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Influence of Statins and Fibrates Drugs on Bone Health and Regeneration

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Journal of Biomaterials and Nanobiotechnology 2024年第1期15卷 1-24页

作者： Octavio Santiago Ivan Nadir Camal Ruggieri Marina Ribeiro Paulini valéria Paula Sassoli Fazan João Paulo Mardegan Issa Sara Feldman LABOATEM Laboratory of Bone Biology and Tissue Engineering School of Medicine Rosario National University Ros&#225rio Argentina School of Dentistry of Ribeirã o Preto University of S&#227o Paulo (FORP/USP) Ribeir&#227o Preto S&#227o Paulo Brazil School of Medicine of Ribeirã o Preto University of S&#227o Paulo (FMRP/USP) Ribeir&#227o Preto S&#227o Paulo Brazil

In the medical and dental field, the importance and need for the study of materials and drugs for use as bone grafts or regeneration in injured areas due to the presence of fractures, infections or tumors that cause extensive loss of bone tissue is observed. Bone is a specialized, vascularized and dynamic connective tissue that changes throughout the life of the organism. When injured, it has a unique ability to regenerate and repair without the presence of scars, but in some situations, due to the size of the defect, the bone tissue does not regenerate completely. Thus, due to its importance, there is a great development in therapeutic approaches for the treatment of bone defects through studies that include autografts, allografts and artificial materials used alone or in association with bone grafts. Pharmaceuticals composed of biomaterials and osteogenic active substances have been extensively studied because they provide potential for tissue regeneration and new strategies for the treatment of bone defects. Statins work as specific inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMG-CoAreductase). They represent efficient drugs in lowering cholesterol, as they reduce platelet aggregation and thrombus deposition;in addition, they promote angiogenesis, reduce the β-amyloid peptide related to Alzheimer’s disease and suppress the activation of T lymphocytes. Furthermore, these substances have been used in the treatment of hypercholesterolemia and coronary artery disease. By inhibiting HMG-CoAreductase, statins not only inhibit cholesterol synthesis, but also exhibit several other beneficial pleiotropic effects. Therefore, there has been increasing interest in researching the effects of statins, including Simvastatin, on bone and osteometabolic diseases. However, statins in high doses cause inflammation in bone defects and inhibit osteoblastic differentiation, negatively contributing to bone repair. Thus, different types of studies with different conc

关键词： Bone Statins Rosuvastatin Sinvastatin Fibrates Fenofibrate Bone Regeneration

Farm buildings and agri-food transitions in Southern France:Mapping dynamics using a stakeholder-based diagnosis

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Effect of different drying methods on the amino acids,α-dicarbonyls and volatile compounds of rape bee pollen

地理学与可持续性（英文） 2024年第1期5卷 108-120页

作者： Orlane Rouquier Coline Perrin Michaël Pouzenc valérie Olivier-Salvagnac UMR 5193 LISST(Laboratoire Interdisciplinaire Solidarités SociétésTerritoires)Univ Toulouse-Jean JaurèsCNRSEHESSENSFEAINU ChampollionToulouseFrance UMR 0951 INNOVATION Univ MontpellierCIRADINRAEInstitut AgroMontpellierFrance UMR TLSE INP-INRAE 1248 AGIR(AGroécologie InnovationsTeRritoires)ToulouseFrance UMR 0951 INNOVATION Univ MontpellierCIRADINRAEInstitut AgroMontpellierFrance UMR 5193 LISST(Laboratoire Interdisciplinaire Solidarités SociétésTerritoires)Univ Toulouse-Jean JaurèsCNRSEHESSENSFEAINU ChampollionToulouseFrance UMR TLSE INP-INRAE 1248 AGIR(AGroécologie InnovationsTeRritoires)ToulouseFrance

This study's goal is to present a dynamic portrait of the farm-buildings environment in Occitania,in Southern France,in order to better identify the transitions underway in agri-food *** this end,we undertook a ter-ritorial diagnosis based on actor statements,using 28 semi-structured interviews across *** diagnosis was enriched by graphic modelling,which enabled the spatialization of the dynamics *** show that the process of standardisation of farm buildings prevails in the majority of the territories *** phenomenon has intensified in recent years with the development of vast photovoltaic-roofed sheds,accentuating the farm-land conversion and soil *** the same time,in areas with strong environmental,landscape and heritage contexts,a'new adventure in farm buildings'(2022 survey)is taking *** is primarily driven by local short food chains,which rely on self-construction,repurposing and refurbishment,the sharing of tools and equipment,and which favour the use and reuse of local *** study shows that farm-buildings dynamics crystallise many challenges confronting the reterritorialisation of agriculture and food production.

关键词： Farm buildings Transition Local food systems Occitania Cartographic modelling

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Food Science and Human Wellness 2024年第1期13卷 517-527页

作者： Yanxiang Bi Jiabao Ni Xiaofeng Xue Zidan Zhou Wenli Tian valérie Orsat Sha Yan Wenjun Peng Xiaoming Fang State Key Laboratory of Resource Insects Institute of Apicultural ResearchChinese Academy of Agricultural SciencesBeijing 100093China College of Engineering China Agricultural UniversityBeijing 100083China Bioresource Engineering Dept. McGill UniversitySte-Anne-de-Bellevue QC H9X 3V9Canada

The significant demand for high quality food has motivated us to adopt appropriate processing methods to improve the food nutritional quality and *** this study,the effects of five drying methods,namely,pulsed vacuum drying(PVD),freeze drying(FD),infrared drying(IRD),hot-air drying(HAD)and sun drying(SD)on free amino acids(FAAs),α-dicarbonyl compounds(α-DCs)and volatile compounds(VOCs)in rape bee pollen(RBP)were *** results showed that FD significantly released the essential amino acids(EAAs)compared with fresh samples while SD caused the highest *** was the dominantα-DCs in RBP and the highest loss was observed after *** were the dominant volatiles of RBP and SD samples contained more new volatile substances(especially aldehydes)than the other four drying ***,FD and PVD would be potential methods to effectively reduce the quality deterioration of RBP in the drying process.

关键词： Drying Bee pollen Free amino acids α-Dicarbonyl compounds Volatile compounds

A high-power electromagnetic source for disabling improvised explosive devices

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High Voltage 2024年第2期9卷 403-409页

作者： Laurent Ariztia Njomza Ibrahimi Alexey Zhabin Antoine Silvestre de Ferron Marc Rivaletto Edson Martinod valérie Bertrand Bucur Novac Laurent Pécastaing Universite de Pau et des Pays de l’Adour E2S UPPASIAMEPauFrance XLIM UMR CNRS BriveLimogesFrance CISTEME LimogesFrance Wolfson School of Mechanical Electrical and Manufacturing EngineeringLoughborough UniversityLoughboroughLeicestershireUK

Ultra-wideband(UWB)microwave sources driven by specialised pulsed power generators have experienced a considerable development in the last decade due to their wide domain of new applications such as defence or counter-terrorism *** authors present the main findings of a research dedicated to the development of a pulsed power-driven electromagnetic field source for disabling improvised explosive devices(IED).The pulsed power generator driving the source is a 13-stage compact Marx producing voltage pulses reaching an amplitude of 0.5 MV,with a pulse repetition frequency(PRF)of up to 100 *** generator is coupled to a bipolar pulse forming line,providing bipolar pulses with a dV/dt of around 1.6 MV/*** pulsed power system feeds an array composed of 16 Koshelev-type UWB antennas through an impedance matching *** resulting electromagnetic source is capable to produce pulsed electric fields(PEFs)having a figure-of-merit(FOM)of 1 ***,practical experiments were carried out to study the effects of the PEFs on *** targets used in the present study are M2B type flashbulbs,known to have the same susceptibility as the US army M6 *** configurations of wires(shielded,twisted,etc)with different lengths were used in connecting items inside these *** tests were performed by placing the flashbulbs at different distances to determine the essential parameters(i.e.,amplitude,duration,and frequency range)of the PEFs required to trigger *** overview of the experimental campaign and the main findings are also presented followed by conclusions.

关键词： power bipolar source

Epidemiology and Clinical Features of Mycobacterium avium Complex Pulmonary Disease in a Brazilian Amazon Cohort

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Advances in Microbiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares Monteiro Adriana Rodrigues Barretto Ruan Seguin Azevedo Quaresma Bianca Miranda Gouveia Ismari Perini Furlaneto Victória Menezes da Costa Yan Corrêa Rodrigues Layana Rufino Ribeiro Ricardo J. de Paula Souza e Guimarães Alex Brito Souza Ana Roberta Fusco da Costa Karla valéria Batista Lima Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center for Biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil Department of Medicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and Mycology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of Mycobacterium avium complex pulmonary disease (MACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of clinical characteristics and treatment response among patients in the Amazon region of Brazil and conduct a retrospective cohort study at a prominent referral hospital in the State of Par, Brazil, from 2012 to 2020. The M. avium group represented 58.9% of cases, followed by M. intracellulare (35.7%), M. colombiense (3.6%), and M. chimaera (1.8%). The majority of patients (73.2%) were female and with an average age of 63 years. Primary clinical manifestations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatment for pulmonary tuberculosis before initiating treatment for MAC infection. The fibrocavitary radiologic form was the most prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a significant prevalence of MAC resistance to drugs in the therapeutic regimen. Despite this, most of the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of MAC infections among middle-aged women, with a history of pulmonary tuberculosis treatment and presenting the fibrocavitary radiological form was predominant.

关键词： MACDP Nontuberculous Mycobacteria Mycobacterium avium Lung Disease

A study on wildfire impacts on greenhouse gas emissions and regional air quality in South of Orléans,France

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Journal of Environmental Sciences 2024年第1期135卷 521-533页

作者： Chaoyang Xue Gisèle Krysztofiak Yangang Ren Min Cai Patrick Mercier Frédéric Le Fur Corinne Robin Benoit Grosselin Véronique Daele Max RMcGillen Yujing Mu valéry Catoire Abdelwahid Mellouki Laboratoire de Physique et Chimie de l’Environnement et de l’Espace(LPC2E) CNRS–UniversitéOrléans–CNES(UMR 7328)Orléans Cedex 245071France Institut de Combustion AérothermiqueRéactivitéEnvironnement(ICARE)CNRSOrléans Cedex 245071France Research Centre for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China Lig’Air-Association de surveillance de la qualitéde l’air en région Centre-val de Loire Saint-Cyr-en-Val 45590France Mohammed V University RabatMorocco

Wildfire events are increasing globally which may be partly associated with climate change,resulting in significant adverse impacts on local,regional air quality and global *** September 2020,a small wildfire(burned area:36.3 ha)event occurred in Souesmes(Loiret-Cher,Sologne,France),and its plume spread out over 200 km on the following day as observed by the MODIS *** on measurements at a suburban site(~50 km northwest of the fire location)in Orléans and backward trajectory analysis,young wildfire plumes were *** increases in gaseous pollutants(CO,CH_(4),N_(2)O,VOCs,etc.)and particles(including black carbon)were found within the wildfire plumes,leading to a reduced air *** factors,defined as EF(X)=ΔX/ΔCO(where,X represents the target species),of various trace gases and black carbon within the young wildfire plumes were determined accordingly and compared with previous *** in the ambient ions(such as ammonium,sulfate,nitrate,chloride,and nitrite in the particle-and gasphase)and aerosol properties(e.g.,aerosol water content,aerosol p H)were also quantified and ***,we estimated the total carbon and climate-related species(e.g.,CO_(2),CH_(4),N_(2)O,and BC)emissions and compared them with fire emission *** biomass burning emission inventories have uncertainties in estimating small fire burned areas and *** instance,we found that the Global Fire Assimilation System(GFAS)may underestimate emissions(e.g.,CO)of this small wildfire while other inventories(GFED and FINN)showed significant *** that it is the first time to record wildfire plumes in this region,related atmospheric implications are presented and discussed.

关键词： Wildfire Air quality Emission factor Emission inventory VOLTAIRE supersite

Piezoelectric resonant ice protection systems–Part1/2:Prediction of power requirement for de-icing a NACA 0024 leading edge

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Chinese Journal of Aeronautics 2024年第3期37卷 92-103页

作者： valerian PALANQUE Jason POTHIN vale′rie POMMIER-BUDINGER Marc BUDINGER Institut Clement Ader University of ToulouseINSAISAE-SUPAEROMINES ALBIUPSCNRSToulouse 31055France ISAE-SUPAERO University of Toulouse10 Avenue Edouard BelinToulouse 31055France

This paper proposes a numerical method to analyze the ice protection capability and predict the power requirements of a piezoelectric resonant de-icing *** method is based on a coupled electro-mechanical finite element analysis which enables the fast computation of the modes of resonance of interest to de-ice curved surfaces and the estimation of the input voltage and current required for a given configuration(defined by its mode,actuator location,ice deposit,etc.).Eventually,the electric power to be supplied can be also *** method is applied to a NACA 0024 leading edge equipped with piezoelectric ***,two extension modes are analyzed and compared with respect to their efficiency and power ***,tests are carried out in an icing tunnel to verify the effectiveness of the piezoelectric ice protection system and the predictions of the maximal required *** system allows de-icing the leading edge in less than 2 s for a glaze ice deposit.

关键词： Ice protection system Piezoelectric Resonance mode Ice fracture Leading edge de-icing

Piezoelectric resonant ice protection systems-Part 2/2:Evaluation of benefits at aircraft level

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Chinese Journal of Aeronautics 2024年第6期37卷 50-63页

作者： valerian PALANQUE Thomas PLANES Pommier-Budinger valERIE Budinger MARC Delbecq SCOTT Institut Clement Ader(ICA) INSAISAE-SUPAEROMINES ALBIUPSCNRSUniversity of Toulouse31400 ToulouseFrance Federation ENAC ISAE-SUPAERO ONERA University of Toulouse31400 ToulouseFrance

Piezoelectric resonant de-icing systems are attracting great *** paper aims to assess the implementation of these systems at the aircraft *** article begins with the model to compute the power requirement of a piezoelectric resonant de-icing system sized from the prototype detailed in Part 1/2 of this *** the mass,drag,and fuel consumption of this system and the subcomponents needed for its implementation are *** features of a piezoelectric resonant de-icing system are finally computed for aircraft similar to Airbus A320 aircraft and aircraft of different categories(Boeing 787,ATR 72 and TBM 900)and compared with the existing thermal and mechanical ice protection systems.A sensitivity analysis of the main key sizing parameters of the piezoelectric de-icing system is also performed to identify the main axes of improvement for this *** study shows the potential of such ice protection *** particular,for the realistic input parameters chosen in this work,the electro-mechanical solution can provide a 54% reduction in terms of mass and a 92% reduction in terms of power consumption for an A320 aircraft architecture,leading to a 74% decrease in the associated fuel consumption compared to the actual air bleed system.

关键词： Ice protection system De-icing Piezoelectric Electro-mechanical system Power Fuel consumption

Contribution of SAR Radar Imagery in the Detection of Suspicious Vessels in the Ivorian EEZ

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World Journal of Engineering and Technology 2024年第1期12卷 200-212页

作者： Koffi Cyprien Yoboue Jean-Baptiste Kassi Eric valère Djagoua Tiemelé Jacque-André Laboratory of Remote Sensing and GIS University Center for Research and Application in Remote Sensing (CURAT) Félix Houphouet-Boigny University of Abidjan Cocody Ivory Coast

The present work proposed a method for match SAR and AIS data to detect vessels carrying out suspicious activity in the Ivorian EEZ. Two superposition methods, detected AIS and SAR data, based on point-to-point association on the one hand and point-to-line on the other hand, were used to detect suspicious vessels in Ivorian marine waters. The results showed that most vessels detected in the Ivorian EEZ do not declare their positions to avoid being spotted. These funds are likely to practice illegal, undeclared and unregulated fishing (INN fishing). This clandestine activity is very recurrent in Ivorian waters. This is illustrated by the number of suspicious vessels detected by SAR radar imagery which is greater compared to declared or authorized vessels.

关键词： INN Fishing CFAR Algorithm AIS Sentinel-1A Ivory Coast