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A Composite State Convergence Scheme for Bilateral Teleoperation Systems

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IEEE/CAA Journal of Automatica Sinica 2019年第5期6卷 1166-1178页

作者： Muhammad Usman Asad Umar Farooq Jason Gu Ghulam Abbas Rong Liu valentina E.Balas the Department of Electrical &Computer Engineering Dalhousie UniversityN.S.Canada the Department of Electrical & Computer Engineering Dalhousie UniversityN.S.Canada the Department of Electrical Engineering University of the Punjab LahorePakistan the Department of Electrical Engineering The University of LahorePakistan the Department of Biomedical Engineering Dalian University of TechnologyChina the Department of Automatics &Applied Software “Aurel Vlaicu” University of AradRomania

State convergence is a novel control algorithm for bilateral teleoperation of robotic systems. First, it models the teleoperation system on state space and considers all the possible interactions between the master and slave systems. Second, it presents an elegant design procedure which requires a set of equations to be solved in order to compute the control gains of the bilateral loop. These design conditions are obtained by turning the master-slave error into an autonomous system and imposing the desired dynamic behavior of the teleoperation system. Resultantly, the convergence of master and slave states is achieved in a well-defined manner. The present study aims at achieving a similar convergence behavior offered by state convergence controller while reducing the number of variables sent across the communication channel. The proposal suggests transmitting composite master and slave variables instead of full master and slave states while keeping the operator's force channel intact. We show that,with these composite and force variables;it is indeed possible to achieve the convergence of states in a desired way by strictly following the method of state convergence. The proposal leads to a reduced complexity state convergence algorithm which is termed as composite state convergence controller. In order to validate the proposed scheme in the absence and presence of communication time delays, MATLAB simulations and semi-real time experiments are performed on a single degree-of-freedom teleoperation system.

关键词： Composite variables linear control systems state convergence teleoperation time delay

Human induced pluripotent stem cells for monogenic disease modelling and therapy

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World Journal of Stem Cells 2016年第4期8卷 118-135页

作者： Paola Spitalieri valentina Rosa Talarico Michela Murdocca Giuseppe Novelli Federica Sangiuolo Department of Biomedicine and Prevention Tor Vergata University

Recent and advanced protocols are now available to derive human induced pluripotent stem cells (hiPSCs) from patients affected by genetic diseases. No curative treatments are available for many of these diseases; thus, hiPSCs represent a major impact on patient’ health. hiPSCs represent a valid model for the in vitro study of monogenic diseases, together with a better comprehension of the pathogenic mechanisms of the pathology, for both cell and gene therapy protocol applications. Moreover, these pluripotent cells represent a good opportunity to test innovative pharmacological treatments focused on evaluating the efficacy and toxicity of novel drugs. Today, innovative gene therapy protocols, especially gene editing-based, are being developed, allowing the use of these cells not only as in vitro disease models but also as an unlimited source of cells useful for tissue regeneration and regenerative medicine, eluding ethical and immune rejection problems. In this review, we will provide an up-to-date of modelling monogenic disease by using hiPSCs and the ultimate applications of these in vitro models for cell therapy. We consider and summarize some peculiar aspects such as the type of parental cells used for reprogramming, the methods currently used to induce the transcription of the reprogramming factors, and the type of iPSC-derived differentiated cells, relating them to the genetic basis of diseases and to their inheritance model.

关键词： Human induced pluripotent stem cells Gene therapy Monogenic diseases Gene editing Foetal cells Reprogramming techniques Differentiation

Psychic euosmia and obsessive compulsive personality disorder

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World Journal of Psychiatry 2018年第3期8卷 105-107页

作者： Massimo Pasquini Annalisa Maraone valentina Roselli Lorenzo Tarsitani Department of Human Neurosciences Sapienza University Department of Neuro- sciences and Mental Health Umberto I General Hospital

Patients with obsessive compulsive personality disorder(OCPD) often refer to a prompt mood improvement upon encountering good scents in general, or fresh laundry borax on their clothes, pillows or home settings. The Authors propose the new term psychic euosmia in the mean of an overstated psychological predisposition for a real pleasant smell that elicits an immediate sense of pleasure, order and calm. The prompt reactions to a pleasant odor might be explained by the involvement of rhinencephalon and its proximity to mood-related limbic circuits, which bypass the cognitive awareness. Cleanliness may not preclude a subject to enjoy a good smell, even if we are representing smells that resemble freshness, in other words order. A potentially even more important argument is given by the continuum of personality disorders and their variability. Not all personality characteristics led to disturbed behaviors. In evolutionary perspectives having the ability to differentiate between unpleasant and pleasant odors should have made the difference in surviving. On the other hand, psychic euosmia could be considered a normal reaction, but in our clinical experience it is over-represented among OCPD subjects with marked orderliness and disgust. Therefore, detecting psychic euosmia might vicariously confirm the relevance of disgust as a cognitive driver of OCPD. Hereby we support research to characterize psychic euosmia as a feature of orderliness and cleanliness for OCPD.

关键词： Psychic euosmia Obsessive compulsive personality disorder Orderliness Pleasure Positive emotion Pesonality

The role of selective internal radiotherapy with Y-90 resin microsphere in first-line therapy for hepatic colorectal metastases

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Hepatobiliary Surgery and Nutrition 2018年第5期7卷 382-385页

作者： Antonio Costanzo valentina Rampulla Antonio Varricchio Fausto Petrelli Surgical Oncology Unit Surgical DepartmentASST Bergamo OvestTreviglioBGItaly Oncology Unit Medical Sciences DepartmentASST Bergamo OvestTreviglioBGItaly

The liver is the primary site of metastases in colorectal cancer (CRC) because the majority of the venous mesenteric drainage enters the hepatic portal venous circulation. More than 50% of patients with CRC will develop hepatic metastases over the course of their life. This ultimately leads to death more than two-thirds of these patients (1).

关键词： hepatic metastases colorectal

Ablative therapies for intrahepatic cholangiocarcinoma

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 192-194页

作者： Antonio Giorgio Pietro Gatti Paolo Matteucci valentina Giorgio Interventional Ultrasound Unit Tortorella Clinical HospitalSalernoItaly Internal Medicine Division Ostuni HospitalOstuni BRItaly Radiation Oncology Institute Campus Biomedico UniversityRomeItaly Pediatric Gastroenterology Unit Sacred Heart UniversityPoliclinico GemelliRomeItaly

Among the 3 sub-types of cholangiocarcinoma (CH), [intrahepatic CH, hylar (CH) and extrahepatic (CH)], intrahepatic cholangiocarcinoma (ICC) accounts for up 8–10% of cholangiocarcinomas and 10–20% of all primary liv... 详细信息

关键词： carcinoma liver for

Bartonella infection in asymptomatic horses and donkeys from Tuscany,Central Italy

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1077-1079页

作者： Edoardo Magni Fabrizio Bertelloni Micaela Sgorbini valentina V.Ebani Department of Veterinary Science University of PisaViale Delle Piagge 256124 PisaItaly

Objective: To investigate the occurrence of Bartonella sp. infection in asymptomatic horses and donkeys living in Tuscany, Central ***: Blood samples were collected from 77 horses and 15 donkeys and tested by indirect immunofluorescent test to detect antibodies against Bartonella sp. and by PCR to detect the ***: Fifty-four(58.69%; 95% CI: 47.95%–68.87%) animals, 9 donkeys and 45 horses, were seropositive with antibody titers ranging from 1:64 to 1:512. PCR assays detected 9 horses positive for Bartonella sp. and 3 donkeys for Bartonella henselae genotype ***: The detected sero-prevalence suggests a common and frequent exposure of equids living in Central Italy to bartonellae and PCR results show that Bartonella *** is possible both in horses and donkeys. At the best of our knowledge, this is the first report of Bartonella henselae infection in donkeys.

关键词： Bartonella Horse Donkey PCR Zoonosis

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BIOCELL 2022年第12期46卷 2525-2530页

作者： MONICA SAVIO valentina MINOIA PAOLA FULGHIERI LUCIA ANNA STIVALA VIRGINIE SOTTILE Department of Molecular Medicine University of PaviaPavia27100Italy

The nutraceutical resveratrol is associated with a range of biological effects,from antibiotic to antiinflammatory *** major axis of research has sought to harness its anti-tumour potential,with promising preclinical results and early clinical trials.A second strong interest relies on the anti-ageing effects ascribed to the compound and its application to stem cell *** is becoming clear however that these possible favourable effects are conditioned by a set concentration range not easily controllable in *** we evoke novel developments in the field that could lead to more reliable conditions for the translational use of resveratrol-based compounds.

关键词： Resveratrol Nutraceutical Cancer Cell Differentiation Dihydroxystilbene

Plasma treatment for enhancement of the sorption capacity of carbon fabric

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Plasma Science and Technology 2021年第12期23卷 150-160页

作者： IIya ZADIRIEV Elena KRALKINA Vladimir SAMOILOV Victoria ELCHANINOVA valentina GORINA Ilya IVANENKO Konstantin VAVILIN Alexander NIKONOV Physical Electronics Department Faculty of PhysicsLomonosov Moscow State University119991 MoscowRussia Research Institute for Graphite-Based Structural Materials‘Nllgrafit’ 1524 MoscowRussia

In this work we carried out an experimental investigation into enhancement of the sorption capacity of carbon fabric using plasma treatment *** fabric is based on viscose fiber and is hydrophobic by *** of the fabric sorption capacity is required for its application in *** this purpose,two plasma treatment methods were considered,*** nonequilibrium radiofrequency(RF)discharge and a vacuum RF plasma source with an external magnetic *** treated by atmospheric discharge demonstrated aging effects during the first week after *** sorption capacity of samples treated by the RF plasma source was stable over the same period and reached values as high as *** of the beam created by the vacuum RF plasma source were analyzed and dependences of the fabric sorption capacity and specific surface area on plasma treatment time were *** found that sorption capacity reached its maximum value after 30 min of treatment and did not change significantly if processing was continued,while the specific surface area reached its maximum after 3 min of treatment and quickly decreased after *** was found that the micropore structure of the fabric remained almost the same during plasma *** volume of mesopores in a unit of the fabric mass(specific volume)doubled during the first 5 min of treatment and returned to initial values after 30 min of *** sorption capacity continued to increase even when the specific surface area decreased after reaching its peak *** indicates the important role of surface functional groups formed on carbon fibers during plasma *** is consistent with the results of x-ray photoelectron spectroscopy analysis showing changes in surface oxidation during plasma treatment.

关键词： carbon fabric sorption plasma treatment radiofrequency

Statins decrease the risk of acute pancreatitis after endoscopic ultrasound fine-needle aspiration of pancreatic cysts

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 74-79页

作者： Antonio Facciorusso Vincenzo Rosario Buccino valentina Del Prete Matteo Antonino Antonella Contaldo Nicola Muscatiello Gastroenterology Unit Department of Medical Sciences University of Foggia AOU Ospedali Riuniti

Background: Basic and clinical studies suggest that statins may prevent and even ameliorate acute pan- creatitis. The present study was to evaluate whether statin decreases the risk of acute pancreatitis in patients undergoing endoscopic ultrasound-guided ne-needle aspiration of pancreatic cysts. Methods: Out of 456 patients with pancreatic cysts referred to our center between 2006 and 2018, 365 were nally included in analyses: 86 were treated with statins and 279 were not at the time of endo- scopic ultrasound ne-needle aspiration. We compared the acute pancreatitis incidence between the two groups, and we also compared other complications such as bleeding and infections. Results: Median age was 64 years [interquartile range (IQR) 62 69] and median cyst size was 24mm (IQR, 21 29). The most frequent histology was intraductal papillary mucinous neoplasm (45.3% and 42.3% in the two groups, respectively;P =0.98). All 13 patients experiencing post-endoscopic ultrasound acute pancreatitis were from the control group (4.7%), of which 3 were classi ed as severe pancreatitis. None of statin users developed post-procedural acute pancreatitis (odds ratio: 0.15;95% con dence interval: 0.03 0.98;P=0.03). No difference was registered with regard to severe pancreatitis and other complications. Conclusions: Statins exert a bene cial role in preventing acute pancreatitis in patients with pancreatic cysts undergoing endoscopic ultrasound-guided ne-needle aspiration. If con rmed in prospective trials, our ndings may pave the way to an extensive use of statins as prophylactic agents in pancreatic inter- ventional endoscopy.

关键词： Endoscopic ultrasound Fine-needle aspiration Pancreas Lesion