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Defining lung cancer stem cells exosomal payload of miRNAs in clinical perspective

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World Journal of Stem Cells 2020年第6期12卷 406-421页

作者： Beatrice Aramini valentina Masciale Khawaja Husnain Haider Department of Medical and Surgical Sciences University of Modena and Reggio EmiliaModena 41124Italy MPharm PhDSulaiman AlRajhi UniveristyAlQaseem 52736Saudi Arabia

Since the first publication regarding the existence of stem cells in cancer[cancer stem cells(CSCs)]in 1994,many studies have been published providing in-depth information about their biology and *** research has paved the way in terms of appreciating the role of CSCs in tumour aggressiveness,progression,recurrence and resistance to cancer *** CSCs for cancer therapy has still not progressed to a sufficient degree,particularly in terms of exploring the mechanism of dynamic interconversion between CSCs and *** the CSC scenario,the problem of cancer dissemination has been analyzed indepth with the identification and isolation of microRNAs(miRs),which are now considered to be compelling molecular markers in the diagnosis and prognosis of tumours in general and specifically in patients with non-small cell lung *** release of miRs via“exosomes”(small membrane vesicles(30-100 nm),the derivation of which lies in the luminal membranes of multi-vesicular bodies)released by fusion with the cell membrane is gaining *** exosomes play a significant role in maintaining a dynamic equilibrium state between CSCs and non-CSCs and their mechanism of activity is as yet *** studies on CSC-related exosomes will provide new perspectives for precision-targeted treatment strategies.

关键词： Cancer Cancer stem cells Exosomes Lungs miRNA Microvesicles Nonsmall cell lung cancer

Eco-physiological studies on desert plants: germination of Halothamnus iraqensis Botsch. seeds under different conditions

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Journal of Arid Land 2019年第1期11卷 75-85页

作者： Arvind BHATT Narayana R BHAT valentina MURRU ANDrea SANTO Kuwait Institute for Scientific Research University of Cagliari Independent Researcher

With the aim to investigate if the halophyte Halothamnus iraqensis Botsch. can be suitable for re-vegetation and remediation of salt-affected lands, this study evaluated(1) the effects of photoperiod, thermoperiod, storage period and wings' presence on its seed germination, and(2) the ability of its seeds to have successful germination recovery after salt stress. Germination tests in different photoperiods(12 h light/12 h darkness and total darkness) and thermoperiods(15℃/20℃ and 20℃/25℃) were conducted for seeds collected in 2012, 2013, 2014, 2015 and 2016. The seeds collected in 2016 were sown under different salinity levels(0, 100, 200, 400 and 600 m M Na Cl) to assess the salinity tolerance during the germination. Wings' presence highly inhibited seed germination of this species in both photoperiods and thermoperiods under all salinity level treatments. In addition, the germination recovery occurred well when seeds were deprived of their wings. The photoperiod of 12 h light/12 h darkness and the thermoperiod of 15℃/20℃ were the best conditions for seed germination. Germination percentages of H. iraqensis seeds decreased with the increasing storage duration, especially after three years of the collection. In addition, H. iraqensis seeds were able to germinate under different salinity levels, and their germination percentages decreased with increasing salinity levels. H. iraqensis seeds have the ability to recover their germination after alleviating the salt stress, irrespective of photoperiod, highlighting the halophilous character of this species.

关键词： wings’ presence storage period photoperiod thermoperiod salt stress Halothamnus iraqensis Botsch

A maintenance driven scheduling cockpit for integrated production and maintenance operation schedule

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Advances in Manufacturing 2022年第2期10卷 205-219页

作者： Mario Arena valentina Di Pasquale Raffaele lannone Salvatore Miranda Stefano Riemma Department of Industrial Engineering University of SalernoFiscianoSAItaly

The production and maintenance functions have objectives that are often in contrast and it is essential for management to ensure that their activities are carried out synergistically,to ensure the maximum efficiency of the production plant as well as the minimization of management *** current evolution of ICT technologies and maintenance strategies in the industrial field is making possible a greater integration between production and *** work addresses this challenge by combining theknowledge of the data collected from physical assets for predictive maintenance management with the possibility of dynamic simulate the future behaviour of the manufacturing system through a digital twin for optimal management of maintenance *** paper,indeed,presents a supporting digital cockpit for production and maintenance integrated *** proposes an innovative approach to manage health data from machines being in any production system and provides support to compare the information about their remaining useful life(RUL)with the respective production *** maintenancedriven schedulingcockpit(MDSC)offers,indeed,a supporting decision tool for the maintenance strategy to be implemented that can help production and maintenance managers in the optimal scheduling of preventive maintenance interventions based on RUL *** simulation is performed by varying the production schedule with the maintenance tasks involvement;opportune decisions are taken evaluating the total costs related to the simulated strategy and the impact on the production schedule.

关键词： Industry 4.0-Maintenance task Production schedule Predictive maintenance Integrated plan

Wilson disease:At the crossroads between genetics and epigeneticsdA review of the evidence

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Liver Research 2017年第2期1卷 121-130页

作者： Dorothy A.Kieffer valentina Medici Department of Internal Medicine Division of Gastroenterology and HepatologyUniversity of CaliforniaDavisCAUSA

Environmental factors,including diet,exercise,stress,and toxins,profoundly impact disease *** review examines how Wilson disease(WD),an autosomal recessive genetic disorder,is influenced by genetic and environmental *** is caused by mutations in the copper-transporter gene ATP7B,leading to the accumulation of copper in the liver and brain,resulting in hepatic,neurological,and psychiatric *** symptoms range in severity and can first appear anytime between early childhood and old *** 300 disease-causing mutations in ATP7B have been identified,but attempts to link genotype to the phenotypic presentation have yielded little insight,prompting investigators to identify alternative mechanisms,such as epigenetics,to explain the highly varied clinical ***,WD is accompanied by structural and functional abnormalities in mitochondria,potentially altering the production of metabolites that are required for epigenetic regulation of gene ***,environmental exposure affects the regulation of gene expression and mitochondrial *** present the“multi-hit”hypothesis of WD progression,which posits that the initial hit is an environmental factor that affects fetal gene expression and epigenetic mechanisms and subsequent“hits”are environmental exposures that occur in the offspring after *** environmental hits and subsequent changes in epigenetic regulation may impact copper accumulation and ultimately WD *** changes,including diet,increased physical activity,stress reduction,and toxin avoidance,might influence the presentation and course of WD,and therefore may serve as potential adjunctive or replacement therapies.

关键词： Wilson disease Modifier gene Epigenetics Mitochondria

ER exit pathways and the control of proteostasis:Crucial role of the UPR,COPII,and ER-phagy in the secretory pathway

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BIOCELL 2022年第5期46卷 1131-1137页

作者： GIUSEPPINA AMODIO valentina PAGLIARA PAOLO REMONDELLI ORNELLA MOLTEDO Dipartimento di Medicina Chirurgia e Odontoiatria“Scuola Medica Salernitana”Universitàdegli Studi di SalernoBaronissi84034Italy2 Dipartimento di FarmaciaUniversitàdegli Studi di SalernoFisciano84084Italy

The endoplasmic reticulum(ER)is the site of entry of all proteins that function in the secretory pathway including the extracellular *** it controls the folding of newly synthesized secretory proteins,the ER is indispensable for the maintenance of proteostasis in the secretory *** the ER and,in part,in post-ER compartments,the quality control of protein folding is under the regulation of the unfolded protein response(UPR)*** UPR strategy is to enhance protein folding,increase the ER degradation pathway of misfolded proteins,and allow the exit from the ER of only correctly folded *** latter is controlled by the multimeric complex COPII,which also provides some of the components for ER-phagy the only route for the disposal of protein *** this overview,we wish to contribute to the introduction of new perspectives in the study of the mechanisms underlying the control of proteostasis within the secretory pathway.

关键词： Proteostasis ER stress Unfolded protein response COPII ER-phagy

Knockdown of OLA1,a regulator of oxidative stress response,inhibits motility and invasion of breast cancer cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第11期10卷 796-804页

作者： Jia-wei ZHANG valentina RUBIO Shu ZHENG Zheng-zheng SHI Cancer Institute (National Ministry of Education Key Laboratory of Cancer Prevention.and Intervention) the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Radiology Methodist Hospital Researeh Institute Houston Texas 77030 USA

To explore the role of a novel Obg-like ATPase 1 （OLA1） in cancer metastasis, small interference RNA （siRNA） was used to knockdown the protein, and the cells were subjected to in vitro cell migration and invasion assays. Knockdown of OLA 1 significantly inhibited cell migration and invasion in breast cancer cell line MDA-MB-231. The knockdown caused no changes in cell growth but affected ROS production. In wound-healing assays, decreased ROS in OLA1-knockdown cells were in situ asso- ciated with the cells＇ decreased motile morphology. Further, treatment ofN-acetylcysteine, a general ROS scavenger, blunted the motility and invasiveness of MDA-MB-231 cells, similar to the effect of OLAl-knockdown. These results suggest that knock- down of OLA1 inhibits breast cancer cell migration and invasion through a mechanism that involves the modulation of intracellular ROS levels.

关键词： Reactive oxygen species Cell migration Cancer metastasis RNA interference

Superlubricity of epitaxial monolayer WS2 on graphene

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Nano Research 2018年第11期11卷 5946-5956页

作者： Holger Buch Antonio Rossi Stiven Forti Domenica Convertino valentina Tozzini Camilla Coletti Center for Nanotechnology Innovation @NEST Istituto Italiano di Tecnologia Piazza S. Silvestro 12 56127 Pisa Italy NEST Istituto Nanoscienze - CNR and Scuola Normale Supefiore Piazza San Silvestro 12 56127 Pisa Italy Graphene Labs Istituto Italiano di Tecnologia Via Morego 30 16163 Genova Italy

We report the superlubric sliding of monolayer tungsten disulfide (WS2) on epitaxial graphene (EG) grown on silicon carbide (SiC). Single-crystalline WS2 flakes with lateral size of hundreds of nanometers are obtained via chemical vapor deposition (CVD) on EG. Microscopic and diffraction analyses indicate that the WS2/EG stack is predominantly aligned with zero azimuthal rotation. The present experiments show that, when perturbed by a scanning probe microscopy (SPM) tip, the WS2 flakes are prone to slide over the graphene surfaces at room temperature. Atomistic force field-based molecular dynamics simulations indicate that, through local physical deformation of the WS2 flake, the scanning tip releases enough energy to the flake to overcome the motion activation barrier and trigger an ultralow-friction rototranslational displacement, that is superlubric. Experimental observations show that, after sliding, the WS2 flakes come to rest with a rotation of nπ/3 with respect to graphene. Moreover, atomically resolved measurements show that the interface is atomically sharp and the WS2 lattice is strain-free. These results help to shed light on nanotribological phenomena in van der Waals (vdW) heterostacks, and suggest that the applicative potential of the WS2/graphene heterostructure can be extended by novel mechanical prospects.

关键词： superlubricity graphene tungsten disulfide scanning tunneling microscopy (STM) two-dimensional (2D) materials nanomechanical

Mucosa-associated lymphoid tissue lymphoma simulating Crohn’s disease:A case report

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World Journal of Clinical Cases 2020年第8期8卷 1454-1462页

作者： Ieva Stundiene Vaidota Maksimaityte valentina Liakina Jonas Valantinas Centre of Hepatology Gastroenterology and DieteticsFaculty of MedicineVilnius UniversityVilnius 03101Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental ScienceVilnius Gediminas Technical UniversityVilnius 10223Lithuania Clinic of Gastroenterology Nephrourology and SurgeryFaculty of MedicineVilnius UniversityVilnius 03101Lithuania

BACKGROUND Differential diagnosis between extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue and inflammatory bowel disease is mainly based on histopathologic evaluation of intestinal biopsies,although there is no single definitive diagnostic investigation and that circumstance can lead to misdiagnosis in particular *** we present a rare,ulcerative form of marginal zone lymphoma which mimics the Crohn’s disease(CD)of upper digestive *** SUMMARY A 50-year-old man was presented with recurrent episodes of malaise and melena also weight *** of the small bowel demonstrated an ulcer in the ***,biopsies showed lymphoplasmacytic *** of CD was *** treatment consisted of prednisone and azathioprine and was followed by azathioprine 100 mg per day with good clinical response in the following 2 years until *** this time the results of endoscopic biopsies derived from proximal wall of stomach revealed Helicobacter pylori-negative marginal zone lymphoma of the gastric *** confirmed atypical CD20-positive cell *** on these biopsies,marginal zone lymphoma of mucosa-associated lymphoid tissue was ***,the contact with the patient was lost until one year later he was hospitalized with nausea,vomiting and severe pain because of gastrointestinal *** months later after laparotomy,the patient was treated with a course of *** remission was observed following 6 cycles of *** This case report highlights the clinical relevance of knowledge and awareness of marginal zone lymphoma simulating CD.

关键词： Crohn disease Mucosa-associated lymphoid tissue lymphoma Rare diagnosis Gastrointestinal diseases Thiopurines Case report

Effect of the rearing diet on gene expression of antimicrobial peptides in Hermetia illucens(Diptera:Stratiomyidae)

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Insect Science 2023年第4期30卷 933-946页

作者： valentina Candian Carlotta Savio Marco Meneguz Laura Gasco Rosemarie Tedeschi Dipartimento di Scienze Agrarie Forestali eAlimentari(DISAFA)University of TorinoGrugliascoItaly NRAE MicalisGMEUniversity of Paris SaclayJouy-en-JosasFrance Laboratory of Entomology Wageningen UniversityWageningenThe Netherlands BEF Biosystems TorinoItaly

Insect proteins have been proposed for human and animal food *** the health status of insects in mass rearing allows to obtain high-quality products and to avoid severe economic losses due to ***,new strategies for preserving insect health must be *** of the insect im-mune system through the diet is one such *** evaluated gene expression of two antimicrobial peptides(one defensin and one cecropin)in Hermetia illucens(L.)(Diptera:Stratiomyidae)reared on different *** were performed on prepupae and 10-day-old larvae reared on cereal-and municipal organic waste-based diets and on only prepupae reared on a cereal-based diet supplemented with sunflower,corn,or soybean *** inclusion of sunflower oil at different points in the cereal-based diet was also ***,diet-driven differences in the inhibitory activity of the hemolymph were tested against Escherichia coli DH5αand Micrococcus yunnanensis HI55 using diffusion assays in solid *** showed that a municipal organic waste-based diet produced a significant overexpression of antimicrobial peptides only in *** of veg-etable oils caused an upregulation of at least one peptide,except for the corn *** expression of both genes was observed when sunflower oil was added 5 days before *** hemolymph samples showed an inhibitory activity against bacteria *** results suggest that municipal organic waste-based diet and vegetable oil-added diet may successfully impact the immune system of *** alternatives may also exist forotherspeciesofeconomic interest.

关键词： cecropin cereal defensin hemolymph organic municipal solid waste vegetable oil