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Feeding broiler chickens with arginine above recommended levels:effects on growth performance,metabolism,and intestinal microbiota

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1528-1541页

作者： Giorgio Brugaletta Marco Zampiga Luca Laghi valentina Indio Chiara Oliveri Alessandra De Cesare Federico Sirri Department of Agricultural and Food Sciences Alma Mater Studiorum-University of BolognaOzzano Dell’Emilia40064 BolognaItaly Department of Veterinary Medical Sciences Alma Mater Studiorum-University of BolognaOzzano Dell’Emilia40064 BolognaItaly Department of Physics and Astronomy Alma Mater Studiorum-University of Bologna40127 BolognaItaly

Background Arginine is an essential amino acid for chickens and feeding diets with arginine beyond the recommended levels has been shown to influence the growth performance of broiler chickens in a positive ***,further research is required to understand how arginine supplementation above the widely adopted dosages affects metabolism and intestinal health of ***,this study was designed to assess the effects of arginine supplementation(i.e.,total arginine to total lysine ratio of 1.20 instead of 1.06-1.08 recommended by the breeding company) on growth performance of broiler chickens and to explore its impacts on the hepatic and blood metabolic profiles,as well as on the intestinal *** this purpose,630 one-day-old male Ross 308 broiler chicks were assigned to 2 treatments(7 replicates each) fed a control diet or a crystalline L-arginine-supplemented diet for 49 *** Compared to control birds,those supplemented with arginine performed significantly better exhibiting greater final body weight at D49(3778 vs.3937 g;P < 0.001),higher growth rate(76.15 vs.79.46 g of body weight gained daily;P < 0.001),and lower cumulative feed conversion ratio(1.808 vs.1.732;P < 0.05).Plasma concentrations of arginine,betaine,histidine,and creatine were greater in supplemented birds than in their control counterparts,as were those of creatine,leucine and other essential amino acids at the hepatic *** contrast,leucine concentration was lower in the caecal content of supplemented *** alpha diversity and relative abundance of Firmicutes and Proteobacteria(specifically Escherichia coli),as well as increased abundance of Bacteroidetes and Lactobacillus salivarius were found in the caecal content of supplemented *** The improvement in growth performance corroborates the advantages of supplementing arginine in broiler *** can be hypothesized that the performance enhancement found in this study is associated with the i

关键词： Arginine Broiler chicken Growth performance Metabolism Microbiota

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Menstrual cycle abnormalities in women with inflammatory bowel disease and effects of biological therapy on gynecological pathology

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World Journal of Clinical Cases 2023年第21期11卷 4989-4995页

作者： Vaidota Malinauskiene Anastasija Zuzo valentina Liakina Edita Kazenaite Ieva Stundiene Clinic of Gastroenterology Nephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental SciencesVilnius TechVilnius 10223Lithuania

Inflammatory bowel disease(IBD)is a chronic condition that affects young individuals in their reproductive *** may have long-term implications on their reproductive,sexual,and mental *** has been related to menstrual ***,the administration of biological therapy can also result in gynecological issues in addition to the disease *** purpose of this review was to present potential menstrual cycle problems in patients with IBD,as well as the impact of adalimumab and other anti-tumor necrosis factor medications on gynecological pathology.

关键词： Menstrual disorders Inflammatory bowel disease Adalimumab Infliximab Anti-tumor necrosis factor-α

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Advances in diagnosis,clinical management and molecular characterization of ovarian Brenner tumors

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Gynecology and Obstetrics Clinical Medicine 2023年第1期3卷 18-21页

作者： valentina Zanfagnin Tiffany Lee Chengquan Zhao Tiannan Wang Department of Pathology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA90033USA Department of Pathology Magee-Womens HospitalUniversity of Pittsburgh Medical CenterPittsburghPA15213USA

Brenner tumors is a very uncommon ovarian epithelial neoplasm,morphologically resembling the transitional cell neoplasm of urinary *** is further classified into three subtypes as a disease spectrum based on histological examination and tumorigenesis:benign Brenner tumors,borderline Brenner tumors(BBTs),and malignant Brenner tumors(MBTs).The etiology of these tumors is not well understood,and literature is limited due to the rarity of this entity,but recent advances,particularly in molecular alterations,have *** scope of this review is to provide an update on the clinical,histopathological,and most recently,molecular characterizations of ovarian Brenner tumors.

关键词： Brenner clinical diagnosis

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The influence of composition of asphaltenes of different genesis on the properties of carbon materials manufactured from them by plasma processing

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Petroleum Science 2023年第6期20卷 3830-3840页

作者： Evgeniya Frantsina Yuliya Petrova valentina Arkachenkova Andrey Grin'ko Alexander Pak Pavel Povalyaev Dmitry Zelentsov Kirill Cherednichenko Surgut State University Institute of Natural and Technical Sciencespr.Lenina 1628412SurgutRussian Federation Tomsk Polytechnic University Laboratory of Advanced Materials for the Energy Industrypr.Lenina30643050TomskRussian Federation National University of Oil and Gas Gubkin University Department of Physical and Colloidal Chemistrypr.Lenina65119991MoscowRussian Federation

The results of experimental studies of carbon materials, which are formed in the plasma of a direct current (DC) arc discharge initiated in open air from the asphaltenes of different origins, extracted from the natural asphaltite and from the oil of the Sredne-Ugutskoye Oilfield, are presented. The influence of the initial asphaltene composition on the composition and properties of the resulting carbon materials is analyzed. The initial asphaltenes and the samples of the carbon materials are characterized by the methods of X-ray diffraction, differential thermal analysis, X-ray fluorescence analysis, IR-Fourier spectroscopy, laser diffraction, transmission and scanning electron microscopy. The changes in the composition and structure of the asphaltenes are determined before and after their plasma treatment and the hypotheses are put forward concerning the chemical processes causing the changes in the molecular structure of the samples. As a result of plasma treatment of asphaltenes (100 A, 30 s), it was shown that graphitization occurs, as well as oxidation, and a decrease in sulfur content. Moreover, nanotubes and nano-onions have been detected using electron microscopy. Petroleum asphaltenes after plasma treatment give a less thermostable carbon material, but with a lower content of heteroatoms, and with a large amount of sulfur in the composition of sulfoxide structural fragments. This method is shown to be a promising technology for processing the petroleum feedstock enriched with heavy asphaltene components for the manufacture of carbon nanomaterials: nanotubes, nano-onions and polyhedral graphite.

关键词： Asphaltenes Natural asphaltite Carbon materials Nanomaterials Plasma treatment Graphite

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Dendritic cell subsets in cancer immunity and tumor antigen sensing

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Cellular & Molecular Immunology 2023年第5期20卷 432-447页

作者： Annalisa Del Prete valentina Salvil Alessandra Soriani Mattia Laffranchi Francesca Sozio Daniela Bosisio Silvano Sozzani Department of Molecular and Translational Medicine University of BresciaBresciaItaly Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti Department of Molecular Medicine Sapienza University of RomeRomeItaly

Dendritic cells(DCs)exhibit a specialized antigen-presenting function and play crucial roles in both innate and adaptive immune *** to their ability to cross-present tumor cell-associated antigens to naïve T cells,DCs are instrumental in the generation of specific T-cell-mediated antitumor effector responses in the control of tumor growth and tumor cell *** an immunosuppressive tumor microenvironment,DC antitumor functions can,however,be severely *** this review,we focus on the mechanisms of DC capture and activation by tumor cell antigens and the role of the tumor microenvironment in shaping DC functions,taking advantage of recent studies showing the phenotype acquisition,transcriptional state and functional programs revealed by scRNA-seq *** therapeutic potential of DC-mediated tumor antigen sensing in priming antitumor immunity is also discussed.

关键词： Dendritic cell subsets Tumor microenvironment Migration Innate immune sensing Immune cell death Tumor-derived extracellularvesicles

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The relationship between sexually transmitted microorganisms and seminal quality in asymptomatic men

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Asian Journal of Urology 2022年第4期9卷 473-479页

作者： valentina Velasquez Rivera Walter D.Cardona Maya Jenniffer Puerta-Suarez Department of Microbiology and Parasitology Medical SchoolUniversity of AntioquiaAntioquiaColombia

Objective:To detect DNA of different microorganisms,in semen samples from apparently healthy men and correlate their presence with seminal ***:Semensamples from 81 healthy volunteers were collected,and semen parameters were *** extraction was performed using the phenol-chloroform technique,and the micro-organisms were detected by the amplification of specific primers using polymerase chain ***:DNA from at least one of the microorganisms was detected in 78 *** most frequent microorganism found in semen were:Lactobacillus spp.(70%),Neisseria gonorrhoeae(***)(36%),Streptococcus epidermidis(64%),Klebsiella pneumoniae(56%),Staphylococcus aureus(32%),Chlamydia trachomatis(***)(28%),Pseudomonas aeru-ginosa(27%).The seminal parameters of all semen samples were over the lower reference values fornormal *** compare with negative samples,seminal volume was higher for the Escherichia coli positive samples and lower for Pseudomonas aeruginosa positive *** samples positive for Staphylococcus aureus had worse sperm *** frequency of progressive motility was higher in positive samples for *** and *** semen samples for *** had a higher concentration per ***:It is common to find microorganisms in semen of asymptomatic men,including those responsible for sexually transmitted *** treatment is recommended only in those individuals with a sexually transmitted infection(*** and ***)and always promote condom use.

关键词： Chlamydia trachomatis Neisseria gonorrhoeae Enterococcus faecalis Streptococcus agalactiae Staphylococcus spp. Seminal quality

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Remotely Activated Nanoparticles for Anticancer Therapy

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Nano-Micro Letters 2021年第1期13卷 174-207页

作者： Luisa Racca valentina Cauda Department of Applied Science and Technology Politecnico di TorinoC.so Duca degli Abruzzi 2410129 TurinItaly

Cancer has nowadays become one of the leading causes of death *** anticancer approaches are associated with different ***,innovative methodologies are being investigated,and several researchers propose the use of remotely activated nanoparticles to trigger cancer cell *** idea is to conjugate two different components,i.e.,an external physical input and *** are given in a harmless dose that once combined together act synergistically to therapeutically treat the cell or tissue of interest,thus also limiting the negative outcomes for the surrounding *** both the properties of the nanomaterial and the involved triggering stimulus,it is possible furthermore to achieve not only a therapeutic effect,but also a powerful platform for imaging at the same time,obtaining a nano-theranostic *** the present review,we highlight the role of nanoparticles as therapeutic or theranostic tools,thus excluding the cases where a molecular drug is *** thus present many examples where the highly cytotoxic power only derives from the active interaction between different physical inputs and *** perform a special focus on mechanical waves responding nanoparticles,in which remotely activated nanoparticles directly become therapeutic agents without the need of the administration of chemotherapeutics or sonosensitizing drugs.

关键词： Anticancer therapy Remotely activated nanomedicine Stimuli-responsive nanoparticles Physical stimulation Radiofrequency Nanoparticle-assisted ultrasound Hyperthermia

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Vessels Segmentation in Angiograms Using Convolutional Neural Network: A Deep Learning Based Approach

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Computer Modeling in Engineering & Sciences 2023年第7期136卷 241-255页

作者： Sanjiban Sekhar Roy Ching-Hsien Hsu Akash Samaran Ranjan Goyal Arindam Pande valentina E.Balas School of Computer Science and Engineering Vellore Institute of TechnologyVellore632014India Department of Computer Science and Information Engineering Asia UniversityTaichung41354Taiwan Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung406Taiwan Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology School of Mathematics and Big DataFoshan UniversityFoshan528000China Medica Superspecialty Hospital Kolkata700099India Automation and Applied Informatics Aurel Vlaicu University of AradArad310130Romania

Coronary arterydisease(CAD)has become a significant causeof heart attack,especially amongthose 40yearsoldor *** is a need to develop new technologies andmethods to deal with this *** researchers have proposed image processing-based solutions for CADdiagnosis,but achieving highly accurate results for angiogram segmentation is still a *** different types of angiograms are adopted for CAD *** paper proposes an approach for image segmentation using ConvolutionNeuralNetworks(CNN)for diagnosing coronary artery disease to achieve state-of-the-art *** have collected the 2D X-ray images from the hospital,and the proposed model has been applied to *** augmentation has been performed in this research as it’s the most significant task required to be initiated to increase the dataset’s ***,the images have been enhanced using noise removal techniques before being fed to the CNN model for segmentation to achieve high *** the output,different settings of the network architecture undoubtedly have achieved different accuracy,among which the highest accuracy of the model is 97.61%.Compared with the other models,these results have proven to be superior to this proposed method in achieving state-of-the-art results.

关键词： Angiogram convolution neural network coronary artery disease diagnosis of CAD image segmentation

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Gut microbiota contribution to hepatocellular carcinoma manifestation in non-alcoholic steatohepatitis

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World Journal of Hepatology 2022年第7期14卷 1277-1290页

作者： valentina Liakina Sandra Strainiene Ieva Stundiene Vaidota Maksimaityte Edita Kazenaite Centre of Hepatology Gastroenterology and DieteticsClinic of GastroenterologyNephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental SciencesVilnius Gediminas Technical University(VILNIUS TECH)Vilnius 10223Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Therapeutic and Radiological Department Antakalnis PolyclinicVilnius 10207Lithuania Department of Pathology Forensic Medicine and PharmacologyInstitute of Biomedical SciencesFaculty of MedicineVilnius UniversityVilnius 01513Lithuania

Recently,the gut microbiota has been recognized as an obvious active player in addition to liver steatosis/steatohepatitis in the pathophysiological mechanisms of the development of hepatocellular carcinoma(HCC),even in the absence of *** from clinical and experimental studies shows the association of specific changes in the gut microbiome and the direct contribution to maintaining liver inflammation and/or cancerogenesis in nonalcoholic fatty liver disease-induced *** composition of the gut microbiota differs significantly in obese and lean individuals,especially in the abundance of pro-inflammatory lipopolysaccharide-producing phyla,and,after establishing steatohepatitis,it undergoes minor changes during the progression of the disease toward advanced *** studies proved that the microbiota of obese subjects can induce steatohepatitis in normally fed *** the contrary,the transplantation of healthy microbiota to obese mice relieves ***,further studies are needed to confirm these findings and the mechanisms *** this review,we have evaluated well-documented clinical and experimental research on the role of the gut microbiota in the manifestation and promotion of HCC in nonalcoholic steatohepatitis(NASH).Furthermore,a literature review of microbiota alterations and consequences of dysbiosis for the promotion of NASH-induced HCC was performed,and the advantages and limitations of the microbiota as an early marker of the diagnosis of HCC were discussed.

关键词： Gut microbiota Hepatocellular carcinoma Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease Microbiome

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Druggable monogenic immune defects hidden in diverse medical specialties:Focus on overlap syndromes

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World Journal of Clinical Pediatrics 2022年第2期11卷 136-150页

作者： valentina Boz Chiara Zanchi Laura Levantino Guglielmo Riccio Alberto Tommasini Department of Medical Surgical and Health SciencesUniversity of TriesteTrieste 34137Italy Department of Pediatrics Institute for Maternal and Child HealthIRCCS Burlo GarofoloTrieste 34137Italy

In the last two decades two new paradigms changed our way of perceiving primary immunodeficiencies:An increasing number of immune defects are more associated with inflammatory or autoimmune features rather than with *** primary immune defects are due to hyperactive pathways that can be targeted by specific inhibitors,providing innovative precision treatments that can change the natural history of *** this article we review some of these“druggable”inborn errors of immunity and describe how they can be suspected and diagnosed in diverse pediatric and adult medicine *** the availability of precision treatments can dramatically impact the course of these diseases,preventing the development of organ damage,it is crucial to widen the awareness of these conditions and to provide practical hints for a prompt detection and cure.

关键词： Inborn errors of immunity Primary immunodeficiency diseases Precision treatments Immunodysregulation Autoimmunity Overlap syndromes

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