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Asian Journal of Andrology 2022年第2期24卷 225-225页

作者： Charles Van Praet valérie Fonteyne Nicolaas Lumen Department of Urology Ghent University HospitalGhent 9000Belgium Department of Radiation Oncology Ghent University HospitalGhent 9000Belgium

In the recent issue of Asian Journal of Andrology,Ni et al.1 explore a therapeutic reflex that we as clinicians have developed over the years when treating patients with metastatic castration-resistant prostate cancer(mCRPC)with abiraterone acetate(AA).With the first signs of progression,usually,this is a rising prostate-specific antigen(PSA)level;we often continue AA but switch corticoid from prednisone to 0.5 mg of dexamethasone *** a subset of patients,this causes a temporary PSA decline lasting several months to occasionally over a *** is a very cheap,well-tolerated,and safe option,although evidence for a long-term oncological benefit,such as an overall survival(OS)increase,is lacking.

关键词： patients acetate metastatic

The interplay between DNA topoisomerase 2a posttranslational modifications and drug resistance

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Cancer Drug resistance 2020年第2期3卷 149-160页

作者： Christophe Lotz valérie Lamour Integrative Structural Biology Department IGBMCUniversitéde StrasbourgCNRS UMR 7104INSERM U1258Illkirch 67404France Hôpitaux Universitaires de Strasbourg Strasbourg 67000 France

The type 2 DNA topoisomerases(Top2)are conserved enzymes and biomarkers for cell *** catalytic activities of the human isoform Top2a are essential for the regulation of DNA topology during DNA replication,transcription,and chromosome ***2a is a prominent target for anti-cancer drugs and is highly regulated by post-translational modifications(PTM).Despite an increasing number of proteomic studies,the extent of PTM in cancer cells and its importance in drug response remains largely *** this review,we highlight the different modifications affecting the human Top2a in healthy and cancer cells,taking advantage of the structure-function information accumulated in the past *** also overview the regulation of Top2a by PTM,the level of PTM in cancer cells,and the resistance to therapeutic compounds targeting the Top2 ***,this review underlines the importance of future studies addressing more systematically the interplay between PTM and Top2 drug resistance.

关键词： DNA topoisomerase drug resistance post-translational modifications etoposide

Heterogeneous tunable Ⅲ-Ⅴ-on-silicon-nitride mode-locked laser emitting wide optical spectra

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Photonics research 2024年第3期12卷 I0021-I0027页

作者： MAXIMILIEN BILLET STIJN CUYVERS STIJN POELMAN ARTUR HERMANS SANDEEP SEEMA SASEENDRA TASUKU NAKAMURA SHINYA OKAMOTO YASUHISA INADA KAZUYA HISADA TAKU HIRASAWA JOAN RAMIreZ DELPHINE NÉEL NICOLAS VAISSIÈre JEAN DECOBERT PHILIPPE SOUSSAN XAVIER ROTTENBERG GUNTHER ROELKENS JONØ.KJELLMAN BART KUYKEN Photonics research Group Department of Information TechnologyGhent University-imec9052 GhentBelgium imec 3001 LeuvenBelgium Technology Division Panasonic Holdings CorporationMoriguchi-CityOsakaJapan Ⅲ-Ⅴ Lab F91767 PalaiseauFrance

We demonstrate a Ⅲ-Ⅴ-on-silicon-nitride mode-locked laser through the heterogeneous integration of a semiconductor optical amplifier on a passive silicon-nitride cavity using the technique of micro-transfer printing. In the initial phase of our study, we focus on optimizing the lasing wavelength to be centered at 1550 nm. This optimization is achieved by conducting experiments with 27 mode-locked lasers, each incorporating optical amplifiers featuring distinct multiple-quantum-well photoluminescence values. Subsequently we present a comprehensive study investigating the behavior of the mode-locking regime when the electrical driving parameters are varied. Specifically, we explore the impact of the gain voltage and saturable absorber current on the locking stability of a tunable mode-locked laser. By manipulating these parameters, we demonstrate the precise control of the optical spectrum across a wide range of wavelengths spanning from 1530 to 1580 nm. Furthermore, we implement an optimization approach based on a Monte Carlo analysis aimed at enhancing the mode overlap within the gain region. This adjustment enables the achievement of a laser emitting a 23-nm-wide spectrum while maintaining a defined 10 dB bandwidth for a pulse repetition rate of 3 GHz.

关键词： tunable amplifier mode

Sequence data reveal a high diversity of Cantharellus associated with endemic vegetation in Madagascar

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Fungal Diversity 2015年第1期70卷 189-208页

作者： Bart Buyck Frank Kauff Emile Randrianjohany valérie Hofstetter Muséum National d’Histoire Naturelle Dépt.Systématique et Evolution CP39UMR 720575005 ParisFrance Fachbereich Biologie Abt.Molekulare PhylogenetikTechnische Universität KaiserslauternPostfach 304967653 KaiserslauternGermany Centre National de recherche sur l’Environnement(CNre) BP 1739Lab.de Microbiologie de l’Environnement(LME)AntananarivoMadagascar Department of plant protection Agroscope Changins-Wädenswil Research Station ACWRte De Duiller1260 NyonSwitzerland

This revision of Cantharellus in Madagascar deals with species that are associated with strictly endemic host trees and *** on morphological differences and molecular sequence data of the tef-1 gene,five new species are proposed(***,***,***,*** and ***),as well as one new subspecies,*** ***,whereas *** and *** *** are epitypified.A key is provided to all Cantharellus that grow with native vegetation in Madagascar.

关键词： Biodiversity Cantharellales Identification key New species Phylogeny Taxonomy Transcription elongation factor 1alpha

科学论文向技术领域扩散的扩散速度与扩散效果研究

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情报理论与实践 2024年第7期47卷 35-47页

作者：李冰丁堃孙晓玲江文森大连理工大学科学学与科技管理研究所辽宁大连116024 蒙特利尔大学加拿大蒙特利尔H3C 3J7

[目的/意义]科学论文向技术领域扩散对技术的创新发展发挥着重要作用,然而论文在技术领域的扩散速度参差不齐,扩散速度的快慢是否影响产生的扩散效果尚不清晰。[方法/过程]文章利用专利引用论文的引用关系,以1980—2009年Web of Scienc... 详细信息

[目的/意义]科学论文向技术领域扩散对技术的创新发展发挥着重要作用,然而论文在技术领域的扩散速度参差不齐,扩散速度的快慢是否影响产生的扩散效果尚不清晰。[方法/过程]文章利用专利引用论文的引用关系,以1980—2009年Web of Science数据库的论文和1980—2020年USPTO数据库的授权专利作为核心数据集,通过论文被引速率和首次被引间隔测度论文向技术领域的扩散速度,通过扩散产生的技术影响强度和技术影响广度综合测度扩散效果,并添加被引间隔和被引速率的交互作用,分析论文扩散速度与扩散效果的关系。此外,选择被专利持续引用的论文作为研究对象,分析不同扩散时期的扩散速率与扩散效果的关系。[结果/结论]研究表明,论文整体扩散速率不断上升;扩散速率与技术影响强度和广度均呈现倒U形关系,被引间隔与技术影响强度和广度均呈现U形关系;被引间隔对扩散速率与扩散效果的关系具有显著调节作用。此外,在不同扩散时期,早期和中期的扩散速率与技术影响强度和广度呈现倒U形关系,而中后期扩散速率与技术影响强度和广度呈现U形关系。

关键词：论文扩散扩散速度技术影响强度技术影响广度专利引用论文

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Molecular evidence for novel Cantharellus (Cantharellales, Basidiomycota) from tropical African miombo woodland and a key to all tropical African chanterelles

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Fungal Diversity 2013年第1期58卷 281-298页

作者： Bart Buyck Frank Kauff Corinne Cruaud valérie Hofstetter Département Systématique etévolution UMR7205Muséum National d’Histoire NaturelleCP39Rue Buffon 1275005 ParisFrance Fachbereich Biologie Abt.Molekulare PhylogenetikTechnische Universität KaiserslauternPostfach 304967653 KaiserslauternGermany Centre national de séquençage Genoscope2 rue Gaston-CrémieuxCP 570691057 Evry cedexFrance Department of plant protection Agroscope Changins-Wädenswil Research Station ACWRte De Duiller1260 NyonSwitzerland

The authors present a combined morphological and molecular approach of the genus Cantharellus in *** descriptions and detailed illustrations are provided for five new species from the Zambezian savannah woodlands in tropical Africa:***,***,***,*** and ***.A maximum likelihood analysis of tef-1 sequences obtained for 83 collections of Cantharellus that are representative of all major groups in world wide Cantharellus,places a total of 13 African chanterelles,including the five newly described *** recognition of a separate genus Afrocantharellus is *** identification key based on the re-examination of all existing type material is provided for all presently known African Cantharellus.

关键词： Afrocantharellus Biodiversity Guineocongolian rain forest Identification key Phylogeny Tanzania Zambezian woodlands

Targeting endothelial senescence by natural products to improve vascular health

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中国药理学与毒理学杂志 2019年第9期33卷 643-644页

作者： valérie SCHINI-KERTH Faculty of Pharmacy Strasbourg University

It is well established in experimental animals and Humans that endothelial cells,which cover the luminal surface of all blood vessels,have a pivotal role in the control of vascular *** protective effect of endothelial cells is mostly due to their ability to respond to circulating hormones,autacoids,blood-and platelet-derived factors,and also to blood flow by inducing potent vasoprotectivemechanismsincluding predominantlythe formation of nitric oxide(NO),and,often also to some extent,endothelium-derived hyperpolarization,and prostacyclin(PGI2).Besides being a potent vasodilator,NO also effectively prevents platelet activation and has anti-thrombotic and anti-atherosclerotic *** endothelial dysfunction characterized by a reduced generation of these endothelium-dependent vasodilator mechanisms associated with vascular oxidative stress and the formation of endothelium-derived contracting factors such as contractile prostanoids is often observed in most types of cardiovascular diseases including hypertension,hypercho⁃lesterolemia,diabetes,and also during physiological ageing in both experimental animals and ***-derived polyphenols such as those from grapes,tea,cocoa,and berries have been shown to stimulate the endothelial formation of NO by activating the Src/PI3-kinase/Akt-dependent phosphorylation of endothelial NO synthase(eNOS)and to enhance eNOS *** a consequence,the active polyphenols will promote a sustained forma⁃tion of NO that contributes to protect the vascular ***-rich products have also been shown to improve an established endothelial dysfunction and to delay the onset of the induction of an endothelial dysfunction in several experimental models of cardiovascular diseases including hypertension and in ***,endothelial senescence characterized by cell cycle arrest and the acquisition of a pro-inflammatory and pro-atherothrombotic phenotype has been identified as an early event promotingthe

关键词： endothelial cells endothelial senescence vascular health

A multilocus phylogeny for worldwide Cantharellus (Cantharellales, Agaricomycetidae)

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Fungal Diversity 2014年第1期64卷 101-121页

作者： Bart Buyck Frank Kauff Guillaume Eyssartier AndréCouloux valérie Hofstetter Départment systématique etévolution CP39 UMR 7205Muséum national d’histoire naturelle75005 ParisFrance Fachbereich Biologie Abt.Molekulare PhylogenetikTechnische Universität KaiserslauternPostfach 304967653 KaiserslauternGermany 78 boulevard Stalingrad24000 PérigueuxFrance Centre national de séquençage Genoscope2 rue Gaston-CrémieuxCP 570691057 Evry cedexFrance Department of Plant Protection Agroscope Changins-Wädenswil Research Station ACWRte De Duiller1260 NyonSwitzerland

After a short historical overview of past systematic studies on Cantharellus,discussing delimitation and species diversity of the genus as well as previous,morphology-based,infrageneric classifications,this paper presents the first molecularly-based infrageneric classification of this genus using a multigene phylogenetic approach(nucLSU,mitSSU,RPB2 and tef-1)on a dataset that covers approximately halve of the described chanterelles worldwide,including many type *** subgenera are recognized and the recognition of subgenus Afrocantharellus as a separate genus is not *** taxonomic value of individual morphological features is discussed as challenged by this new multigene phylogeny which comprises five new sections,one new subgenus and many emendations for previously recognized infrageneric *** paper discusses the observed discrepancy in biodiversity of Cantharellus when comparing between studies that focus either on below-or above-ground presence.A preliminary biogeographic hypothesis suggests an‘out of Africa’Gondwanan origin as a result of vicariance and subsequent migrations.

关键词： Biogeography Ectomycorrhiza Gondwana mitSSU nucLSU RPB2 tef-1 Systematics

Second-line therapy for advanced hepatocellular carcinoma with regorafenib or cabozantinib:Multicenter French clinical experience in real-life after matching

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1510-1527页

作者： Xavier Adhoute Marie De Matharel Laurent Mineur Guillaume Pénaranda Dann Ouizeman Clemence Toullec Albert Tran Paul Castellani Armelle Rollet valérie Oules HervéPerrier Si Nafa Si Ahmed Marc Bourliere Rodolphe Anty Department of Gastroenterology and Hepatology Hôpital Saint-JosephMarseille 13000France Department of Gastroenterology and Hepatology Hôpital Universitaire de l’ArchetNice 06000France Department of Oncology Institut Sainte-CatherineAvignon 84000France Department of Biostatistics AlphaBio LaboratoryMarseille 13000France

BACKGROUND Starting a second-line systemic treatment for hepatocellular carcinoma(HCC)is a common *** only therapeutic options in France are two broadspectrum tyrosine kinase inhibitors(TKIs),regorafenib(reG)and cabozantinib(CBZ),but no comparative real-life studies are *** To evaluate the progression-free survival(PFS)of patients treated with reG or CBZ,we investigated the disease control rate(DCR),overall survival(OS),and safety of both *** identify the variables associated with disease progression over *** A retrospective multicenter study was performed on the clinical data of patients attending one of three referral centers(Avignon,Marseille,and Nice)between January 2017 and March 2021 using propensity score *** and OS were assessed using the Kaplan-Meier *** analysis(MA)of progression risk factors over time was performed in matched-pair *** Fifty-eight patients 68(62-74)years old with HCC,Barcelona clinic liver cancer(BCLC)B/C(86%),Child-Pugh(CP)-A/B(24%)received reG for 3.4(1.4-10.5)mo as second-line *** patients 68(60-73)years,BCLC B/C(75%),CP-A/B(25%)received CBZ for 3.7(1.8-4.9)mo after first-line treatment with sorafenib[3(2-4)(CBZ)vs 4(2.9-11.8)mo(reG),P=0.0226].Twenty percent of patients received third-line *** matching,PFS and DCR were not significantly different after a median follow-up of 6.2(2.7-11.7)mo(reG)vs 5.2(4-7.2)mo(CBZ),P=*** was no difference in grade 3/4 toxicities,dose reductions,or *** OS of CP-A patients was 8.3(5.2-24.8)vs 4.9(1.6-11.7)mo(CP-B),P=*** MA of risk factors for progression over time identified C-reactive protein(CRP)>10 mg/L,neutrophil-to-lymphocyte ratio(NLR)>3,and aspartate aminotransferase(AST)>45 IU as predictive *** This multicenter indirect comparative study found no significant difference in PFS between reG and CBZ as second-line therapy for advanced *** levels of inflam

关键词： Hepatocellular carcinoma regorafenib Cabozantinib C-reactive protein Neutrophillymphocyte ratio

Long-term high fructose and saturated fat diet affects plasma fatty acid profile in rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第4期13卷 307-317页

作者： Fabrice TRANCHIDA Léopold TCHIAKPE Zo RAKOTONIAINA valérie DEYRIS Olivier RAVION Abel HIOL Institute of Molecular Sciences of Marseilles iSm2 UMR 7313CNRSAix-Marseille University13397 Marseilles Cedex 20France Laboratory of Nutrition-Dietetics Faculty of PharmacyAix-Marseille University13385 Marseilles Cedex 5France Food Sciences Department of Biotechnology EngineeringInstitute of TechnologyUniversity of the French West Indies and GuianaSaint-Claude 97120France

As the consumption of fructose and saturated fatty acids(FAs) has greatly increased in western diets and is linked with an increased risk of metabolic syndrome,the aim of this study was to investigate the effects of a mod-erate(10 weeks) and a prolonged(30 weeks) high fructose and saturated fatty acid(HFS) diet on plasma FA com-position in *** effects of a few weeks of HFS diet had already been described,but in this paper we tried to es-tablish whether these effects persist or if they are modified after 10 or 30 *** hypothesized that the plasma FA profile would be altered between 10 and 30 weeks of the HFS *** fed with either the HFS or a standard diet were tested after 10 weeks and again after 30 *** 10 weeks of feeding,HFS-fed rats developed the metabolic syndrome,as manifested by an increase in fasting insulinemia,total cholesterol and triglyceride levels,as well as by impaired glucose ***,the plasma FA profile of the HFS group showed higher proportions of monounsaturated FAs like palmitoleic acid [16:1(n-7)] and oleic acid [18:1(n-9)],whereas the proportions of some polyunsaturated n-6 FAs,such as linoleic acid [18:2(n-6)] and arachidonic acid [20:4(n-6)],were lower than those in the control *** 30 weeks of the HFS diet,we observed changes mainly in the levels of 16:1(n-7)(decreased) and 20:4(n-6)(increased).Together,our results suggest that an HFS diet could lead to an adaptive response of the plasma FA profile over time,in association with the development of the metabolic syndrome.

关键词： High fructose and saturated fatty acid diet Metabolic syndrome Plasma fatty acids Adaptive response Rats