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Finite element analysis of controlled low strength materials

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Frontiers of structural and Civil Engineering 2019年第5期13卷 1243-1250页

作者： vahid ALIZADEH Gildart Haase school of Computer sciences & Engineering Fairleigh Dickinson UniversityTeaneckNJ 07666USA

Controlled low strength materials (CLsM) are flowable and self-compacting construction materials that have been used in a wide variety of applications. This paper describes the numerical modeling of CLsM fills with finite element method under compression loading and the bond performance of CLsM and steel rebar under pullout loading. The study was conducted using a plastic-damage model which captures the material behavior using both classical theory of elasto-plasticity and continuum damage mechanics. The capability of the finite element approach for the analysis of CLsM fills was assessed by a comparison with the experimental results from a laboratory compression test on CLsM cylinders and pullout tests. The analysis show's that the behavior of a CLsM fill w'hile subject to a failure compression load or pullout tension load can be simulated in a reasonably accurate manner.

关键词： CLsM finite element method compressive strength pullout numerical modeling plastic damage model

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Phytolith evidence for human-plant subsistence in Yahuai Cave(Guangxi, south China) over the past 30000 years

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science China Earth sciences 2020年第11期63卷 1745-1757页

作者： Yan WU Guangmao XIE limi MAO Zhijun ZHAO Miriam BELMAKER Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China CAs Center for Excellence in Life and Paleoenvironment Beijing 100044China College of History Culture and TourismGuangxi Normal UniversityGuilin 541001China Guangxi Institute of Cultural Relic Protection and Archaeology Nanning 530022China state Key Laboratory of Palaeobiology and stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Institute of Archaeology Chinese Academy of Social SciencesBeijing 100710China Department of Anthropology University of TulsaTulsaOklahoma 74104USA

south China preserves a rich archaeological record elucidating the evolution of early modern humans during the Late ***,few studies on plant utilization were conducted in this *** used phytolith analysis from Yahuai Cave,Guangxi,to infer human use of plant resources over the past 30000 *** 14C dating was used to constrain the chronological *** indicate that several economically essential species were present throughout the sequence including Urticineae(*** sp.),which appears in the lower layers of the sequence(Marine Isotope stage 3 through Heinrich 1);bamboo and palm which appear throughout the sequence,and wild rice which appears in a clear archaeological context dating to 16000 years *** is the earliest record of wild rice in south China and a prerequisite for rice *** unique stone tool assemblages,which resemble those in north China as opposed to south China,point to the possibility that humans,seeking refuge from the colder north,brought their tool kit with them and utilized familiar northern *** south China would have served as a refuge for human populations escaping the cold,harsh climate in the north with more ameliorate conditions in the south.

关键词： Phytolith Wild rice south China Bamboo Late Pleistocene

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Understanding activity of butyrate at a cellular level

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Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber

Microglial dysfunction and genetic risk for neurodegenerative disease

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Neural Regeneration Research 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald Jay Penney Department of Biomedical sciences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations *** tremendous progress has been made,our understanding of the mechanisms that underlie the development of these diseases remains far from com *** troubling,despite the growing emotional and financial toll being to ken by neurodegenerative disorders,existing treatment options are limited almost exclusively to those that help manage symptoms but that lack the ability to alter the progression of the disease(Liu et al.,2022).

关键词： degenerative diseases

Effects of foundation rocking and uplifting on displacement amplification factor

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Earthquake Engineering and Engineering Vibration 2018年第3期17卷 511-525页

作者： Mohammad Khanmohammadi vahid Mohsenzadeh school of Civil Engineering University of Tehran Department of Civil Engineering Mc Master University

Prediction of displacement demand to assess seismic performance of structures is a necessary step where nonlinear static procedures are *** such predictions have been well established in literature for fixed-base structures,fewer bodies of researches have been carried out on the effect of rocking and uplifting of shallow foundations supported by soil,on such *** paper aimed to investigate the effect of soil structure interaction on displacement amplification factor C1 using the beam on nonlinear Winkler foundation concept.A practical range of natural period,force reduction factors,and wide range of anticipated behavior from rocking,uplifting and hinging are considered and using thousands nonlinear time history analysis,displacement amplification factors are *** results indicate that the suggested equations in current rehabilitation documents underestimate displacement demands in the presence of foundation rocking and ***,using regression analyses,new equations are proposed to estimate mean values of C1.

关键词： soil-structure interaction rocking and uplifting foundations displacement amplification factor

Dielectric microspheres enhance microscopy resolution mainly due to increasing the effective numerical aperture

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Light(science & Applications) 2023年第1期12卷 17-19页

作者： Arash Darafsheh vahid Abbasian Department of Radiation Oncology Washington University School of Medicine in St.LouisSt.LouisMO 63110USA

Microsphere-assisted microscopy utilizing a microsphere in immediate proximity of the specimen boosts the imaging resolution mainly as a result of an increase in the effective numerical aperture of the system.

关键词： resolution numerical utilizing