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World Journal of Clinical Cases 2023年第21期11卷 4989-4995页

作者： vaidota malinauskiene Anastasija Zuzo Valentina Liakina Edita Kazenaite Ieva Stundiene Clinic of Gastroenterology Nephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental SciencesVilnius TechVilnius 10223Lithuania

Inflammatory bowel disease(IBD)is a chronic condition that affects young individuals in their reproductive *** may have long-term implications on their reproductive,sexual,and mental *** has been related to menstrual ***,the administration of biological therapy can also result in gynecological issues in addition to the disease *** purpose of this review was to present potential menstrual cycle problems in patients with IBD,as well as the impact of adalimumab and other anti-tumor necrosis factor medications on gynecological pathology.

关键词： Menstrual disorders Inflammatory bowel disease Adalimumab Infliximab Anti-tumor necrosis factor-α

Gut microbiota contribution to hepatocellular carcinoma manifestation in non-alcoholic steatohepatitis

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World Journal of Hepatology 2022年第7期14卷 1277-1290页

作者： Valentina Liakina Sandra Strainiene Ieva Stundiene vaidota Maksimaityte Edita Kazenaite Centre of Hepatology Gastroenterology and DieteticsClinic of GastroenterologyNephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental SciencesVilnius Gediminas Technical University(VILNIUS TECH)Vilnius 10223Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Therapeutic and Radiological Department Antakalnis PolyclinicVilnius 10207Lithuania Department of Pathology Forensic Medicine and PharmacologyInstitute of Biomedical SciencesFaculty of MedicineVilnius UniversityVilnius 01513Lithuania

Recently,the gut microbiota has been recognized as an obvious active player in addition to liver steatosis/steatohepatitis in the pathophysiological mechanisms of the development of hepatocellular carcinoma(HCC),even in the absence of *** from clinical and experimental studies shows the association of specific changes in the gut microbiome and the direct contribution to maintaining liver inflammation and/or cancerogenesis in nonalcoholic fatty liver disease-induced *** composition of the gut microbiota differs significantly in obese and lean individuals,especially in the abundance of pro-inflammatory lipopolysaccharide-producing phyla,and,after establishing steatohepatitis,it undergoes minor changes during the progression of the disease toward advanced *** studies proved that the microbiota of obese subjects can induce steatohepatitis in normally fed *** the contrary,the transplantation of healthy microbiota to obese mice relieves ***,further studies are needed to confirm these findings and the mechanisms *** this review,we have evaluated well-documented clinical and experimental research on the role of the gut microbiota in the manifestation and promotion of HCC in nonalcoholic steatohepatitis(NASH).Furthermore,a literature review of microbiota alterations and consequences of dysbiosis for the promotion of NASH-induced HCC was performed,and the advantages and limitations of the microbiota as an early marker of the diagnosis of HCC were discussed.

关键词： Gut microbiota Hepatocellular carcinoma Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease Microbiome

Metastatic multifocal melanoma of multiple organ systems:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10136-10145页

作者： vaidota Maksimaityte Rosita Reivytyte Gabriele Milaknyte Ugnius Mickys Gintare Razanskiene Domantas Stundys Edita Kazenaite Jonas Valantinas Ieva Stundiene Institute of Clinical Medicine Faculty of MedicineVilnius UniversityVilnius 01513Lithuania Faculty of Medicine Vilnius UniversityVilnius 01513Lithuania Institute of Biomedical Sciences Faculty of MedicineVilnius UniversityVilnius 01513Lithuania

BACKGROUND Malignant melanoma is becoming more common among middle-aged individuals all over the *** metastasis can be found in various organs,although metastases to the spleen and stomach are *** we present a rare metastatic multifocal melanoma,clinically and histologically mimicking lymphoma,with metastases of multiple *** SUMMARY A 46-year-old Caucasian male with a history of nodular cutaneous malignant melanoma was presented with nausea,general weakness,shortness of breath,abdominal enlargement,and night *** abdominal ultrasound revealed enlarged liver and spleen with multiple *** tomography demonstrated multiple lesions in the lungs,liver,spleen,subcutaneous tissue,bones and a pathological lymphadenopathy of the *** biopsy and the biopsy from the enlarged lymph node were *** cells showed diffuse or partial positivity for melanocytic markers,such as microphthalmia-associated transcription factor,S100,HMB45 and *** tumor harbored BRAF V600E mutation,demonstrated by immunohistochemical labelling for BRAF V600E and detected by real-time polymerase chain reaction *** combined all the findings,a diagnosis was made of a metastatic multifocal melanoma of the stomach,duodenum,liver,spleen,lungs,lymph nodes and *** patient refused treatment and died a week *** This case report highlights the clinical relevance of rare metastatic multifocal melanoma of multiple organ systems.

关键词： Metastatic melanoma Gastrointestinal tract Nodular Multifocal BRAF V600E Case report

Mucosa-associated lymphoid tissue lymphoma simulating Crohn’s disease:A case report

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World Journal of Clinical Cases 2020年第8期8卷 1454-1462页

作者： Ieva Stundiene vaidota Maksimaityte Valentina Liakina Jonas Valantinas Centre of Hepatology Gastroenterology and DieteticsFaculty of MedicineVilnius UniversityVilnius 03101Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental ScienceVilnius Gediminas Technical UniversityVilnius 10223Lithuania Clinic of Gastroenterology Nephrourology and SurgeryFaculty of MedicineVilnius UniversityVilnius 03101Lithuania

BACKGROUND Differential diagnosis between extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue and inflammatory bowel disease is mainly based on histopathologic evaluation of intestinal biopsies,although there is no single definitive diagnostic investigation and that circumstance can lead to misdiagnosis in particular *** we present a rare,ulcerative form of marginal zone lymphoma which mimics the Crohn’s disease(CD)of upper digestive *** SUMMARY A 50-year-old man was presented with recurrent episodes of malaise and melena also weight *** of the small bowel demonstrated an ulcer in the ***,biopsies showed lymphoplasmacytic *** of CD was *** treatment consisted of prednisone and azathioprine and was followed by azathioprine 100 mg per day with good clinical response in the following 2 years until *** this time the results of endoscopic biopsies derived from proximal wall of stomach revealed Helicobacter pylori-negative marginal zone lymphoma of the gastric *** confirmed atypical CD20-positive cell *** on these biopsies,marginal zone lymphoma of mucosa-associated lymphoid tissue was ***,the contact with the patient was lost until one year later he was hospitalized with nausea,vomiting and severe pain because of gastrointestinal *** months later after laparotomy,the patient was treated with a course of *** remission was observed following 6 cycles of *** This case report highlights the clinical relevance of knowledge and awareness of marginal zone lymphoma simulating CD.

关键词： Crohn disease Mucosa-associated lymphoid tissue lymphoma Rare diagnosis Gastrointestinal diseases Thiopurines Case report

Gastrectomy impact on the gut microbiome in patients with gastric cancer:A comprehensive review

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World Journal of Gastrointestinal Surgery 2021年第7期13卷 678-688页

作者： vaidota Maksimaityte Augustinas Bausys Marius Kryzauskas Martynas Luksta Ieva Stundiene Klaudija Bickaite Bernardas Bausys Tomas Poskus Rimantas Bausys Kestutis Strupas Clinic of Gastroenterology Nephrourologyand SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 03101Lithuania Department of Abdominal Surgery and Oncology National Cancer InstituteVilnius 08660Lithuania Faculty of Medicine Vilnius Universityilnius 03101Lithuania

Gastric cancer is one of the most common malignancies worldwide and gastrectomy remains the only potentially curative treatment option for this ***,the surgery leads to significant physiological and anatomical changes in the gastrointestinal(GI)tract including loss of the gastric barrier,an increase in oxygenation levels in the distal gut,and biliary diversion after *** changes in the GI tract influence the composition of the gut microbiome and thus,host ***-induced dysbiosis is characterized by increased abundance of typical oral cavity bacteria,an increase in aero-tolerant bacteria(aerobes/facultative anaerobes),and increased abundance of bile acidtransforming ***,this dysbiosis is linked to intestinal inflammation,small intestinal bacterial overgrowth,various GI symptoms,and an increased risk of colorectal cancer.

关键词： Gut microbiota Dysbiosis Gastric cancer Gastrectomy Microbiome Comprehensive review