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Mechanisms of tyrosine kinase inhibitor resistance in renal cell carcinoma

Cancer Drug Resistance 2023年第4期6卷 858-873页

作者： Patrick L.sweeney Yash suri Arnab Basu vadim s.koshkin Arpita Desai Deming Department of Medicine Tulane University School of MedicineNew OrleansLA 70112USA University of Arizona College of Medicine TucsonAZ 85724USA Division of Hematology and Oncology Department of MedicineUniversity of Alabama at Birmingham Heersink School of MedicineBirminghamAL35233USA Division of Hematology and Oncology Department of MedicineUniversity of California at San Francisco School of MedicineSanFranciscoCA94143USA

Renal cell carcinoma(RCC),the most prevalent type of kidney cancer,is a significant cause of cancer morbidity and mortality *** tyrosine kinase inhibitors(TKls),in combination with immune checkpoint inhibitors(ICls),are among the first-line treatment options for patients with advanced *** therapies target the vascular endothelial growth factor receptor(VEGFR)tyrosine kinase pathway and other kinases crucial to cancer proliferation,survival,and *** have yielded substantial improvements in progression-free survival(PFs)and overall survival(Os)for patients with advanced ***,nearly all patients eventually progress on these drugs as resistance *** review provides an overview of TKl resistance in RCC and explores different mechanisms of resistance,including upregulation of alternative proangiogenic pathways,epithelial-mesenchymal transition(EMT),decreased intracellular drug concentrations due to efflux pumps and lysosomal sequestration,alterations in the tumor microenvironment including bone marrow-derived cells(BMDCs)and tumor-associated fibroblasts(TAFs),and genetic factors such as single nucleotide polymorphisms(sNPs).A comprehensive understanding of these mechanisms opens the door to the development of innovative therapeutic approaches that can effectively overcome TKl resistance,thereby improving outcomes for patients with advanced RCC.

关键词： Antiangiogenic tyrosine kinase inhibitors renal cell carcinoma acquired resistance sunitinib tumor microenvironment immune checkpoint inhibitors

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Thermogravimetric,kinetic study and gas emissions analysis of the thermal decomposition of waste-derived fuels

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Journal of Environmental sciences 2024年第3期137卷 155-171页

作者： vadim V.Dorokhov Galina s.Nyashina Pavel A.strizhak Heat and Mass Transfer Laboratory National Research Tomsk Polytechnic University30 Lenin AvenueTomsk 634050Russia

A wide range of wastes can potentially be used to generate thermal and electrical *** co-combustion of several types of waste as part of water-containing waste-derived fuels is a promising method for their *** this research,we use thermogravimetric analysis and differential scanning calorimetry to study the thermal behavior and kinetics of coal slime,biomass,waste oils,and blends on their *** also analyze the concentrations of gaseous *** results show that biomass,oils,and coal slime significantly affect each other in the course of their co-combustion when added to slurry *** preparation of coal-water slurry based on slime and water reduced the ignition and burnout temperature by up to 16%.Adding biomass and waste oils additionally stimulated the slurry ignition and burnout,which occurred at lower *** to dry coal slime,threshold ignition temperatures and burnout temperatures decreased by 6%–9%and 17%–25%,***,the use of biomass and waste oils as part of slurries inhibited NOхand sO_(2)emission by 2.75 *** to the kinetic analysis,added biomass and waste turbine oil provide a 28%–51%reduction in the activation energy as compared to a coal-water slurry without additives.

关键词： Coal-water slurry Water-containing composite fuels Combustion Emission Kinetic TGA-DsC

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Lattice-based digital signatures

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National science Review 2021年第9期8卷 9-10页

作者： vadim Lyubashevsky Zurich Research Laboratory IBM Research

Digital signatures and key exchange protocols are the two most important public key cryptographic primitives used in the electronic transmission of data. The goal of key exchange is to preserve the secrecy of the communication, while the goal of digital signatures is to guarantee the authenticity of the exchanged messages. Constructions of digital signature schemes based on classical mathematical assumptions appeared shortly following the invention of public key cryptography in the late 1970s. And just like with key exchange,

关键词： lattice cryptography digital signatures standardization

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Kaapvaal lamproite melts(aka orangeites):A new type of alkalicarbonate liquid?insights from olivine-hosted multiphase inclusions(silvery Home,south Africa)

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Geoscience Frontiers 2024年第5期15卷 308-322页

作者： Adam Abersteiner Alexey Tarasov Alexander Golovin Geoffrey H.Howarth vadim s.Kamenetsky Department of Geosciences and Geography Research Programme of Geology and Geophysics(GeoHel)University of HelsinkiFinland Institute for sustainability Energy and ResourcesThe University of AdelaideAdelaide SA-5005Australia Department of Earth sciences School of Physical SciencesThe University of AdelaideAdelaide SA-5005Australia V.s.sobolev Institute of Geology and Mineralogy siberian Branch Russian Academy of SciencesRussia Department of Geological sciences University of Cape TownRondebosch 7701South Africa Center of Deep sea Research Institute of OceanologyChinese Academy of Sciences266071 QingdaoChina

Kaapvaal lamproites(aka orangeites)are a group of volatile-rich(H_(2)O,CO_(2)),micaceous,ultrapotassic igneous rocks that are unique to the Kaapvaal craton in southern ***,the composition of the melts that give rise to these rocks remains poorly understood due to overprinting effects of contamination by mantle and crustal material,volatile exsolution,fractional crystallisation and post-magmatic ***,this lack of reliable data on the initial composition of the Kaapvaal lamproite melts hampers our understanding of their source,petrogenesis and ascent *** is a common mineral comprising the Kaapvaal lamproites that has both xenocrystic(i.e.,mantle)and magmatic *** inclusions(melt/fluid)entrapped within olivine have been consistently demonstrated as an effective tool for gaining fundamental insights into the composition and evolution of melts that produce both kimberlites and lamproites,prior to processes,such as eruption,devolatization and syn-/post-magmatic *** this study,multiphase inclusions of both secondary and pseudosecondary origin hosted in olivine from a Kaapvaal lamproite(silvery Home,south Africa)provide novel insights into the composition of the melt(s)that initially transported olivine to the surface and then crystallised after emplacement to form the lamproite *** inclusions in our study contain daughter mineral assemblages consisting of diverse Ca-Mg carbonates,including K-,Na-,Ba-,and sr-bearing varieties,moderate K-rich silicates(phlogopite,tetraferriphlogopite),and subordinate oxides,phosphates,sulphides,sulphates,and *** on these daughter mineral assemblages,we suggest that the composition of the melt entrapped by olivine was siO_(2)-poor,Ca-Mg carbonate-rich and contained elevated concentrations of K,Na,Ba,sr,P and *** mineral and reconstructed melt compositions are in stark contrast to the mineral association of the groundmass and the bulk-rock composition

关键词： Lamproite Kaapvaal Multiphase inclusions Olivine Orangeite

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A Numerical Analysis of Turbulent Compressible Radial Channel Flow with Particular Reference to Pneumatic Controllers

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Journal of Thermal science 2004年第1期13卷 24-29页

作者： Gilles Roy Dinh Vo-Ngoc vadim Bravine Faculty of Engineering Université de MonctonMonctonNBCanadaE1A 3E9Faculty of EngineeringUniversité de MonctonMonctonNBCanadaE1A 3E9Faculty of EngineeringUniversité de MonctonMonctonNBCanadaE1A 3E9

A numerical analysis of turbulent axisymmetric radial compressible channel flow between a nozzle and a flat plate is presented in this paper. In particular, the application of this type of flow situation in pneumatic dimensional control systems is considered. The spalart-Allmaras one-equation turbulence model is used. The resulting highly coupled PDE system has been solved using the control volume based numerical approach where the power-law scheme was used extensively to compute the diffusive and convective fluxes of momentum. Results show that local Mach numbers can easily achieve and surpass unity for typical industrial configurations. Also, in the case of a standard industrial nozzle geometry, the presence of a toroidal recirculation zone that moves radially outward is clearly identified in most cases. separated flow areas are of particular concern as it has been shown previously that they can cause nozzle fouling in industrial applications. It has been shown that the size of this region is dependant on feed pressure. Considerable differences between results obtained using the spalart-Allmaras and standard k- εturbulence models have also been noticed.

关键词： compressible radial flow numerical simulation pneumatic controllers impinging jet with confinement.

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Russian Nuclear Rocket Engine Design for Mars Exploration

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Tsinghua science and Technology 2007年第3期12卷 256-260页

作者： vadim Zakirov Vladimir Pavshook Tsinghua space Center School of AerospaceTsinghua University Russian Research Center "Kurchatov Institute" Kurchatov Sq.1Moscow 123182Russia

This paper is to promote investigation into the nuclear rocket engine （NRE） propulsion option that is considered as a key technology for manned Mars exploration. Russian NRE developed since the 1950s in the former soviet Union to a full-scale prototype by the 1990s is viewed as advantageous and the most suitable starting point concept for manned Mars mission application study. The main features of Russian heterogeneous core NRE design are described and the most valuable experimental performance results are summarized. These results have demonstrated the significant specific impulse performance advantage of the NRE over conventional liquid rocket engine （LRE） propulsion technologies. Based on past experience, the recent developments in the field of high-temperature nuclear fuels, and the latest conceptual studies, the developed NRE concept is suggested to be upgraded to the nuclear power and propulsion system （NPPs）, more suitable for future manned Mars missions. Although the NRE still needs development for space application, the problems are solvable with additional effort and funding.

关键词： nuclear rocket engine Mars exploration propulsion technology design

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Propulsion Challenges for small spacecraft: 2005

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Tsinghua science and Technology 2006年第5期11卷 507-514页

作者： vadim Zakirov 李路明 Tsinghua space Center School of Aerospace Tsinghua University

small （〈100 kg） spacecrafts are being developed in many countries but their propulsion systems still have many challenges. Although there is demand for small spacecraft propulsion, the number of missions at present is small due to several commercial and technical reasons. Poor performance of existing small spacecraft propulsion systems is one of the main reasons for the small number of missions. several reasons are given for the poor performance of existing small spacecraft propulsion. suggested improvements focus on small spacecraft and propulsion hardware mass optimization rather than on specific impulse enhancement. Propellantless propulsion systems are also recommended for small spacecraft interplanetary missions.

关键词： propulsion small spacecraft performance enhancement payload

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The Berezitovoe gold-polymetallic deposit(Upper Amur region,Russia)：structure,mineralogy and genetic aspects

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Geoscience Frontiers 2016年第3期7卷 483-494页

作者： Alexandr s. Vakh vadim G. Khomich Natalia G. Boriskina M. santosh far East Geological Institute Far East Branch of Russian Academy of Sciences 159 Prospect 100 let Vladivastoku Vladivostok 690022 Russia school of Engineering Far Eastern Federal University 8 Suhanova St. Vladivostok 690950 Russia Department of Earth sciences University of Adelaide SA 5005 Australia school of Earth sciences and Resources China University of Geosciences Beijing 29 Xueyuan Road Beijing 100083 China

The Berezitovoe deposit in the sergachi volcano-plutonic and metallogenic belt preserves evidence for polymetallic mineralization of multiple *** steeply dipping gamet-tourmaline-muscovite-quartz metasomatites（with K-Ar ages of 132 ± 2.9 and 127 ± 4.4 Ma） carry two distinct stages of mineralization developed at different times：（1） polymetallic mineralization and（2） *** deposit is located within Paleozoic gneissose granitoids of the Pikansky complex（dated as 379 ± 1.1 Ma by zircon U-Pb method） intruded by early Cretaceous porphyry-like granites of the Haikta pluton（dated as137 ± 0.67 Ma by zircon U-Pb method） and late Cretaceous dikes of porphyrites,porphyries,and *** suggests the action of late gold-bearing hydrothermal fluids on the early polymetallic ores and the selective mobilization of some elements from these lead to redeposition together with complex sulphosalts.

关键词： Amur River head Gold Early Cretaceous Metallogeny Tectonics

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Effect of spring grass fires on vegetation patterns and soil quality in abandoned agricultural lands at local and landscape scales in Central European Russia

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Ecological Processes 2018年第1期7卷 448-466页

作者： Larisa G.Khanina vadim E.smirnov Michael s.Romanov Maxim V.Bobrovsky Institute of Mathematical Problems of Biology RAs branch of the M.V.Keldysh Institute of Applied Mathematics of the Russian Academy of Sciences1 Prof.Vitkevich StPushchinoMoscow Region 142290Russia Center for Forest Ecology and Productivity of the Russian Academy of sciences 84/32 bldg.14 Profsoyuznaya StMoscow 117997Russia Institute of Physico-Chemical and Biological Problems in soil science of the Russian Academy of sciences 2 Institutskaya StPushchinoMoscow Region 142290Russia

Introduction:Abandonment of agricultural land is often happening all over the world and widespread in *** lands are subject to successional changes in vegetation and it seems necessary to provide effective methods for a sustainable ecosystem management of those ***,factors which determine successional processes,especially fires,have not been studied in *** aim of this article is to reveal how spring grass fires affect the abandoned arable lands in the study area at the landscape and local ***:A region of 265.5 km2 located in the south of Moscow was *** the landscape scale,we analyzed the spatial characteristics of the area in relation with a 30-year history of spring fire events extracted from the Landsat archive,and climatic *** regression was *** the local scale,we sampled soil and vegetation at two sites and in three biotopes at each site:mature forest and two neighboring biotopes affected and unaffected by *** species diversity,soil quality,and relationship between soil and vegetation were assessed by ANOVA,v test,NMDs,and ***:Abandoned lands covered 39%of the study area and not less than 72% of these were affected by grass fires,happening mainly between 1998 and *** causes the ignition of the field layer accidentally,but the area over which the fire spreads is determined by climatic factors and the presence of flammable material(dry grass and litter)for *** March temperatures and low precipitation values in April increase the inflammability of dry grasses which are abundant on the former *** a result,burnt areas are steadily expanding in abandoned lands where trees are *** abandoned lands that were either affected or unaffected by fires,two different plant communities developed,respectively:grassy vegetation mainly dominated by Calamagrostis epigeios and young forest of pioneer trees with high crown *** all soil variables were statistically diffe

关键词： soil forest landscape

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Peculiarities of Ethylene Polymerization Reactions with Bis(imino)pyridyl Complexes of CoCl_(2) and FeCl_(2)

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Chinese Journal of Polymer science 2024年第4期42卷 492-500页

作者： Laura A.Rishina Yury V.Kissin svetlana s.Lalayan Artem A.Antonov vadim G.Krasheninnikov Alexander A.Gulin N.N.semenov Federal Research Center for Chemical Physics Russian Academy of Sciences4 Kosygin St.Moscow119991Russia Department of Chemistry and Chemical Biology RutgersThe State University of New Jersey123 Bevier Rd.PiscatawayNJ08854USA Boreskov Institute of Catalysis Russian Academy of Sciences5 Lavrentieva Prosp.Novosibirsk630090Russia

The article describes ethylene polymerization reactions with transition metal catalysts based on complexes of CoCl_(2) and FeCl_(2) with an N,N,N-tridentate ligand 2,6-bis[1-(2,6-dimethylphenylimino)ethyl]pyridine. The complexes are converted into polymerization catalysts by reacting them either with polymethylalumoxane (MAO) or with a combination of Al(C2H5)2Cl and Mg(C4H9)2 at an [Al]:[Mg] ratio of ~3. Both MAO-activated complexes readily polymerize ethylene at 35 ℃ with the formation of linear, low molecular weight polymers with a narrow molecular weight distribution. The same complexes, when activated with the Al(C2H5)2Cl-Mg(C4H9)2 combination, form multi-center catalysts and generate polyethylenes with a broad molecular weight distribution.

关键词： Ethylene polymerization Bis(imino)pyridyl complexes of CoCl_(2)and FeCl_(2) Molecular-weight distribution Polymer chain structure

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