acne lesions.A combination of an intense pulsed light system and a specially designed appliqu´e with a pattern of absorbing centers has been used to create the lattice of islets of damage(LID).Quantitative analysis has included estimation of the following parameters:redness,diameter,and height of acne *** photography has been used to document dynamics of lesion development at successive visits(two hours,24 hours and one week post-treatment).Seven subjects have participated in the *** difference in lesion dynamics between the treatment and control groups was observed at two-hours *** 24-hours/one-week follow-ups,TmC-injected and TmC-LID-delivered groups have demonstrated 82%/93%and 80%/89%improvement in height of lesions in comparison to control(60%/68%).Delivery of TmC with the newly proposed LID technique is at least as effective as intralesional injection for treating inflammatory acne *** of skin permeability using LID approach is a promising technique for accelerating delivery of various compounds to their target areas in the skin.

关键词： Acne vulgaris drug delivery skin permeability enhancement.

Kinetics and mechanism of the low-energy β-a phase transition of the second kind in 2,4-dinitroanisole

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Defence Technology（防务技术） 2024年第10期40卷 210-224页

作者： Aleksandr v.Stankevich nikolay A.Rasputin Anisa KhRudina Gennady L.Rusinov vera I.Filyakova valery n.Charushin I.Ya. Postovsky Institute of Organic Synthesis Ural Branch of the Russian Academy of Sciencesekaterinburg 620108russia Russian Federal nuclear Center-Zababakhin All-Russia Research Institute of Technical Physics snezhinsk 456770russia Kazan national Research Technological University kazan 420015russia

In this work, comprehensive studies of 2,4-dinitroanisole(2,4DnAn) were carried out using powder thermorentgenography of the internal standard. The time of the complete polymorphic transition in the solid phase β→a in 2,4DnAn under various combinations of conditions has been determined. It has been established that, regardless of the season of manufacture of the substance, when it is stored for 8-9months, with a change in ambient temperature from minus 30℃ to plus 30℃, a complete polymorphic transition β→a occurs. When stored in conditions below minus 5℃, polymorphic transition does not occur. When stored in conditions above plus 30℃ in a closed container, polymorphic transition occurs within 3 weeks. The polymorphic transition is accompanied by a decrease in density by 1.3%-1.5% and an increase in melting temperature by 10-12℃, depending on the degree of purity of the starting substance. The activation energy of the molecular rearrangement was 68-70 k J/mol(16.5 ± 3 kcal/mol). The mechanism of polymorphic transition has been evaluated, which is presumably based on internal homodiffusion and energy transfer to the surface of the mass of powder particles and the product. The average activation energy of the polymorphic transition process was 110 ± 6.2 k J/mol(26.2 kcal/mol). In an open container, reactions proceed by a homogeneous mechanism, and in a closed container by a heterogeneous mechanism involving the gas phase.

关键词： Energetic materials melt-castable 2,4-Dinitroanisole Polymorphic transition Kinetics mechanism Homodiffusion Sublimation

Shedding light on biology and healthcare--preface to the special issue on Biomedical Optics

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Light(Science & Applications) 2022年第7期11卷 1315-1317页

作者： Peng Xi Xunbin Wei Junle Qu valery v.Tuchin Department of Biomedical Engineering College of Future TechnologyPeking University100871BeijingChina Department of Biomedical Engineering Peking University100081BeijingChina Center for Biomedical Optics and Photonics(CBOP)&College of Physics and Optoelectronic Engineering Key Laboratory of Optoelectronic Devices and Systems of Guangdong Province and Ministry of EducationShenzhen University518060ShenzhenChina Saratov State University 83 Astrakhanskaya str.Saratov410012Russia

During the past decade,there has been an explosion in the development of novel optical techniques in biomedical research and clinical *** progress has been made in optical imaging and detection to provide necessary biological information for disease diagnosis and in-depth understanding of biological ***,recent advances integrating laser technology with biomarkers have enabled novel diagnostic and treatment approaches for different types of diseases.

关键词： optical integrating diagnosis