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A Seismic Hazard map Based on Geology and Shear-wave Velocity in Rawalpindi–Islamabad,Pakistan

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Acta Geologica Sinica(English Edition) 2021年第2期95卷 659-673页

作者： Sarfraz KHAN muhammad WASEEm m.Asif KHAN National Centre of Excellence in Geology University of Peshawar 25130KPPakistan University of Peshawar 25120 KPPakistan

The‘twin cities’district of Rawalpindi–Islamabad is among the most endangered seismic regions in Pakistan,with the seismic hazard assessed(0.32 g)to intensity IX mmI for a 475-year return period.A seismic hazard map for Rawalpindi–Islamabad is presented herein,based on 85 shear-wave velocity(VS)profiles obtained through geophysical H/V measurements and from the geological map of the *** between the average top thirty-meter shear-wave velocities(VS30)and surficial geological units have been *** peak ground acceleration(PGA)maps for 150,475 and 2475-year return periods were converted into a seismic intensity *** increments for different soils were used to compute PGA values for 150,475 and 2475-year return *** located on softer ground experienced a higher degree of damage from moderate *** to the presence of soft clay or liquefiable soil and lateral spreading,a few locations may be classified as hybrid sites class C and *** map is a critical step in facilitating code-based site classification and seismic design throughout Rawalpindi–*** the seismic hazard map based on seismic intensities is no longer used in engineering geology,it is still important in seismological analysis and for civil protection purposes.

关键词： seismic hazard site classification intensity increment engineering geology Rawalpindi-Islamabad

Dendritic cells in cancer immunology

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Cellular & molecular Immunology 2022年第1期19卷 3-13页

作者： Theresa L.murphy Kenneth m.murphy Department of Pathology and Immunology Washington University in St.LouisSchool of MedicineSt.LouisMO 63110USA

The clinical success of immune checkpoint therapy(ICT)has produced explosive growth in tumor immunology research because ICT was discovered through basic studies of immune *** of the current translational efforts are aimed at enhancing ICT by identifying therapeutic targets that synergize with CTLA4 or PD1/PD-L1 blockade and are solidly developed on the basis of currently accepted *** these principles through continuous basic research may help broaden translational *** this mindset,we focused this review on three threads of basic research directly relating to mechanisms underlying ***,this review covers three aspects of dendritic cell(DC)biology connected with antitumor immune responses but are not specifically oriented toward therapeutic ***,we review recent advances in the development of the cDC1 subset of DCs,identifying important features distinguishing these cells from other types of ***,we review the antigen-processing pathway called cross-presentation,which was discovered in the mid-1970s and remains an *** pathway serves an essential in vivo function unique to cDC1s and may be both a physiologic bottleneck and therapeutic ***,we review the longstanding field of helper cells and the related area of DC licensing,in which CD4 T cells influence the strength or quality of CD8 T cell *** topic is connected with ICT in some manner but is also a fundamental aspect of cell-mediated immunity directed toward intracellular pathogens.

关键词： Dendritic cells transcription factors cross-presentation tumor rejection CD4 help

Calculation of the VKI turbine blade with LES and DES

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Journal of Thermal Science 2007年第4期16卷 321-327页

作者： F.magagnato B.Pritz m.Gabi FSm University of KarlsruheGermany

The prediction of the laminar to turbulent transition is essential in the calculation of turbine blades, compressor blades or airfoils of airplanes since a non negligible part of the flow field is laminar or transitional. In this paper we compare the prediction capability of the Detached Eddy Simulation （DES） with the Large Eddy Simulation （LES） using the high-pass filtered （HPF） Smagorinsky model （Stolz et al.[1]） when applied to the calculation of transitional flows on turbine blades. Detailed measurements from Canepa et al.[2] of the well known VKI-turbine blade served to compare our results with the experiments. The calculations have been made on a fraction of the blade （10%） using non-reflective boundary conditions of Freund at the inlet and outlet plane extended to internal flows by magagnato et al.[3] in combination with the Synthetic Eddy method （SEm） proposed by Jarrin et al.[4]. The SEm has also been extended by Pritz et al.[5] for compressible flows. It has been repeatedly shown that hybrid approaches can satisfactorily predict flows of engineering relevance. In this work we wanted to investigate if they can also be used successfully in this difficult test case.

关键词： Turbine blade LES DES transition

Comparison of three-dimensional fluorescence analysis methods for predicting formation of trihalomethanes and haloacetic acids

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Journal of Environmental Sciences 2015年第1期27卷 159-167页

作者： Nicolás m.Peleato Robert C.Andrews Department of Civil Engineering University of Toronto

This work investigated the application of several fluorescence excitation–emission matrix analysis methods as natural organic matter（NOm） indicators for use in predicting the formation of trihalomethanes（THms） and haloacetic acids（HAAs）. Waters from four different sources（two rivers and two lakes） were subjected to jar testing followed by 24 hr disinfection by-product formation tests using chlorine. NOm was quantified using three common measures： dissolved organic carbon, ultraviolet absorbance at 254 nm, and specific ultraviolet absorbance as well as by principal component analysis, peak picking,and parallel factor analysis of fluorescence spectra. Based on multi-linear modeling of THms and HAAs, principle component（PC） scores resulted in the lowest mean squared prediction error of cross-folded test sets（THms： 43.7（μg/L）^2, HAAs： 233.3（μg/L）^2）. Inclusion of principle components representative of protein-like material significantly decreased prediction error for both THms and HAAs. Parallel factor analysis did not identify a protein-like component and resulted in prediction errors similar to traditional NOm surrogates as well as fluorescence peak picking. These results support the value of fluorescence excitation–emission matrix–principal component analysis as a suitable NOm indicator in predicting the formation of THms and HAAs for the water sources studied.

关键词： Natural organic matter Fluorescence Principal component analysis PARAFAC Disinfection byproducts Drinking water

Processing map for hot working of SiC_p/7075 Al composites

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Transactions of Nonferrous metals Society of China 2010年第4期20卷 668-674页

作者： m.RAJAmUTHAmILSELVAN S.RAmANATHAN R.KARTHIKEYAN Department of manufacturing Engineering Annamalai University Department of mechanical Engineering Birla Institute of Technology and Sciences

The hot deformation behaviour of 7075 aluminium alloy reinforced with 10%of SiC particles was studied by employing both"processing maps"and microstructural *** composite was characterized by employing optical microscope to evaluate the microstructural transformations and instability *** material investigated was deformed by compression in the temperature and strain rate ranges of 300-500℃and 0.001-1.0 s-1,*** deformation efficiency was calculated by strain rate sensitivity(m)values obtained by hot compression *** power dissipation efficiency and instability parameters were evaluated and processing maps were constructed for strain of *** optimum domains and instability zone were obtained for the *** optimum processing conditions are obtained in the strain rate range of 0.1-0.9 s-1and temperature range of 390-440 ℃with the efficiency of 30%.

关键词： hot deformation processing maps recrystallization flow instability

Dufour and Soret effects on mHD flow of viscous fluid between radially stretching sheets in porous medium

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Applied mathematics and mechanics(English Edition) 2012年第11期33卷 1403-1418页

作者： m. NAWAZ T. HAYAT A. ALSAEDI Department of Humanities and Sciences Institute of Space Technology Department of mathematics Quaid-I-Azam University Department of mathematics Faculty of Science King Abdulaziz University

The aim of this paper is two-dimensional magnetohydrodynamic viscous fluid bounded by infinite sheets to examine the Dufour and Soret effects on the （mHD） steady flow of an electrically conducting An incompressible viscous fluid fills the porous space. The mathematical analysis is performed in the presence of viscous dissipation, Joule heating, and a first-order chemical reaction. With suitable transformations, the governing partial differential equations through momentum, energy, and concentration laws are transformed into ordinary differential equations. The resulting equations are solved by the homotopy analysis method （HAm）. The convergence of the series solutions is ensured. The effects of the emerging parameters, the skin friction coefficient, the Nusselt number, and the Sherwood number are analyzed on the dimensionless velocities, temperature, and concentration fields.

关键词： magnetohydrodynamic (mHD) flow radial stretching Soret and Dufoureffects porous medium skin friction coefficient

Optimizing micaceous soil stabilization using response surface method

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Journal of Rock mechanics and Geotechnical Engineering 2021年第1期13卷 212-220页

作者： J.Zhang A.Deng m.Jaksa School of Civil Environmental and Mining EngineeringUniversity of AdelaideAdelaideSA 5000Australia

micaceous soil is a problematic soil due to its low strength and poor *** this context,the performances of micaceous soils were improved by applying a combination of granulated blast furnace slag,fiber and polymer *** dosages examined included 0%e30%mica,3%e15%slag and 0.25%e1.25%fiber by weight,and 0.1e0.5 g/L polymer *** of the combinations were found to increase the material strength and ductility,yet to be *** refine the dosage,response surface method was used to conduct experimental design and develop predictive models for material *** developed models formulate the material strength as a nonlinear function of dosages and,by interrogating it,can optimize additive contents in terms of target *** models were verified through trials and can be used to determine dosages to upscale micaceous soils to field conditions.

关键词： Fiber Polymer Central composite design Unconfined compression strength(UCS) mica

Local geoid height approximation and interpolation using moving least squares approach

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Geodesy and Geodynamics 2020年第2期11卷 120-126页

作者： m.Kiani School of Surveying and Geospatial Data Engineering University of TehranTehranIran

In this paper an introduction of the moving least squares approach is presented in the context of data approximation and interpolation problems in *** application of this method is presented for geoid height approximation and interpolation using different polynomial basis functions for the approximant and interpolant,respectively,in a regular grid of geoid height data in the region 16.0417°≤φ≤47.9583°and 36.0417°≤λ≤69.9582°,with increment 0.0833°in both latitudal and longitudal *** results of approximation and interpolation are then compared with the geoid height data from GPS-Levelling *** the standard deviation of the difference of the results,it is shown that the planar interpolant,with reciprocal of distance as weight function,is the best choice in this local approximation and interpolation problem.

关键词： Approximation and interpolation points GPS-Levelling moving Least Squares Geoid height Grid points

Social Isolation in male Rats During Adolescence Inhibits the Wnt/β-Catenin Pathway in the Prefrontal Cortex and Enhances Anxiety and Cocaine-Induced Plasticity in Adulthood

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Neuroscience Bulletin 2020年第6期36卷 611-624页

作者： Santiago Cuesta Alejandrina Funes Alejandra m.Pacchioni Area Toxicologia Departamento de Ciencias de los Alimentos y del MedioambienteFacultad de Ciencias Bioquimicas y FarmaceuticasUniversidad Nacional de RosarioSuipacha 5312000 RosarioSanta FeArgentina Consejo Nacional de Investigaciones Cientificas y Tecnicas RosarioArgentina Present Address:Department of microbiology University of Texas Southwestern Medical CenterDallasTX 75390USA

In adult animals,it is well established that stress has a proactive effect on psychostimulant ***,whether only a short period of stress during adolescence can also affect cocaine responses later in life and what mechanisms are involved are ***,we showed that 5 days of social isolation during rat adolescence had a long-term impact on anxiety-like behaviors,cocaine-induced conditioned place preference,and the expression of sensitization during *** the molecular level,social isolation decreased the activity of the Wnt/β-catenin pathway in the prefrontal cortex(PFC).Furthermore,after the expression of cocaine sensitization,isolated rats showed an increase in this pathway in the nucleus ***,these findings suggest that,adolescent social isolation by altering the Wnt/β-catenin pathway in the developing PFC might increase the cocaine responses during adulthood,introducing this pathway as a novel neuroadaptation in the cortical-accumbens connection that may mediate a stress-induced increase in vulnerability to drugs.

关键词： Social isolation Adolescence Cocaine vulnerability Wnt/(i-catenin pathway