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Chinese Journal of Aeronautics 2024年第3期37卷 92-103页

作者： valerian PALANQUE Jason POTHIN vale′rie pommier-budinger Marc budinger Institut Clement Ader University of ToulouseINSAISAE-SUPAEROMINES ALBIUPSCNRSToulouse 31055France ISAE-SUPAERO University of Toulouse10 Avenue Edouard BelinToulouse 31055France

This paper proposes a numerical method to analyze the ice protection capability and predict the power requirements of a piezoelectric resonant de-icing *** method is based on a coupled electro-mechanical finite element analysis which enables the fast computation of the modes of resonance of interest to de-ice curved surfaces and the estimation of the input voltage and current required for a given configuration(defined by its mode,actuator location,ice deposit,etc.).Eventually,the electric power to be supplied can be also *** method is applied to a NACA 0024 leading edge equipped with piezoelectric ***,two extension modes are analyzed and compared with respect to their efficiency and power ***,tests are carried out in an icing tunnel to verify the effectiveness of the piezoelectric ice protection system and the predictions of the maximal required *** system allows de-icing the leading edge in less than 2 s for a glaze ice deposit.

关键词： Ice protection system Piezoelectric Resonance mode Ice fracture Leading edge de-icing

Optimization of a hydrogen-based hybrid propulsion system under aircraft performance constraints

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Chinese Journal of Aeronautics 2023年第5期36卷 41-56页

作者： Vincenzo PALLADINO Nathalie BARTOLI valérie pommier-budinger Emmanuel BENARD Peter SCHMOLLGRUBER Arnaud JORDAN ATR Aircraft Blagnac 31712France ONERA/DTIS-Universitéde Toulouse Toulouse 31055France ISAE-SUPAERO Toulouse 31055France

This paper addresses the topic of the conceptual design of a regional aircraft with hybrid electric propulsion based on hydrogen fuel *** aims at providing an optimization-based method to design a hybrid propulsive system comprising two power sources(jet fuel and hydrogen)for the generation of the required propulsive power and at studying the impact of fuel cell technologies on the aircraft ***,by performing optimizations for two hybrid propulsive systems using either low temperature or high temperature proton-exchange membrane fuel cells,this study provides a preliminary assessment of the impact of the fuel cell operating temperature on the system design and the overall aircraft ***,this paper gives a description of the baseline turboprop regional aircraft with a focus on its high speed and low speed flight performances which will serve as requirements for the design of the hybrid ***,the hybrid electric architecture and the sizing models of the propulsion system are ***,optimizations are performed to design two parallel hybrid propulsive systems based on different fuel cells technologies and aimed at minimizing the block fuel per passenger over a mission of 200 n *** show how the proposed methodology and models lead to design two propulsive systems capable of reducing the fuel consumption per passenger by more than 30%compared to the baseline *** study also shows that the choice of fuel cell operating temperature has a first-order impact on the total mass.

关键词： Aircraft design Hybrid aircraft Hydrogen aircraft Propulsion Regional aircraft

Piezoelectric resonant ice protection systems-Part 2/2:Evaluation of benefits at aircraft level

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Chinese Journal of Aeronautics 2024年第6期37卷 50-63页

作者： valerian PALANQUE Thomas PLANES pommier-budinger valErie budinger MARC Delbecq SCOTT Institut Clement Ader(ICA) INSAISAE-SUPAEROMINES ALBIUPSCNRSUniversity of Toulouse31400 ToulouseFrance Federation ENAC ISAE-SUPAERO ONERA University of Toulouse31400 ToulouseFrance

Piezoelectric resonant de-icing systems are attracting great *** paper aims to assess the implementation of these systems at the aircraft *** article begins with the model to compute the power requirement of a piezoelectric resonant de-icing system sized from the prototype detailed in Part 1/2 of this *** the mass,drag,and fuel consumption of this system and the subcomponents needed for its implementation are *** features of a piezoelectric resonant de-icing system are finally computed for aircraft similar to Airbus A320 aircraft and aircraft of different categories(Boeing 787,ATR 72 and TBM 900)and compared with the existing thermal and mechanical ice protection systems.A sensitivity analysis of the main key sizing parameters of the piezoelectric de-icing system is also performed to identify the main axes of improvement for this *** study shows the potential of such ice protection *** particular,for the realistic input parameters chosen in this work,the electro-mechanical solution can provide a 54% reduction in terms of mass and a 92% reduction in terms of power consumption for an A320 aircraft architecture,leading to a 74% decrease in the associated fuel consumption compared to the actual air bleed system.

关键词： Ice protection system De-icing Piezoelectric Electro-mechanical system Power Fuel consumption

Distribution of atrial cardiomyopathy markers and association with atrial fibrillation detected after ischaemic stroke in the SAFAS study

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Stroke & Vascular Neurology 2024年第2期9卷 165-173,I0426,I0427页

作者： Romain Didier Lucie Garnier Gauthier Duloquin Alexandre Meloux Audrey Sagnard Mathilde Graber Geoffrey Dogon Karim Benali Thibaut pommier Gabriel Laurent Catherine Vergely Yannick Bejot Charles Guenancia Cardiology CHU Dijon BourgogneDijonFrance Dijon Stroke Registry Department of NeurologyUniversity Hospital Centre DijonDijonFrance PEC 2 Universitéde BourgogneDijonFrance Cardiology CHU Saint EtienneSaint EtienneFrance

Background Atrial cardiomyopathy(AC)is an emerging concept explaining the pathophysiology of cardioembolic strokes in absence of atrial fibrillation(AF).A definition based on the presence of electrical abnormality(P-wave terminal force in lead V1(PTFV1)>5000µV×ms),N-Terminal pro-B-type natriuretic peptide(NT pro BNP)>250pg/mL and/or indexed left atrial diameter(LADI)>3cm/m^(2)is currently tested in the ARCADIA(AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke)*** set out to estimate the prevalence of AC as defined in the ARCADIA trial,its determinants and its association with AF detected after stroke(AFDAS).Methods Stepwise screening for silent Atrial Fibrillation After Stroke(SAFAS)study prospectively included 240 ischaemic stroke *** markers were complete for 192 of them and 9 were not included in this analysis because AF had been diagnosed on *** A total of 183 patients were analysed,of whom 57%(104 patients)met the AC criteria(79 NT-proBNP,47 PTFV1,4 LADI).In the multivariate logistic regression,C reactive protein>3mg/L(OR(95%CI)2.60(1.30 to 5.21),p=0.007)and age(OR(95%CI)1.07(1.04 to 1.10),p34mL/m^(2),OR 2.35(CI 1.09 to 5.06)p=0029).Conclusion AC as defined in ARCADIA is mostly based on NT pro BNP elevation(76%of patients)and is associated with age and ***,AC was not independently associated with AFDAS at *** ARCADIA trial,which compares aspirin to apixaban in patients with embolic strokes of undetermined source with AC markers and must,therefore be analysed in the light of these limitations.

关键词： atrial cardiomyopathy prevention

High frequency of severe liver dysfunction in critically ill Dengue patients in the French West Indies

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Journal of Intensive Medicine 2024年第3期4卷 403-404页

作者： Laurent Camous Samuel Markowicz Cecile Loraux Julien Jabot Jean David pommier Réanimation Médicale et Chirurgicale CHU de GuadeloupeChemin ChauvelLes Abymes97139 GuadeloupeFrance Service de Maladies infectieuses et tropicales CHU de GuadeloupeChemin ChauvelLes Abymes97139 GuadeloupeFrance Service de Microbiologie CHU de GuadeloupeChemin ChauvelLes Abymes97139 GuadeloupeFrance Médecine Intensive et Réanimation Centre hospitalier universitaire de la Réunion 97460 Saint-PaulFrance Institut Pasteur de la Guadeloupe Morne Jolivière97183 AbymesFrance

Dear Editor,Dengue is a worldwide zoonosis,transmitted by mosquitoes and highly prevalent in tropical and subtropical *** recent years,its incidence has increased with a massive healthcare burden worldwide[1]and recent climatic changes have expanded the geographic range of the insect vector with described outbreaks in Europe.[2]Most patients present pauci-symptomatic infections,but some patients could present severe manifestations with high reported mortality[[3],[4],[5]]and no specific *** bleeding,hemodynamic failure and various organ damage(cardiac,renal,neurological,and hepatic)are described in severe dengue(SD)patients.[5]In the future,intensivists worldwide will be increasingly treating SD and the spectrum of severe organ impairment should be well known.

关键词： patients mortality expanded

Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells

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Acta Pharmacologica Sinica 2004年第6期 54-60页

作者： Yves pommier Laboratory of MolecularPharmacology MD 20892 NCI/NIH USA

AIM: To investigate whether 7-hydroxystaurosporine (UCN-01) affects cell cycle progression in arabinosylcytosine (ara-C) treatedhuman coloncarcinoma HT-29cells. METHODS:Cytotoxicity, DNA synthesis, cell cycle distribution, protein level, and kinase activity were determined by clonogenic assay, flow cytometry, DNA synthesis assay, immunoblotting, and kinase assays, respectively. RESULTS: UCN-01 abrogated an S/G2-phase checkpoint in HT- 29 cells treated with ara-C. When UCN-01 was added after treatment with ara-C, the rate of recovery of DNA synthesis was enhanced and colony-forming ability diminished. Thus, premature recovery of DNA synthesis was associated with increased cytotoxicity. Measurements of cyclin A and B protein levels, Cdk2 and Cdc2 kinase activities, Cdc25C phosphorylation, and Chk1 kinase activity were consistent with UCN-01-induced abrogation of the S/G2-phase checkpoint in ara-C treated cells. CONCLUSION: The abrogation of the S/G2 checkpoint may be due to inhibition of Chk1 kinase by UCN-01. The enhanced cytotoxicity produced when UCN-01 was combined with ara-C suggested a rationale for the use of this drug combination for tumors that might be susceptible to cell cycle checkpoint abrogation.

关键词： hydroxystaurosporine chk1 protein kinase DNA repair cell cycle

Diverse organic carbon activates soil microbiome functioning via niche modulation

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Soil Ecology Letters 2023年第4期5卷 5-7页

作者： Thomas pommier UMR INRAE 1418 Ecologie Microbienne UniversitéClaude Bernard Lyon 1F-69622 VilleurbanneFrance

Considering the“One Health”framework,the soil microbial community is essential for plant,animal,and ultimately to human health(Banerjee and van der Heijden,2023).Similar to the microbiome in human gut(Berendsen et al.,2012),the plant-associated microbiota drives key functions in agroecosystems,such as supporting nutrient uptake,suppressing plant pathogens,or improving host stress tolerance(Hartmann and Six,2023).However,continuous mono-cropping run in intensified agroecosystems often leads to the loss of soil biodiversity,reduces resistance to plant pathogens,and ultimately causes the outbreak of soil-borne diseases(Tsiafouli et al.,2015;Raaijmakers and Mazzola,2016).This represents a major threat to global food security and sustainable development in agriculture(Strange and Scott,2005;Butler,2013).Accordingly,soil microbiome engineering is widely recognized as a promising approach to promote plant health and agricultural sustainability(Raaijmakers and Mazzola,2016;Hartman et al.,2018).

关键词： soil intensified supporting

Rhizosphere immunity: targeting the underground for sustainable plant health management

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Frontiers of Agricultural Science and Engineering 2020年第3期7卷 317-328页

作者： Zhong WEI Vill-Petri FRIMAN Thomas pommier Stefan GEISEN Alexandre JOUSSET Qirong SHEN Key Laboratory of Plant Immunity Jiangsu Key Laboratory for Organic Solid Waste UtilizationNational Engineering Research Center for Organic-Based FertilizersNanjing Agricultural UniversityNanjing 210095China Department of Biology University of YorkYorkYO105DDUK Ecologie Microbienne UMR1418French National Institute for Agricultural Research(INRA)University Lyon IF-69622 VilleurbanneFrance Laboratory of Nematology Wageningen University and Research6700ES Wageningenthe Netherlands Institute of Environmental Biology Ecology and BiodiversityUtrecht University3584CH Utrechtthe Netherlands

Managing plant health is a great challenge formodern food production and is further complicated by thelack of common ground between the many disciplinesinvolved in disease control. Here we present the concept ofrhizosphere immunity, in which plant health is consideredas an ecosystem level property emerging from networks ofinteractions between plants, microbiota and the surround-ing soil matrix. These interactions can potentially extendthe innate plant immune system to a point where therhizosphere immunity can fulfil all four core functions ofafull immune system: pathogen prevention, recognition,response and homeostasis. We suggest that consideringplant health from a meta-organism perspective will help indeveloping multidisciplinary pathogen management stra-tegies that focus on steering the whole plant-microbe-soilnetworks instead of individual components. This might beachieved by bringing together the latest discoveries inphytopathology, microbiome research, soil science andagronomy to pave the way toward more sustainable andproductive agriculture.

关键词： rthizosphere soil microbiome plant immunity microbial ecology plant health soilborme pathogens

Novel Anticancer Lead Compounds Discovered by Virtual Screening on Top1 Demonstrated Potent Activity against CPT Resistant Tumor Cells

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Novel Anticancer Lead Compounds Discovered by Virtual Screen...

第六届全国化学生物学学术会议

作者： Tom Dexheimer Yves pommier Mark Cushman School of Pharmacy Second Military Medical University 325 Guohe Road

＜正＞DNA topoisomeraseⅠ（Top1） has become an important target for the design of novel antitumor *** is a ubiquitous and essential nuclear enzyme for DNA replication and *** classical Camptothecin（CPT） derivatives were Top1 inhibitors,among which topotecan and irinotecan have shown great benefits in cancer chemotherapy and several CPT derivatives have entered clinical or preclinical *** overcome the lactone *** of the drug-target

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汽车生活 2011年第2期 104-111页

作者： SCOTT pommier

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关键词：夹克外衣衬衫