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Palliative care for end-stage liver disease and acute on chronic liver failure:A systematic review

World Journal of Methodology 2024年第4期14卷 131-148页

作者： vakaola i pulotu mafi Jonathan Soldera Post-Graduate Program Acute MedicineUniversity of South WalesCardiff CF371DLUnited Kingdom

BACKGROUND End stage liver disease(ESLD)represents a growing health concern characterized by elevated morbidity and mortality,particularly among individual ineligible for liver *** demand for palliative care(PC)is pronounced in patients grappling with ESLD and acute on chronic liver failure(ACLF).Unfortunately,the historical underutilization of PC in ESLD patients,despite their substantial needs and those of their family caregivers,underscores the imperative of seamlessly integrating PC principles into routine healthcare practices across the entire disease *** To comprehensively investigate the evidence surrounding the benefits of incorporating PC into the comprehensive care plan for individuals confronting ESLD and/or *** A systematic search in the Medline(PubMed)database was performed using a predetermined search command,encompassing studies published in English without any restrictions on the publication ***,the retrieved studies were manually *** descriptive analyses were employed to summarize the *** The search strategies yielded 721 *** the final analysis,32 fulllength references met the inclusion criteria and were consequently incorporated into the *** data extraction from these 32 studies was undertaken,leading to the execution of a comprehensive narrative systematic *** review found that PC provides significant benefits,reducing symptom burden,depressive symptoms,readmission rates,and hospital ***,barriers like the appeal of transplants and misconceptions about PC hinder optimal *** PC early,upon the diagnosis of ESLD and ACLF,regardless of transplant eligibility and availability,improves the quality of life for these *** Despite the substantial suffering and poor prognosis associated with ESLD and ACLF,where liver transplantation stands as the only curative treatment,albeit largely inaccessible,PC services h

关键词： End stage liver disease Acute on chronic liver failure Palliative care Liver transplantation Quality of life

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