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Determination of iohexol by capillary blood microsampling and UHPLC-MS/MS

Journal of Pharmaceutical Analysis 2019年第4期9卷 259-265页

作者： valentin ion Caroline Legoff Etienne Cavalier Pierre Delanaye Anne-Catherine Servais Daniela-Lucia Muntean Marianne Fillet Laboratory for the Analysis of Medicines (LAM) Center for Interdisciplinary Research on Medicines (CIRM) University of Liege Liege Belgium Analytical Chemistry and Drug Analysis Department Faculty of Pharmacy University of Medicine Pharmacy Science and Technology from Tirgu Mures 540139 Tirgu Mures Romania Department of Clinical Chemistry Center for Interdisciplinary Research on Medicines (CIRM) University of Liege CHU Sart-Tilman Liege Belgium Department of Nephrology-Dialysis-Transplantation University of Liege CHU Sart-Tilman Liege Belgium

One of the most important tools used to evaluate kidney function in the context of chronic kidney disease or other renal function related pathologies is the exploration of glomerular filtration rate (GFR). Iohexol is up to this moment a good candidate molecule for the GFR assessment since it exhibits minimum protein binding rates and minimum extra-renal clearance, being neither secreted nor reabsorbed at the tubular level. This study proposes and evaluates a new LC-MS/MS method for the iohexol determination from capillary blood, prelevated using volumetric absorbative microsampling (VAMS) systems. As an alternative to VAMS, a brand new HemaPEN■ device for micro-prelevation was also tested. A new high throughput sample preparation protocol adapted for iohexol quantification from whole blood VAMS samples was developed. The medium term stability study of iohexol in dried whole blood VAMS samples that was conducted showed a good stability of this molecule for up to 12 days. By collecting only 10 mL of blood, iohexol can be analyzed from dried whole blood VAMS samples for concentration ranges between 1 and 250 mg/mL. Due to the analyte stability in VAMS for up to 12 days, this approach might be successfully applied for GFR assessment for clinical cases allowing minimum invasiveness and even delayed analysis.

关键词： Microsampling Iohexol VAMS LC-MS/MS HemaPEN

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Zeolites for the environment

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Green Carbon 2024年第1期2卷 12-32页

作者： Qiaolin Lang Peng Lu Xiaobo Yang valentin Valtchev The ZeoMat Group Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesLaoshan DistrictQingdao CN-266101China Normandie University ENSICAENUNICAENCNRSLaboratoire Catalyse et SpectrochimieCaen F-14000France

Zeolites are characterized by their microporous,crystalline structures with a four-connected framework with variable compositions,predominantly *** are extensively utilized as adsorbents,catalysts,and ion exchangers across domestic and industrial *** the ongoing energy transition from fossil fuels to renewable sources and the pursuit of environmentally sustainable development,zeolites are increasingly being explored beyond their traditional application *** are investigated for their adsorption and catalytic capabilities in the protection and restoration of air,water,and soil quality,as well as in the environmentally friendly“green”production of *** review article details these novel and potential applications of zeolites,emphasizing the unique properties that render them suitable for each specific use case and discussing how these properties can be fine-tuned through material selection or tailored synthesis methods.

关键词： Zeolite Environment Sorption Catalysis Air,water and soil protection Green production of chemicals

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Multimodality treatment strategies have changed prognosis of peritoneal metastases

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World Journal of Gastrointestinal Oncology 2016年第1期8卷 67-82页

作者： corneliu lungoci aurel ion mironiuc valentin muntean traian oniu hubert leebmann max mayr pompiliu piso department of surgery "iuliu htieganu"university of medicine and pharmacy cluj-napoca400015 Cluj-NapocaCluj ProvinceRomania clinic of visceral and general surgery krankenhaus barmherzige bruederacademic teaching hospitals of the university regensburgBavaria ProvinceGermany

For a long time, treatment of peritoneal metastases(PM) was mostly palliative and thus, this status was link with "terminal status/despair". The current multimodal treatment strategy, consisting of cytoreductive surgery(CRS) and hyperthermic intraperitoneal chemotherapy(HIPEC), has been strenuously achieved over time, but seems to be the best treatment option for PM patients. As we reviewed the literature data, we could emphasize some milestones and also, controversies in the history of proposed multimodal treatment and thus, outline the philosophy of this approach, which seems to be an unusual one indeed. Initially marked by nihilism and fear, but benefiting from a remarkable joint effort of human and material resources(multi-center and-institutional research), over a period of 30 years, CRS and HIPEC found their place in the treatment of PM. The next 4 years were dedicated to the refinement of the multimodal treatment, by launching research pathways. In selected patients, with requires training, it demonstrated a significant survival results(similar to the Hepatic Metastases treatment), with acceptable risks and costs. The main debates regarding CRS and HIPEC treatment were based on the oncologists' perspective and the small number of randomized clinical trials. It is important to statement the PM patient has the right to be informed of the existence of CRS and HIPEC, as a real treatment resource, the decision being made by multidisciplinary teams.

关键词： Hyperthermic intraperitoneal chemotherapy Peritonectomy procedures Systemic chemotherapy Peritoneal metastases Survival

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Detection of CO2 and O2 by iron loaded LTL zeolite films

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Frontiers of Chemical Science and Engineering 2018年第1期12卷 94-102页

作者： Veselina Georgieva Richard Retoux Valerie Ruaux valentin Valtchev Svetlana Mintova Laboratoire Catalyse et Spectrochimie (LCS) ENSICAEN CNRS Normandy University 14000 Caen France Laboratoire de Cristallographie et Sciences des Matériaux (CRISMAT) ENSICAEN CNRS Normandy University 14000 Caen France

Detection of oxygen and carbon dioxide is important in the field of chemical and biosensors for atmosphere and biosystem monitoring and fermentation processes. The present study reports on the preparation of zeolite films doped with iron nanoparticles for detection of CO2 and O2 in gas phase. Pure nanosized LTL type zeolite with monomodal particle size distribution loaded with iron （Fe-LTL） was prepared under hydrothermal condition from colloidal precursor suspensions. The zeolite was loaded with iron to different levels by ion exchange. The Fe-LTL suspensions were used for preparation of thin films on silicon wafers via spin coating method. The reduction of the iron in the zeolite films was carried out under H2 flow （50% H2 in Ar） at 300 ℃. The presence of iron nanoparticles is proved by in situ ultra-violet-visible spectroscopy. The properties of the films including surface roughness, thickness, porosity, and mechanical stability were studied. In addition, the loading and distribution of iron in the zeolite films were investigated. The Fe-LTL zeolite films were used to detect O2 and CO2 in a concentration dependent mode, followed by IR spectroscopy. The changes in the IR bands at 855 and 642 cm^-1 （Fe O-H and Fe-O bending vibrations） and at 2363 and 2333 cm^-1 （CO2 asymmetric stretching） corresponding to the presence of O2 and CO2, respectively, were evaluated. The response to O2 and CO2 was instant, which was attributed to great accessibility of the iron in the nanosized zeolite crystals. The saturation of the Fe-LTL films with CO2 and O2 at each concentration was reached within less than a minute. The Fe-LTL films detected both oxygen and carbon dioxide in contrast, to the pure LTL zeolite film.

关键词： zeolite films detection of CO2 and O2 adsorption

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Pure Lithium Metal Deposited on a 3-Dimensional Copper Current Collector as an Anode for Lithium-ion Batteries

Pure Lithium Metal Deposited on a 3-Dimensional Copper Curre...

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作者： valentin BARBE-RICHAUD 上海交通大学

学位级别：硕士

随着科学技术的发展,人们对于高效的储能技术有了更高的需求,促使着锂电池向更高容量和轻量化发展。金属锂由于具有3861m Ah.g-1的超高理论容量而被视为性能最佳的负极材料。然而锂金属负极在充放电时,存在锂枝晶和体积效应的问题,一直...

随着科学技术的发展,人们对于高效的储能技术有了更高的需求,促使着锂电池向更高容量和轻量化发展。金属锂由于具有3861m Ah.g-1的超高理论容量而被视为性能最佳的负极材料。然而锂金属负极在充放电时,存在锂枝晶和体积效应的问题,一直限制锂电池的发展。在过去的几年,研究人员致力于探索能够抑制锂枝晶生长的方式,从而推进锂电池的发展。其中,设计三维集流体负极材料被认为是一种有效可行的方法。但是通常,三维集流体的制备成本高,因此难以规模化生产。本文通过简单的电沉积方法制备了三维铜锥纳米阵列,并电镀锂金属作为负极材料。根据SEM、循环伏安法和阻抗测试结果,这种方法制备的负极材料表现出了优异的电化学性能,在1C倍率下首圈循环时的容量可以达到2644 m Ah.g-1,300次循环后的容量为472m Ah.g-1。

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Decomposition Method for Complex 3D Problems in Electron Optics

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Journal of Physical Science and Application 2015年第2期5卷 96-100页

作者： valentin Ivanov Institute of Computational Technologies SB RAS. 6 Acad. Lavrentiev Prosp. Novosibirsk 630090 Russia

The decomposition method was successfully used in solving of 3D problems with complex geometry shape in electron optics for the FDM （Finite Difference Method） and FEM （Finite Element Method） mostly to implement fast and robust parallel algorithms and computer codes. We suggest a new version of similar approach for the BEM （Boundary Element Method） based on the alternating method by Schwartz. This approach substantially reduce the dimension of dense global matrix of algebraic system produced by BEM algorithm to solve a complex problem on as single CPU （Central Processor Unit） desktop computer. New algorithm is iterative one, but exponential convergence for the Schwatlz＇s algorithm creates the fast numerical procedures. We describe the results of numerical simulation for a multi electrode ion transport system. The algorithms were implemented in the computer code ＂POISSON-3＂.

关键词： Electron optics decomposition method numerical-analytical technique boundary element method.

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Security Improvement of the Protection of Mobile Networks 3G Communication Channels, Based on Chaotic Cryptographic Algorithms

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通讯和计算机（中英文版） 2013年第3期10卷 346-354页

作者： ion Sima Daniel Tarmurean Adrian-Viorel diaconu valentin Stan IT&C Department Lumina- The University of South-East Europe Bucharest 021187 Romania ETTI Faculty Politehnica University of Bucharest Bucharest 060042 Romania TET Faculty Politehnica University of Bucharest Bucharest 060042 Romania

Mobile communication networks are nowadays rather known as Wi-Fi for internet networks and less the classical radio voice communications networks. The most used mobile networks remains however the well known and a little bit old from now GSM/2G (global system for mobile communication/2nd generation) and the former new entry, but full used UMTS/3G (universal mobile telecommunication system/3rd generation). Of course, the trend is now going to make changes for 4G and 5G mobile networks. Opposite to this extraordinary progress of the mobile communication networks, is now rising a hidden danger against the users, especially when they use to access the bank accounts via mobile terminals. The probability to eavesdropping conversations is only the top of the iceberg. More important is how to protect the data exchange information against third party interceptors when a banking operation is done via mobile communication terminal. Thus, it seems that even nowadays, they can deal with the weaknesses of some embedded security algorithms still in use: A5/3 for GSM (2G) networks and f8 and f9 for UMTS (3G) networks. The paper shows an alternative for these algorithms, in order to improve the crypto protection of the data (and voice) in such mobile networks.

关键词：混沌加密算法移动网络加密保护通信通道 3G 安全性移动通信网络移动通信终端

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铜箔在石墨烯表面沉积的多弧离子电镀工艺研究

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机械制造与自动化 2017年第6期46卷 45-48页

作者： valentin Russier 南京航空航天大学江苏南京210016

一项新的铜箔在石墨烯薄膜上的沉积工艺已经被研究出来。和以往通过CVD法在铜箔上生长石墨烯的研究相比较,该研究应用了一种无接触式电子加工工艺的多弧离子电镀法。在实验中,石墨烯表面成功地形成了一层薄的铜膜,表明这种铜箔沉积工艺... 详细信息

一项新的铜箔在石墨烯薄膜上的沉积工艺已经被研究出来。和以往通过CVD法在铜箔上生长石墨烯的研究相比较,该研究应用了一种无接触式电子加工工艺的多弧离子电镀法。在实验中,石墨烯表面成功地形成了一层薄的铜膜,表明这种铜箔沉积工艺的实用性。此外,通过滚压可显著加快工艺过程,实现大量生产。

关键词：石墨烯薄膜铜箔多弧离子电镀法工艺

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三维超分子锌/锰配合物的合成、晶体结构及理论计算（英文）

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无机化学学报 2018年第3期34卷 515-524页

作者：王志涛瓦伦丁.瓦尔切夫方千荣李秀梅潘亚茹通化师范学院化学学院通化134002 吉林大学无机合成与制备化学国家重点实验室长春130012

通过水热法合成了2个新的三维超分子配合物{[Zn_2(pzdc)(L)_2(H_2O)]·H_2O}_n(1)和[Mn(μ_2-O)(H_2O)_2(HL)]·NIPH(2)(H_2pzdc=吡嗪-2,3-二甲酸,H_2NIPH=5-硝基间苯二甲酸,HL=3-(2-吡啶基)吡唑))。并对其进行了元素分析、红外光谱、紫外光谱、热重、荧光光谱、X射线单晶和粉末衍射测定。配合物1是二维网状结构,配合物2为零维结构,这2个配合物通过氢键和π-π相互作用形成了三维超分子网状结构。此外,还用高斯09程序PBE0/LANL2DZ方法对配合物1和2进行了自然键轨道(NBO)分析,计算结果表明配位原子与Zn、Mn离子之间存在着共价作用。

关键词：水热合成晶体结构锌配合物锰配合物自然键轨道

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