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Defining lung cancer stem cells exosomal payload of miRNAs in clinical perspective

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World Journal of Stem Cells 2020年第6期12卷 406-421页

作者： Beatrice Aramini valentina Masciale Khawaja Husnain Haider Department of Medical and Surgical Sciences University of Modena and Reggio EmiliaModena 41124Italy MPharm PhDSulaiman AlRajhi UniveristyAlQaseem 52736Saudi Arabia

Since the first publication regarding the existence of stem cells in cancer[cancer stem cells(CSCs)]in 1994,many studies have been published providing in-depth information about their biology and *** research has paved the way in terms of appreciating the role of CSCs in tumour aggressiveness,progression,recurrence and resistance to cancer *** CSCs for cancer therapy has still not progressed to a sufficient degree,particularly in terms of exploring the mechanism of dynamic interconversion between CSCs and *** the CSC scenario,the problem of cancer dissemination has been analyzed indepth with the identification and isolation of microRNAs(miRs),which are now considered to be compelling molecular markers in the diagnosis and prognosis of tumours in general and specifically in patients with non-small cell lung *** release of miRs via“exosomes”(small membrane vesicles(30-100 nm),the derivation of which lies in the luminal membranes of multi-vesicular bodies)released by fusion with the cell membrane is gaining *** exosomes play a significant role in maintaining a dynamic equilibrium state between CSCs and non-CSCs and their mechanism of activity is as yet *** studies on CSC-related exosomes will provide new perspectives for precision-targeted treatment strategies.

关键词： Cancer Cancer stem cells Exosomes Lungs miRNA Microvesicles Nonsmall cell lung cancer

Eco-physiological studies on desert plants: germination of Halothamnus iraqensis Botsch. seeds under different conditions

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Journal of Arid Land 2019年第1期11卷 75-85页

作者： Arvind BHATT Narayana R BHAT valentina MURRU ANDrea SANTO Kuwait Institute for Scientific Research University of Cagliari Independent Researcher

With the aim to investigate if the halophyte Halothamnus iraqensis Botsch. can be suitable for re-vegetation and remediation of salt-affected lands, this study evaluated(1) the effects of photoperiod, thermoperiod, storage period and wings' presence on its seed germination, and(2) the ability of its seeds to have successful germination recovery after salt stress. Germination tests in different photoperiods(12 h light/12 h darkness and total darkness) and thermoperiods(15℃/20℃ and 20℃/25℃) were conducted for seeds collected in 2012, 2013, 2014, 2015 and 2016. The seeds collected in 2016 were sown under different salinity levels(0, 100, 200, 400 and 600 m M Na Cl) to assess the salinity tolerance during the germination. Wings' presence highly inhibited seed germination of this species in both photoperiods and thermoperiods under all salinity level treatments. In addition, the germination recovery occurred well when seeds were deprived of their wings. The photoperiod of 12 h light/12 h darkness and the thermoperiod of 15℃/20℃ were the best conditions for seed germination. Germination percentages of H. iraqensis seeds decreased with the increasing storage duration, especially after three years of the collection. In addition, H. iraqensis seeds were able to germinate under different salinity levels, and their germination percentages decreased with increasing salinity levels. H. iraqensis seeds have the ability to recover their germination after alleviating the salt stress, irrespective of photoperiod, highlighting the halophilous character of this species.

关键词： wings’ presence storage period photoperiod thermoperiod salt stress Halothamnus iraqensis Botsch

A maintenance driven scheduling cockpit for integrated production and maintenance operation schedule

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Advances in Manufacturing 2022年第2期10卷 205-219页

作者： Mario Arena valentina Di Pasquale Raffaele lannone Salvatore Miranda Stefano Riemma Department of Industrial Engineering University of SalernoFiscianoSAItaly

The production and maintenance functions have objectives that are often in contrast and it is essential for management to ensure that their activities are carried out synergistically,to ensure the maximum efficiency of the production plant as well as the minimization of management *** current evolution of ICT technologies and maintenance strategies in the industrial field is making possible a greater integration between production and *** work addresses this challenge by combining theknowledge of the data collected from physical assets for predictive maintenance management with the possibility of dynamic simulate the future behaviour of the manufacturing system through a digital twin for optimal management of maintenance *** paper,indeed,presents a supporting digital cockpit for production and maintenance integrated *** proposes an innovative approach to manage health data from machines being in any production system and provides support to compare the information about their remaining useful life(RUL)with the respective production *** maintenancedriven schedulingcockpit(MDSC)offers,indeed,a supporting decision tool for the maintenance strategy to be implemented that can help production and maintenance managers in the optimal scheduling of preventive maintenance interventions based on RUL *** simulation is performed by varying the production schedule with the maintenance tasks involvement;opportune decisions are taken evaluating the total costs related to the simulated strategy and the impact on the production schedule.

关键词： Industry 4.0-Maintenance task Production schedule Predictive maintenance Integrated plan

Wilson disease:At the crossroads between genetics and epigeneticsdA review of the evidence

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Liver Research 2017年第2期1卷 121-130页

作者： Dorothy A.Kieffer valentina Medici Department of Internal Medicine Division of Gastroenterology and HepatologyUniversity of CaliforniaDavisCAUSA

Environmental factors,including diet,exercise,stress,and toxins,profoundly impact disease *** review examines how Wilson disease(WD),an autosomal recessive genetic disorder,is influenced by genetic and environmental *** is caused by mutations in the copper-transporter gene ATP7B,leading to the accumulation of copper in the liver and brain,resulting in hepatic,neurological,and psychiatric *** symptoms range in severity and can first appear anytime between early childhood and old *** 300 disease-causing mutations in ATP7B have been identified,but attempts to link genotype to the phenotypic presentation have yielded little insight,prompting investigators to identify alternative mechanisms,such as epigenetics,to explain the highly varied clinical ***,WD is accompanied by structural and functional abnormalities in mitochondria,potentially altering the production of metabolites that are required for epigenetic regulation of gene ***,environmental exposure affects the regulation of gene expression and mitochondrial *** present the“multi-hit”hypothesis of WD progression,which posits that the initial hit is an environmental factor that affects fetal gene expression and epigenetic mechanisms and subsequent“hits”are environmental exposures that occur in the offspring after *** environmental hits and subsequent changes in epigenetic regulation may impact copper accumulation and ultimately WD *** changes,including diet,increased physical activity,stress reduction,and toxin avoidance,might influence the presentation and course of WD,and therefore may serve as potential adjunctive or replacement therapies.

关键词： Wilson disease Modifier gene Epigenetics Mitochondria

ER exit pathways and the control of proteostasis:Crucial role of the UPR,COPII,and ER-phagy in the secretory pathway

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BIOCELL 2022年第5期46卷 1131-1137页

作者： GIUSEPPINA AMODIO valentina PAGLIARA PAOLO REMONDELLI ORNELLA MOLTEDO Dipartimento di Medicina Chirurgia e Odontoiatria“Scuola Medica Salernitana”Universitàdegli Studi di SalernoBaronissi84034Italy2 Dipartimento di FarmaciaUniversitàdegli Studi di SalernoFisciano84084Italy

The endoplasmic reticulum(ER)is the site of entry of all proteins that function in the secretory pathway including the extracellular *** it controls the folding of newly synthesized secretory proteins,the ER is indispensable for the maintenance of proteostasis in the secretory *** the ER and,in part,in post-ER compartments,the quality control of protein folding is under the regulation of the unfolded protein response(UPR)*** UPR strategy is to enhance protein folding,increase the ER degradation pathway of misfolded proteins,and allow the exit from the ER of only correctly folded *** latter is controlled by the multimeric complex COPII,which also provides some of the components for ER-phagy the only route for the disposal of protein *** this overview,we wish to contribute to the introduction of new perspectives in the study of the mechanisms underlying the control of proteostasis within the secretory pathway.

关键词： Proteostasis ER stress Unfolded protein response COPII ER-phagy

Knockdown of OLA1,a regulator of oxidative stress response,inhibits motility and invasion of breast cancer cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第11期10卷 796-804页

作者： Jia-wei ZHANG valentina RUBIO Shu ZHENG Zheng-zheng SHI Cancer Institute (National Ministry of Education Key Laboratory of Cancer Prevention.and Intervention) the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Radiology Methodist Hospital Researeh Institute Houston Texas 77030 USA

To explore the role of a novel Obg-like ATPase 1 （OLA1） in cancer metastasis, small interference RNA （siRNA） was used to knockdown the protein, and the cells were subjected to in vitro cell migration and invasion assays. Knockdown of OLA 1 significantly inhibited cell migration and invasion in breast cancer cell line MDA-MB-231. The knockdown caused no changes in cell growth but affected ROS production. In wound-healing assays, decreased ROS in OLA1-knockdown cells were in situ asso- ciated with the cells＇ decreased motile morphology. Further, treatment ofN-acetylcysteine, a general ROS scavenger, blunted the motility and invasiveness of MDA-MB-231 cells, similar to the effect of OLAl-knockdown. These results suggest that knock- down of OLA1 inhibits breast cancer cell migration and invasion through a mechanism that involves the modulation of intracellular ROS levels.

关键词： Reactive oxygen species Cell migration Cancer metastasis RNA interference

Molecular survey on zoonotic tick—borne bacteria and chlamydiae in feral pigeons(Columba livia domestica)

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 316-319页

作者： valentina Virginia Ebani Fabrizio Bertelloni Paolo Mani Department of Veterinary Science University of Pisa

Objective;To determine the presence of zoonotic tick-borne bacteria in feral pigeons(Columba lixia domestica) from urban ***:Spleen samples from 84 feral pigeons,found dead with traumatic injuries in urban areas,were examined by PCR to detect DNA of Anaplasma phagocytophilum,Bartonella spp.,Borrelia burgdorferi sensu *** *** spp.,and Chlamydnphila ***:Twenty(23.8%) pigeons were infected by tick-borne agents,in particular 2(2.38%) animals resulted positive for Bartonella spp.,5(5.95%) for Coxiella burnetii.5(5.95%) for Rickettsia spp.,13(15.47%) for Borrelia burgdorferi sensu *** birds scored negative for anaplasma ***,17(20.23%) pigeons were positive for Chlamydophila *** among them 10(11.9%) for Chlamydophila psittaci,Mixed infections by two or three agents were detected in 8(9.52%) ***:Feral pigeons living in urban and periurban areas are a hazard for the human health as source of several *** obtained results confirm pigeons as reservoirs of chlamydial agents and suggest that they may be involved in the epidemiology of zoonotic tick-borne infections too.

关键词： Pigeon(Columba livia domestica) Tick-borne bacteria Chlamydophila psittaci PCR

Superlubricity of epitaxial monolayer WS2 on graphene

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Nano Research 2018年第11期11卷 5946-5956页

作者： Holger Buch Antonio Rossi Stiven Forti Domenica Convertino valentina Tozzini Camilla Coletti Center for Nanotechnology Innovation @NEST Istituto Italiano di Tecnologia Piazza S. Silvestro 12 56127 Pisa Italy NEST Istituto Nanoscienze - CNR and Scuola Normale Supefiore Piazza San Silvestro 12 56127 Pisa Italy Graphene Labs Istituto Italiano di Tecnologia Via Morego 30 16163 Genova Italy

We report the superlubric sliding of monolayer tungsten disulfide (WS2) on epitaxial graphene (EG) grown on silicon carbide (SiC). Single-crystalline WS2 flakes with lateral size of hundreds of nanometers are obtained via chemical vapor deposition (CVD) on EG. Microscopic and diffraction analyses indicate that the WS2/EG stack is predominantly aligned with zero azimuthal rotation. The present experiments show that, when perturbed by a scanning probe microscopy (SPM) tip, the WS2 flakes are prone to slide over the graphene surfaces at room temperature. Atomistic force field-based molecular dynamics simulations indicate that, through local physical deformation of the WS2 flake, the scanning tip releases enough energy to the flake to overcome the motion activation barrier and trigger an ultralow-friction rototranslational displacement, that is superlubric. Experimental observations show that, after sliding, the WS2 flakes come to rest with a rotation of nπ/3 with respect to graphene. Moreover, atomically resolved measurements show that the interface is atomically sharp and the WS2 lattice is strain-free. These results help to shed light on nanotribological phenomena in van der Waals (vdW) heterostacks, and suggest that the applicative potential of the WS2/graphene heterostructure can be extended by novel mechanical prospects.

关键词： superlubricity graphene tungsten disulfide scanning tunneling microscopy (STM) two-dimensional (2D) materials nanomechanical

A Postcolonial Perspective on the Evolution of National Identity in the Novels of Margaret Atwood

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A Postcolonial Perspective on the Evolution of National Iden...

作者： Frolova valentina 华中师范大学

学位级别：硕士

The question of national identity is one of the most contradictory ones in postcolonial era and postcolonial *** can be considered the most important issue due to the existence of the identity crisis in all postcolonial *** process of decolonization of the countries subjected to colonial rule triggered a remarkable movement towards restoration of the national identities of the newly freed *** wasn’t an *** phenomenon is explored in most of Margaret Atwood’s novels,yet it has never so far become the subject of a full-scale analysis throughout the author’s entire fictional *** study examines the process of Canadian national identity’s evolution and transformation,reflected in the novels of ***,through the prism of postcolonial critical *** primary material consists of seven novels:The Edible Woman（1969）,Surfacing（1972）,Lady Oracle（1976）,Life Before Man（1979）,Cat’s Eye（1988）,The Robber Bride（1993）and The Blind Assassin（2000）.Grounding arguments in the works of theorists in the sphere of national identity including Benedict Anderson’s study on national identity’s construction,Northrop Frye’s study on Canadian identity crisis,Edward Said’s Orientalism,***’s research on the production of discriminatory identities the researcher attempts to conduct a deeper analysis of ***’s views on the problem of national identity’s acquisition by *** thesis’s methodological basis lies in postcolonial literary criticism and new historical literary *** of these approaches are necessary in order to reach an adequate understanding of the author’s philosophical and ideological position,that is,the influence of the question of the national identity’s recreation in a postcolonial society on Atwood’s literary *** study also examines the reverse process,*** influence of ***’s novels on the process of strengthening the national identity of the Canadian *** thesis is divided into s

关键词： Canadian literature Margaret Atwood identity formation national identity postcolonial critical theory new historicism