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Comparative study in vivo of the osseointegration of 3D-printed and plasma-coated titanium implants

World Journal of Orthopedics 2023年第9期14卷 682-689页

作者： Stanislav Bondarenko Volodymyr Filipenko Nataliya Ashukina valentyna maltseva Gennadiy Ivanov Iurii Lazarenko Dmytro Sereda Ran Schwarzkopf Department of Joint Pathology Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of UkraineKharkiv 61024Ukraine Laboratory of Connective Tissue Morphology Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of UkraineKharkiv 61024Ukraine Experimental Pathology Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of UkraineKharkiv 61024Ukraine Department of Traumatology Military medical clinical center of the Central regionVinnytsia 21018Ukraine Department of Surgery Odesa city hospital 11Odesa 65006Ukraine Hospital for Joint Diseases NYU Langone Orthopedic HospitalNY 10003United States

BACKGROUND Total hip arthroplasty is a common surgical treatment for elderly patients with osteoporosis,particularly in postmenopausal *** such cases,highly porous acetabular components are a favorable option in achieving ***,further discussion is needed if use of such acetabular components is justified under the condition of normal bone *** To determine the features of osseointegration of two different types of titanium implants[3-dimensional(3D)-printed and plasma-coated titanium implants]in bone tissue of a distal metaphysis in a rat femur *** This study was performed on 20 white male laboratory rats weighing 300-350 g aged 6 *** were divided into two groups of 10 animals,which had two different types of implants were inserted into a hole defect(2×3 mm)in the distal metaphysis of the femur:GroupⅠ:3D-printed titanium implant(highly porous);GroupⅡ:Plasma-coated titanium *** 45 and 90 d following surgery,the rats were sacrificed,and their implanted femurs were extracted for histological *** relative perimeter(%)of bone trabeculae[bone-implant contact(BIC%)]and bone marrow surrounding the titanium implants was *** Trabecular bone tissue was formed on the 45th day after implantation around the implants regardless of their type.45 d after surgery,group I(3D-printed titanium implant)and groupⅡ(plasma-coated titanium implant)did not differ in BIC%(83.51±8.5 vs 84.12±1.73;P=0.838).After 90 d,the BIC%was higher in group I(87.04±6.99 vs 81.24±7.62;P=0.049),compared to groupⅡ.The relative perimeter of the bone marrow after 45 d did not differ between groups and was 16.49%±8.58%for groupⅠ,and 15.88%±1.73%for groupⅡ.Futhermore,after 90 d,in groupⅠthe relative perimeter of bone marrow was 1.4 times smaller(12.96±6.99 vs 18.76±7.62;P=0.049)compared to the relative perimeter of bone marrow in groupⅡ.CONCLUSION The use of a highly porous titanium implant,manufactured with 3D printing,for acetabular com

关键词： Rats Hip arthroplasty Femur Porosity 3-dimensional printing Microscopy

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Osseointegration of porous titanium and tantalum implants in ovariectomized rabbits:A biomechanical study

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World Journal of Orthopedics 2021年第4期12卷 214-222页

作者： Stanislav Bondarenko Volodymyr Filipenko Michael Karpinsky Olena Karpinska Gennadiy Ivanov valentyna maltseva Ahmed Amine Badnaoui Ran Schwarzkopf Department of Joint Pathology Sytenko Institute of Spine and Joint PathologyKharkiv 61124Ukraine Department of Biomechanics Sytenko Institute of Spine and Joint PathologyKharkiv 61124Ukraine Department of Experimental Pathology Sytenko Institute of Spine and Joint PathologyKharkiv 61124Ukraine Morphology of Connective Tissue Department Sytenko Institute of Spine and Joint PathologyKharkiv 61124Ukraine Department of Orthopedic Surgery NYU Langone Orthopedic HospitalHospital for Joint DiseasesNew YorkNY 10003United States

BACKGROUND Today,biological fixation of uncemented press-fit acetabular components plays an important role in total hip ***-term stable fixation of these implants depends on the osseointegration of the acetabular cup bone tissue into the acetabular cup implant,and their ability to withstand functional *** To compare the strength of bone-implant osseointegration of four types of porous metal implants in normal and osteoporotic bone in *** The study was performed in 50 female California rabbits divided into nonovariectomized(non-OVX)and ovariectomized groups(OVX)at 6 mo of *** were sacrificed 8 wk after the implantation of four biomaterials[TTM,CONCELOC,Zimmer Biomet's Trabecular Metal(TANTALUM),and ATLANT]in a 5-mm diameter defect created in the left femur.A biomechanical evaluation of the femur was carried out by testing implant breakout *** force was gradually increased until complete detachment of the implant from the bone *** The breakout force needed for implant detachment was significantly higher in the non-OVX group,compared with the OVX group for all implants(TANTALUM,194.7±6.1 N vs 181.3±2.8 N;P=0.005;CONCELOC,190.8±3.6 N vs 180.9±6.6 N;P=0.019;TTM,186.3±1.8 N vs 172.0 N±11.0 N;P=0.043;and ATLANT,104.9±7.0 N vs 78.9 N±4.5 N;P=0.001).In the OVX group,The breakout forces in TANTALUM,TTM,and CONCELOC did not differ significantly(P=0.066).The breakout force for ATLANT in the OVX group was lower by a factor of 2.3 compared with TANTALUM and CONCELOC,and by 2.2 compared with TTM(P=0.001).In the non-OVX group,the breakout force for ATLANT was significantly different from all other implants,with a reduction in fixation strength by a factor of 1.9(P=0.001).CONCLUSION TANTALUM,TTM,and CONCELOC had equal bone-implant osseointegration in healthy and in osteoporotic *** had significantly decreased osseointegration(P=0.001)in healthy and in osteoporotic bone.

关键词： Animals Bone-implant interface Osteoporosis Femur Tantalum Titanium

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An Ensemble Methods for Medical Insurance Costs Prediction Task

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Computers, Materials & Continua 2022年第2期70卷 3969-3984页

作者： Nataliya Shakhovska Nataliia Melnykova valentyna Chopiyak Michal Gregus ml Department of Artificial Intelligence Lviv Polytechnic National UniversityLviv79013Ukraine Department of Clinical Immunology and Allergology Danylo Halytsky Lviv National Medical UniversityLviv79010Ukraine Faculty of Management Comenius UniversityBratislava81499Slovakia

The paper reports three new ensembles of supervised learning predictors for managing medical insurance *** open dataset is used for data analysis methods *** usage of artificial intelligence in the management of financial risks will facilitate economic wear time and money and protect patients’*** learning is associated withmany expectations,but its quality is determined by choosing a good algorithm and the proper steps to plan,develop,and implement the *** paper aims to develop three new ensembles for individual insurance costs prediction to provide high prediction *** coefficient and Boruta algorithm are used for feature *** boosting,stacking,and bagging ensembles are built.A comparison with existing machine learning algorithms is *** modes based on regression tree and stochastic gradient descent is *** CART and Random Forest algorithms are *** boosting and stacking ensembles shown better accuracy than *** tuning parameters for boosting do not allow to decrease the RMSE ***,bagging shows its weakness in generalizing the *** stacking is developed using K Nearest Neighbors(KNN),Support Vector Machine(SVM),Regression Tree,Linear Regression,Stochastic Gradient *** random forest(RF)algorithm is used to combine the *** hundred trees are built *** Square Error(RMSE)has lifted the to 3173.213 in comparison with other *** quality of the developed ensemble for RootMean Squared Error metric is 1.47 better than for the best weak predictor(SVR).

关键词： Healthcare medical insurance prediction task machine learning ensemble data analysis

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Effect of a specific Escherichia coli Nissle 1917 strain on minimal/mild hepatic encephalopathy treatment

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World Journal of Hepatology 2022年第3期14卷 634-646页

作者： Elina Manzhalii valentyna Moyseyenko Vitalii Kondratiuk Nataliia Molochek Tetyana Falalyeyeva Nazarii Kobyliak Department of Propedeutics of Internal Medicine Bogomolets National Medical UniversityKyiv 01601Ukraine Educational and Scientific Centre“Institute of Biology and Medicine” Taras Shevchenko National University of KyivKyiv 01601Ukraine Department of Pediatrics Bogomolets National Medical UniversityKyiv 01601Ukraine Department of Scientific Medical Laboratory CSDKyiv 01004Ukraine Department of Endocrinology Bogomolets National Medical UniversityKyiv 01601Ukraine

BACKGROUND Hepatic encephalopathy(HE)can be considered a result of dysregulated gutliver-brain axis function,where cognitive impairment can be reversed or prevented by the beneficial effects induced by"gut-centric"therapies,such as the administration of nonabsorbable disaccharides,nonabsorbable antibiotics,probiotics and *** To assess the short-term efficacy and safety of the probiotic Escherichia coli Nissle(EcN)1917 strain compared to lactulose and rifaximin in patients with minimal/mild *** From January 2017 to March 2020,a total of 45 patients with HE were enrolled in this prospective,single-centre,open-label,randomized *** were randomly assigned at a ratio of 1:1:1 to one of the treatment groups:The EcN group(n=15),lactulose group(n=15)or rifaximin group(n=15)for a 1 mo intervention *** main primary outcomes of the study were changes in serum ammonia and Stroop test *** secondary outcomes were markers of a chronic systemic inflammatory response(ІL-6,ІL-8,and IFN-γ)and bacteriology of the stool flora evaluated by specialized nonculture techniques after a 1 mo intervention *** Patients who were given rifaximin or EcN showed a more significant reduction in serum ammonia and normalization of Bifidobacteria and Lactobacilli abundance compared to the lactulose ***,the most pronounced restoration of the symbiotic microflora was associated with EcN administration and characterized by the absence of *** with altered properties and pathogenic enterobacteria in patient *** the primary outcome analysis,improvements in the Stroop test parameters in all intervention groups were ***,EcN-treated patients performed 15%faster on the Stroop test than the lactulose group patients(P=0.017).Both EcN and rifaximin produced similar significant reductions in the proinflammatory cytokines INF-γ,IL-6 and *** was more efficient than lactulose in reducing proinflammatory cytokine ***

关键词： Hepatic encephalopathy Chronic liver disease cirrhosis Gut microbiota E.coli Nissle 1917 Cognitive functions Stroop test Rifaximin Lactulose

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Consistent response of nematode communities to management of coniferous plantations

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Forest Ecosystems 2022年第4期9卷 483-490页

作者： Haifeng Yin Yu Su Size Liu Xiangjun Li Xianwei Li Chuan Fan Pingting Guan Zhijing Xie Simin Wang Stefan Scheu valentyna Krashevska College of Forestry Sichuan Agricultural UniversityChengdu611130China J.F.Blumenbach Institute of Zoology and Anthropology University of G€ottingenG€ottingen37073Germany Sichuan Academy of Forestry Chengdu610036China State Forestry and Grassland Administration Key Laboratory of Forest Resources Conservation and Ecological Safety on the Upper Reaches of the Yangtze River Sichuan Agricultural UniversityChengdu611130China State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration School of EnvironmentNortheast Normal UniversityChangchun130117China Centre of Biodiversity and Sustainable Land Use University of GottingenGottingen37073Germany

Background:Crop-tree thinning (CTT) is a forest management practice aiming at enhancing the growth of target trees in plantations by harvesting neighboring trees. Along with the positive effect on tree growth, thinning represents a disturbance, which likely affects belowground organisms and may feed back to stand ***, the impact of CTT on the belowground food web is poorly understood. Since nematodes are species-rich and abundant belowground organisms, occupying a variety of trophic positions in soil food webs and being sensitive to disturbances, they serve as ecological indicators of ecosystem ***:We studied the effect of CTT on the soil nematode community structure in pine (Pinus massoniana Lamb.),Chinese fir (Cunninghamia lanceolata (Lamb.) Hook.) and cypress (Cupressus funebris Endl.) plantations in the Sichuan Basin three years after applying CTT. Crop-tree thinning significantly increased the abundance of soil nematodes in each of the plantations. Moreover, CTT significantly increased the relative abundance of herbivorous nematodes in each of the plantations. Furthermore, CTT increased the proportion of stress tolerators (c-p 1)and enrichment opportunists (c-p 2) and reduced the maturity, structure and enrichment indices of nematodes in Chinese fir and cypress plantations, while only subtle changes were observed in pine plantations. Interestingly,across plantations, the effects of CTT on soil nematode communities were mainly due to changes in microbial biomass nitrogen and understory vegetation ***:Forest management practices resulting in more open canopies uniformly affect soil food webs by changing the quantity and quality of resources associated with increased understory cover and diversity as well as microbial food. These insights increase our understanding of the impacts of forest management on the structure and functioning of belowground communities, which may contribute to management and conservation po

关键词： Soil nematodes Crop-tree thinning Understory vegetation Forest management Soil fauna

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基于多线激光雷达的道路和障碍物检测

基于多线激光雷达的道路和障碍物检测

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作者： Aloshyna valentyna 北京工业大学

学位级别：硕士

Today there is a huge number of vehicles(cars, trains, planes) in the world. In one hand, it greatly simplifies our daily lives but in the other hand, it poses many problems that must be a solved. Research about vehicle recognition and adaptive cruise control is recently emerging. Many well-known vehicle manufacturers introduce new technologies in their production that gives the opportunity to increase the safety of our lives. Vehicle recognition and adaptive cruise control using various sensory resources. There are many sensors like cameras, GPS, accelerometers, radars etc., that are used for detecting edges of the road, traffic signs, cars or pedestrians. There are many different sensors to access the objects' data *** paper presents obstacle road detection. To accomplish this task, from the entire set of available sensors the multilayer LIDAR(Light, Detection and Ranging) with four levels was chosen. This allows obtaining reliable information about the location of objects. The so-obtained data have parameters relative to the coordinate system, the distance of each point from the sensor, which opens up great opportunities for ***, this paper considers how to obtain data from the laser, with detailed consideration of its options. At this stage, the important step is data preprocessing, which includes consideration of only those points that are included in the scan range. The elimination of *** second step is the most important task is how to detect the road and objects on it. The solution to this problem requires the use of a variety of methods. It was viewed a large number of sources in this field and the following data processing methods. It is known that for the detection of the road can be considered a method of determining direct. Today, one of the most widely used methods is the Hough method. Its detailed implementation is proposed in this work. For the detection of objects is regarded, the least squares method. This metho

关键词： drivable road recognition Theil–Sen estimator multilayer LIDAR k-mean clustering Hough method Сanny edge detection

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Histone H1/MBP hydrolysing antibodies - novel potential marker in diagnosis of disease severity in systematic lupus erythematosus patients

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Health 2010年第10期2卷 1204-1207页

作者： valentyna Chopyak Yaroslav Tolstiak Iryna Magoryvska Rostyslav Bilyy Rostyslav Bilyy Natalya Korniy Yuriy Kit Rostyslav Stoika 不详

Recently we have shown the presence of catalytically active IgGs, capable to cleave histone H1 and bovine myelin basic protein (MBP), in blood serum of SLE patients. Here we present data that demonstrate the correlation between a) proteolytic activity towards histone H1 and MBP of IgG-antibodies from blood serum of SLE patients and b) disease severity level in these patients. IgGs were isolated from blood serum by chromatography on protein G-sepharose. Commercial preparations of bovine myelin basic proteins (MBP) and calf thymus histone H1 were used as substrates. Analysis of the proteolytic activity showed that 16 of 38 lgG-preparations (42,1%) obtained from blood serum of SLE patients were capable of cleaving both histone H1 and MBP with different efficiency. It was revealed that the presence in blood serum of lgGs possessing proteolytic activity towards both histone H1 and bMBP closely correlates with manifestation of the disease severity in SLE patients.

关键词： System Lupus Erythematosus Proteolytic Activity IgG-Antibodies Disease Severity

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Dissection of a rapidly evolving wheat resistance gene cluster by long-read genome sequencing accelerated the cloning of Pm69

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Plant Communications 2024年第1期5卷 69-83页

作者： Yinghui Li Zhen-Zhen Wei Hanan Sela Liubov Govta valentyna Klymiuk Rajib Roychowdhury Harmeet Singh Chawla Jennifer Ens Krystalee Wiebe Valeria Bocharova Roi Ben-David Prerna B.Pawar Yuqi Zhang Samidha Jaiwar Istvan Molnar Jaroslav Dolezel Gitta Coaker Curtis J.Pozniak Tzion Fahima Institute of Evolution University of HaifaMt.CarmelHaifa 3498838Israel The Department of Evolutionary and Environmental Biology University of HaifaMt.CarmelHaifa 3498838Israel The Institute of Plant Protection Sichuan Academy of Agricultural SciencesChengdu 610066China Crop Development Centre and Department of Plant Sciences University of Saskatchewan51 Campus DriveSaskatoonSK S7N 5A8Canada Department of Vegetables and Field Crops Institute of Plant SciencesAgricultural Research Organization(ARO)–Volcani CenterRishon Lezion 7505101Israel Department of Crop Genomics and Bioinformatics China Agricultural UniversityBeijing 100094China Institute of Experimental Botany of the Czech Academy of Sciences Centre of the Region Hana´for Biotechnological and Agricultural ResearchSlechtitelu 3177900 OlomoucCzech Republic Plant Pathology Department University of CaliforniaDavisDavisCA 95616USA Present address:Department of Plant Science University of ManitobaWinnipegMB R3T 2N2Canada Present address:Agricultural Institute Centre for Agricultural ResearchELKHMartonvasar 2462Hungary

Gene cloning in repeat-rich polyploid genomes remains ***,we describe a strategy for overcoming major bottlenecks in cloning of the powdery mildew resistance gene(R-gene)Pm69 derived from tetraploid wild emmer wheat.A conventional positional cloning approach was not effective owing to suppressed *** sorting was compromised by insufficient purity.A Pm69 physical map,constructed by assembling Oxford Nanopore Technology(ONT)long-read genome sequences,revealed a rapidly evolving nucleotide-binding leucine-rich repeat(NLR)R-gene cluster with structural variations.A single candidate NLR was identified by anchoring RNA sequencing reads from susceptible mutants to ONT contigs and was validated by virus-induced gene ***69 is likely a newly evolved NLR and was discovered in only one location across the wild emmer wheat distribution range in ***69 was successfully introgressed into cultivated wheat,and a diagnostic molecular marker was used to accelerate its deployment and pyramiding with other R-genes.

关键词： cluster resistance Israel

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