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Assessment of Rapid Diagnostic Tests Algorithms in Transfusion Medicine Setting

Advances in Biological Chemistry 2021年第1期11卷 52-63页

作者： Modibo Coulibaly Bakary Maiga Dramane Samaké Moussa Diawara Mahamadou Traoré valentin sagara Bréhima Traoré Oumar Guindo Amagana Dolo Department of Biomedical Laboratory Sominé DOLO Hospital Mopti Mali Department of Research and Training National Center for Transfusion Bamako Mali Faculty of Medicine and Odonto-Stomatology University of Sciences Techniques and Technologies Bamako Mali Department of Medicine Sominé DOLO Hospital Mopti Mali Department of Public Health Sominé DOLO Hospital Mopti Mali Faculty of Pharmacy University of Sciences Techniques and Technologies Bamako Mali

Background: The rapid diagnostic tests play a pivotal role in the screening of viral markers in blood qualification for transfusion in limited resource setting. Therefore, it is important to assess their analytical performances to ensure their proper functioning. Material and Methods: We performed a cross- sectional study by successive recruitment to assess the diagnostic value of rapid diagnostic tests algorithms using ELISA as a reference test. A total of 661 blood from donors were enrolled for this study. Rapid Diagnostic Tests (RDTs) and ELISA tests were performed for each sample by a couple of double-blinded biotechnologists. Data were collected on case report form and captured in Microsoft Excel then the file was imported and analyzed using R software version 4.0.3. Results: The diagnostic accuracy for the algorithms are summarized in Table 1. For HIV-algorithm, the internal validity parameters were as follow: sensitivity (sens) 99.0% (95% CI = 97.8, 99.5);specificity (spec) 98.3% (95% CI = 90.9, 99.7);positive likelihood ratio (PLR) 57.4 (95% CI = 8.2, 401.0);negative likelihood ratio (NLR) 0.01

关键词： Rapid Diagnostic Tests Analytical Performances Assessment Transfusion Medicine

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Cardiovascular Risk Factors among Outpatients: An Alarming Sign of the Epidemiological Transition in Developing Country?

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World Journal of Cardiovascular Diseases 2021年第3期11卷 181-194页

作者： Modibo Coulibaly Dramane Samaké Sonfo Boubacar Lamine Sidibé Moussa Diawara Mamoudou Barry valentin sagara Bréhima Traoré Oumar Guindo Bakary Maiga Amagana Dolo Department of Biomedical Laboratory Hospital of Mopti Mopti Mali Department of Medicine Hospital of Mopti Mopti Mali Department of Cardiology Teaching Hospital of Kati Bamako Mali Department of Public Health Hospital of Mopti Mopti Mali Faculty of Medicine and Odonto Stomatology University of Science Technical and Technologies de Bamako Bamako Mali Faculty of Pharmacy University of Science Technical and Technologies de Bamako Bamako Mali

Background: Noncommunicable diseases are the leading cause of death in the world and low and middle-income countries suffer from preventable premature death. The aim of this study was to assess the risk factors for non- communicable disease (NCDs) in general and particular cardiovascular diseases (CVDs) among the outpatients of our department of medicine. Methods: We performed a cross-sectional study from April to December 2017 by the consecutive enrollment of outpatients who attended in our department of medicine of Hôpital Sominé DOLO de Mopti, Mali. Clinical and laboratory data were measured for cardiovascular risk assessment. Framingham Risk Score (FRS) and Systemic Coronary Risk Estimation (SCORES) were computed by using Framingham and SCORE equations. Metabolic syndrome was defined using the harmonized criteria from the International Diabetes Federation (IDF) and the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI). Data were captured in excel and analyzed with R version 4.0.3. The statistical significance was set at p = 0.05. Results: A total of 292 patients were enrolled in this study. The prevalence of traditional cardiovascular risk factors was 36.64%, 21.57%, 14.04%, and 13.01% for high blood pressure, hyperglycemia, smoking, and alcohol consumption, respectively. The metabolic syndrome accounted for 23.63%. The mean body mass index was 26.10 ± 7 kg/m2. The overall 10-year risk for cardiovascular events or death was 26.3% and 8.6% according to the FRS and SCORE equation, respectively. The 10-year risk of cardiovascular events according to the FRS was significantly higher in subjects aged 50 and above compared to subjects aged under 50 years, 34.46% vs 13.16%, p < 0.001. Likewise, the 10-year risk for cardiovascular death acc

关键词： Cardiovascular Risk Factors Framingham Risk Score SCORE Metabolic Syndrome

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