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Combined Oxidative Phosphorylation Deficiency-20-Exome as a Diagnostic Implement

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Journal of Biosciences and Medicines 2024年第6期12卷 7-12页

作者： Paulo Roberto Matos-Neto Lucas Antonissen Lima Verde Airton Ferreira da Ponte-Filho Luís Eduardo Oliveira Matos Amandha Espavier Trés Paulo Roberto lacerda Leal Gerardo Cristino-Filho Regina Coeli de Carvalho Porto Carneiro Faculty of Medicine Federal University of Cear Sobral Cear Brazil Department of Neurosurgery Federal University of Cear Sobral Cear Brazil Department of Neuropediatrics Federal University of Cear Sobral Cear Brazil

Mitochondrial disorders are phenotypically varied, with serious clinical repercussions. Among them, there is the deficiency of combined oxidative phosphorylation of type 20, which occurs due to a defect in the VARS2 gene. This article presents a case of a 2-year-old female with progressive myoclonic epilepsy and psychomotor regression, with refractoriness to multiple anticonvulsants. The diagnosis was only made after the examination was carried out. Therefore, this article highlights the aspects of this rare disease and the importance of the exome for the diagnosis of rare conditions.

关键词： Oxidative Phosphorylation Epilepsy Exome Mitochondrial Defect VARS2

Arrested development? Investigating the role of bamboo in Araucaria Forest succession in Southern Brazil

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Journal of Plant Ecology 2019年第6期12卷 1034-1046页

作者： Betina Kellermann AndréEduardo Biscaia lacerda EMBRAPA Forestry Brazilian Agriculture Research CorporationEstrada da Ribeirakm 111Caixa Postal 319Colombo 83411-000PRBrazil

Aims Assessing the role of a dominant native bamboo species on tree species diversity and structure in the medium *** Over a 7-year period,we studied the natural regeneration of two dominant forest types in Southern Brazil(Araucaria Forest or AF;Bamboo Forest or BF)after a bamboo(Merostachys skvortzovii Send.)die-off between 2004 and *** study was carried out in the Embrapa Research Station in Cacador,Santa Catarina State,*** Findings The die-off provided ideal conditions for the establishment of several species and it kickstarted forest succession dynamics,which in turn affected regeneration *** species richness was relatively stable with a transitory increase between 2007 and 2014 in both AF and ***,species richness rose in BF because of a relative increase in abundance of some species(especially late and secondary species)while a plunge in some pioneer species drove an increase in ***,we found that BF has a lower diversity of recruits and that density declined over time,while AF is more diverse,with a more stable *** BF,the bamboo die-off created optimal conditions for initial regeneration development(mainly fast-growing pioneer trees),which quickly transited to higher size ***,after this initial stage of pioneer recruitment,the number of recruits dropped followed by a virtual absence of growth regardless of the species group as a result of a quick bamboo *** bamboo recreated a dense understory it reduced species diversity to original levels,suggesting a self-maintaining cycle that halts forest *** the other hand,the bamboo die-off had little impact on AF where a slow recruitment process typical of old-growth forests was *** results indicate that the die-off event had a temporary effect on species diversity *** to forests where bamboos are dominant in a similar process described in other southern South American *** the first study to obser

关键词： dominant species Merostachys skvortzovii Send. forest succession biodiversity forest regeneration

Effect of Pressure on Intermediate Valence States in Cerium Kondo Compounds

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Journal of Rare Earths 2004年第1期22卷 7-12页

作者： Oomi G Kagayama T Smith J L lacerda A H Kaji S Ohashi M Department of Physics Kyushu University Ropponmatsu Fukuoka 810-8560 Japan Department of Mechanical Engineering and Materials Sciences Kumamoto University Kumamoto 860-8555 Japan Materials Science and Technology Los Alamos National Laboratory Los Alamos NM 87545 USA

Electrical resistance, thermal expansion, lattice constants of the intermediate valence materials, α-Ce and CeBe 13, were measured at high pressure. It is found that the Grüneisen parameters of Kondo temperature T K are 13 and 42 for α-Ce and CeBe 13, respectively, and it decreases with increasing pressure. The magnetoresistance of α-Ce shows H2 dependence and its coefficient increases with pressure below 1 GPa, but becomes nearly constant above 1 GPa. The results indicate that the intermediate valence states are enhanced at high pressure indicating the enhancement of hybridization between the 4f electron and conduction band.

关键词： condensel physics intermediate valence materials cerium rare earths

Multi-objective forest harvesting under sustainable and economic principles

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林业研究:英文版 2023年第5期34卷 1379-1394页

作者： Talles Hudson Souza lacerda Luciano Cavalcante de Jesus Franca Isáira Leite e Lopes Sammilly Lorrayne Souza lacerda Evandro OrfanóFigueiredo Bruno Henrique Groenner Barbosa Carolina Souza Jarochinski e Silva Lucas Rezende Gomide Suzano SA Sao JoséDos CamposSao PauloBrazil Institute of Agricultural Sciences Federal University of Uberlandia–UFUMonte CarmeloMinas GeraisBrazil Department of Forest Sciences Federal University of Lavras–UFLALavrasMinas GeraisBrazil Brazilian Agricultural Research Corporation–EMBRAPA Rio BrancoAcreBrazil Department of Systems and Automation Federal University of Lavras–UFLALavrasMinas GeraisBrazil

Selective logging is well-recognized as an effective practice in sustainable forest ***,the ecological efficiency or resilience of the residual stand is often in *** time depends on operational variables,diversity,and forest *** logging is excellent but is open to *** may be resolved by mathematical programming and this study integrates the economic-ecological aspects in multi-objective function by applying two evolutionary *** function maximizes remaining stand diversity,merchantable logs,and the inverse of distance between trees for harvesting and log landings *** Brazilian rainforest database(566 trees)was used to simulate our 216-ha *** log landing design has a maximum volume limit of 500 *** nondominated sorting genetic algorithm was applied to solve the main optimization *** parallel,a sub-problem(p-facility allocation)was solved for landing allocation by a genetic *** frontier analysis was applied to distinguish the gradientsα-economic,β-ecological,andγ-*** expected,the solutions have high diameter changes in the residual stand(average removal of approximately 16 m^(3) ha^(-1)).All solutions showed a grouping of trees selected for harvesting,although there was no formation of large clearings(percentage of canopy removal<7%,with an average of 2.5 ind ha^(-1)).There were no differences in floristic composition by preferentially selecting species with greater frequency in the initial stand for *** implies a lower impact on the demographic rates of the remaining *** methodology should support projects of reduced impact logging by using spatial-diversity information to guide better practices in tropical forests.

关键词： Amazon rainforest management Computational intelligence Multi-objective functions Evolutionary computing

X-ray-induced radiophotodynamic therapy （RPDT） using lanthanide micelles： Beyond depth limitations

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Nano Research 2015年第7期8卷 2373-2379页

作者： Slavka Kascakova Alexandre Giuliani Sara lacerda Agnes Pallier Pascal Mercere eva Toth Matthieu Refregiers Synchrotron SOLEIL L'Orme des Merisiers 91190 Gif-sur-Yvette France Universite Paris-Sud XI UMR-S I 193 94800 Villejuif France INRA UAR 1008 Caracterisation et elaboration des Produits Issus de I'Agriculture 44316 Nantes France Centre de Biophysique Moleculaire CNRS Rue Charles Sadron 45071 Orleans Cedex 2 France

We report lanthanide-based micelles integrating hypericin （Hyp） for X-ray- triggered photodynamic therapy （PDT）. The lanthanide luminescence induced by X-ray irradiation excites the photosensitizer, which leads to the generation of singlet oxygen. This versatile approach can be extended to other photosensitizers or other types of liponanoparticles and can allow for magnetic resonance imaging （MRI） guidance.

关键词： photodynamic therapy liponanoparticles,x-ray deep tumour photosensitizer

Environmental parameters and tree physiology in two semiarid land use systems in Brazil

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Journal of Forestry Research 2019年第2期30卷 397-407页

作者： Marlete Moreira Mendes Ivanov Claudivan Feitosa de lacerda Francisco Eden Fernandes Paiva Ana Clara Rodrigues Cavalcante Teogenes Senna de Oliveira Departamento de Biologia Universidade Federal do Piaui Departamento de Engenharia Agricola Campus do PiciUniversidade Federal do Ceara Embrapa Caprinos e Ovinos Departamento de Solos Universidade Federal de Vicosa

To determine if reduced tree densities(number of trees per unit area) lead to changes in micro-meteorological and tree physiological characteristics, two areas with different tree densities were assessed. One was an agrosilvopastoral system(AGP) with low tree density, and the other, a secondary forest(SF) with greater tree numbers, both located in a semiarid region of Brazil. Data were collected simultaneously by two automated weather stations: rainfall, air(T_a) and soil temperatures(T_(s5 cm)), relative humidity(RHair), photosynthetically active radiation(PAR), soil moisture at two depths(M_(s30 cm)and M_(s50 cm)),and wind velocity(Vw). Net photosynthesis in Cordia oncocalyx Allema?o trees was measured with an infrared gas analyzer in February, March, May, July, August and September 2011, which encompasses a rainy period followed by a dry period. Average values of Ta, T_(s5 cm), Vwand PAR were greater and average values of RHairand M_(s50 cm) were lesser in the AGP. Photosynthetic rates were greater in plants growing under the AGP at the onset of the dry season when Vw, PAR and T_(s5 cm)were greater and M_(s50 cm) was lesser. Photosynthetic rates correlated strongly with physical parameters during the dry season, especially under SF. Differences in tree numbers between AGP and SF led to differences in physical environmental parameters;however, the latter had less influence on photosynthetic rates in C. oncocalyx during the rainy season. During the dry season, all physical parameters had an impact on net photosynthesis under SF but not under AGP. This indicates a certain independence of plants in AGP.

关键词： Agrosilvopastoral system Net photosynthesis Secondary forest Tree density

Wittgenstein and Kuhn on Paradigm

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Journal of Philosophy Study 2012年第6期2卷 411-416页

作者： Ines lacerda Arauj o Federal University of Parana

Wittgenstein in Philosophical Investigations and On Certainty develops a revolutionary conception of knowledge, of philosophy of language, and of philosophy of science. Very close to language-games is a concept that is important but did not attract much attention, the one of paradigm. In this paper this concept is analyzed together with notions such as context, use, reference, language-games, reality, science, truth, method, propositions, among others by means of which a new view of epistemology emerges. As for Kuhn, paradigm is his most known notion and his biggest contribution to innovate the history of science. I contrast these two conceptions and conclude that they have different uses, and that some difficulties that emerge from Kuhn＇s concept of paradigm would be dissolved if we take into consideration Witt^enstein＇s aooroaches of language and the uses it has in our life forms.

关键词： epistemology Wittgenstein Kuhn paradigm philosophy of science

Measurement uncertainty in pharmaceutical analysis and its application

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Journal of Pharmaceutical Analysis 2014年第1期4卷 1-5页

作者： Marcus Augusto Lyrio Traple Alessandro Morais Saviano Fabiane lacerda Francisco Felipe Rebello Lourencon Department of Pharmacy Faculty of Pharmaceutical Sciences University of Sao Paulo

The measurement uncertainty provides complete information about an analytical result. This is very important because several decisions of compliance or non-compliance are based on analytical results in pharmaceutical industries. The aim of this work was to evaluate and discuss the estimation of uncertainty in pharmaceutical analysis. The uncertainty is a useful tool in the assessment of compliance or non-compliance of in-process and final pharmaceutical products as well as in the assessment of pharmaceutical equivalence and stability study of drug products.

关键词： Measurement uncertainty Method validation Pharmaceutical analysis Quality control

Integrating Informal and Formal Areas in Rio de Janeiro

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Integrating Informal and Formal Areas in Rio de Janeiro