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Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function

Health（健康） 2012年第7期

作者： Bhaskar Purohit Ashok wadhwa

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World Journal of Gastroenterology 2016年第20期22卷 4918-4925页

作者： Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja Department of Gastroenterology Q3 Cleveland Clinic Department of Radiology Cleveland Clinic Department of Cardiothoracic Surgery Cleveland Clinic

AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in ***: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for ***: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg res

关键词： Achalasia Dysphagia Heller myotomy Peroral endoscopic myotomy Manometry Pneumatic dilation

高性能水性环氧固化剂及其在水性环氧自流平体系中的应用

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高性能水性环氧固化剂及其在水性环氧自流平体系中的应用

胎盘促肾上腺皮质激素释放激素、自发早产与胎儿宫内发育迟缓:一项前瞻性调查

2019年全国地坪行业技术创新研讨大会

作者：朱亚菲 Daniel Suckley Achim Klippstein Neeraj Tripathi Anil wadhwa 阿迪塔亚博拉化学品(泰国)有限公司-环氧部门德国CTP(GmbH)

本文介绍一种聚合物乳液形态超高分子量环氧树脂-胺加成物水性环氧固化剂EPOTECTHW-4509的特点及其在厚涂水性环氧自流平体系中的应用。EPOTECTHW-4509使水性环氧自流平体系具有低VOC、高体积稳定性、高水蒸气透过性及很好的早期硬度与... 详细信息

本文介绍一种聚合物乳液形态超高分子量环氧树脂-胺加成物水性环氧固化剂EPOTECTHW-4509的特点及其在厚涂水性环氧自流平体系中的应用。EPOTECTHW-4509使水性环氧自流平体系具有低VOC、高体积稳定性、高水蒸气透过性及很好的早期硬度与强度发展等特点。

关键词：水性环氧固化剂水性环氧自流平体积稳定性硬度强度

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世界核心医学期刊文摘（妇产科学分册） 2005年第3期1卷 10-11页

作者： wadhwa P.D. Garite T.J. Porto M. 程广艳

Recent advances in the physiology of human pregnancy have implicated placental corticotropin releasing hormone (CRH) as one of the primary endocrine mediators of parturition and possibly also of fetal development. The aim of this study was (1) to prospectively assess the relationship of maternal plasma concentrations of CRH in the early third trimester of gestation with two prematurity related outcomes spontaneous preterm birth (PTB), and small for gestational age birth (SGA), and (2) to determine whether the effects of CRH on each of these outcomes are independent from those of other established obstetric risk factors. In a sample of 232 women with a singleton, intrauterine pregnancy, maternal plasma was collected at 33 weeks gestation and CRH concentrations were determined by radioimmunoassay. Each pregnancy was dated on the basis of last menstrual period and early ultrasonography. Parity, obstetric risk conditions for prematurity, mode of delivery, and birth outcomes were abstracted from the medical record. After adjusting for the effects of established obstetric risk factors, elevated CRH levels at 33 weeks gestation were significantly associated with a 3.3 fold increase in the adjusted relative risk (RR) for spontaneous preterm birth and with a 3.6 fold increase in the adjusted relative risk for fetal growth restriction. Women who delivered postterm had significantly lower CRH levels in the early third trimester than those who delivered at term. When outcomes were stratified by gestational length and birth weight, the lowest CRH levels at 33 weeks gestation were associated with the term non SGA births, intermediate and approximately equal CRH levels were associated with the preterm non SGA and term SGA births, and the highest CRH levels were associated with the preterm SGA births. For deliveries occurring after 33 weeks gestation (the time of CRH sampling in this study), our findings support the notion that in humans placental CRH may play an impending, dir

关键词：前瞻性调查胎儿发育末次月经分娩发动足月分娩过期妊娠妊娠早期分娩孕妇小于胎龄儿宫内妊娠

Vaccines and Antibodies for Therapeutic Use in Cancers

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Journal of Cancer Therapy 2016年第6期7卷 370-377页

作者： G. P. Talwar Jagdish C. Gupta M. Diwan J. Frick S. K. Sharma S. N. wadhwa R. M. Gupta S. K. Gupta Shilpi Purswani Hemant K. Vyas Talwar Research Foundation New Delhi India Urologische Zentrum Salzburg Salzburg Austria Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh India Sir Ganga Ram Hospital New Delhi India National Institute of Immunology New Delhi India

This review describes briefly the beneficial use of two vaccines developed by us for treatment of cancers. The vaccine against Luteinizing Hormone Releasing Hormone (LHRH) is effective in carcinoma of prostate as well as in breast cancers dependent on androgens and estrogens respectively. LHRH being identical in both males and females, the same vaccine is usable in both Prostate and Breast steroid hormones-dependent-cancers. Monoclonal antibodies are finding therapeutic utility in several cancers, and many have received Drugs Regulatory approval. The monoclonals developed by us against hCG and against epitopes present on androgen-independent castration resistant prostate cancers are briefly recapitulated. Anti-hCG antibodies kill several cancers expressing hCG. An example is given of A549 lung carcinoma. MoAb730 and MoAb7B2G10 kill DU-145 and PC-3 androgen-independent castration resistant prostate cancer cells. Some cancers such as MOLT-4, a T-lymphoblastic leukemia, though expressing hCG are not killed by PiPP, the high affinity anti-hCG antibody. Linking the antibody to curcumin however works like a “Magic Bullet”. All MOLT-4 cells are killed by this conjugate, the antibody homes selectively to cancer cells expressing hCG to deliver curcumin which exercises the killing effect. A recombinant vaccine, hCGβ-LTB (human chorionic gonadotropin subunit β linked to B subunit of heat-labile enterotoxin of E. coli) has been made, which induces high titre bioeffective antibodies not only in BalbC, but also in other genetic strains of mice. The vaccine employs autoclaved Mycobacterium indicus pranii (MiP) as adjuvant. MiP invigorates both humoral and cell mediated immune responses against Human chorionic gonadotropin (hCG). Besides being a potent adjuvant, MiP used alone heals anogenital warts in humans and has the property of preventing and curing SP2/O Myelomas in mice.

关键词： Human Chorionic Gonadotropin (hCG) LHRH Prostate Cancer Breast Cancer Antibody-Curcumin Magic Bullets

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制造业凭什么重返美国

浙商 2012年第15期 -页

作者： Vivek wadhwa 奇点大学学术创新委员会

中国不动产和基础设施泡沫令人感到十分担心,但这些都只是短期的挑战,中国应该有能力走出这些困境.对中国经济来说,真正的威胁是更大而且更长期的,那就是其制造业泡沫.通过提供补助金、廉价劳动力以及宽松的监管措施等方式,中国得以吸... 详细信息

中国不动产和基础设施泡沫令人感到十分担心,但这些都只是短期的挑战,中国应该有能力走出这些困境.对中国经济来说,真正的威胁是更大而且更长期的,那就是其制造业泡沫.通过提供补助金、廉价劳动力以及宽松的监管措施等方式,中国得以吸引美国公司将其制造业务迁往这一市场.成百万的美国工作岗位已经迁往中国,而制造业已经成为中国经济增长和繁荣的支柱.但是,上升中的劳动力成本、有关IP盗窃案的担忧情绪,以及生产时间的延迟已经促使陶氏化学、卡特彼勒、通用电气和福特汽车等公司开始将部分制造业务从中国转回到美国本土市场上.谷歌也在最近宣布,其Nexus Q流媒体播放器将在美国本土制造,这同时还将对苹果造成压力,推动其开始仿效.

关键词：制造业中国经济美国媒体播放器廉价劳动力劳动力成本业务陶氏化学本土市场生产时间泡沫卡特彼勒经济增长监管措施基础设施工作岗位福特汽车盗窃案不动产补助金

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印度的成功在于培养本土人才

国际人才交流 2011年第12期 13-13页

作者： Vivek wadhwa 美国杜克大学普拉特工程学院哈佛大学法学院

吸引海外的人才固然重要，但前提是把内部的核心问题解决好，否则就不会有创新。

关键词：本土人才培养成功印度

Treatment Outcomes of Germ Cell Tumors of Ovary:Single Institutional Study

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Journal of Oncology Research 2021年第1期3卷 17-21页

作者： Rohit Kumar Jha Ajit Kumar Kushwaha Mukunda Kumar Sunaina wadhwa Sumedha Gargy Department of surgical oncology Rajendra Institute of Medical SciencesRanchi Department of Biochemistry All India Institute of Medical SciencesPatna Ex-fellow Department of Gynaecological OncologyTMCKolkata

5%of all ovarian tumours are accounted to germ cell tumours(GCT’s).Affecting mostly young women,the highest incidence is seen in second and third decade of *** are highly malignant but chemosensitive and more curable than their epithelial *** these tumors with effective surgery and combination chemotherapy survival rates have dramatically improved in recent *** present our experience of ovarian germ cell tumours in the department of Surgical Oncology,Rajendra Institute of Medical Sciences(RIMS),Ranchi with special emphasis on treatment outcomes.A retrospective review of hospital medical records of patients with ovarian germ cell tumours diagnosed and treated at RIMS from June 2019 to August 2020,was *** profile and treatment outcome of patients were recorded.A total of 19 patients met *** median age at diagnosis was 20 years(range 11-42 years)and all had good performance *** except two patients underwent surgery,70.6%and 29.4%in upfront and interval debulking surgery(IDS)setting *** preserving surgery was done in 75%patients in the primary surgery group and 60%undergoing IDS.83.3%patients received BEP as adjuvant chemotherapy whereas 80%as neo-adjuvant ***(31.5%)patients had dysgerminoma as final histology,followed by mixed histology(26.3%),yolk sac tumour(15.7%),immature teratoma(15.7%)and choriocarcinoma(10.5%).47.3%patients were in Stage I at the time of diagnosis.78.9%patients were alive without disease,10.5%recurred,and 10.5%were lost to follow up.

关键词： Germ cell tumour Dysgerminoma BEP Fertility sparing surgery Yolk sac tumour

Incremental value of magnetic resonance neurography of Lumbosacral plexus over non-contributory lumbar spine magnetic resonance imaging in radiculopathy: A prospective study

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World Journal of Radiology 2016年第1期8卷 109-116页

作者： Avneesh Chhabra Sahar J Farahani Gaurav K Thawait Vibhor wadhwa Allan J Belzberg John A Carrino Musculoskeletal Radiology University of Texas Southwestern Medical Center The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Department of Radiology University of Arkansas for Medical Sciences Department of Neurosurgery Johns Hopkins University School of Medicine Department of Radiology and Imaging Hospita for Special Surgery

AIM: To test the incremental value of 3T magnetic resonance neurography(MRN) in a series of unilateral radiculopathy patients with non-contributory magnetic resonance imaging(MRI).METHODS: Ten subjects(3 men,7 women; mean age54 year and range 22-74 year) with unilateral lumbar radiculopathy and with previous non-contributory lumbar spine MRI underwent lumbosacral(LS) plexus MRN over a period of one year. Lumbar spine MRI performed as part of the MRN LS protocol as well as bilateral L4-S1 nerves,sciatic,femoral and lateral femoral cutaneous nerves were evaluated in each subject for neuropathy findings on both anatomic(nerve signal,course and caliber alterations) and diffusion tensor imaging(DTI)tensor maps(nerve signal and caliber alterations).Minimum fractional anisotropy(FA) and mean apparent diffusion coeffcient(ADC) of L4-S2 nerve roots,sciatic and femoral nerves were ***: All anatomic studies and 80% of DTI imaging received a good-excellent imaging quality grading. In a blinded evaluation,all 10 examinations demonstrated neural and/or neuromuscular abnormality corresponding to the site of radiculopathy. A number of contributory neuropathy findings including double crush syndrome were observed. On DTI tensor maps,nerve signal and caliber alterations were more conspicuous. Although individual differences were observed among neuropathic appearing nerve(lower FA and increased ADC) as compared to its contralateral counterpart,there were no significant mean differences on statistical comparison of LS plexus nerves,femoral and sciatic nerves(P > 0.05).CONCLUSION: MRN of LS plexus is useful modality for the evaluation of patients with non-contributory MRI of lumbar spine as it can incrementally delineate the etiology and provide direct objective and non-invasive evidence of neuromuscular pathology.

关键词： Magnetic resonance imaging Neurography Lumbosacral plexus Radiculopathy

3T magnetic resonance neurography of pudendal nerve with cadaveric dissection correlation

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World Journal of Radiology 2016年第7期8卷 700-706页

作者： Avneesh Chhabra Courtney A McKenna Vibhor wadhwa Gaurav K Thawait John A Carrino Gary P Lees A Lee Dellon Musculoskeletal Radiology University of Texas Southwestern Medical Center the Russell H.Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Department of Art As Applied to Medicine Johns Hopkins University Department of Radiology University of Arkansas for Medical Sciences Department of Radiology and Imaging Hospital for Special Surgery Department of Plastic Surgery and Neurosurgery Johns Hopkins University School of Medicine

AIM: To evaluate the pudendal nerve segments that could be identified on magnetic resonance neurography(MRN) before and after surgical marking of different nerve ***: The hypothesis for this study was that pudendal nerve and its branches would be more easily seen after the surgical nerve marking. Institutional board approval was obtained. One male and one female cadaver pelvis were obtained from the anatomy board and were scanned using 3 Tesla MRI scanner using MR neurography sequences. All possible pudendal nerve branches were identified. The cadavers were then sent to the autopsy lab and were surgically dissected by a peripheral nerve surgeon and an anatomist to identify the pudendal nerve branches. Radiological markers were placed along the course of the pudendal nerve and its branches. The cadavers were then closed and rescanned using the same MRN protocol as the premarking scan. The remaining pudendal nerve branches were attempted to be identified using the radiological markers. All scans were read by an experienced musculoskeletal ***: The pre-marking MR Neurography scans clearly showed the pudendal nerve at its exit from the lumbosacral plexus in the sciatic notch, at the level of the ischial spine and in the Alcock's Canal in both cadavers. Additionally, the right hemorrhoidal branch could be identified in the male pelvis cadaver. The perineal and distal genital branches could not be identified. On post-marking scans, the markers were used as identifiable structures. The location of the perineal branch, the hemorroidal branch and the dorsal nerve to penis(in male cadaver)/clitoris(in female cadaver) could be seen. However, the visualization of these branches was suboptimal. The contralateral corresponding nerves were poorly seen despite marking on the surgical side. The nerve was best seen on axial T1W and T2W SPAIR images. The proximal segment could be seen well on 3D DW PSIF sequence. T2W SPACE was not very useful in visualizat

关键词： Pudendal nerve Cadaver Magnetic resonance neurography Chronic pelvic pain