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Exploring fs-laser irradiation damage subthreshold behavior of dielectric mirrors via electrical measurements

High Power Laser Science and Engineering 2024年第2期12卷 24-32页

作者： Petrisor Gabriel Bleotu Radu Udrea Alice Dumitru Olivier Uteza Maria-Diana Mihai Dan Gh Matei Daniel Ursescu Stefan Irimiciuc valentin craciun Extreme Light Infrastructure-Nuclear Physics(ELI-NP) Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH)MagureleRomania Doctoral School of Physics University of BucharestMagureleRomania LULI-CNRS CEAUniversite SorbonneEcole PolytechniqueInstitut Polytechnique de ParisPalaiseau CEDEXFrance Apel Laser IlfovRomania Aix-Marseille University CNRSLP3 UMR 7341MarseilleFrance Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH) MagureleRomania University Politehnica of Bucharest BucharestRomania National Institute for Lasers Plasma and Radiation Physics MagureleRomania

With ultrafast laser systems reaching presently 10 PW peak power or operating at high repetition rates,research towards ensuring the long-term,trouble-free performance of all laser-exposed optical components is *** work is focused on providing insight into the optical material behavior at fluences below the standardized laser-induced damage threshold(LIDT)value by implementing a simultaneous dual analysis of surface emitted particles using a Langmuir probe(LP)and the target current(TC).HfO_(2) and ZrO_(2) thin films deposited on fused silica substrates by pulsed laser deposition at various O_(2) pressures for defect and stoichiometry control were irradiated by Gaussian,ultrashort laser pulses(800 nm,10 Hz,70 fs)in a wide range of *** TC and LP collected signals were in good agreement with the existing theoretical description of laser–matter interaction at an ultrashort time *** approach for an in situ LIDT monitoring system provides measurable signals for below-threshold irradiation conditions that indicate the endurance limit of the optical surfaces in the single-shot energy scanning *** LIDT value extracted from the LP-TC system is in line with the multipulse statistical analysis done with ISO 21254-2:2011(E).The implementation of the LP and TC as on-shot diagnostic tools for optical components will have a significant impact on the reliability of next-generation ultrafast and high-power laser systems.

关键词： HfO_(2) in situ detection Langmuir probe laser-induced damage threshold target current ZrO_(2)

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Statistical Medical Pattern Recognition for Body Composition Data Using Bioelectrical Impedance Analyzer

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Computers, Materials & Continua 2021年第5期67卷 2601-2617页

作者： Florin valentin Leuciuc Maria Daniela craciun Iulian Stefan Holubiac Mazin Abed Mohammed Karrar Hameed Abdulkareem Gheorghe Pricop Stefan cel Mare University of Suceava Suceava720229Romania The Interdisciplinary Research Center for Human Motricity and Health Sciences Suceava720229Romania College of Computer Science and Information Technology University of AnbarRamadi31001Iraq College of Agriculture Al-Muthanna UniversitySamawah66001Iraq

Identifying patterns,recognition systems,prediction methods,and detection methods is a major challenge in solving different medical *** categories of devices for personal and professional assessment of body composition are *** impedance analyzer is a simple,safe,affordable,mobile,non-invasive,and less expensive alternative device for body composition *** the body composition pattern of different groups with varying age and gender is a major challenge in defining an optimal level because of the body shape,body mass,energy requirements,physical fitness,health status,and metabolic ***,this research aims to identify the statistical medical pattern recognition of body composition data by using a bioelectrical impedance *** previous studies,a pattern was identified for four indicators that concern body composition(e.g.,body mass index(BMI),body fat,muscle mass,and total body water).The novelty of our study is the fact that we identified a recognition pattern by using medical statistical methods for a body composition that contains seven indicators(e.g.,body fat,visceral fat,BMI,muscle mass,skeletal muscle mass,sarcopenic index,and total body water).The youth that exhibited the body composition pattern identified in our study could be considered *** deviation of one or more parameters outside the margins of the pattern for body composition could be associated with health issues,and more medical investigations would be needed for a *** is considered a valid and reliable device to assess body composition along with medical statistical methods to identify a pattern for body composition according to the age,gender,and other relevant parameters.

关键词： Statistical method pattern recognition body composition assessment

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Pulmonary complications of portal hypertension:The overlooked decompensation

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World Journal of Clinical Cases 2022年第17期10卷 5531-5540页

作者： Rares craciun Tudor Mocan Bogdan Procopet Andrada Nemes Cristian Tefas Mihaela Sparchez Lavinia-Patricia Mocan Zeno Sparchez 3^(rd)Medical Clinic Department of Internal Medicine"Iuliu Hatieganu"University of Medicine and PharmacyCluj-Napoca 400162Romania Gastroenterology Clinic "Prof.Dr.O.Fodor"Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400162Romania Intensiv Care Unit I Cluj County Emergency HosptialCluj-Napoca 400006Romania 2^(nd)Paediatric Clinic "Iuliu Hatieganu"University of Medicine and PharmacyCluj-Napoca 400126Please enter the state or provinceRomania Department of Histology "Iuliu Hatieganu"University of Medicine and PharmacyCluj-Napoca 400349Romania

The systemic nature of cirrhosis and portal hypertension has long been recognized,and the amount of data characterizing the interplay between each system is becoming ever so *** involvement was among the first described associated entities in cirrhosis,with reports dating back to the late nineteenth ***,it appears that throughout the years,interest in the pulmonary complications of portal hypertension has generally faded,especially in contrast to other decompensating events,as expertise in this field has primarily been concentrated in highly experienced tertiary care facilities and liver transplantation *** affecting up to 10%-15%of patients with advanced liver disease and having a proven prognostic impact,hepato-pulmonary syndrome,porto-pulmonary hypertension,and hepatic hydrothorax are frequently misdiagnosed,mistreated,or *** lack of precision might adversely impact patient care,referral to expert centers,and,ultimately,liver disease-related mortality and successful transplantation *** present minireview aims to increase awareness of the pulmonary complications of chronic liver disease by providing a brief overview of each of the three *** paper focuses on the essential theoretical aspects,addressing the most critical knowledge gaps on the one hand and,on the other hand,critically discussing one key issue for each complication.

关键词： Hepato-pulmonary syndrome Porto-pulmonary hypertension Hepatic hydrothorax Cirrhosis Portal hypertension Advanced liver disease

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Viscoelastic tests in liver disease: where do we stand now?

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World Journal of Gastroenterology 2021年第23期27卷 3290-3302页

作者： Alina Buliarca Adelina Horhat Tudor Mocan Rares craciun Bogdan Procopet Zeno Sparchez The Third Medical Department “Iuliu Hatieganu”University of Medicine and PharmacyInstitute for Gastroenterology and Hepatology“Prof.Dr.O.Fodor”Cluj-Napoca 400162Romania

Hemostasis is a complex physiological process based on the balance between procoagulant and anticoagulant systems to avoid pathological bleeding or *** changes in standard coagulation tests in liver disease were assumed to reflect an acquired bleeding disorder,and cirrhotic patients were considered naturally *** the light of the new evidence,the theory of rebalanced hemostasis replaced the old *** to this model,the hemostatic alteration leads to a unique balance between pro-coagulant,anticoagulant,and fibrinolytic *** the balance is fragile and may prone to bleeding or thrombosis depending on various risk *** standard coagulation tests[INR(international normalized ratio),platelet count and fibrinogen]only explore parts of the hemostasis,not offering an entire image of the *** thromboelastometry(ROTEM)and thromboelastography(TEG)are both point of care viscoelastic tests(VET)that provide real-time and dynamic information about the entire hemostasis process,including clot initiation(thrombin generation),clot kinetics,clot strength,and clot stability(lysis).Despite prolonged PT/INR(international normalized ratio of prothrombin time)and low platelet counts,VET is within the normal range in many patients with both acute and chronic liver ***,bleeding remains the dominant clinical issue in patients with liver diseases,especially when invasive interventions are *** has been shown to asses more appropriately the risk of bleeding than conventional laboratory tests,leading to decrial use of blood products *** clotting is common but often subtle and may be challenging to predict even with the help of *** VET has shown its benefit,more studies are needed to establish cut-off values for TEG and ROTEM in these populations and standardization of transfusion guidelines before invasive interventions in cirrhotic patients/orthotopic liver transplantation.

关键词： Liver diseases Viscoelastic tests Portal vein thrombosis Acute-on-chronic liver failure Bleeding risk Invasive procedures

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Endoscopic or percutaneous biliary drainage in hilar cholangiocarcinoma:When and how?

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2050-2063页

作者： Tudor Mocan Adelina Horhat Emil Mois Florin Graur Cristian Tefas Rares craciun Iuliana Nenu Mihaela Spârchez Zeno Sparchez Third Medical Department "Iuliu Hatieganu"University of Medicine and PharmacyCluj-Napoca 400162Romania Institute for Gastroenterology and Hepatology Cluj-Napoca 400162Romania Second Pediatric Department University of Medicine and Pharmacy"Iuliu Hatieganu"Cluj-Napoca 400162Romania

Hilar cholangiocarcinoma (hCCA) is a primary liver tumor associated with a dimprognosis. The role of preoperative and palliative biliary drainage has long beendebated. The most common techniques are endoscopic retrograde cholangiopancreatography(ERCP) and percutaneous transhepatic biliary drainage (PTBD);however, recently developed endoscopic ultrasound-assisted methods are gainingmore atention. Selecting the best available method in any specific scenario iscrucial, yet sometimes challenging. Thus, this review aimed to discuss theavailable techniques, indications, perks, pitfalls, and timing-related issues in themanagement of hCCA. In a preoperative setting, PTBD appears to have someadvantages: low risk of postprocedural complications (namely cholangitis) andbetter priming for surgery. For palliative purposes, we propose ERCP/PTBDdepending on the experience of the operators, but also on other factors: the levelof bilirubin (if very high, rather PTBD), length of the stenosis and the presence ofcholangitis (PTBD), ERCP failure, or altered biliary anatomy.

关键词： Hilar cholangiocarcinoma Endoscopic biliary drainage Percutaneous biliary drainage Endoscopic ultrasound biliary drainage Surgical oncology

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Combined treatments in hepatocellular carcinoma:Time to put them in the guidelines?

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 1896-1918页

作者： Zeno Sparchez Pompilia Radu Adrian Bartos Iuliana Nenu Rares craciun Tudor Mocan Adelina Horhat Mihaela Spârchez Jean-François Dufour 3^(rd)Medical Department “Ïuliu Hatieganu”University of Medicine and PharmacyInstitute for Gastroenterology and HepatologyCluj-Napoca 400162Romania Department of Visceral Surgery and Medicine HepatologyInselspitalBern University HospitalUniversity of BernBern 3010Switzerland Department of Surgery “Ïuliu Hatieganu”University of Medicine and PharmacyInstitute for Gastroenterology and HepatologyCluj-Napoca 400162Romania Department of Mother and Child 2nd Paediatric Clinic“Ïuliu Hatieganu”University of Medicine and PharmacyCluj-Napoca 400177Romania Department for BioMedical Research HepatologyUniversity of BernBern 3008Switzerland

The time for battling cancer has never been more suitable than nowadays and fortunately against hepatocellular carcinoma(HCC)we do have a far-reaching ***,because liver cancer comprises a plethora of stages-from very early to advanced disease and with many treatment options–from surgery to immunotherapy trials–it leaves the clinician a wide range of *** scope of our review is to throw light on combination treatments that seem to be beyond guidelines and to highlight these using evidence-based analysis of the most frequently used combination therapies,discussing their advantages and flaws in comparison to the current standard of *** particular combination therapy seems to be in the forefront:Transarterial chemoembolization plus ablation for medium-size non-resectable HCC(3-5 cm),which is currently at the frontier between Barcelona Clinic Liver Cancer classification A and *** only does it improve the outcome in contrast to each individual therapy,but it also seems to have similar results to ***,the abundance of immune checkpoint inhibitors that have appeared lately in clinical trials are bringing promising results against *** the path of combination therapies in HCC is still filled with uncertainty and caveats,in the following years the hepatology and oncology fields could witness an HCC guideline revolution.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Radiofrequency ablation Microwave ablation Systemic therapy Immunotherapy combined treatments

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Transcriptional output, cell-type densities, and normalization in spatial transcriptomics

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Journal of Molecular Cell Biology 2020年第11期12卷 906-908页

作者： Manuel Saiseletlft Joel Rodrigues-Vitoria Adrien Tourneur Ligia craciun Alex Spinette Denis Larsimont Guy Andry Joakim Lundeberg Carine Maenhaut Vincent Detours IRIBHM Universite Libre de Bruxelles(ULB)1070 BrusselsBelgium Department of Pathology jules Bordet InstituteUniversite Libre de Bruxelles(ULB)1000 BrusselsBelgium Department of Head&Neck and Thoracic Surgery Jules Bordet InstituteUniversite Libre de Bruxelles(ULB)1000 BrusselsBelgium Science for Life Laboratory Department of Gene TechnologyKTH Royal Institute of TechnologySE-10691 StockholmSweden Department of Bioengineering Stanford UniversityStanfordCA 94305-4245USA

Dear Editor,Spatial transcriptomics(ST)makes it possible to perform RNA-seq at hundreds of precisely located spots on the surface of a histological slice(Stahl et al.,2016).Since mRNA diffusion is minimal during tissues permeabilization and mRNA capture,the transcriptome of each spot is thought to aggregate the transcriptomes of the cells it contains.

关键词： al. histological hundreds

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Malnutrition and non-compliance to nutritional recommendations in patients with cirrhosis are associated with a lower survival

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World Journal of Hepatology 2020年第10期12卷 829-840页

作者： Dana Crisan Bogdan Procopet Alexandra Epure Horia Stefanescu Alina Suciu Andreea Fodor Emil Mois Rares craciun Nicolae Crisan Internal Medicine Department “Iuliu Hatieganu”University of Medicine and PharmacyCluj-Napoca 400126Romania 3rd Medical Clinic “Iuliu Hatieganu”University of Medicine and PharmacyCluj-Napoca 400126Romania Hepatology Unit “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400162Romania Surgery Department “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400126Romania Hepatology Unit “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400126Romania

BACKGROUND Malnutrition is frequently encountered in patients with cirrhosis and appears to significantly impact their *** evaluating the burden of malnutrition in cirrhosis is gathering momentum,as suggested by multiple recently published reports,there is still a persistent scarcity of solid data in the field,especially with regards to the role of nutritional *** To assess the prevalence of malnutrition in patients with advanced cirrhosis and to evaluate its impact on *** One hundred and one consecutive patients with advanced cirrhosis were screened for malnutrition using the Subjective Global Assessment(SGA)criteria and the mid-arm circumference(MAC).Malnutrition was defined as SGA class B and C and MAC<10th *** patients were interviewed regarding their food intake using an adapted ***,total energy intake was calculated and further subdivided in main *** data were then compared to the available recommendations at the time of analysis to assess *** 54/79 patients(68.4%)in the decompensated group had malnutrition,while only 3/22 patients(13.6%)were malnourished in the compensated *** a median follow-up time of 27 mo(0-53),the overall mortality was 70%.Survival was significantly lower among patients with *** mortality rates were 50%at 1 year and 63%at 2 years for the patients with malnutrition,compared to 21%at 1 year and 30%at 2 years for patients without malnutrition(P=0.01).On multivariate analysis,the factors independently associated with mortality were age,creatinine level and adherence to the protein intake *** mortality was lower in patients with the appropriate protein intake:8%at 1 year and 28%at 2 years in the adherent group,compared to 47%at 1 year and 56%at 2 years in the non-adherent *** The prevalence of malnutrition is high among patients with advanced cirrhosis and might be related in part to a low adherenc

关键词： Malnutrition Decompensated cirrhosis Survival Subjective global assessment Protein intake

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Graphene electronic fibres with touch-sensing and lightemitting functionalities for smart textiles

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npj Flexible Electronics 2018年第1期2卷 231-236页

作者： Elias Torres Alonso Daniela P.Rodrigues Mukond Khetani Dong-Wook Shin Adolfo De Sanctis Hugo Joulie Isabel de Schrijver Anna Baldycheva Helena Alves Ana I.S.Neves Saverio Russo Monica F.craciun Centre for Graphene Science College of EngineeringMathematics and Physical SciencesUniversity of ExeterEX44QL ExeterUnited Kingdom Department of Physics and CICECO University of Aveiro3819-130 AveiroPortugal Centexbel Technologiepark-Zwijnaarde 79052 GhentBelgium Department of Physics Instituto Superior TécnicoUniversity of LisbonAv.Rovisco Pais 11040-001 LisbonPortugal

The true integration of electronics into textiles requires the fabrication of devices directly on the fibre itself using high-performance materials that allow seamless incorporation into *** electronics and opto-electronics,attained by intertwined fibres with complementary functions are the emerging and most ambitious technological and scientific *** we demonstrate graphene-enabled functional devices directly fabricated on textile fibres and attained by weaving graphene electronic fibres in a *** touch-sensors and light-emitting devices were produced using a roll-to-roll-compatible patterning technique,opening new avenues for woven textile ***,the demonstration of fabric-enabled pixels for displays and position sensitive functions is a gateway for novel electronic skin,wearable electronic and smart textile applications.

关键词： textiles smart functional

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Risk management in radiology departments

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World Journal of Radiology 2015年第6期7卷 134-138页

作者： Horea craciun Kshitij Mankad Jeremy Lynch University Hospitals of Morecambe Bay NHS Trust Great Ormond Street Hospital for Children NHS Trust Chelsea Westminster Hospital NHS Trust

Medical imaging and interventional radiology sustained prompt changes in the last few years, mainly as aresult of technology breakthroughs, rise in workload, deficit in workforce and globalization. Risk is considered to be the chance or possibility of incurring loss or of a negative event happening that may cause injury to patients or medical practitioners. There are various causes of risks leading to harm and injury in radiology departments, and it is one of the objectives of this paper to scrutinize some of the causes. This will drive to consideration of some of the approaches that are used in managing risks in radiology. This paper aims at investigating risk management in radiology, and this will be achieved through a thorough assessment of the risk control measures that are used in the radiology department. It has been observed that the major focus of risk management in such medical setting is to reduce and eliminate harm and injury to patients through integration of various medical precautions. The field of Radiology is rapidly evolving due to technology advances and the globalization of healthcare. This ongoing development will have a great impact on the level of quality of care and service delivery. Thus, risk management in radiology is essential in protecting the patients, radiologists, and the medical organization in terms of capital and widening of the reputation of the medical organization with the patients.

关键词： Risk management Radiology Patient safety

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