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Association between Liver Enzymes and Dyslipidemia in Yemeni Patients with Type Two Diabetes Mellitus

Journal of Diabetes Mellitus 2021年第2期11卷 41-51页

作者： lotfi S. Bin Dahman Mariam A. Humam Omer H. Barahim Omer M. Barahman Mohamed A. Balfas Medical Laboratory Sciences Department College of Medicine and Health Sciences Hadhramout University Mukalla Yemen Medicine Department College of Medicine and Health Sciences Hadhramout University Mukalla Yemen Basic Medical Sciences College of Medicine and Health Sciences Hadhramout University Mukalla Yemen

The correlation between liver enzymes and lipid profile in T2D patients in the Yemeni population has been evaluated. This is a case-control study comprising 142 T2D patients and 142 healthy control subjects were carried out at the outpatient clinics of Ibn-Sina hospital, Mukalla, during the period from January to May 2020. Serum fasting blood glucose (FBG), total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) were analyzed using the Cobas Integra Plus 400 autoanalyzer. Also, anthropometric and blood pressure measurements were taken from each participant. Independent sample T-test and Pearson correlation coefficient were used. T2D patients had significantly higher FBG (P ≤ 0.0001), total cholesterol (P ≤ 0.0001), LDL-C (P ≤ 0.0001), and GGT (P ≤ 0.0001) while HDL-C was significantly lower in T2D patients (P = 0.021). In correlation analysis, serum GGT was positively associated with FBG (r = 0.216;P ≤ 0.0001), total cholesterol (r = 0.196;P = 0.0001), triglyceride (r = 0.123;P = 0.038), and LDL-C (r = 0.209;P ≤ 0.0001). Also, serum ALT was positively associated with FBG (r = 0.145, P = 0.014) and triglyceride (r = 0.172, P = 0.004). In conclusion, higher levels of ALT and GGT are used as the predictive biomarkers for NAFLD in T2D patients with hyperlipidemia. Thus, routine screening of liver enzymes and lipid profile in T2D patients is recommended for the early detection of liver abnormalities and diminish diabetes complications.

关键词： Liver Enzymes Dyslipidemia Type 2 Diabetes Mellitus Yemeni Patients

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Randomized controlled trial of remote ischemic preconditioning and atrial fibrillation in patients undergoing cardiac surgery

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World Journal of Cardiology 2016年第10期8卷 615-622页

作者： Amir S lotfi Hossein Eftekhari Auras R Atreya Ananth Kashikar Senthil K Sivalingam Miguel Giannoni Paul Visintainer Daniel Engelman Department of Cardiology Baystate Medical Center Tufts University School of Medicine Department of Anesthesiology Baystate Medical Center Tufts University School of Medicine Department of Epidemiology and Biostatistics Baystate Medical Center Tufts University School of Medicine Department of Cardiac Surgery Baystate Medical Center Tufts University School of Medicine

AIM To study whether remote ischemic preconditioning(RIPC) has an impact on clinical outcomes, such as post-operative atrial fibrillation(POAF).METHODS This was a prospective, single-center, single-blinded,randomized controlled study. One hundred and two patients were randomized to receive RIPC(3 cycles of 5 min ischemia and 5 min reperfusion in the upper arm after induction of anesthesia) or no RIPC(control). Primary outcome was POAF lasting for five minutes or longer during the first seven days after surgery. Secondary outcomes included length of hospital stay, incidence of inpatient mortality, myocardial infarction, and stroke. RESULTS POAF occurred at a rate of 54% in the RIPC group and 41.2% in the control group(P = 0.23). No statistically significant differences were noted in secondary outcomes between the two groups. CONCLUSION This is the first study in the United States to suggest that RIPC does not reduce POAF in patients with elective or urgent cardiac surgery. There were no differences in adverse effects in either group. Further studies are required to assess the relationship between RIPC and POAF.

关键词：长期的 ischemic 心疾病心脏的外科冠的动脉疾病另外的治疗遥远的 ischemic preconditioning 手术后的 atrial 纤维性颤动

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Evaluation of the Three Glucometer Devices Performance in Comparison with the Cobas Integra 400 Plus Autoanalyzer in Measuring Blood Glucose Levels: A Comparative Cross-Sectional Study

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Journal of Diabetes Mellitus 2021年第4期11卷 132-142页

作者： lotfi S. Bin Dahman Ahmed M. Daakeek Hussein S. Alghazali Abdullah M. Kaity Munir S. Obbed Department of Medical Biochemistry College of Medicine and Health Sciences Hadhramout University Mukalla Yemen Department of Internal Medicine College of Medicine and Health Sciences Hadhramout University Mukalla Yemen Department of Community Medicine and Public Health College of Nurse Hadhramout University Mukalla Yemen Department of Chemistry College of Science Hadhramout University Mukalla Yemen

Objective: The study aimed to evaluate the performance of the three glucometers compared to standard the laboratory method (Cobas Integra 400 Plus) in measuring blood glucose levels. Patients and Methods: A total of 100 Yemeni diabetic patients were randomly recruited into a comparative cross-sectional study. Venous and finger-pricked blood samples were obtained from all participants and used for blood glucose levels measurement following the standard procedures. Results: The mean blood glucose levels for one-hundred diabetic patients using the Gluco Contour TS and Gluco SD Codefree were not significantly different compared with the Cobas Integra 400 Plus (12.14 ± 6.89 mmol/L vs. 12.85 ± 8.83 mmol/L, P = 0.159;12.50 ± 7.18 mmol/L vs. 12.85 ± 8.83 mmol/L, P = 0.490), respectively. However, there is a significant difference using the Gluco Alert device from that of the Cobas Integra 400 Plus (11.83 ± 6.94 mmol/L vs. 12.85 ± 8.83 mmol/L, P = 0.046). Furthermore, using the ROC curve at a 95% confidence interval, the Cobas Integra 400 Plus showed a significant agreement with the Gluco Contour TS (51.4%), Gluco SD Codefree (50.4%), and Gluco Alert (39.3%), respectively. For determining accuracy, the sensitivity of the glucometer devices was the following: Gluco SD Codefree (87.3%), Contour TS (85.9%), and Gluco Alert (78.9%). In this regard, the highest specificity was related to Gluco Contour TS (65.5%). Conclusion: The correlation between both methods was good, with high sensitivity and specificity in measuring blood glucose levels as indicated by the ROC curve. Thus, we suggest using these glucometers at homes and hospitals as a point of care for diabetic patients.

关键词： Diabetes Mellitus Blood Glucose Levels Glucometers Cobas Integra 400 Plus Autoanalyzer

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Does Argan Oil Supplementation Affect Metabolic Parameters and Behavior in Wistar Rats?

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Food and Nutrition Sciences 2015年第9期6卷 816-824页

作者： Rim Bousalham Laila Jahidi Rhazali Amal Harmouch Hamid lotfi Bouchra Benazzouz Aboubaker El Hessni Ali Ouichou Omar Akhouayri Abdelhalem Mesfioui Laboratory of Genetic Neuroendocrinology and Biotechnology Faculty of Sciences Ibn Tofail University Kenitra Morocco Laboratory RHAZALI of Pathological Anatomy Kenitra Morocco Laboratory DHL of Biomedical Analysis Kenitra Morocco

Argan oil is renowned for its particular biochemical profile: high-fat oleic and linoleic acids, tocopherols, sterols, polyphenols. This composition gives it nutritional, therapeutic and preventive properties against dermatological, metabolic and proliferative diseases. The composition of argan oil assigns its benefits to mental health;it would be provided with possible effects on the prevention and/or cure of stress related disorder. This work aims to evaluate the impact of argan oil dietary on the behavioral response, biochemical and hematological constants and histological profiles of adrenal involved in emotional responses to stress. The variation of these parameters was evaluated in Wistar rats receiving dietary 10 ml/Kg/day of argan oil, starting from weaning, for 13 weeks. Our results show that supplementation has resulted in an increase in locomotor activity, reduced sensitivity to frightening environments with sex dependent variation. Moreover, lipid markers, corticosterone and lymphocytes show a rising trend. If the important role of argan oil diet in cardio-metabolic health is generally well recognized;for mental health, it is the first study that needs further investigation linking between the nervous system, inflammation parameters and metabolism.

关键词： Argan Oil Supplementation Wistar Rats Biochemical Profile Hematological Profile Behavioral Tests Histological Study Stress Related Disorders Epigenetic

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The influence of chromium ions on the growth of the calcium hydroxyapatite crystal

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Journal of Biophysical Chemistry 2012年第4期3卷 283-286页

作者： Samira M. Sallam Khairi M. Tohami Abdelsattar M. Sallam lotfi I. Abo Salem Faten Adel Mohamed Department of BioPhysics Science College Ain Shams University Cairo Egypt Department of BioPhysics Science College Cairo Egypt Department of Physics Science College Benha University Benha Egypt

Hydroxyapatite (Ca10(PO4)6(OH)2) is widely used as bio-ceramic materials and as adsorbents for separation of bio-molecules. These materials have also been used as adsorbents for heavy metals, supports and as catalysts in oxidation and dehydrogenation reactions. The catalytic performance of these materials depend on the lattice substitution of Ca sites in Hydroxyapatite structure by varied cations as Na, Mg, Sr and Mn, which result in changes in various structural pro perties as crystallinity and morphology. Pure calcium hydroxyapatite (S1) and Cr loaded hydroxyl apatite (S2, S3, S4 and S5) of different chromium concentrations have been prepared by wet precipitated method. An in-vitro examination is essential to investigate the mechanism of the deficient HA and tissue interface reaction by preparing SBF (Simulated Body Fluid) through the elemental and chemical analysis of Ca, P and Cr. FTIR used to analyze the samples after incubation in SBF for 24 day. PH of the samples also was measured at the first period of immersion time. At high loading of chromium ions, the formation of carbonate apatite decrease. The concentrations of the chromium in the Cr_HA crystal during the soaking in SBF are very safe dose for human.

关键词： Hydroxyapatite Crystal Calcium Growth Crystallinity Bioceramics

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Synthesis and characterization of hydroxyapatite contain chromium

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Journal of Biophysical Chemistry 2012年第4期3卷 278-282页

作者： Samira M. Sallam Khairi M. Tohami Abdelsattar M. Sallam lotfi I. Abo Salem Faten Adel Mohamed Department of BioPhysics Science College Ain Shams University Cairo Egypt Department of BioPhysics Science College El Azhar University Cairo Egypt Department of Physics Science College Benha University Banha Egypt

Hydroxy apatite (HA) is a biocompatible material used as bone-substitute materials in both orthopedics and dentistry due to its excellent osteo-conductive and chemical composition similar to that of the inorganic part of bone in comparison with other implant materials . HA (S1) and Cr loaded hydroxy apatite (S2, S3, S4 and S5) of different chromium concentrations have been prepared. many techniques used to analyze the changes occurred due to the substitution. The XRD (X-ray diffraction) and FTIR (Fourier transform infrared radiation )spectroscopy were used as analytical techniques for the prepared HA and Cr loaded HA. The effect of the heat treatment on structural change of the samples was examined by DTA. It was found that all the samples have the same crystalline structure. The crystallinity of the samples decreased as the chromium ions concentration increase.

关键词： Component Formatting Style Styling Insert

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求解逻辑函数的最简积之模2和表达式组

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计算机工程与设计 1981年第3期 63-71页

作者： Z.M.lotfi 王汉生杨冬平

用异或运算覆盖方程式求解逻辑函数的最简积之模2和表达式。

关键词：函数代表方程式方程卡诺图等式表达式异或运算积之二进制变量结构成本异或门门电路

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A comparison study of the nutritional, mineral and volatile compositions of three dry forms of ginger rhizomes, and antioxidant properties of their ethanolic and aqueous extracts

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Journal of Coastal Life Medicine 2017年第2期5卷 70-76页

作者： Aicha Jelled Hassiba Chahdoura Guido Flamini Amira Thouri Amira El Arem Khawla Adouni Zohra Haouas Isabel C.F.R.Ferreira lotfi Achour Hassen Ben Cheikh Laboratory of Histology and Cytogenetics(UR12ES10) Faculty of MedicineUniversity of MonastirMonastirTunisia Laboratory of Bioressources Integrative Biology and Valorisation(LR14ES06)High Institute of BiotechnologyUniversity of MonastirMonastirTunisia Mountain Research Centre Higher Agricultural SchoolPolytechnic Institute of BragancaCampus of Santa Apolonia11725301-855 BragancaPortugal Interdepartmental Research Centre"Nutraceutical and Food for Health" University of PisaPisaItaly

Objective:To compare the most accessible dry forms of ginger rhizomes (Zingiber officinale) used as a spice and as a remedy in order to choose the best ginger for medicinal purpose. Methods:Freshly air dried ginger, commercially dry rhizomes and ginger available in powder form are investigated in terms of nutritional values (proximate and mineral compositions) and volatiles profile. Ethanolic and aqueous extracts (decoctions and infusions) were prepared for total phenolic, flavonoid and tannin contents determination. Also, three standard tests were established in order to estimate the best extract with the better antioxidant potential. Results:The results showed unlike proximate composition revealing different nutritional values. In fact, freshly dried ginger contained much ash, while already dry samples contained much protein. In addition, mineral contents of studied samples indicated their dissimilar richness especially in Ca, Mg, Na, K, Cu, Fe, and Mn. Solid phase micro-extraction gave volatile profiles with many interesting compounds, only 26 from the 51 identified components were common to studied samples with bioactive compounds predominance in freshly dried sample. Also, the antioxidant potential established by three different tests was higher in already dry samples and was positively correlated with their higher contents in the determined phytochemicals. The ethanolic extracts showed higher antioxidant activities than aqueous extracts. Decoctions and infusions were almost similar proving that long cooking time did not affect ginger antioxidant potential. Conclusions:This work highlighted the benefits of traditional preparations of ginger as sources of bioactive compounds, namely antioxidants, and proved that the available commercial samples are not identical and encouraged analyzing samples before uses depending on needs.

关键词： Zingiber officinale Dry forms Minerals Aroma volatiles Antioxidant properties

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Aerobic Spore-Forming Bacteria in the Ultra High Temperature Milk Produced in the North West of Algeria

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Journal of Agricultural Science and Technology(A) 2013年第9期3卷 697-702页

作者： lotfi Ghellai Boumediene Moussaboudjemaa Department of Biology Laboratory of Applied Microbiology in Food Biomedical and Environment (LAMAABE) University ofTlemcen Tlerncen 13000 Algeria

The occurrence of the spore-forming bacteria in different segments of production lines of Ultra High Temperature (UHT) milk of a commercial plant and its transfer to the final product was studied. The samples were collected from different segments of production lines from reception to packaging sections, over a period of 75 days at a rate of one sampling a week, from plants in North West of Algeria. The total colony count of aerobic spore-forming bacteria was done using Plate Count Agar (PCA) method. The results showed that there was more than 1 × 103 CFU/mL at the level of 50%, 25%, 37.5%, 62.5% and 37.5% of the analyzed samples of milk powder, pasteurized milk, UHT milk (before storage), UHT milk stored at 55 °C for 7 days and UHT milk stored at 30 °C for 14 days, respectively. The mean total colony count of aerobic spore-forming bacteria was considerably lower in the UHT milk than in the other samples, while the higher proportion of aerobic spore-forming bacteria was noticed to be 32.58% and 30.90% in the UHT milk stored at 55 °C and 30 °C, respectively. The results obtained by the classic biochemical identification (Bacillus API 20E), interpreted by software of calculation for microbial identification reflected the presence of especially Bacillus sphaericus. The other species found were: Bacillus cereus, Bacillus subtilis, Bacillus coagulans, Bacillus licheniformis and Bacillus stearothermophilus. The study reveals that the proportion of aerobic spore-forming bacteria in the final product depends on temperature and storage periods.

关键词：细菌菌落总数超高温灭菌奶孢子形成阿尔及利亚好氧西北球形芽孢杆菌嗜热脂肪芽孢杆菌

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Evaluation of Liver Function tests （AST ＆ ALT） in Patients with Hepatitis B and C in Tabriz-lran （2013）

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Journal of Pharmacy and Pharmacology 2015年第1期3卷 27-32页

作者： Navid Sarakhs Asbaghi Kazem Ghahreman Zadeh Taher Faraj Zadeh Javid lotfi Attari Zahra Javan Masoomi Rana Faraj Zadeh Mohammad Reza Tarmohammadi Alireza Bakhtarai Behzad Bahrain Zadeh Babak Morshed Zadeh Faculty of Basic Sciences Department of Genetics lslamic Azad University Tabriz 51589 Iran Clinical Central Lab of Province Tabriz 51589 Iran

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