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Journal of Intelligent Learning Systems and Applications 2010年第1期2卷 36-42页

作者： Johnson A. Asumadu vaidhyanathan jagannathan Arkhom Chachavalnanont 不详

An intelligent fuzzy logic inference pipeline for the control of a dc-dc buck-boost converter was designed and built using a semi-custom VLSI chip. The fuzzy linguistics describing the switching topologies of the converter was mapped into a look-up table that was synthesized into a set of Boolean equations. A VLSI chip–a field programmable gate array (FPGA) was used to implement the Boolean equations. Features include the size of RAM chip independent of number of rules in the knowledge base, on-chip fuzzification and defuzzification, faster response with speeds over giga fuzzy logic inferences per sec (FLIPS), and an inexpensive VLSI chip. The key application areas are: 1) on-chip integrated controllers;and 2) on-chip co-integration for entire system of sensors, circuits, controllers, and detectors for building complete instrument systems.

关键词： Multi-Fuzzy Logic Controller (MFLC) Field Programmable Gate Array (FPGA) Buck-Boost Converter Boolean Look-Up Table Co-Integration

Synthesis of Nonlinear Control of Switching Topologies of Buck-Boost Converter Using Fuzzy Logic on Field Programmable Gate Array (FPGA)

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Online optimal control of nonlinear discrete-time systems using approximate dynamic programming

Journal of Intelligent Learning Systems and Applications（智能学习系统与应用） 2010年第1期

作者： Johnson A. Asumadu vaidhyanathan jagannathan Arkhom Chachavalnanont

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控制理论与应用（英文版） 2011年第3期9卷 361-369页

作者： Travis DIERKS Sarangapani jagannathan DRS Sustainment Systems Inc.201 Evans Lane Department of Electrical and Computer Engineering Missouri University of Science and Technology

In this paper,the optimal control of a class of general affine nonlinear discrete-time(DT) systems is undertaken by solving the Hamilton Jacobi-Bellman(HJB) equation online and forward in *** proposed approach,referred normally as adaptive or approximate dynamic programming(ADP),uses online approximators(OLAs) to solve the infinite horizon optimal regulation and tracking control problems for affine nonlinear DT systems in the presence of unknown internal *** the regulation and tracking controllers are designed using OLAs to obtain the optimal feedback control signal and its associated cost ***,the tracking controller design entails a feedforward portion that is derived and approximated using an additional OLA for steady state *** update laws for tuning the unknown parameters of the OLAs online are *** techniques are used to show that all signals are uniformly ultimately bounded and that the approximated control signals approach the optimal control inputs with small bounded *** the absence of OLA reconstruction errors,an optimal control is *** results verify that all OLA parameter estimates remain bounded,and the proposed OLA-based optimal control scheme tunes itself to reduce the cost HJB equation.

关键词： Online nonlinear optimal control Hamilton Jacobi-Bellman Online approximators Discrete-time systems

Hyperbaric oxygen therapy and chemokine administration - a combination with potential therapeutic value for treating diabetic wounds

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World Journal of Diabetes 2022年第12期13卷 1122-1130页

作者： jagannathan Venkataseshan Pragasam Viswanathan School of Bio Sciences and Technology Vellore Institute of TechnologyVellore 632014Tamil NaduIndia

Non-healing wounds impart serious medical problems to people with *** 15%of diabetic patients,the incidence of foot ulcer is the most prevailing,which confers a significant risk of limb amputation,mainly due to hypoxia and impairment in cell *** in the expression of chemokines and the related factors in diabetic conditions delays the recruitment of different cell types,including fibroblasts,keratinocytes,and immune cells such as macrophages to the site of injury,further impairing neovasculogenesis,reepithelialization,and extracellular matrix ***,proper activation of effector cells through an accurate signal pathway is necessary for better therapeutic *** oxygen therapy(HBOT)is the current treatment prescribed by medical practitioners,shown to have increased the wound healing rate by reducing the need for significant amputation among the diabetic ***,the risk of morbidity associated with HBOT needs complete attention through rigorous research to avoid adverse *** the level of pro-angiogenic chemokines may regulate the inflammatory response,further promote vascularization,and enhance the complete healing of wounds in diabetic ***,a combination of better therapeutic approaches could pave the way for developing a successful treatment for diabetic foot and wound healing.

关键词： Diabetic foot Wound healing Hyperbaric oxygen therapy Chemokines Combinatorial therapy

Near Optimal Output Feedback Control of Nonlinear Discrete-time Systems Based on Reinforcement Neural Network Learning

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IEEE/CAA Journal of Automatica Sinica 2014年第4期1卷 372-384页

作者： Qiming Zhao Hao Xu Sarangapani jagannathan the DENSO International America Inc. with the College of Science and Engineering Texas A&M University the Department of Electrical&Computer Engineering Missouri University of Science and Technology

In this paper, the output feedback based finitehorizon near optimal regulation of nonlinear affine discretetime systems with unknown system dynamics is considered by using neural networks(NNs) to approximate Hamilton-JacobiBellman(HJB) equation solution. First, a NN-based Luenberger observer is proposed to reconstruct both the system states and the control coefficient matrix. Next, reinforcement learning methodology with actor-critic structure is utilized to approximate the time-varying solution, referred to as the value function, of the HJB equation by using a NN. To properly satisfy the terminal constraint, a new error term is defined and incorporated in the NN update law so that the terminal constraint error is also minimized over time. The NN with constant weights and timedependent activation function is employed to approximate the time-varying value function which is subsequently utilized to generate the finite-horizon near optimal control policy due to NN reconstruction errors. The proposed scheme functions in a forward-in-time manner without offline training phase. Lyapunov analysis is used to investigate the stability of the overall closedloop system. Simulation results are given to show the effectiveness and feasibility of the proposed method.

关键词： Approximation methods Artificial neural networks Feedback Learning (artificial intelligence) Nonlinear dynamical systems Observers Optimal control Finite-horizon Hamilton-Jacobi-Bellman equation approximate dynamic programming neural network optimal regulation Optimal control Approximation method Output Feedback Control Feedback Nonlinear dynamical systems Observers System dynamics Artificial neural networks Neural network dynamic programming

Optimal regulation of uncertain dynamic systems using adaptive dynamic programming

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Journal of Control and Decision 2014年第3期1卷 226-256页

作者： Hao Xu Qiming Zhao S.jagannathan Department of Electrical and Computer Engineering Missouri University of Science and TechnologyRollaMOUSA

In this tutorial paper,the finite-horizon optimal adaptive regulation of linear and nonlinear dynamic systems with unknown system dynamics is presented in a forward-in-time manner using adaptive dynamic programming(ADP).An adaptive estimator(AE)is introduced with the idea of Q-learning to relax the requirement of system dynamics in the case of linear system,while neural network-based identifier is utilised for nonlinear *** time-varying nature of the solution to the Bellman/Hamilton–Jacobi–Bellman equation is handled by utilising a time-dependent basis function,while the terminal constraint is incorporated as part of the update law of the AE/Identifier in solving the optimal feedback *** an initial admissible control,the proposed optimal regulation scheme of the uncertain linear and nonlinear system yields a forward-in-time and online solution without using value and/or policy *** adaptive observer is utilised for linear systems in order to relax the need for state availability so that the optimal adaptive control design depends only on the reconstructed ***,the optimal control is covered for nonlinear-networked control systems where in the feedback loop is closed via a communication *** of the proposed approach is verified by simulation *** end result is a variant of a roll-out scheme in ADP wherein an initial admissible policy is selected as the base policy and the control policy is enhanced using a one-time policy improvement at each sampling interval.

关键词： adaptive dynamic programming finite horizon optimal control

S gene drop-out predicts super spreader H69del/V70del mutated SARS-CoV-2 virus

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Asian Pacific Journal of Tropical Medicine 2021年第5期14卷 236-237页

作者： Mahadevan Ganesan jagannathan Renganathan Vaithiyanadhaswamy Vasuki Raj Joseph Viral Research and Diagnostic Laboratory Department of MicrobiologyGovernment Thiruvarur Medical CollegeThiruvarur-610004TamilnaduIndia Department of Microbiology Government Thiruvarur Medical College Thiruvarur-610004TamilnaduIndia

Emergence of newer SARS-CoV-2 variants,especially strain B.1.1.7/SARS-CoV-2 VUI 202012/01,discovered in the United Kingdom with H69del/V70del mutation in spike S gene was reported with higher transmissibility of up to 70%[1].Identification of this variant was sparsely done in India because performing routine diagnosis as well as genomic surveillance using a single kit is the hour of *** our knowledge,two publications identified the aforesaid mutation by phenomena called S gene drop-out using Applied Biosystems TaqPath COVID-19 Combo kit(Thermo Fisher Scientific,Waltham,USA)[2-4].

关键词： Combo knowledge routine

Magnesium incorporated chitosan based scaffolds for tissue engineering applications

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Bioactive Materials 2016年第2期1卷 132-139页

作者： Udhab Adhikari Nava PRijal Shalil Khanal Devdas Pai jagannathan Sankar Narayan Bhattarai Department of Mechanical Engineering North Carolina A&T State UniversityGreensboroNCUSA Department of Chemical Biological and BioengineeringNorth Carolina A&T State UniversityGreensboroNCUSA Department of Energy and Environmental Systems North Carolina A&T State UniversityGreensboroNCUSA NSF ERC for Revolutionizing Metallic Biomaterials North Carolina A&T State UniversityGreensboroNCUSA

Chitosan based porous scaffolds are of great interest in biomedical applications especially in tissue engineering because of their excellent biocompatibility in vivo,controllable degradation rate and tailorable mechanical *** paper presents a study of the fabrication and characterization of bioactive scaffolds made of chitosan(CS),carboxymethyl chitosan(CMC)and magnesium gluconate(MgG).Scaffolds were fabricated by subsequent freezing-induced phase separation and lyophilization of polyelectrolyte complexes of CS,CMC and *** scaffolds possess uniform porosity with highly interconnected pores of 50-250 μm size *** strengths up to 400 kPa,and elastic moduli up to 5 MPa were *** scaffolds were found to remain intact,retaining their original threedimensional frameworks while testing in in-vitro *** scaffolds exhibited no cytotoxicity to 3T3 fibroblast and osteoblast *** observations demonstrate the efficacy of this new approach to preparing scaffold materials suitable for tissue engineering applications.

关键词： Chitosan Magnesium gluconate Carboxymethyl chitosan Tissue engineering Composite scaffolds

High amplitude high frequency oscillations during posttraumatic epileptogenesis

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Brain Science Advances 2023年第4期9卷 275-282页

作者： jagannathan Rangarajan Udaya Kumar Department of Neurology University of California Los AngelesLos Angeles 90024CaliforniaU.S.A.

Background: The aim of the present study was to investigate if high amplitude high frequency oscillations(haHFOs) could be a biomarker of posttraumatic epileptogenesis. Methods: After an initial craniotomy of rats and inducement of traumatic brain injury(TBI) through a fluid percussion, recording microelectrodes were implanted bilaterally in different brain *** brain electrical activity was recorded intermittently from Day 1 of TBI and continued till week 21. HaHFO analysis was performed during the first 4 weeks to investigate whether the occurrence of this brain activity predicted development of epilepsy or not. Results: Of the 21 rats which received the TBI, 9 became epileptic(E+) and 12 did not(E-). HaH FOs were observed in the prefrontal and perilesional cortices, hippocampus, and striatum in both E+ and E-group. In comparison to the rats in E-, the E+ group showed a significant increase in the rate of haHFO from weeks 1 to 4 after ***: The results indicate that an increase in the rate of haHFOs after TBI could be an electroencephalographic biomarker of posttraumatic epileptogenesis.

关键词： traumatic brain injury epilepsy high frequency oscillations biomarker

Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria

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Cellular & Molecular Immunology 2020年第8期17卷 799-806页

作者： Stephen Tukwasibwe Annettee Nakimuli James Traherne Olympe Chazara Jyothi Jayaraman John Trowsdale Ashley Moffett Prasanna jagannathan Philip JRosenthal Stephen Cose Francesco Colucci Makerere University KampalaUganda University of Cambridge CambridgeUK University of Cambridge Centre for Trophoblast Research CambridgeUK School of Medicine Stanford UniversityStanfordCAUSA University of California San FranciscoCAUSA MRC/UVRI and LSHTM Uganda Research Unit KampalaUganda Department of Obstetrics&Gynaecology National Institute for Health Research Cambridge Biomedical Research CentreUniversity of CambridgeCambridgeCB20SWUK

Malaria is one of the deadliest infectious diseases in the world. Immune responses to Plasmodium falciparum malaria vary among individuals and between populations. Human genetic variation in immune system genes is likely to play a role in this heterogeneity. Natural killer (NK) cells produce inflammatory cytokines in response to malaria infection, kill intraerythrocytic Plasmodium falciparum parasites by cytolysis, and participate in the initiation and development of adaptive immune responses to plasmodial infection. These functions are modulated by interactions between killer-cell immunoglobulin-like receptors (KIRs) and human leukocyte antigens (HLAs). Therefore, variations in KIR and HLA genes can have a direct impact on NK cell functions. Understanding the role of KIRs and HLAs in immunity to malaria can help to better characterize antimalarial immune responses. In this review, we summarize the different KIRs and HLAs associated with immunity to malaria thus far.

关键词： Genetic variation Human Leukocyte Antigen Innate immunity Killer-cell immunoglobulin-like receptor Malaria Natural killer cells