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RISE AND SHINE Indie Rock Icons The kooks Continueto Charm a Decade On

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城市漫步（GBA版） 2019年第11期 32-33页

作者： valerie Osipov 不详

The British rock renaissance that dominated the early 2000s gave birth to a number of iconic bands,such as The Libertines,the Arctic Monkeys and Bloc *** groups have cemented themselves as essentially'landfill indie... 详细信息

关键词： landfill indie RISE

NTR/NRX Define a New Thioredoxin System in the Nucleus of Arabidopsis thaliana Cells

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Molecular Plant 2014年第1期7卷 30-44页

作者： Corinne Marchal valerie Delorme-Hinoux Laetitia Bariat Wafi Siala Christophe Belin Julio Saez-Vasquez Christophe Riondet Jean-Philippe Reichheld Universite Perpignan Via Domitia CNRS Laboratoire Genome et Developpement des Plantes UMR 5096 58 Avenue Paul Alduy-Bat T F-66860 Perpignan France Pharmacologie cellulaire et moleculaire Louvain Drug Research Institute Universite catholique de Louvain Brussels Belgium

Thioredoxins （TRX） are key components of cellular redox balance, regulating many target proteins through thiol/disulfide exchange reactions. In higher plants, TRX constitute a complex multigenic family whose members have been found in almost all cellular compartments. Although chloroplastic and cytosolic TRX systems have been largely studied, the presence of a nuclear TRX system has been elusive for a long time. Nucleoredoxins （NRX） are potential nuclear TRX found in most eukaryotic organisms. In contrast to mammals, which harbor a unique NRX, angiosperms gen- erally possess multiple NRX organized in three subfamilies. Here, we show thatArabidopsis thaliana has two NRXgenes （AtNRX1 and AtNRX2）, respectively, belonging to subgroups I and III. While NRX1 harbors typical TRX active sites （WCG/ PPC）, NRX2 has atypical active sites （WCRPC and WCPPF）. Nevertheless, both NRXl and NRX2 have disulfide reduction capacities, although NRX1 alone can be reduced by the thioredoxin reductase NTRA. We also show that both NRX1 and NRX2 have a dual nuclear/cytosolic localization. Interestingly, we found that NTRA, previously identified as a cytosolic protein, is also partially localized in the nucleus, suggesting that a complete TRX system is functional in the nucleus. We show that NRX1 is mainly found as a dimer in vivo. nrxl and nrx2 knockout mutant plants exhibit no phenotypic perturbations under standard growth conditions. However, the nrxl mutant shows a reduced pollen fertility phenotype, suggesting a specific role of NRX1 at the haploid phase.

关键词： thioredoxin nucleoredoxin nucleus Arabidopsis.

Levels and correlates of 24-hour movement behaviors among South koreans:Results from the korea National Health and Nutrition Examination Surveys,2014 and 2015

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Journal of Sport and Health Science 2019年第4期8卷 376-385页

作者： Eun-Young,Lee valerie Carson Justin Y.Jeon John C.Spence Mark S.Tremblay School of kinesiology and Health Studies Queen's UniversityKingston ON K7L 2N9Canada Faculty of kinesiology Sportand RecreationUniversity of AlbertaEdmonton AB T6G 2H9Canada Department of Sport Industry Faculty of Education SciencesYonsei UniversitySeoul 03722Republic of Korea Healthy Active Living and Obesity(HALO)Research Group CHEO Research InstituteOttawa ON KIH 8L1Canada

*** study aimed to examine the levels and correlates of 24-h movement behaviors(i.e.,physical activity,sedentary time,and sleep),and different patterns of these behaviors in a nationally representative sample of South koreans aged 12 years and *** study also aimed to examine the sociodemographic correlates of 24?h movement behaviors stratified by age ***-reported,repeated cross-sectional data from 10,708 participants in the 2014 and 2015 korea National Health and Nutrition Examination surveys were *** variables included moderate-to-vigorous intensity physical activity,muscular strengthening exercises,walking,active transportation,sedentary time,and *** variables included age,sex,household income,area of residence,and education *** statistics by sex and age as well as general linear models by age group were *** proportions of individuals meeting the moderate-to-vigorous intensity physical activity,muscular strengthening exercises,and sleep guidelines were,respectively,21.6%,22.1%,and 32.5%in male youth;6.9%,4.5%,and 22.8%in female youth;55.5%,30.8%,and 54.0%in male adults;48.8%,14.4%,and 57.6%in female adults;44.0%,30.6%,and 45.5%in male older adults;and 29.5%,8.9%,and 37.3%in female older *** proportions of individuals showing the most ideal combinations of 24-h movement behaviors were only 3.2%in youth,0.4%in adults,and 0 in older ***,older age,female sex,or living in metro Seoul were associated with unfavorable patterns of 24-h movement behaviors across different age ***,the associations of income and education with movement behaviors were mixed across age ***,the proportion of South koreans with a healthy 24-h movement behavior pattern is *** sociodemographic correlates of different types of 24-h movement behaviors should be considered when designing targeted interventions for the promotion of healthy active living for

关键词： 24-h movement behavior Behavioral epidemiology Guideline adherence Health behavior surveillance

Magnetic resonance imaging may predict deep remission in patients with perianal fistulizing Crohn's disease

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World Journal of Gastroenterology 2017年第23期23卷 4285-4292页

作者： Lucie Thomassin Laura Armengol-Debeir Cloé Charpentier valerie Bridoux Edith koning Guillaume Savoye Céline Savoye-Collet Department of Gastroenterology Rouen University HospitalUniversity of Rouen Department of Radiology Rouen University HospitalUniversity of Rouen Department of Digestive Surgery Rouen University HospitalUniversity of Rouen

To evaluate the imaging course of Crohn’s disease (CD) patients with perianal fistulas on long-term maintenance anti-tumor necrosis factor (TNF)-α therapy and identify predictors of deep *** patients with perianal CD treated with anti-TNF-α therapy at our tertiary care center were evaluated by magnetic resonance imaging (MRI) and clinical assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after. Clinical assessment (remission, response and non-response) was based on Present’s criteria. Rectoscopic patterns, MRI Van Assche score, and MRI fistula activity signs (T2 signal and contrast enhancement) were collected for the two MR examinations. Fistula healing was defined as the absence of T2 hyperintensity and contrast enhancement on MRI. Deep remission was defined as the association of both clinical remission, absence of anal canal ulcers and healing on MRI. Characteristics and imaging patterns of patients with and without deep remission were compared by univariate and multivariate ***-nine consecutive patients (31 females and 18 males) were included. They ranged in age from 14-70 years (mean, 33 years). MRI and clinical assessment were performed after a mean period of exposure to anti-TNF-α therapy of 40 ± 3.7 mo. Clinical remission, response and non-response were observed in 53.1%, 20.4%, and 26.5% of patients, respectively. Deep remission was observed in 32.7% of patients. Among the 26 patients in clinical remission, 10 had persisting inflammation of fistulas on MRI (T2 hyperintensity, n = 7; contrast enhancement, n = 10). Univariate analysis showed that deep remission was associated with the absence of rectal involvement and the absence of switch of anti-TNF-α treatment or surgery requirement. Multivariate analysis demonstrated that only the absence of rectal involvement (OR = 4.6; 95%CI: 1.03-20.5) was associated with deep *** remission is achieved i

关键词： Crohn’s disease Anal fistula Magnetic resonance imaging Anus disease/diagnosis Biotherapy

ENARGEIA IN CICERO's PARADOXA STOICORUM

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Journal of Ancient Civilizations 2003年第1期18卷 93-96页

作者： Michele valerie Ronnick Wayne State University

ENARGEIA IN CICERO's PARADOXA STOICORUM

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Journal of Ancient Civilizations 2003年 93-95页

作者： Michele valerie Ronnick Wayne State University

An exploratory study on perceived relationship of alcohol, caffeine, and physical activity on hot flashes in menopausal women

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Health 2010年第9期2卷 989-996页

作者： Jay kandiah valerie Amend 不详

This study examined the effects of caffeine, alcohol, and physical activity (PA) on the perceived frequency and severity of hot flashes in menopausal women. Female employees at a Mid-Western university were invited to participate in an on-line survey. The 26-itemized Wo- men’s Health Survey (WHS) included questions regarding demographics, menopausal stage, experience of hot flashes, consumption of caffeinated beverages and alcohol, and participation in PA. One-hundred and ninety-six women completed the study. Ordinary Least Squares regressions revealed PA, caffeine, and alcohol intake were significant in predicting the severity of hot flashes (R2 = 0.068, F(6,180) = 2.195, p = 0.046), though they did not predict frequency of hot flashes (R2 = 0.043, F(6,184) = 1.39, p = 0.221). Participation in aerobic PA increased frequency of hot flashes (p = 0.031);while higher intensity of aerobic PA had an inverse relationship on both frequency and severity of hot flashes (p = 0.011, p = 0.003, respectively). Spearman correlations demonstrated a positive relationship between caffeinated soda intake and frequency (r = 0.17, p = 0.06) and severity (r = 0.19, p = 0.04) of hot flashes. Beverage consumption and PA may predict severity of hot flashes in women. Less frequent, higher intensity aerobic PA may lead to fewer, less severe hot flashes.

关键词： Hot Flashes Caffeine Alcohol Physical Activity

Deep brain stimulation for Tourette’s syndrome

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Translational Neurodegeneration 2020年第1期9卷 20-38页

作者： Wenying Xu Chencheng Zhang Wissam Deeb Bhavana Patel Yiwen Wu valerie Voon Michael S.Okun Bomin Sun Department of Functional Neurosurgery Ruijin HospitalShanghai Jiao Tong University School of MedicineRuijin Hospital197 Ruijin Er RoadShanghai 200025China Norman Fixel Institute for Neurological Diseases Department of NeurologyCollege of MedicineUniversity of FloridaGainesvilleFL 32608USA Department of Neurology&Institute of Neurology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry University of CambridgeCambridgeUK

Tourette syndrome(TS)is a childhood-onset neuropsychiatric disorder characterized by the presence of multiple motor and vocal *** usually co-occurs with one or multiple psychiatric *** behavioral and pharmacological treatments for TS are available,some patients do not respond to the available *** these patients,TS is a severe,chronic,and disabling *** recent years,deep brain stimulation(DBS)of basal ganglia-thalamocortical networks has emerged as a promising intervention for refractory TS with or without psychiatric *** major challenges need to be addressed to move the field of DBS treatment for TS forward:(1)patient and DBS target selection,(2)ethical concerns with treating pediatric patients,and(3)DBS treatment optimization and improvement of individual patient outcomes(motor and phonic tics,as well as functioning and quality of life).The Tourette Association of America and the American Academy of Neurology have recently released their recommendations regarding surgical treatment for refractory ***,we describe the challenges,advancements,and promises of the use of DBS in the treatment of *** summarize the results of clinical studies and discuss the ethical issues involved in treating pediatric *** aim is to provide a better understanding of the feasibility,safety,selection process,and clinical effectiveness of DBS treatment for select cases of severe and medically intractable TS.

关键词： Tourette syndrome Deep brain stimulation Capsulotomy Adaptive close loop Connectivity

Inflammasome-IL-1-Th17 response in allergic lung inflammation

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分子细胞生物学报:英文版 2012年第1期4卷 3-10页

作者： Anne-Gaelle Besnard Dieudonnee Togbe Isabelle Couillin Zoming Tan Song Guo Zheng Francois Erard Marc Le Bert valerie Quesniaux Bernhard Ryffel University of Orleans and Molecular Immunology and Embryology CNRS UMR6218OrleansFrance Artimmune SAS Centre d’InnovationOrleansFrance Division of Rheumatology and Immunology Department of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA University of Cape Town IIDMMCape TownSouth Africa

Allergic asthma has increased dramatically in prevalence and severity over the last three *** clinical and experimental data support an important role of Th2 cell response in the allergic *** investigations revealed that airway exposure to allergen in sensitized individuals causes the release of ATP and uric acid,activating the NLRP3 inflammasome complex and cleaving pro-IL-1b to mature IL-1b through *** production of pro-IL-1b requires a toll-like receptor(TLR)4 signal which is provided by the ***-1b creates a pro-inflammatory milieu with the production of IL-6 and chemokines which mobilize neutrophils and enhance Th17 cell differentiation in the ***,we review our results showing that NLRP3 inflammasome activation is required to develop allergic airway inflammation in mice and that IL-17 and IL-22 production by Th17 cells plays a critical role in established ***,inflammasome activation leading to IL-1b production contributes to the control of allergic asthma by enhancing Th17 cell differentiation.

关键词： asthma NLRP3 inflammasome IL-1 Th17 cells IL-17 IL-22