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Characterization of inflammation and insulin resistance in high-fat diet-induced male C57BL/6J mouse model of obesity

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Animal Models and Experimental Medicine 2019年第4期2卷 252-258页

作者： Dimiter Avtanski valentin a.pavlov Kevin J.Tracey Leonid Poretsky Lenox Hill Hospital Friedman Diabetes InstituteNorthwell HealthNew YorkNYUSA The Feinstein Institutes for Medical Research Northwell HealthManhassetNYUSA Donald and Barbara Zucker School of Medicine at Hofstra/Northwell HempsteadNYUSA

Background: Animal models of diet-induced obesity(DIO) are commonly used in medical research for mimicking human diseases. There is no universal animal model, and careful evaluation of variety of factors needs to be considered when designing new experiments. Here, we investigated the effect of 9 weeks high-fat diet(HFD) intervention, providing 60% energy from fat, on parameters of inflammation and insulin resistance in male C57 BL/6 J ***: Six weeks old mice were initiated on regular diet(RD) or HFD providing 60 kcal energy from fat for 9 weeks. Fasting blood glucose levels were measured by glucometer, and fasting plasma levels of insulin and proinflammatory cytokines by Luminex assay. Insulin sensitivity was evaluated by using QUICKI and HOMA2 ***: HFD mice showed ~ 40% higher body weight and ~ 20% larger abdominal circumference, due to an increase in the white adipose tissue mass. Liver examination revealed increased size and higher hepatic lipid accumulation in livers from HFD mice compared to their RD counterparts. Animals from the HFD group were characterized with significantly higher presence of crown-like structures(CLS) in WAT and higher plasma levels of proinflammatory cytokines(TNF-α, IL-6, leptin, MCP-1, PAI-1, and resistin). HFD-fed mice also demonstrated impaired insulin sensitivity(lower QUICKI, higher HOMA-insulin resistance(HOMA-IR), and lower HOMA-percent sensitivity(HOMA-%S)) index ***: Male C57 BL/6 J mice on 9 weeks HFD providing 60 kcal energy from fat display impaired insulin sensitivity and chronic inflammation, thus making this DIO mouse model appropriate for studies of early stages of obesity-related pathology.

关键词： diet high‐fat insulin resistance mouse model

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Development and testing of a high-power S-band klystron at BINP SB RAS

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Nuclear Science and Techniques 2024年第7期35卷 58-67页

作者： A.Levichev A.Barnyakov S.Samoylov D.Nikiforov V.Ivanov M.Arsentyeva D.Chekmenev O.pavlov I.Pivovarov Budker Institute of Nuclear Physics Lavrentyeva Av.11NovosibirskRussia630090 Novosibirsk State University Pirogova Str.2NovosibirskRussia630090

This paper details the development and testing of the first working prototype of the S-band high-power klystron,accomplished at the Budker Institute of Nuclear Physics,Siberian Branch,Russian Academy of Sciences(BINP SB RAS).Upon testing,the klystron demonstrated the following parameters:an operating frequency of 2856 MHz and a peak power output of 50 *** paper presents the klystron's design,its constituent units,and pertinent processing procedures,along with discussions on the measurement of its parameters.

关键词： Klystron Linear accelerator Electron beam

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Growth of carbon nanotube arrays on various CtxMey alloy films by chemical vapour deposition method

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Journal of Materials Science & Technology 2018年第3期34卷 472-480页

作者： Pawel Mierczynski Sergey V.Dubkov Sergey V.Bulyarskii Alexander a.pavlov Sergey N.Skorik Alexey Yu Trifonov Agnieszka Mierczynska Eugene P.Kitsyuk Sergey A.Gavrilov Tomasz P.Maniecki Dmitry G.Gromov Institute of General and Ecological Chemistry Lodz University of TechnologyZeromskiego 116Lodz 90-924Poland National Research University of Electronic Technology Shokin SquareZelenogradMoscow 124498Russia Institute of Nanotechnology of Microelectronics of the RAS INMEMoscow 11-9991Russia Scientific-Manufacturing Complex'Technological Center' ZelenogradMoscow 124498Russia Scientific Research Institute of Physical Problems named after F V.Lukin Proezd 4806.6ZelenogradMoscow 124460Russia The Australian Wine Research Institute Waite PrecinctHartley Grove cnr Paratoo RoadUrrbrae AdelaideSA 5064Australia

Carbon nanotube （CNT） arrays were fabricated on Ct-Me-N-（O） alloys with content of Ct in the range of 6-40 at.% by chemical vapour deposition. The Ct was a catalytic metal from the group of the following elements： Ni, Co, Fe, Pd, while Me was a transition metal from the group of IV-VII of the periodic table （where Me=Ti, V, Cr, Zr, Nb, Mo, Ta, W, Re）. Carbon nanotubes were found to grow efficiently on the alloy surface with its composition containing Ti, V, Cr, Zr, Hf, Nb or Ta. The growth of CNTs was not observed when the alloy contained W or Re. Additions of oxygen and nitrogen in the alloy facilitated the formation of oxynitrides and catalyst extrusion on the alloy surface. Replacement of the metals in alloy composition affected the diameter of the resulting CNTs. The obtained results showed that the alloy films of varying thickness （10-500 nm） may be used for the CNTs growth. The resulting CNT material was highly homogenous and its synthesis reproducible.

关键词： Carbon nanotubes Amorphous alloys Chemical vapour deposition Catalytic processes Thin films

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Trapping the Short-Chain Odd Carbon Number Olefins Using Nickel(Ⅱ)-Catalyzed Tandem Ethylene Oligomerization and Friedel-Crafts Alkylation of Toluene

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Chinese Journal of Chemistry 2023年第21期41卷 2855-2865页

作者： Sergey V.Zubkevich Vladislav A.Tuskaev Svetlana Ch.Gagieva Alexander a.pavlov Victor N.Khrustalev Fei Wang Li Pan Yuesheng Li Daniele Saracheno Anton A.Vikhrov Dmitry N.Zarubin Boris M.Bulychev Department of Chemistry Lomonosov Moscow State UniversityLeninskie Gory 1Moscow119991 Russian Federation Materials Research and Technology Department Luxembourg Institute of Science and Technology5Avenue des Hauts-FourneauxL-4362 Esch-sur-AlzetteLuxembourg A N Nesmeyanov Institute of Organoelement Compounds Russian Academy of SciencesVavilova st.28Moscow119991 Russian Federation BMSTU Center of National Technological Initiative“Digital Material Science:New Material and Substances” Bauman MoscowState Technical University2nd Baumanskaya st.5MoscowRussian Federation Peoples’Friendship University of Russia(RUDN University) Miklukho-Maklay St.6Moscow117198 Russian Federation Zelinsky Institute of Organic Chemistry Russian Academy of SciencesLeninsky Prospekt 47Moscow119991 Russian Federation Institute of Advanced Polymer Materials School of Materials Science and EngineeringTianjin UniversityTianjin300350 China

Nickel(Ⅱ)complexes with pyrazole-based ligands are widely employed in catalysis of ethylene oligomerization and subsequent Friedel-Crafts alkylation of *** have prepared ten new nickel(Ⅱ)dibromide complexes with various substituted bis(azolyl)*** have been characterized using^(1)H NMR,IR,high resolution mass spectrometry and elemental *** structures of three complexes have been unambiguously established using X-ray *** was found that these complexes in the presence of Et2AlCl or Et_(3)Al_(2)Cl_(3)are active both in ethylene oligomerization and Friedel-Crafts alkylation processes(activity up to 3720 kgoligomer·mol[Ni]^(−1)·h^(−1)).The use of Et_(3)Al_(2)Cl_(3)results in a higher share of alkylated products(up to 60%).Moreover,catalytic systems activated with Et_(3)Al_(2)Cl_(3)produced small amounts of odd carbon number olefins(up to 0.8%).The Friedel-Crafts alkylation was used as a trap for previously undetected short-chain odd carbon number olefins(C_(3)and C_(5)).

关键词： Ethylene oligomerization Friedel-Crafts alkylation Nickel(Ⅱ)complexes N-ligands Odd carbon number olefins

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PEP06 polypeptide 30 is a novel clusterdissociating agent inhibiting αv integrin/FAK/Src signaling in oral squamous cell carcinoma cells

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Acta Pharmaceutica Sinica B 2019年第6期9卷 1163-1173页

作者： Gulnara Tuguzbaeva Er Yue Xi Chen Lina He Xinlei Li Jiaming Ju Ying Qin valentin pavlov Yanjie Lu Wenting Jia Yunlong Bai Yumei Niu Baofeng Yang Central Laboratory of Scientific Research Bashkir State Medical UniversityUfa 450008Russian Federation Department of Pharmacology(State-Province Key Laboratories of BiomedicineePharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbin 150081China Department of Endodontics the First Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Department of Orthopedic Dentistry and Maxillofacial Surgery Bashkir State Medical UniversityUfa 450008Russian Federation

Collectively migrating tumor cells have been recently implicated in enhanced metastasis of epithelial *** oral squamous cell carcinoma(OSCC),av integrin is a crucial mediator of multicellular clustering and collective movement in vitro;however,its contribution to metastatic spread remains to be *** to the emerging therapeutic concept,dissociation of tumor clusters into single cells could significantly suppress metastasis-seeding ability of *** study aimed to investigate the anti-OSCC potential of novel endostatin-derived polypeptide PEP06 as a clusterdissociating therapeutic agent in ***,we found marked enrichment ofαv integrin in collectivelyinvading multicellular clusters in human *** study revealed that metastatic progression of OSCC was associated with augmented immunostaining of av integrin in cancerous *** PEP06treatment,cell clustering on fibronectin,migration,multicellular aggregation,anchorage-independent survival and colony formation of OSCC were significantly ***,PEP06 suppressed av integrin/FAK/Sre signaling in OSCC ***06-induced loss of active Src and E-cadherin from cell-cell contacts contributed to diminished collective migration of OSCC in ***,these results suggest that PEP06 polypeptide 30 inhibiting av integrin/FAK/Src signaling and disrupting E-cadherin-based intercellular junctions possesses anti-metastatic potential in OSCC by acting as a cluster-dissociating therapeutic agent.

关键词： Oral squamous cell carcinoma Tumor cell clusters Collective migration Metastasis αv integrin/FAK/RC signaling RGD

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Modulating the growth of cysteine-capped cadmium sulfide quantum dots with enzymatically produced hydrogen peroxide

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Nano Research 2017年第6期10卷 1932-1941页

作者： Ruta Grinyte Javier Barroso Laura Saa Valeri pavlov Biosensing Unit CIC BiomaGUNE Parque Tecnologico de San Sebastian Paseo Miramon 182 Donostia-San Sebastian 20014 Spain

Cysteine （CSH） readily stabilizes cadmium sulfide quantum dots （CdS QDs） that grow in aqueous buffered solutions. The oxidation of CSH by hydrogen peroxide （H202） at room temperature yields cystine （CSSC）, which is less efficient in stabilizing CdS QDs compared to CSH. Herein, we demonstrate that such oxidation causes a decrease in the formation rate of CSH-capped CdS QDs from Cd^2＋ and S^2- ions. For the first time, we combined the oxidation of CSH with the glucose oxidase （GOx）-assisted biocatalytic oxidation of D-glucose, which leads to a buildup of H2O2 in the reaction mixture. The enzymatically modulated in situ growth of CdS QDs was monitored using two techniques： fluorescence spectroscopy and photoelectrochemical （PEC） analysis. This system enables quantification of GOx and glucose in human serum.

关键词： quantum dots photoelectrochemistry enzyme fluorescence hydrogen peroxide

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Using a needle for sacrospinous ligament fixation for pelvic organ prolapse based on the Miyazaki technique

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Gynecology and Obstetrics Clinical Medicine 2022年第2期2卷 82-85页

作者： Ilnur Irekovich Musin Alfiya Galimovna Yashchuk valentin Nikolaevich pavlov Jianliu Wang Xiuli Sun Raisa Arkadevna Naftulovich Elena Mikhailovna Popova Federal State Budgetary Educational Institution of Higher Education Bashkir State Medical University of the Ministry of Health of the Russian Federation Lenina 3UfaRepublic of Bashkortostan450008Russia Department of Obstetrics and Gynecology Peking University People's Hospital11th Xizhimen South StreetXicheng DistrictBeijing100044China

Background:Approximately 7%of all women will require surgery to correct pelvic organ prolapse during their *** these,approximately 10%-13%will require another operation within 5 years due to recurrence of the *** in life expectancy and elderly individuals with estrogen deficiencies will mean higher rates of pelvic organ prolapse,significantly reducing the quality of life for millions of *** study introduces technologies that can help treat pelvic prolapse while reducing the rate of ***:This paper outlines how to properly perform sacrospinous ligament fixation using the Miyazaki ***:A needle was used to successfully perform a sacrospinous ligament fixation using Miyazaki's ***:Considering the Food and Drug Administration’s 2019 decision to permit surgeries with native tissue,this method can be used with sacrospinous ligament fixation as the primary treatment option for pelvic organ prolapse.

关键词： Pelvic organ prolapse Sacrospinous ligament fixation Sacrocolpopexy Pelvic surgery

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A third superchron during the Early Paleozoic

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Episodes 2005年第2期28卷 78-84页

作者： V.pavlov Y.Gallet DepartmentoftheMainGeomagnetic.Field InstituteofPhysicsofthe.EarthMoscow：Russia／／LaboratoiredePaléomagnétismeInstitutdePhysiqueduGlobedePansFrance LaboratoiredePaléomagnétisme InstitutdePhysiqueduGlobedePansFrance

Research on geomagnetic reversal chronology has established the existence of two superchrons, one during the Cretaceous and the other (Kiaman) during the Late *** the past few years, we have performed several magnetostratigraphic studies on Early Paleozoic (Cambrian and Ordovician) sedimentary sequences from Siberia. Our results show high magnetic reversal frequencies during the Middle Cambrian. In contrast, several records show the occurrence of a -20 Myr long reversed polarity interval in the Lower and Middle Ordovician, suggesting the presence of a third superchron. We propose to give the name of “Moyero” to this new superchron; this name is attributed to the Siberian section which first yielded a complete record of this reversed polarity interval.

关键词：古生代地磁反演地质年代学白垩纪沉积序列

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Experimental study of a low-pressure hybrid RF discharge

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Plasma Science and Technology 2020年第5期22卷 70-82页

作者： Elena KRALKINA Polina NEKLIUDOVA Vladimir pavlov Konstantin VAVILIN Ilya ZADIRIEV and Chen ZHAO Physical Electronics Department Faculty of PhysicsLomonosov Moscow State University119991 MoscowRussia

Experimental study of the low-pressure hybrid RF discharge with both inductive and capacitive channels was carried out. The RF power unit consists of inductor(antenna) and capacitor plates connected in parallel to the same RF power source. A separating capacitor Csepis included into the circuit between the antenna ends and the lead connected to the discharge capacitor plate in order to prevent the closing of the capacitive circuit through direct current by inductor and to control the contribution of capacitive channel to discharge sustaining. It is shown that at low power of the RF power source, power coupling to the discharge mainly occurs through the capacitive channel. Increasing the power of the RF power source increases the power coupled in the inductive channel, electron density, and current flowing through the capacitive channel. This leads to increasing voltage drop on the separating capacitor and partial cutoff of the capacitive channel. At separating capacitance values below certain value(below 50 pF in the present experiments), the self-bias of the loaded plate of the discharge capacitor becomes positive indicating that the thickness of the electrode sheath of the loaded electrode decreases compared to thickness of the sheath of the grounded electrode. The thickness of the space-charge sheath of the grounded electrode decreases with increasing power coupled to the plasma. At separating capacitance below 50 pF, higher harmonics of the RF voltage and current are actively generated in the capacitive discharge channel. Increasing the separating capacitance leads to decreasing electron density, increasing effective electron temperature and more effective RF energy coupling to plasma due to increasing relative importance of the capacitive discharge channel.

关键词： radio-frequency discharge plasma E-mode H-mode

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Laser speckle imaging and wavelet analysis of cerebral blood flow associated with the opening of the blood–brain barrier by sound

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Chinese Optics Letters 2017年第9期15卷 2-6页

作者： O.Semyachkina-Glushkovskaya A.Abdurashitov a.pavlov A.Shirokov N.Navolokin O.pavlova A.Gekalyuk M.Ulanova N.Shushunova A.Bodrova E.Saranceva A.Khorovodov I.Agranovich V.Fedorova M.Sagatova A.E.Shareef C.Zhang D.Zhu V.Tuchin Saratov National Research State University Saratov 410012Russia Yuri Gagarin State Technical University of Saratov Saratov 410054Russia Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of SciencesSaratov 410049Russia Saratov State Medical University Saratov 410012Russia Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics(WNLO)Huazhong University of Science and Technology(HUST)Wuhan 430074China Key Laboratory for Biomedical Photonics HUSTMinistry of EducationWuhan 430074China National Research Tomsk State University Tomsk 634050Russia Institute of Precision Mechanics and Control Russian Academy of SciencesSaratov 410028Russia

The cerebral blood flow（CBF） alterations related to sound-induced opening of the blood–brain barrier（BBB） in adult mice are studied using laser speckle contrast imaging（LSCI） and wavelet analysis of vascular *** results clearly show that the opening of the BBB is accompanied by the changes of venous but not microvessel circulation in the brain. The elevation of the BBB permeability is associated with the decrease of venous CBF and the increase of its complexity. These data suggest that the cerebral veins rather than microvessels are sensitive components of the CBF related to the opening BBB.

关键词： BBB Laser speckle imaging and wavelet analysis of cerebral blood flow associated with the opening of the blood brain barrier by sound

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